Research Topics
| Loren G MillerSummaryAffiliation: University of California Country: USA Publications
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Publications
Staphylococcus aureus colonization among household contacts of patients with skin infections: risk factors, strain discordance, and complex ecologyLoren G Miller
Division of Infectious Diseases, Harbor UCLA Medical Center, and Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90509, USA
Clin Infect Dis 54:1523-35. 2012..aureus infections in the U.S. However, epidemiologic characteristics of S. aureus household transmission are poorly understood...
High-risk sexual behavior in Los Angeles: who receives testing for HIV?L G Miller
Division of Infectious Diseases, VA Greater Los Angeles Healthcare System, UCLA Medical Center, and UCLA AIDS Institute, Los Angeles, California 90509, USA
J Acquir Immune Defic Syndr 22:490-7. 1999..However, testing among this group remains suboptimal. Future public health campaigns should intensify efforts to encourage HIV testing among this population...- Clinical and epidemiologic characteristics cannot distinguish community-associated methicillin-resistant Staphylococcus aureus infection from methicillin-susceptible S. aureus infection: a prospective investigationLoren G Miller
Division of Infectious Diseases, Harbor University of California Los Angeles UCLA Medical Center, Torrance, CA 90509, USA
Clin Infect Dis 44:471-82. 2007..aureus infections who have risk factors for acquisition of MRSA. However, there are no prospective data examining this approach... - A prospective investigation of outcomes after hospital discharge for endemic, community-acquired methicillin-resistant and -susceptible Staphylococcus aureus skin infectionLoren G Miller
Division of Infectious Diseases, Harbor University of California Los Angeles UCLA Medical Center, Torrance, CA 90509, USA
Clin Infect Dis 44:483-92. 2007..Although community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection has become increasingly common, prospective data on outcomes of patients with skin infection remain poorly defined... 
Clinical practice: colonization, fomites, and virulence: rethinking the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infectionLoren G Miller
Division of Infectious Diseases, Harbor University of California Los Angeles, Torrance, CA, USA
Clin Infect Dis 46:752-60. 2008....- Staphylococcus aureus: a community pathogenLoren G Miller
Harbor UCLA Medical Center, Division of Infectious Diseases, Infection Control Program, 1000 W Carson Street, Box 466, Torrance CA 90509, USA
Infect Dis Clin North Am 23:35-52. 2009..This article reviews current knowledge of the epidemiology and clinical manifestations of community-associated S aureus and CA-MRSA infections... - Impact of methicillin-resistant Staphylococcus aureus prevalence among S. aureus isolates on surgical site infection risk after coronary artery bypass surgeryLoren G Miller
Infectious Diseases Clinical Outcomes Research Unit ID CORE, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Los Angeles, California, USA
Infect Control Hosp Epidemiol 32:342-50. 2011..aureus isolates (hereafter, "MRSA prevalence"); however, "high" remains undefined. We sought to identify the MRSA prevalence at which glycopeptide prophylaxis would minimize SSIs relative to β-lactam prophylaxis... - No evidence of an association between transient HIV viremia ("Blips") and lower adherence to the antiretroviral medication regimenLoren G Miller
Division of Infectious Diseases, Harbor UCLA Medical Center, and Harbor UCLA Research and Education Institute, and UCLA AIDS Institute Center for AIDS Research, University of California Los Angeles, Los Angeles, California, USA
J Infect Dis 189:1487-96. 2004..We investigated this relationship in a prospective observational cohort of 128 patients initiating a new regimen... - Prospective investigation of nasal mupirocin, hexachlorophene body wash, and systemic antibiotics for prevention of recurrent community-associated methicillin-resistant Staphylococcus aureus infectionsLoren G Miller
Harbor UCLA Medical Center, Torrance, California, USA
Antimicrob Agents Chemother 56:1084-6. 2012..The mean number of MRSA infections after the intervention decreased significantly from baseline (0.03 versus 0.84 infections/month, P = <0.0001). This regimen appears promising at preventing recurrent CA-MRSA infections... - Knowledge of antiretroviral regimen dosing and adherence: a longitudinal studyLoren G Miller
Division of Infectious Diseases, Harbor University of California, Los Angeles UCLA Medical Center, Torrance 90502, USA
Clin Infect Dis 36:514-8. 2003..03). Because knowledge deficits are common after antiretroviral regimen initiation, clinicians should assess patients' understanding of medication dosing soon after regimen initiation or change... - Impact of antiretroviral regimen switches on adherenceLoren G Miller
Division of Infectious Diseases, Harbor UCLA Medical Center, Torrance, California 90509, USA
HIV Clin Trials 3:355-60. 2002..We investigated whether a switch in antiretroviral medications affected adherence by examining a prospective observational cohort of 128 patients who began a new antiretroviral regimen... - How well do clinicians estimate patients' adherence to combination antiretroviral therapy?Loren G Miller
Division of Infectious Diseases, Harbor UCLA Medical Center, Torrance Calif, 90509 USA
J Gen Intern Med 17:1-11. 2002..However, little is known about the accuracy of these assessments. We sought to describe the accuracy of clinicians' estimates of patients' adherence to combination antiretroviral therapy... - Patient preferences regarding antiretroviral therapyLoren G Miller
Division of Infectious Diseases, Harbor UCLA Medical Center, Torrance, California 90509, USA
Int J STD AIDS 13:593-601. 2002..Pill burden was of least importance among the domains studied. These preferences should be considered when selecting a regimen and developing interventions to improve antiretroviral adherence and patient outcomes... - Human immunodeficiency virus infection unresponsive to highly active antiretroviral therapy: denial of poor medication adherence or recalcitrant infection?Loren G Miller
UCLA AIDS Institute, Los Angeles, California, USA
AIDS Patient Care STDS 16:355-9. 2002..An approach to evaluating patients for causes of poor response to antiretroviral therapy and nonadherence and implications for clinical practice are discussed... - Repeated measures longitudinal analyses of HIV virologic response as a function of percent adherence, dose timing, genotypic sensitivity, and other factorsHonghu Liu
Division of General Internal Medicine and Health Services Research, Department of Medicine, University of California Los Angeles UCLA, 911 Broxton Plaza, Los Angeles, CA 90095 1736, USA
J Acquir Immune Defic Syndr 41:315-22. 2006..The contribution of dose timing and other factors to achieving virologic suppression has received less scrutiny... - Repeated measures analyses of dose timing of antiretroviral medication and its relationship to HIV virologic outcomesHonghu Liu
UCLA Department of Medicine, Division of General Internal Medicine and Health Services Research, Los Angeles, CA 90095 1736, USA
Stat Med 26:991-1007. 2007..Investigations of adherence to antiretrovirals would benefit from measuring not only per cent adherence but dose timing adherence... - A comprehensive evaluation of survey questions for adherence to antiretroviral medications and exploratory analyses for identifying optimal sets of survey questionsHonghu Liu
Division of General Internal Medicine and Health Services Research, UCLA Department of Medicine, Los Angeles, California 90095 1736, USA
AIDS Patient Care STDS 20:760-72. 2006..Because these variables are readily obtainable in clinical settings, these selected questions may provide a clinically useful means of screening patients for antiretroviral medication nonadherence... - A practical method to calibrate self-reported adherence to antiretroviral therapyHonghu Liu
Division of General Internal Medicine and Health Services Research, Department of Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095 1736, USA
J Acquir Immune Defic Syndr 43:S104-12. 2006..We investigated methods to calibrate patients' self-reported adherence to match objectively measured adherence more closely for the purpose of developing a practical and more accurate self-reported adherence measure... - Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los AngelesLoren G Miller
Division of Infectious Diseases, Harbor-UCLA Medical Center and the Los Angeles Biomedical Institute at Harbor-UCLA, Torrance, California, USA
N Engl J Med 352:1445-53. 2005..In areas in which community-associated MRSA infection is endemic, empirical treatment of suspected necrotizing fasciitis should include antibiotics predictably active against this pathogen... - Community-associated methicillin-resistant Staphylococcus aureus isolates causing healthcare-associated infectionsCynthia L Maree
David Geffen School of Medicine, University of California, Los Angeles, California90509, USA
Emerg Infect Dis 13:236-42. 2007..In conclusion, MRSA isolates phenotypically similar to CA strains have become the predominant isolates associated with HA-MRSA in our hospital... - Adjunctive use of rifampin for the treatment of Staphylococcus aureus infections: a systematic review of the literatureJoshua Perlroth
Division of Infectious Diseases, Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
Arch Intern Med 168:805-19. 2008..Rifampin is often used as adjunctive therapy to treat S aureus infections, but there have been no systematic investigations examining the usefulness of such an approach... - Staphylococcus aureus Panton-Valentine leukocidin targets muscle tissues in a child with myositis and necrotizing fasciitisDeborah Lehman
Division of Pediatric Infectious Diseases, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Clin Infect Dis 50:69-72. 2010..aureus strain. Immunostaining showed strong binding of the Panton-Valentine leukocidin toxin to necrotic muscle tissues... - Nitrofurantoin compares favorably to recommended agents as empirical treatment of uncomplicated urinary tract infections in a decision and cost analysisJames A McKinnell
Division of Infectious Disease Clinical Outcome Research Unit IDCORE, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90509, USA
Mayo Clin Proc 86:480-8. 2011..To analyze the costs of nitrofurantoin use compared to those of other antibiotics recommended for treatment of uncomplicated urinary tract infection (UTI)... - Postpartum iliopsoas pyomyositis due to community-acquired methicillin-resistant Staphylococcus aureusKaren M Sokolov
Department of Radiation Oncology, University of California Los Angeles, CA, USA
Obstet Gynecol 110:535-8. 2007..A new, serious community-acquired MRSA manifestation, postpartum iliopsoas pyomyositis is described... - Risk factors for infection and colonization with community-associated methicillin-resistant Staphylococcus aureus in the Los Angeles County jail: a case-control studyCynthia L Maree
University of California, Los Angeles, California, USA
Clin Infect Dis 51:1248-57. 2010..Spread of these infections can be extremely difficult to control. Development of effective prevention protocols requires an understanding of MRSA risk factors in incarcerated persons... - Asymptomatic sexually transmitted infections in HIV-infected men who have sex with men: prevalence, incidence, predictors, and screening strategiesGunter Rieg
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, California 90502, USA
AIDS Patient Care STDS 22:947-54. 2008..Our data support current Center for Disease Control and Prevention STI guidelines that recommend routine screening at increased frequency for HIV-infected MSM... - Evidence for the insufficient evaluation and undertreatment of chronic hepatitis B infection in a predominantly low-income and immigrant populationChin W Jung
Harbor UCLA Medical Center, Torrance, California, USA
J Gastroenterol Hepatol 25:369-75. 2010..The aim of the present study was to determine the rates of laboratory evaluation and treatment of HBV infection in a predominantly low-income and immigrant population... - Clinical characteristics and mortality in hepatitis C-positive haemodialysis patients: a population based studyKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center 1000 West Carson Street, Torrance, CA 90509 2910, USA
Nephrol Dial Transplant 20:1662-9. 2005..The association between hepatitis C virus (HCV) infection and clinical and laboratory measures in maintenance haemodialysis (MHD) patients are poorly understood... - Hepatitis C infection in dialysis patients: a link to poor clinical outcome?Kamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90509 2910, USA
Int Urol Nephrol 39:247-59. 2007..In this article, we review the link between the HCV infection and mortality in dialysis patients and compare HCV antibody to molecular methods to detect HCV infection in these individuals... - Diagnostic discordance for hepatitis C virus infection in hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
Am J Kidney Dis 46:290-300. 2005.... - Association between vancomycin-resistant Enterococci bacteremia and ceftriaxone usageJames A McKinnell
Infectious Disease Clinical Outcomes Research Unit, Division of Infectious Disease, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
Infect Control Hosp Epidemiol 33:718-24. 2012..We measured antimicrobial usage and VRE bloodstream infection (VRE-BSI) incidence to test our hypothesis that increased ceftriaxone usage would be associated with a higher incidence of VRE-BSI... - Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injuryChing Wen Tseng
Division of Pediatric Infectious Diseases and the Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
PLoS ONE 4:e6387. 2009..PVL could contribute to the increased incidence of myositis in CA-MRSA infection, and the toxin could mediate tissue injury by mechanisms other than direct killing of phagocytes... - Quantifying the impact of extranasal testing of body sites for methicillin-resistant Staphylococcus aureus colonization at the time of hospital or intensive care unit admissionJames A McKinnell
Infectious Disease Clinical Outcomes Research Unit, Division of Infectious Disease, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA, USA
Infect Control Hosp Epidemiol 34:161-70. 2013..However, MRSA colonization at extranasal sites is increasingly recognized. We conducted a systematic review of the literature to identify the yield of extranasal testing for MRSA... - Survival and transmission of community-associated methicillin-resistant Staphylococcus aureus from fomitesRishi Desai
Division of Pediatric Infectious Diseases, Childrens Hospital Los Angeles, CA, USA
Am J Infect Control 39:219-25. 2011..However, the amount and duration of transmissibility of MRSA have not been quantified... - Treatment of uncomplicated urinary tract infections in an era of increasing antimicrobial resistanceLoren G Miller
Division of Infectious Diseases and the Research and Education Institute, Harbor UCLA Medical Center, Torrance, Calif 90509, USA
Mayo Clin Proc 79:1048-53; quiz 1053-4. 2004..We review options for management of uncomplicated UTIs in light of these considerations... - Levofloxacin penetration into a renal cyst in a patient with autosomal dominant polycystic kidney diseaseLauren Hiyama
Cedars-Sinai Medical Center, Los Angeles, CA, USA
Am J Kidney Dis 47:e9-13. 2006..Therefore, levofloxacin may be useful in the management of renal cyst infection, particularly for the treatment of gram-positive organisms... - Diagnostic accuracy in patients admitted to hospitals with cellulitisConsuelo V David
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Dermatol Online J 17:1. 2011..Inclusion of decision support tools early in the diagnostic workflow may reduce misdiagnosis and result in more efficient healthcare management... - Visualizing coronary calcium is associated with improvements in adherence to statin therapyNove K Kalia
Division of Cardiology, Harbor-UCLA Medical Center, Research and Education Institute, Torrance, CA, USA
Atherosclerosis 185:394-9. 2006..Outcome studies and randomized trials need to be done to quantify the true value and cost-effectiveness of this approach... - Hepatitis C virus and death risk in hemodialysis patientsKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
J Am Soc Nephrol 18:1584-93. 2007..More diligent efforts to prevent and treat HCV infection may improve outcomes in MHD patients... - Trends in antimicrobial drug development: implications for the futureBrad Spellberg
Research and Education Institute and Department of Medicine, Harbor-University of California, Los Angeles Medical Center, Torrance, California 90502, USA
Clin Infect Dis 38:1279-86. 2004..Despite the critical need for new antimicrobial agents, the development of these agents is declining. Solutions encouraging and facilitating the development of new antimicrobial agents are needed... - Cognitive-behavioral intervention to enhance adherence to antiretroviral therapy: a randomized controlled trial (CCTG 578)Glenn J Wagner
RAND Corporation, 1776 Main Street, Santa Monica, CA 90407, USA
AIDS 20:1295-302. 2006..We conducted a randomized, multi-site, controlled trial of a cognitive-behavioral adherence intervention for patients initiating or changing an antiretroviral (ART) regimen... - A prospective study of predictors of adherence to combination antiretroviral medicationCarol E Golin
Department of Health Behavior and Health Education, University of North Carolina at Chapel Hill, Sheps Center for Health Services Research, Chapel Hill, NC 27599 7590, USA
J Gen Intern Med 17:756-65. 2002..We sought to assess predictors of long-term (up to 1 year) adherence to newly initiated combination ART using an accurate, objective adherence measure... - Is the influence of social desirability on patients' self-reported adherence overrated?Glenn Wagner
J Acquir Immune Defic Syndr 35:203-4. 2004 - Treatment of community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections with drainage but no antibiotic therapyLoren G Miller
Pediatr Infect Dis J 23:795; author reply 795-6. 2004 - Incidence of and risk factors for clinically significant methicillin-resistant Staphylococcus aureus infection in a cohort of HIV-infected adultsWm Christopher Mathews
Department of Medicine, University of California, San Diego, Owen Clinic, UCSD Medical Center, San Diego, CA 92103, USA
J Acquir Immune Defic Syndr 40:155-60. 2005..This study's purpose was to estimate trends in the incidence of and risk factors for clinically significant MRSA (CS-MRSA) infection in a cohort of HIV-infected adults... - Spider bites and infections caused by community-associated methicillin-resistant Staphylococcus aureusLoren G Miller
Surg Infect (Larchmt) 5:321-2; author reply 322. 2004 - In vitro production of panton-valentine leukocidin among strains of methicillin-resistant Staphylococcus aureus causing diverse infectionsStephanie M Hamilton
Veterans Affairs Medical Center, Boise, Idaho 83702, USA
Clin Infect Dis 45:1550-8. 2007..Greater than 75% of these strains carry the genes for Panton-Valentine leukocidin (PVL), suggesting that this toxin may mediate these severe infections. However, to date, studies have not provided evidence of toxin production... - Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with menBinh An Diep
University of California, San Francisco, San Francisco, CA 94110, USA
Ann Intern Med 148:249-57. 2008..Infection with multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus (MRSA) has been reported but seems to be isolated... - Does in vitro fluoroquinolone resistance predict clinical failure in urinary tract infections?Loren G Miller
Int J Antimicrob Agents 29:605-7. 2007 - An estimate of the incidence of Candiduria among hospitalized patients in the United StatesAnthony C Shay
Infect Control Hosp Epidemiol 25:894-5. 2004
Research Grants
- THE SIGNIFICANCE OF FUNGURIA IN HOSPITALIZED PATIENTSLoren Miller; Fiscal Year: 2004....
- A Randomized Clinical Trial to Prevent Recurrent CA-MRASA InfectionLoren Miller; Fiscal Year: 2007..Additionally, our studies will advance our understanding of the pathogenesis and scope of recurrent CA-MRSA infection. ..