L V Miller

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Human zinc metabolism: advances in the modeling of stable isotope data
    L V Miller
    Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
    Adv Exp Med Biol 445:253-69. 1998
  2. ncbi request reprint Development of a compartmental model of human zinc metabolism: identifiability and multiple studies analyses
    L V Miller
    Section of Nutrition, Department of Pediatrics and Center for Human Nutrition, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1671-84. 2000
  3. pmc A mathematical model of zinc absorption in humans as a function of dietary zinc and phytate
    Leland V Miller
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 137:135-41. 2007
  4. pmc Zinc bioavailability and homeostasis
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Denver, CO, USA
    Am J Clin Nutr 91:1478S-1483S. 2010
  5. ncbi request reprint Dysprosium as a nonabsorbable fecal marker in studies of zinc homeostasis
    Xiao Yang Sheng
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 82:1017-23. 2005
  6. ncbi request reprint Multi-point estimation of total energy expenditure: a comparison between zinc-reduction and platinum-equilibration methodologies
    Bakary J Sonko
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Anal Biochem 323:211-7. 2003
  7. pmc Dietary reference intakes for zinc may require adjustment for phytate intake based upon model predictions
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado, School of Medicine, Denver, CO 80262, USA
    J Nutr 138:2363-6. 2008
  8. ncbi request reprint Intestinal excretion of endogenous zinc in Guatemalan school children
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 137:1747-9. 2007
  9. ncbi request reprint Changes in zinc absorption during development
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Pediatr 149:S64-8. 2006
  10. ncbi request reprint Zinc homeostasis during lactation in a population with a low zinc intake
    Lei Sian
    Section of Nutrition, The Department of Pediatrics, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 75:99-103. 2002

Detail Information

Publications19

  1. ncbi request reprint Human zinc metabolism: advances in the modeling of stable isotope data
    L V Miller
    Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
    Adv Exp Med Biol 445:253-69. 1998
    ..While identifiability could not be demonstrated a priori due to the model's complexity, parameter statistics for the fitted models did show most parameters to be adequately identified a posteriori...
  2. ncbi request reprint Development of a compartmental model of human zinc metabolism: identifiability and multiple studies analyses
    L V Miller
    Section of Nutrition, Department of Pediatrics and Center for Human Nutrition, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1671-84. 2000
    ..The model was judged to be valid based on criteria described elsewhere...
  3. pmc A mathematical model of zinc absorption in humans as a function of dietary zinc and phytate
    Leland V Miller
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 137:135-41. 2007
    ..The model was judged to be valid and of immediate value for studying and predicting absorption. A version of the model incorporating a passive absorption mechanism was not supported by the available data...
  4. pmc Zinc bioavailability and homeostasis
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Denver, CO, USA
    Am J Clin Nutr 91:1478S-1483S. 2010
    ..The effects of phytate on intestinal losses of endogenous zinc merit further investigation but are probably not of the same magnitude as its inhibitory effects on absorption of exogenous zinc...
  5. ncbi request reprint Dysprosium as a nonabsorbable fecal marker in studies of zinc homeostasis
    Xiao Yang Sheng
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 82:1017-23. 2005
    ..Dysprosium is a nonabsorbable rare earth element that has had successful application as a marker for fecal excretion of unabsorbed zinc...
  6. ncbi request reprint Multi-point estimation of total energy expenditure: a comparison between zinc-reduction and platinum-equilibration methodologies
    Bakary J Sonko
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Anal Biochem 323:211-7. 2003
    ..The data demonstrated that the Zn-reduction method could be replaced by the Pt-equilibration method when TEE was estimated using the "Multi-Point" technique. Furthermore, D equilibration time was significantly reduced...
  7. pmc Dietary reference intakes for zinc may require adjustment for phytate intake based upon model predictions
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado, School of Medicine, Denver, CO 80262, USA
    J Nutr 138:2363-6. 2008
    ..4 mg Zn/d. Extrapolation of the model suggested, for example, that with 900 mg/d phytate, 100 mg dietary Zn is required to attain 6.4 mg absorbed Zn/d. Experimental studies with higher Zn intakes are required to test these predictions...
  8. ncbi request reprint Intestinal excretion of endogenous zinc in Guatemalan school children
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 137:1747-9. 2007
    ..Supported by other recent childhood data, these results suggest that the current estimates of EFZ(PR) used in the calculation of Zn requirements for children are misleadingly low...
  9. ncbi request reprint Changes in zinc absorption during development
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Pediatr 149:S64-8. 2006
    ..Normal homeostatic mechanisms in the premature infant prevented efficient absorption of the quantity of Zn required or/and optimal conservation of endogenous Zn...
  10. ncbi request reprint Zinc homeostasis during lactation in a population with a low zinc intake
    Lei Sian
    Section of Nutrition, The Department of Pediatrics, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 75:99-103. 2002
    ....
  11. ncbi request reprint Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants
    Nancy F Krebs
    Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Clin Nutr 84:1340-3. 2006
    ..Small-for-gestational-age (SGA) infants are susceptible to postnatal zinc deficiency, but whether this susceptibility is due to intrauterine factors or to high postnatal growth requirements is unknown...
  12. pmc Zinc absorption during late pregnancy in rural southern Ethiopia
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 84:1102-6. 2006
    ..Little is yet known about zinc absorption in late pregnancy, and no information on absorption from the total diet is available...
  13. ncbi request reprint Measurements of zinc absorption: application and interpretation in research designed to improve human zinc nutriture
    K Michael Hambidge
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Box C225, 4200 E 9th Av, Denver, Colorado, 80262, USA
    Int J Vitam Nutr Res 75:385-93. 2005
    ..They also suggest the potential utility of measurements of the quantity of zinc absorbed when evaluating the zinc status of populations...
  14. ncbi request reprint Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis
    Nancy F Krebs
    Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 133:1498S-501S. 2003
    ..We conclude that the amount of absorbed zinc is not tightly regulated, and that endogenous fecal zinc is dependent on and responsive to the zinc status of the organism...
  15. pmc Absorption of calcium from tortilla meals prepared from low-phytate maize
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 82:84-7. 2005
    ..Bioavailability of calcium is, however, compromised by phytate, which is present in large quantities in maize kernels and is only modestly reduced by nixtamalization...
  16. ncbi request reprint Zinc absorption as a function of the dose of zinc sulfate in aqueous solution
    Cuong D Tran
    Section of Nutrition, Department of Pediatrics, The University of Colorado Health Science Center, Denver, USA
    Am J Clin Nutr 80:1570-3. 2004
    ..Zinc supplements are used extensively in medicine and research and for public health purposes in the prevention and treatment of zinc deficiency. However, little is known about the efficiency of zinc utilization after different doses...
  17. ncbi request reprint Zinc absorption from low-phytate hybrids of maize and their wild-type isohybrids
    K Michael Hambidge
    University of Colorado Health Sciences Center, Department of Pediatrics, Section of Nutrition, Denver 80262, USA
    Am J Clin Nutr 79:1053-9. 2004
    ....
  18. pmc The use of dysprosium to measure endogenous zinc excretion in feces eliminates the necessity of complete fecal collections
    Leland V Miller
    University of Colorado Denver, Department of Pediatrics, Aurora, CO 80045, USA
    J Nutr 140:1524-8. 2010
    ..We found that the measurement of the sample Dy:Zn ratio was useful for selecting samples for measurement. We conclude that the Dy method of determining EFZ is a valid and less burdensome alternative to current techniques...
  19. ncbi request reprint Zinc absorption and exchangeable zinc pool sizes in breast-fed infants fed meat or cereal as first complementary food
    Sanju Jalla
    Johns Hopkins University, Baltimore, Maryland, USA
    J Pediatr Gastroenterol Nutr 34:35-41. 2002
    ....