Research Topics
Genomes and GenesSpecies | Jeffery S MillerSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine productionMichelle K Gleason
Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA
Mol Cancer Ther 11:2674-84. 2012....- New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancerDavid F Stroncek
Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, USA
J Transl Med 10:48. 2012..In the future, combinations of adoptive transfer of T cells and specific vaccination against the cognate antigen can be envisaged to further enhance the effectiveness of these therapies... 
Diminished neo-antigen response to keyhole limpet hemocyanin (KLH) vaccines in patients after treatment with chemotherapy or hematopoietic cell transplantationJeffrey S Miller
Divisions of Medical and Pediatric Hematology Oncology and Transplantation, The Blood and Marrow Transplant Program, Department of Biostatistics, and The University of Minnesota Cancer Center, MN 55455, USA
Clin Immunol 117:144-51. 2005..KLH vaccines are safe and require only a single injection to test neo-antigen responses providing an optimal platform for definitive testing of strategies to improve diminished immune recovery after chemotherapy or post-HCT...- Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancerJeffrey S Miller
Division Medical and Pediatric Hematology Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Blood 105:3051-7. 2005..These findings suggest that haploidentical NK cells can persist and expand in vivo and may have a role in the treatment of selected malignancies used alone or as an adjunct to HCT... - Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI aloneJeffrey S Miller
Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Blood 110:2761-3. 2007..This trial was registered at www.clinicaltrials.gov as no. NCT00303693 and www.cancer.gov/clinicaltrials as no. NCT00167180... - NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Jeffrey S Miller
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 16:565-86. 2010..Optimal strategies to precisely balance immune responses to favor GVL without harmful graft-versus-host disease (GVHD) are needed to protect against relapse, treat persistent disease and improve disease-free survival after HSCT... - Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCTJeffery S Miller
Divisions of Adult and Pediatric Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Harvard Street at East River Road, Minneapolis, MN 55455, USA
Blood 109:5058-61. 2007..58, 95% CI 1.13-2.22; P = .008). These data support a genetically determined role for NK cells following unrelated HCT in myeloid leukemia... - Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcomeMichael B Tomblyn
Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
J Clin Oncol 27:3634-41. 2009..Analysis of hematopoietic cell transplantation (HCT) for high-risk or recurrent acute lymphoblastic leukemia (ALL) using different donor sources is confounded by variable conditioning and supportive care... - The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulationsHongbo Wang
Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, USA
Blood 110:1530-9. 2007..Collectively, these studies show that CSA influences NK-cell function and phenotype, which may have important implications for graft-versus-leukemia effects... - A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immatureSarah Cooley
Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Minneapolis 55455, USA
Blood 110:578-86. 2007..These findings have implications for the function of NK cells reconstituting after transplantation and support a model for in vivo development in which CD56(bright) cells precede CD56(dim) cells... - KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantationSarah Cooley
Division of Hematology-Oncology and Transplantation, University of Minnesota Cancer Center, University of Minnesota, National Marrow Donor Program, MMC 806, Harvard St at E River Rd, Minneapolis, MN 55455, USA
Blood 106:4370-6. 2005..These results support the notion that T cells in the graft affect NK cell reconstitution in vivo. Understanding these mechanisms may result in strategies to improve clinical outcomes from unrelated HCT... 
Thoracoscopic versus thoracotomy approaches to lobectomy: differential impairment of cellular immunityBryan A Whitson
Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Ann Thorac Surg 86:1735-44. 2008..Specifically, we assessed the cytotoxic capacity of peripheral blood mononuclear cells (PBMCs) of patients undergoing lobectomy for non-small-cell lung cancer by either VATS or thoracotomy...- Reduced intensity compared with high dose conditioning for allotransplantation in acute myeloid leukemia and myelodysplastic syndrome: a comparative clinical analysisCatherine M Flynn
Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Am J Hematol 82:867-72. 2007..Advances in GVHD management and new approaches for relapsed or refractory disease are necessary to improve these outcomes... - Impact of bone marrow hematogones on umbilical cord blood transplantation outcomes in patients with acute myeloid leukemiaTheodore Honebrink
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 18:930-6. 2012..01). This study shows that BM hematogone percentages may be useful prognostic indicators in patients with acute myeloid leukemia after umbilical cord blood transplantation and should be routinely reported in BM differential counts... - Cutting edge: KIR antisense transcripts are processed into a 28-base PIWI-like RNA in human NK cellsFrank Cichocki
Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
J Immunol 185:2009-12. 2010.... - A novel method for KIR-ligand typing by pyrosequencing to predict NK cell alloreactivityGong Yun
Division of Adult Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, MMC 806, Harvard Street at East River Road, Minneapolis, MN 55455, USA, and Anthony Nolan Research Institute, Royal Free Hospital, London, UK
Clin Immunol 123:272-80. 2007..Pyrosequencing is sensitive, specific, high-throughput, inexpensive, and can rapidly screen KIR-ligand status to evaluate potential alloreactive NK cell or transplant donors... - Donor chimerism does not predict response to donor lymphocyte infusion for relapsed chronic myelogenous leukemia after allogeneic hematopoietic cell transplantationElena G Chiorean
Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis 55455, USA
Biol Blood Marrow Transplant 10:171-7. 2004.... - Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensityClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Blood 113:5628-34. 2009..8; 95% CI, 1.0-3.1; P = .05). Our results do not support the selection of UCB units based on KIR-L status and suggest that KIR-L mismatching should be avoided in reduced intensity UCB transplantation... - BCR/ABL alters the function of NK cells and the acquisition of killer immunoglobulin-like receptors (KIRs)Elena G Chiorean
Division of Hematology-Oncology and Transplantation, University of Minnesota Cancer Center, Minneapolis, 55455, USA
Blood 101:3527-33. 2003..This is the first study to show that BCR/ABL, well known for its effects on the myeloid lineage, can alter the function of lymphoid cells, which may be associated with the defect in innate immunity associated with CML progression... - Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activityPetter S Woll
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 175:5095-103. 2005..These cells may also provide a source for innovative cellular immune therapies... - Use of natural killer cells as immunotherapy for leukaemiaBartosz Grzywacz
Division of Blood and Marrow Transplantation, University of Minnesota, MN, USA
Best Pract Res Clin Haematol 21:467-83. 2008..Future modifications to improve NK cell adoptive immunotherapy by means of increasing target recognition and reducing inhibitory signalling are being explored... - Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15Valarie McCullar
Division of Medical, University of Minnesota Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Exp Hematol 36:598-608. 2008..Human natural killer (NK) cell maturation involves the orderly acquisition of NK cell receptors. Our aim was to understand how stromal interactions and cytokines are important in this developmental process... - Activated notch supports development of cytokine producing NK cells which are hyporesponsive and fail to acquire NK cell effector functionsVeronika Bachanova
Division of Adult and Pediatric Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 15:183-94. 2009..However, these NK cells are immature in their cytokine production profile, are hyporesponsive, and poorly acquire NK cell receptors involved in self-tolerance and effector function... - Long-term results of autologous stem cell transplantation for primary refractory or relapsed Hodgkin's lymphomaNavneet S Majhail
Blood and Marrow Transplant Program, Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 12:1065-72. 2006..A risk-adapted approach should be followed in determining treatment options for patients with PR REF and REL HL... - Biology of natural killer cells in cancer and infectionJeffrey S Miller
Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Box 806, Harvard Street at East River Road, Minneapolis, MN 55455, USA
Cancer Invest 20:405-19. 2002..Understanding NK cell function and homing may lead to novel therapeutic strategies for the treatment of human disease... - Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemiaSarah Cooley
University of Minnesota, Minneapolis, USA
Blood 113:726-32. 2009..KIR genotyping of prospective donors, in addition to HLA typing, should be performed to identify HLA-matched donors with B KIR haplotypes... - Minimally invasive versus open Roux-en-Y gastric bypass: effect on immune effector cellsBryan A Whitson
Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Surg Obes Relat Dis 5:181-93. 2009..We hypothesized that the open approach to Roux-en-Y gastric bypass (RYGB) has a more deleterious, negative, quantifiable effect on the peripheral blood mononuclear cells than does the MIS approach... - Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancyJuliet N Barker
Blood and Marrow Transplant Program, Division of Medical and Pediatric Oncology, University of Minnesota, Box 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
Blood 105:1343-7. 2005..Therefore, transplantation of 2 partially HLA-matched UCB units is safe, and may overcome the cell-dose barrier that limits the use of UCB in many adults and adolescents... - Promising progression-free survival for patients low and intermediate grade lymphoid malignancies after nonmyeloablative umbilical cord blood transplantationClaudio G Brunstein
University of Minnesota Blood and Marrow Transplant Program, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 15:214-22. 2009..Based on our data, we conclude that a nonmyeloablative conditioning regimen followed by UCB transplantation is an effective treatment for patients with advanced lymphoid malignancies who lack a suitable sibling donor... - Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioningJuliet N Barker
Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN, USA
Blood 102:1915-9. 2003..These data demonstrate that 0-2 antigen mismatched UCB is sufficient to engraft most adults after reduced-intensity conditioning and is associated with a low incidence of severe acute GVHD... - Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 unitsMichael R Verneris
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Blood 114:4293-9. 2009..This trial was registered at http://clinicaltrials.gov as NCT00309842... - Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantationJill C Beck
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 16:215-22. 2010..01) and lower OS (P=.02). Thus, although recipient CMV serostatus and CMV reactivation have little demonstrable impact on UCB transplant outcomes, the development of CMV disease remains a risk, associated with inferior outcomes... - The phenotypic and functional characteristics of umbilical cord blood and peripheral blood natural killer cellsMichael R Verneris
Department of Paediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA
Br J Haematol 147:185-91. 2009..Activation and expansion protocols for UCB NK cells are briefly reviewed. Lastly, we outline the early use of UCB NK cells in clinical trials... - In vitro development of human Killer-Immunoglobulin Receptor-positive NK cellsFrank Cichocki
University of Minnesota Cancer Center, Minneapolis, MN, USA
Methods Mol Biol 612:15-26. 2010..The necessary soluble factors and contact-dependent conditions for in vitro human NK cell development have been worked out in our laboratory over the past 16 years... - Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptorStella M Davies
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis 55455, USA
Blood 100:3825-7. 2002..It is possible that there will be a benefit of NK cell alloreactivity if strategies of haploidentical transplantation are used: high stem cell doses, extensive T-cell depletion, and no postgrafting immune suppression... - Trastuzumab and interleukin-2 in HER2-positive metastatic breast cancer: a pilot studyTanya Repka
Division of Hematology-Oncology and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Clin Cancer Res 9:2440-6. 2003..These preliminary data suggest that this strategy may benefit heavily pretreated metastatic breast cancer patients... - Determinants of survival after human leucocyte antigen-matched unrelated donor bone marrow transplantation in adultsJuliet N Barker
The University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN 55455, USA
Br J Haematol 118:101-7. 2002..Future efforts should focus on improving the outcome for older BMT recipients, especially those with diagnoses other than CML... - Allogeneic natural killer cells for refractory lymphomaVeronika Bachanova
Blood and Marrow, Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Cancer Immunol Immunother 59:1739-44. 2010..Cell therapy trials should incorporate novel strategies to limit Treg expansion... - Clinical-scale selection of anti-CD3/CD28-activated T cells after transduction with a retroviral vector expressing herpes simplex virus thymidine kinase and truncated nerve growth factor receptorPaul J Orchard
Program in Blood and Marrow Transplantation, Department of Pediatrics, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
Hum Gene Ther 13:979-88. 2002..3% vs. 23.5%). We conclude that a strategy based on activation of human T cells with anti-CD3/CD28 beads can result in sufficient transduction, expansion, and purification based on NGFR expression for clinical trials... - iTRAQ is a useful method to screen for membrane-bound proteins differentially expressed in human natural killer cell typesTroy C Lund
Department of Medicine, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, 670 CCRB, 425 East River Road, Minneapolis, MN 55455, USA
J Proteome Res 6:644-53. 2007..This is the first demonstration and verification using iTRAQ to screen for membrane-bound protein differences in human NK cells and represents a powerful new tool in the field of proteomics... - Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cellsKeli L Hippen
University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone, Blood and Marrow Transplantation, Minneapolis, USA
Blood 112:2847-57. 2008..These data offer a novel approach for UCB Treg expansion using aAPCs, including those coexpressing OX40L or 4-1BBL... - Similar and promising outcomes in lymphoma patients treated with myeloablative or nonmyeloablative conditioning and allogeneic hematopoietic cell transplantationMarcie Tomblyn
Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 14:538-45. 2008..Modifications to refine patient assignment to the preferred conditioning intensity and reduce relapse risks with NMA approaches are needed... - Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cellsBartosz Grzywacz
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 425 E. River Rd, Suite 660, Minneapolis, MN 55455, USA
Blood 108:3824-33. 2006..The identified stages of NK-cell differentiation provide evidence for coordinated acquisition of HLA-specific inhibitory receptors (ie, CD94/NKG2A) and function in developing human NK cells... - Suppressor function of umbilical cord blood-derived CD4+CD25+ T-regulatory cells exposed to graft-versus-host disease drugsStephen B Porter
University of Minnesota Cancer Center and the Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
Transplantation 82:23-9. 2006.... - Good manufacturing practices production of natural killer cells for immunotherapy: a six-year single-institution experienceDavid H McKenna
Department of Laboratory Medicine and Pathology, Division of Transfusion Medicine, University of Minnesota Medical School, Minnesota 55108, USA
Transfusion 47:520-8. 2007..Herein is a report on the experience of clinical-scale, good manufacturing practices (GMPs) production of NK cells to treat advanced cancer... - Chronic graft-versus-host disease (cGVHD) following unrelated donor hematopoietic stem cell transplantation (HSCT): higher response rate in recipients of unrelated donor (URD) umbilical cord blood (UCB)Mukta Arora
Blood and Marrow Transplant Program, Departments of Medicine and Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 13:1145-52. 2007..In addition, progressive onset of cGVHD was a significant predictor of increased mortality in URD cohort. These data suggest that cGVHD following UCB transplant may be more responsive to therapy and also lead to a lower NRM... - The BCR/ABL transgene causes abnormal NK cell differentiation and can be found in circulating NK cells of advanced phase chronic myelogenous leukemia patientsHikaru Nakajima
Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
J Immunol 168:643-50. 2002..This study provides the first evidence that BCR/ABL is responsible for the altered differentiation of NK cells and that the NK cell lineage can be involved with the malignant clone in advanced stage CML... - Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic diseaseClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis MN, USA
Blood 110:3064-70. 2007..01) and use of 2 UCB units (P = .07). These findings support the use of UCB after a nonmyeloablative conditioning as a strategy for extending the availability of transplantation therapy, particularly for older patients... - The Minnesota Molecular and Cellular Therapeutics Facility: a state-of-the-art biotherapeutics engineering laboratoryDavid H McKenna
Division of Minnesota Molecular and Cellular Therapeutics Facility, University of Minnesota, Saint Paul, MN 55108, USA
Transfus Med Rev 19:217-28. 2005..Here we provide an overview of the Minnesota Molecular and Cellular Therapeutics (MMCT) Facility, detailing our approach to the manufacture of novel therapeutics and highlighting current and future activities... - FLT3 ligand administration after hematopoietic cell transplantation increases circulating dendritic cell precursors that can be activated by CpG oligodeoxynucleotides to enhance T-cell and natural killer cell functionWei Chen
University of Minnesota Cancer Center, Minneapolis, Minnesota 5455, USA
Biol Blood Marrow Transplant 11:23-34. 2005..These findings suggest that FLT3-L mobilization of DC precursors followed by a specific DC stimulus such as CpG ODN may provide a novel strategy to manipulate antitumor immunity in patients after HCT... - Reduced-intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donorNavneet S Majhail
Blood and Marrow Transplant Program, Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 14:282-9. 2008..A careful review of existing comorbidities is necessary when considering older patients for HCT... - Autologous large multivalent immunogen vaccine in patients with metastatic melanoma and renal cell carcinomaArkadiusz Z Dudek
Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware St SE, MMC 480, Minneapolis, MN 55455, USA
Am J Clin Oncol 31:173-81. 2008..To evaluate the safety and activity of large multivalent immunogen (LMI), prepared by immobilizing autologous tumor cell plasma membrane on 5-microm diameter silica beads, in patients with melanoma and renal cell carcinoma (RCC)... - Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kineticsClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
Blood 117:1061-70. 2011..These results set the stage for a definitive study of UCB Treg to determine its potency in preventing allogeneic aGVHD. This study is registered at http://www.clinicaltrials.gov as NCT00602693... - Long-term follow-up after autologous hematopoietic stem cell transplantation for low-grade non-Hodgkin lymphomaNoel Laudi
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 11:129-35. 2005.... - First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancerArkadiusz Z Dudek
University of Minnesota Cancer Center, Minneapolis, Minnesota and 3M Pharmaceuticals, St Paul, Minnesota 55455, USA
Clin Cancer Res 13:7119-25. 2007..Our goal was to define the tolerated dose, pharmacokinetics, pharmacodynamics, and immunologic effects of 852A in humans... - Randomized comparison of granulocyte colony-stimulating factor versus granulocyte-macrophage colony-stimulating factor plus intensive chemotherapy for peripheral blood stem cell mobilization and autologous transplantation in multiple myelomaMukta Arora
Department of Medicine, University of Minnesota, Minneapolis 55455, USA
Biol Blood Marrow Transplant 10:395-404. 2004..Two cycles of priming chemotherapy plus autologous transplantation yields survival rates similar to those in published reports, including those using tandem transplantation... - Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemiaSarah Cooley
Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Blood 116:2411-9. 2010..Adopting this practice could result in superior disease-free survival for patients with AML... - A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-IDeepali Sachdev
Department of Medicine, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Cancer Res 63:627-35. 2003..These results indicate that such chimeric single-chain antibodies against IGF1R have future potential in breast cancer therapy by causing down-regulation of receptor... - Umbilical cord blood T cells express multiple natural cytotoxicity receptors after IL-15 stimulation, but only NKp30 is functionalQin Tang
Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 181:4507-15. 2008..These results demonstrate differences between UCB and PB T cells regarding NCR expression and function. Such findings challenge the concept that NCRs are NK cell specific... - Natural killer cell killing of acute myelogenous leukemia and acute lymphoblastic leukemia blasts by killer cell immunoglobulin-like receptor-negative natural killer cells after NKG2A and LIR-1 blockadeRobert Godal
Division of Adult Hematology, Oncology and Transplantation, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 16:612-21. 2010..Thus strategies to interrupt NKG2A and LIR-1 in combination with anti-KIR blockade hold promise for exploiting NK cell therapy in acute leukemias... - Development of IL-22-producing NK lineage cells from umbilical cord blood hematopoietic stem cells in the absence of secondary lymphoid tissueQin Tang
Division of Hematology Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
Blood 117:4052-5. 2011..Thus, IL-22-producing NK cells can be generated in the absence of SLT. HSC-derived NK22 cells will be valuable in understanding this rare NK subset and create the opportunity for human translational clinical trials... - The transcription factor c-Myc enhances KIR gene transcription through direct binding to an upstream distal promoter elementFrank Cichocki
Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Blood 113:3245-53. 2009..This finding provides a direct link between NK-cell activation signals and KIR expression required for acquisition of effector function during NK-cell education... - Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancersMelissa A Geller
Department of Obstetrics, Gynecology and Women s Health, University of Minnesota, MMC 395 420 Delaware St SE, Minneapolis, MN, 55455, USA
Cancer Immunol Immunother 59:1877-84. 2010..Secondary objectives included assessment of safety and immune system activation... - The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the center for international blood and marrow transplant research, the European blood and marrow transplant registry, and the Dutch registrySherif S Farag
The Ohio State University, Columbus, Ohio 43210, USA
Biol Blood Marrow Transplant 12:876-84. 2006..There were no differences in leukemia recurrence between the 4 groups. These results do not support the choice of an unrelated donor on the basis of KIR ligand mismatch determined from HLA typing... - Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonistsKevin S Gorski
3M Pharmaceuticals, Department of Pharmacology, 3M Center, 270 2S 06, St Paul, MN 55144, USA
Int Immunol 18:1115-26. 2006..We conclude that IRMs can modulate NK-cell function both in vitro and in vivo and that distinct indirect pathways control human NK-cell activation by TLR-7 and TLR-8 agonists... - Epigenetic control of highly homologous killer Ig-like receptor gene allelesHuei-Wei Chan
Department of Pathology and Laboratory Medicine, University of Kentucky, KY 40536, USA
J Immunol 175:5966-74. 2005..Our findings suggest that KIR transcription is primarily controlled by DNA methylation...
Research Grants
- NK Cells, Their Receptors and Unrelated Donor TransplantJeffrey Miller; Fiscal Year: 2007....
- LYMPHOID DIFFERENTIATION FROM STEM CELLSJeffrey Miller; Fiscal Year: 2007..Specific Aim 1: NK Cell development from the hematopoietic stem cell. Specific Aim 2: Mechanisms of KIR acquisition in developing NK cells. Specific Aim 3: The lineage relationship between CD56[+bright] and CD56[+dim] NK cells ..
- LYMPHOID DIFFERENTIATION FROM STEM CELLSJeffrey Miller; Fiscal Year: 2003..Preliminary data suggests a role for targeting TCF-1 as an initial focus using this approach. ..
- NK Cell Differentiation from Stem CellsJeffrey S Miller; Fiscal Year: 2010..A thorough understanding of these mechanisms may allow us to manipulate NK cells for therapeutic purposes to treat cancer. ..