C J Miller

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Use of nonhuman primate models to develop mucosal AIDS vaccines
    Meritxell Genesca
    Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
    Curr HIV/AIDS Rep 7:19-27. 2010
  2. pmc Antiviral antibodies are necessary for control of simian immunodeficiency virus replication
    Christopher J Miller
    Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, Davis, California 95616, USA
    J Virol 81:5024-35. 2007
  3. ncbi request reprint Target cells in vaginal HIV transmission
    Christopher J Miller
    Department of Veterinary Pathology, Microbiology and Immunology, Center for Comparative Medicine, School of Veterinary Medicine, California National Primate Research Center, University of California Davis, Davis, CA 95616, USA
    Microbes Infect 5:59-67. 2003
  4. pmc Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus
    Christopher J Miller
    Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA
    J Virol 79:9217-27. 2005
  5. pmc Low-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb step trial of a similar HIV-1 vaccine
    Huma Qureshi
    Center for Comparative Medicine, University of California, Davis, California, USA
    J Virol 86:2239-50. 2012
  6. ncbi request reprint Localization of Simian immunodeficiency virus-infected cells in the genital tract of male and female Rhesus macaques
    C J Miller
    California Regional Primate Research Center, Department of Veterinary Pathology, School of Veterinary Medicine, University of California Davis, 95616, USA
    J Reprod Immunol 41:331-9. 1998
  7. pmc T cell-tropic simian immunodeficiency virus (SIV) and simian-human immunodeficiency viruses are readily transmitted by vaginal inoculation of rhesus macaques, and Langerhans' cells of the female genital tract are infected with SIV
    C J Miller
    Virology and Immunology Unit, California Regional Primate Research Center, University of California Davis, Davis, CA 95616, USA
    J Infect Dis 179:S413-7. 1999
  8. pmc In vivo replication capacity rather than in vitro macrophage tropism predicts efficiency of vaginal transmission of simian immunodeficiency virus or simian/human immunodeficiency virus in rhesus macaques
    C J Miller
    California Regional Primate Research Center, and Department of Veterinary Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis 95616, USA
    J Virol 72:3248-58. 1998
  9. pmc Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239
    C J Miller
    California Regional Primate Research Center, Department of Pathology, School of Veterinary Medicine, University of California Davis, 95616, USA
    J Virol 71:1911-21. 1997
  10. ncbi request reprint Anti-HIV and -SIV immunity in the vagina
    Christopher J Miller
    Virology and Immunology Unit, California Regional Primate Research Center and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    Int Rev Immunol 22:65-76. 2003

Research Grants

  1. 25th Annual Symposium on Nonhuman Primate Models for AIDS
    Christopher Miller; Fiscal Year: 2007
  2. Effect of Microbicides on Mucosal HIV Transmission
    Christopher Miller; Fiscal Year: 2004
  3. DEVELOPMENT OF THE PRIMATE IMMUNOLOGY RESOURCE
    Christopher Miller; Fiscal Year: 2003
  4. ANNUAL SYMPOSIUM ON NONHUMAN PRIMATE MODELS FOR AIDS
    Christopher Miller; Fiscal Year: 2002
  5. PROTECTIVE MECHANISMS WITH ATTENUATED LENTIVIRAL VACCINE
    Christopher Miller; Fiscal Year: 2002

Collaborators

Detail Information

Publications63

  1. pmc Use of nonhuman primate models to develop mucosal AIDS vaccines
    Meritxell Genesca
    Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
    Curr HIV/AIDS Rep 7:19-27. 2010
    ..Nonhuman primate models offer the best system for preclinical evaluation of these approaches...
  2. pmc Antiviral antibodies are necessary for control of simian immunodeficiency virus replication
    Christopher J Miller
    Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, Davis, California 95616, USA
    J Virol 81:5024-35. 2007
    ..0001). These observations indicate that antiviral antibody responses are critical in maintaining effective control of SIV replication at early time points postinfection...
  3. ncbi request reprint Target cells in vaginal HIV transmission
    Christopher J Miller
    Department of Veterinary Pathology, Microbiology and Immunology, Center for Comparative Medicine, School of Veterinary Medicine, California National Primate Research Center, University of California Davis, Davis, CA 95616, USA
    Microbes Infect 5:59-67. 2003
    ....
  4. pmc Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus
    Christopher J Miller
    Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA
    J Virol 79:9217-27. 2005
    ....
  5. pmc Low-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb step trial of a similar HIV-1 vaccine
    Huma Qureshi
    Center for Comparative Medicine, University of California, Davis, California, USA
    J Virol 86:2239-50. 2012
    ..Further studies are necessary to confirm the enhancement of virus acquisition and to discern associated mechanisms...
  6. ncbi request reprint Localization of Simian immunodeficiency virus-infected cells in the genital tract of male and female Rhesus macaques
    C J Miller
    California Regional Primate Research Center, Department of Veterinary Pathology, School of Veterinary Medicine, University of California Davis, 95616, USA
    J Reprod Immunol 41:331-9. 1998
    ....
  7. pmc T cell-tropic simian immunodeficiency virus (SIV) and simian-human immunodeficiency viruses are readily transmitted by vaginal inoculation of rhesus macaques, and Langerhans' cells of the female genital tract are infected with SIV
    C J Miller
    Virology and Immunology Unit, California Regional Primate Research Center, University of California Davis, Davis, CA 95616, USA
    J Infect Dis 179:S413-7. 1999
    ..This is the first in vivo demonstration that Langerhans' cells in the genital tract are infected with SIV and that dendritic cells are significant reservoirs for lentiviruses...
  8. pmc In vivo replication capacity rather than in vitro macrophage tropism predicts efficiency of vaginal transmission of simian immunodeficiency virus or simian/human immunodeficiency virus in rhesus macaques
    C J Miller
    California Regional Primate Research Center, and Department of Veterinary Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis 95616, USA
    J Virol 72:3248-58. 1998
    ..However, we did find that the level to which these viruses replicate in vivo after intravenous inoculation predicts the outcome of intravaginal inoculation with each virus...
  9. pmc Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239
    C J Miller
    California Regional Primate Research Center, Department of Pathology, School of Veterinary Medicine, University of California Davis, 95616, USA
    J Virol 71:1911-21. 1997
    ..These results suggest that protection from sexual transmission of HIV may be possible by effectively stimulating both humoral and cellular antiviral immunity in the systemic and genital mucosal immune compartments...
  10. ncbi request reprint Anti-HIV and -SIV immunity in the vagina
    Christopher J Miller
    Virology and Immunology Unit, California Regional Primate Research Center and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    Int Rev Immunol 22:65-76. 2003
    ..HIV/SIV-specific CD8+ cytotoxic T lymphocytes are present in the cervicovaginal mucosa of infected women and rhesus macaques. A vaccine that can elicit strong antiviral immunity may provide protection for hetorosexual HIV-1 transmission...
  11. pmc Protective attenuated lentivirus immunization induces SIV-specific T cells in the genital tract of rhesus monkeys
    M Genesca
    Center for Comparative Medicine, University of California, Davis, California, USA
    Mucosal Immunol 1:219-28. 2008
    ..Thus, an attenuated SHIV vaccine induces persistent antiviral T cells in tissues, including the vagina, where these effector T-cell responses may mediate the consistent protection from vaginal SIV challenge observed in this model...
  12. pmc Route of simian immunodeficiency virus inoculation determines the complexity but not the identity of viral variant populations that infect rhesus macaques
    J L Greenier
    California Regional Primate Research Center, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Virol 75:3753-65. 2001
    ..In addition, our results clearly demonstrate that the route of inoculation is associated with the extent and breadth of the genetic complexity of the viral variant population in the earliest stages of systemic infection...
  13. pmc Antiviral CD8+ T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89.6
    M Genesca
    Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, CA 95616, USA
    J Intern Med 265:67-77. 2009
    ....
  14. pmc Abrogation of attenuated lentivirus-induced protection in rhesus macaques by administration of depo-provera before intravaginal challenge with simian immunodeficiency virus mac239
    Kristina Abel
    Center for Comparative Medicine, and California National Primate Research Center, University of California at Davis, Davis, California 95616, USA
    J Infect Dis 190:1697-705. 2004
    ..6-immunized macaques. In the primate model of sexual transmission of human immunodeficiency virus, treatment with progesterone before IVAG challenge with a pathogenic virus can decrease the efficacy of a model "vaccine."..
  15. ncbi request reprint Efficacy of a SHIV 89.6 proviral DNA vaccine against mucosal SIVmac239 challenge
    Marc Busch
    California National Primate Research Center, University California Davis, County Road 98, Hutchison Drive, Davis, CA 95616, USA
    Vaccine 23:4036-47. 2005
    ..These results suggest that the delay in systemic infection resulting from delivery of SHIV 89.6 as a plasmid decreased the effectiveness of this live attenuated vaccine...
  16. pmc Simian-human immunodeficiency virus SHIV89.6-induced protection against intravaginal challenge with pathogenic SIVmac239 is independent of the route of immunization and is associated with a combination of cytotoxic T-lymphocyte and alpha interferon respon
    Kristina Abel
    Center for Comparative Medicine, California National Primate Research Center, School of Veterinary Medicine, University of California Davis, California 95616, USA
    J Virol 77:3099-118. 2003
    ..Thus, innate as well as cellular anti-SIV immune responses appeared to contribute to the SHIV89.6-induced protection against intravaginal challenge with pathogenic SIVmac239...
  17. pmc Immunoglobulin concentrations and antigen-specific antibody levels in cervicovaginal lavages of rhesus macaques are influenced by the stage of the menstrual cycle
    F X Lu
    California Regional Primate Research Center, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    Infect Immun 67:6321-8. 1999
    ..The results of this study are consistent with the hypothesis that the ovarian hormones that drive the menstrual cycle influence genital tract immunity in female primates...
  18. pmc Antiviral cytotoxic T lymphocytes in vaginal mucosa of simian immunodeficiency virus-infected rhesus macaques
    B L Lohman
    California Regional Primate Research Center, School of Veterinary Medicine, University of California Davis 95616, USA
    J Immunol 155:5855-60. 1995
    ..These results provide the first demonstration that antiviral CTL are present in the vaginal epithelium, and suggest that a vaccine may be able to generate anti-HIV CTL in the genital mucosa...
  19. pmc Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes
    Y Q Tang
    Department of Pathology, University of California, Irvine, California 92697, USA
    Infect Immun 67:6139-44. 1999
    ..This study is the first to characterize the sequences and activities of alpha-defensins from nonhuman primates, data that should aid in delineating the role of these peptides in rhesus macaque host defense...
  20. pmc Titration of an SIVmac251 stock by vaginal inoculation of Indian and Chinese origin rhesus macaques: transmission efficiency, viral loads, and antibody responses
    M L Marthas
    California Regional Primate Research Center, Department of Veterinary Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    AIDS Res Hum Retroviruses 17:1455-66. 2001
    ....
  21. pmc High beta-chemokine expression levels in lymphoid tissues of simian/human immunodeficiency virus 89.6-vaccinated rhesus macaques are associated with uncontrolled replication of simian immunodeficiency virus challenge inoculum
    Lisa LaFranco-Scheuch
    Center for Comparative Medicine, California National Primate Research Center, University of California Davis, 1 Shields Ave, Davis, CA 95616, USA
    J Virol 78:6399-408. 2004
    ..6-mediated control of viral replication after intravaginal challenge with SIVmac239...
  22. ncbi request reprint The number and distribution of immune cells in the cervicovaginal mucosa remain constant throughout the menstrual cycle of rhesus macaques
    Z Ma
    California Regional Primate Research Center, University of California, Davis, California 95616, USA
    Clin Immunol 100:240-9. 2001
    ..We conclude that steroid hormones do not influence genital mucosal immunity by changing the number or distribution of immune cells in the lower reproductive tract...
  23. ncbi request reprint Anatomic site and immune function correlate with relative cytokine mRNA expression levels in lymphoid tissues of normal rhesus macaques
    K Abel
    Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA
    Cytokine 16:191-204. 2001
    ..Pro-inflammatory cytokine mRNA expression levels were highest in lymphoid tissues draining mucosal surfaces. Thus, a correlation exists between cytokine mRNA levels in lymphoid tissues and the anatomical site...
  24. pmc Enhanced antibody responses elicited by a CpG adjuvant do not improve the protective effect of an aldrithiol-2-inactivated simian immunodeficiency virus therapeutic AIDS vaccine
    Yichuan Wang
    Center for Comparative Medicine, University of California, Davis, 95616, USA
    Clin Vaccine Immunol 16:499-505. 2009
    ..The lack of benefit may be related to the high levels of SIV-specific lymphocyte proliferation in the CpG adjuvant group...
  25. pmc The strength of B cell immunity in female rhesus macaques is controlled by CD8+ T cells under the influence of ovarian steroid hormones
    F X Lu
    California Regional Primate Research Center, School of Veterinary Medicine, University of California Davis, CA 95616, USA
    Clin Exp Immunol 128:10-20. 2002
    ..Understanding, and eventually manipulating, the CD8+ regulatory cell-B cell interactions in females may produce novel therapeutic approaches for autoimmune diseases and new vaccine strategies to prevent sexually transmitted diseases...
  26. pmc Limited dissemination of pathogenic SIV after vaginal challenge of rhesus monkeys immunized with a live, attenuated lentivirus
    Mars Stone
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616 USA
    Virology 392:260-70. 2009
    ..These findings suggest that replication of a pathogenic AIDS virus can be controlled at the site of mucosal inoculation by live-attenuated lentivirus immunization...
  27. pmc With minimal systemic T-cell expansion, CD8+ T Cells mediate protection of rhesus macaques immunized with attenuated simian-human immunodeficiency virus SHIV89.6 from vaginal challenge with simian immunodeficiency virus
    Meritxell Genesca
    CNPRC, UC Davis, One Shields Ave, Davis, CA 95616, USA
    J Virol 82:11181-96. 2008
    ....
  28. pmc Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors
    S Crotty
    Department of Microbiology and Immunology, University of California, San Francisco, California 94143-0414, USA
    J Virol 75:7435-52. 2001
    ....
  29. ncbi request reprint Experimental measles. I. Pathogenesis in the normal and the immunized host
    M B McChesney
    California Regional Primate Research Center, University of California, Davis 95616, USA
    Virology 233:74-84. 1997
    ....
  30. pmc Depo-Provera abrogates attenuated lentivirus-induced protection in male rhesus macaques challenged intravenously with pathogenic SIVmac239
    Meritxell Genesca
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    J Med Primatol 36:266-75. 2007
    ..Progesterone administration prior to intravaginal challenge with pathogenic SIVmac239 decreases the protective efficacy of live attenuated vaccines in rhesus macaques...
  31. ncbi request reprint CD4+ T cells and monocytes elicited by immunization of rhesus monkeys with antigen-pulsed dendritic cells control SIV replication
    Gerhardt S Wagner
    California Regional Primate Research Center and Department of Pathology, School of Medicine, University of California Davis, Davis, California 95616, USA
    AIDS Res Hum Retroviruses 18:143-8. 2002
    ..Optimizing this immunization strategy may result in a strong antiviral DTH response that could better control a mucosal lentiviral infection...
  32. pmc The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques
    Yichuan Wang
    California National Primate Research Center, University of California Davis, Davis, California 95616, USA
    J Virol 79:14355-70. 2005
    ..We conclude that induction of mucosal innate immunity including an IFN-alpha response is not sufficient to prevent sexual transmission of human immunodeficiency virus...
  33. ncbi request reprint Detection of antigen-specific T cell interferon gamma expression by ELISPOT and cytokine flow cytometry assays in rhesus macaques
    Bapi Pahar
    California National Primate Research Center, University of California Davis, Davis, CA 95616, USA
    J Immunol Methods 282:103-15. 2003
    ....
  34. ncbi request reprint Co-immunization of rhesus macaques with plasmid vectors expressing IFN-gamma, GM-CSF, and SIV antigens enhances anti-viral humoral immunity but does not affect viremia after challenge with highly pathogenic virus
    P Lena
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Vaccine 20:A69-79. 2002
    ..These results underscore the need for further testing of cytokines as vaccine adjuvants in relevant animal models...
  35. pmc Pegylated interferon-alpha 2a treatment of chronic SIV-infected macaques
    D M Asmuth
    Division of Infectious Diseases, Department of Internal Medicine, University of California Davis Medical Center, 4150 V Street, Sacramento, CA 95817, USA
    J Med Primatol 37:26-30. 2008
    ..Limited investigations have explored the innate or adaptive immune responses of IFN-alpha on SIV replication in vivo...
  36. pmc Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid den
    Kristina Abel
    Center for Comparative Medicine, University of California Davis, CA 95616, USA
    Clin Diagn Lab Immunol 12:606-21. 2005
    ..Based on these findings, A and C class CpG ODN, but not B class CpG ODN, may be particularly suited for use as therapeutic or prophylactic antiviral interventions...
  37. pmc A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculations
    Zhong Min Ma
    California National Primate Research Center, University of California Davis, CA, USA
    J Virol 78:14048-52. 2004
    ..Further, antiviral cellular immune responses were present prior to the establishment of a classic systemic infection in the low-dose vaginal SIV transmission model...
  38. pmc A limited number of simian immunodeficiency virus (SIV) env variants are transmitted to rhesus macaques vaginally inoculated with SIVmac251
    Mars Stone
    CNPRC, UC Davis, One Shields Ave, Davis, CA 95616, USA
    J Virol 84:7083-95. 2010
    ..Furthermore, the SIV rhesus macaque model can be used to understand the factors that influence the transmission of single versus multiple SIV variants...
  39. pmc Alphavirus replicon-based adjuvants enhance the immunogenicity and effectiveness of Fluzone ® in rhesus macaques
    Timothy D Carroll
    Center for Comparative Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Vaccine 29:931-40. 2011
    ..These results demonstrate that null VRP dramatically improve both the immunogenicity and protection elicited by a licensed inactivated influenza vaccine...
  40. pmc Temporal and anatomic relationship between virus replication and cytokine gene expression after vaginal simian immunodeficiency virus infection
    Kristina Abel
    UC Davis, CCM CNPRC, County Rd 98 Hutchison Dr, Davis, CA 95616, USA
    J Virol 79:12164-72. 2005
    ....
  41. ncbi request reprint Use of a replication-defective vector to track cells initially infected by SIV in vivo: infected mononuclear cells rapidly appear in the draining lymph node after intradermal inoculation of rhesus monkeys
    Yichuan Wang
    California National Primate Research Center, Center for Comparative Medicine, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    AIDS Res Hum Retroviruses 20:1298-305. 2004
    ..The results in this SIV vector model probably reflect the short time (less than 16 hr) required for HIV to move from a site of epithelial penetration to the lymphoid tissues via lymphatic vessels...
  42. pmc Gamma interferon-mediated inflammation is associated with lack of protection from intravaginal simian immunodeficiency virus SIVmac239 challenge in simian-human immunodeficiency virus 89.6-immunized rhesus macaques
    Kristina Abel
    Center for Comparative Medicine, California National Primate Research Center, University of California Davis, Davis, California 95616, USA
    J Virol 78:841-54. 2004
    ..Unlike all unvaccinated monkeys, most monkeys vaccinated with SHIV89.6 did not develop IFN-gamma-driven inflammation, but they did develop effective antiviral CD8(+)-T-cell responses...
  43. pmc The relationship between simian immunodeficiency virus RNA levels and the mRNA levels of alpha/beta interferons (IFN-alpha/beta) and IFN-alpha/beta-inducible Mx in lymphoid tissues of rhesus macaques during acute and chronic infection
    Kristina Abel
    Center for Comparative Medicine, University of California Davis, 95616, USA
    J Virol 76:8433-45. 2002
    ..In fact, Mx mRNA levels were associated with high viral RNA levels in lymphoid tissues of chronically infected animals...
  44. ncbi request reprint Comparison of virology and immunology in SHIV 89.6 proviral DNA and virus-inoculated rhesus macaques
    Marc Busch
    California National Primate Research Center and Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    J Med Primatol 32:240-6. 2003
    ..Thus, the data support the concept that plasmid DNA encoding an attenuated virus could be used instead live virus for vaccination...
  45. pmc Effects of ovarian steroids on immunoglobulin-secreting cell function in healthy women
    Fabien X Lu
    California National Primate Research Center, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    Clin Diagn Lab Immunol 10:944-9. 2003
    ..Thus, endogenous ovarian steroids regulate the ISC frequency and this may explain why women are more resistant to viral infections and tend to have more immune-mediated diseases than men do...
  46. pmc Live attenuated lentivirus infection elicits polyfunctional simian immunodeficiency virus Gag-specific CD8+ T cells with reduced apoptotic susceptibility in rhesus macaques that control virus replication after challenge with pathogenic SIVmac239
    Meritxell Genesca
    Center for Comparative Medicine, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Immunol 179:4732-40. 2007
    ..Thus, the polyfunctional capacity and increased survival potential of CD8+ SIV-specific T cells may account for live attenuated, SHIV89.6-mediated protection from uncontrolled SIV replication...
  47. pmc High specific infectivity of plasma virus from the pre-ramp-up and ramp-up stages of acute simian immunodeficiency virus infection
    Zhong Min Ma
    California National Primate Research Center, University of California at Davis, Davis, California 95616, USA
    J Virol 83:3288-97. 2009
    ..These findings have implications for the understanding of the natural history of SIV and human immunodeficiency virus infection and transmission...
  48. ncbi request reprint Interferon-induced expression of MxA in the respiratory tract of rhesus macaques is suppressed by influenza virus replication
    Timothy D Carroll
    California National Primate Research Center, and Center for Comparative Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    J Immunol 180:2385-95. 2008
    ..These results demonstrate for the first time that uncontrolled influenza A virus replication actively suppresses MxA gene expression and emphasize the critical role of innate immunity in controlling influenza virus replication in vivo...
  49. pmc Functional and morphological development of lymphoid tissues and immune regulatory and effector function in rhesus monkeys: cytokine-secreting cells, immunoglobulin-secreting cells, and CD5(+) B-1 cells appear early in fetal development
    Norbert Makori
    California National Primate Research Center, Center for Comparative Medicine, University of California, Davis, California 95616 8542, USA
    Clin Diagn Lab Immunol 10:140-53. 2003
    ..Thus, by the second trimester, the lymphoid tissues of the rhesus monkey fetus have a complete repertoire of properly organized antigen-presenting cells, T cells, and B cells...
  50. ncbi request reprint A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins
    Y Q Tang
    Department of Pathology, College of Medicine, University of California, Irvine, CA 92697, USA
    Science 286:498-502. 1999
    ..Thus, host defense cells possess mechanisms for synthesis and granular packaging of macrocyclic antibiotic peptides that are components of the phagocyte antimicrobial armamentarium...
  51. ncbi request reprint Vaccination in humans generates broad T cell cytokine responses
    Stephen C De Rosa
    Vaccine Research Center, National Institute of Allery and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 173:5372-80. 2004
    ..The presence and variability of these complex response profiles introduce the possibility that selective functional expression patterns may provide correlates for vaccine efficacy or disease progression...
  52. ncbi request reprint HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages
    Elena Izmailova
    Department of Medicine, Children s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 9:191-7. 2003
    ..These results show that HIV-1 Tat reprograms host dendritic cell gene expression to facilitate expansion of HIV-1 infection...
  53. ncbi request reprint Immune mechanisms associated with protection from vaginal SIV challenge in rhesus monkeys infected with virulence-attenuated SHIV 89.6
    Christopher J Miller
    California National Primate Research Center
    J Med Primatol 34:271-81. 2005
    ..6 mounted effective anti-viral CD8+ T cell responses while avoiding the self-destructive inflammatory cycle found in the lymphoid tissues of unprotected and unvaccinated monkeys...
  54. ncbi request reprint A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates
    Naoto Yoshino
    Department of Oral Biology and Microbiology, Immunobiology Vaccine Center, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 173:6850-7. 2004
    ..These results clearly show that mCT E112K is an effective and safe mucosal adjuvant for the development of a nasal HIV/AIDS vaccine...
  55. pmc Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges
    Zandrea Ambrose
    HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland 21702, USA
    J Virol 82:6591-9. 2008
    ..These results highlight the unpredictability of antiviral compounds as topical microbicides and suggest that repeated exposures to candidate treatments should be considered for in vivo evaluation...
  56. pmc Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    Valentina Cecchinato
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 180:5439-47. 2008
    ..These data provide the first direct evidence that immune activation drives viral replication, and suggest caution in the use of therapeutic approaches for HIV infection in vivo that increase CD4(+) T cell proliferation...
  57. pmc Characterization of virus-responsive plasmacytoid dendritic cells in the rhesus macaque
    Eugene Chung
    UMDNJ NJMS, Department of Pathology and Laboratory Medicine, 185 S Orange Ave, Newark, NJ 07101, USA
    Clin Diagn Lab Immunol 12:426-35. 2005
    ..These findings establish the phenotypic and functional similarity of human and macaque PDC and confirm the utility of tools developed for studying human PDC in this animal model...
  58. ncbi request reprint Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis 55455, USA
    Nature 434:1148-52. 2005
    ..The scale of this CD4+ T-cell depletion has adverse effects on the immune system of the host, underscoring the importance of developing countermeasures to SIV that are effective before infection of GALT...
  59. pmc Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac23
    Eun Young Kim
    Division of Infectious Diseases, The Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA
    J Virol 79:4886-95. 2005
    ..These findings show that recombination can occur readily in vivo after mucosal SIV exposure and thus contributes to the generation of viral genetic diversity and enhancement of viral fitness...
  60. ncbi request reprint Detection of macaque perforin expression and release by flow cytometry, immunohistochemistry, ELISA, and ELISpot
    Bartek Zuber
    Mabtech, Box 1233, SE 131 28 Nacka, Sweden
    J Immunol Methods 312:45-53. 2006
    ..These macaque PFN-reactive mAbs and immunoassays will be valuable new tools for investigation of cytotoxic T lymphocyte (CTL) responses in non-human primate models of infectious diseases as well as for vaccine development...
  61. pmc Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infection
    Maire F Quigley
    Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Virol 80:3083-7. 2006
    ..These findings demonstrate the presence of a robust perforin-positive response in gastrointestinal CD8 T cells during acute, but not chronic, SIV infection...
  62. pmc CD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: too late and too little
    Matthew R Reynolds
    Wisconsin Primate Research Center, University of Wisconsin, Madison 53715, USA
    J Virol 79:9228-35. 2005
    ....
  63. pmc Whither or wither microbicides?
    Robert M Grant
    J David Gladstone Institutes, University of California San Francisco, San Francisco, CA 94518, USA
    Science 321:532-4. 2008
    ....

Research Grants16

  1. 25th Annual Symposium on Nonhuman Primate Models for AIDS
    Christopher Miller; Fiscal Year: 2007
    ..Feedback from the participants will be obtained through written questionnaires or oral comments to members of the organizing committee. This format has been successfully followed using NCRR support for the previous Annual symposium. ..
  2. Effect of Microbicides on Mucosal HIV Transmission
    Christopher Miller; Fiscal Year: 2004
    ..Further, these studies will determine if individuals that consistently and correctly use of microbicides in the face of repeated viral exposure develop anti-viral immune responses or local infection. ..
  3. DEVELOPMENT OF THE PRIMATE IMMUNOLOGY RESOURCE
    Christopher Miller; Fiscal Year: 2003
    ..This type of sustained support for assay development is required if immune studies in non-human primates are going to significantly advance in the near future. ..
  4. ANNUAL SYMPOSIUM ON NONHUMAN PRIMATE MODELS FOR AIDS
    Christopher Miller; Fiscal Year: 2002
    ..There will also be an evening banquet at the Monterey Bay Aquarium. ..
  5. PROTECTIVE MECHANISMS WITH ATTENUATED LENTIVIRAL VACCINE
    Christopher Miller; Fiscal Year: 2002
    ....