Brian G Miller

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Catalytic proficiency: the unusual case of OMP decarboxylase
    Brian G Miller
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706 1544, USA
    Annu Rev Biochem 71:847-85. 2002
  2. ncbi Carbon isotope effect study on orotidine 5'-monophosphate decarboxylase: support for an anionic intermediate
    Jeremy L Van Vleet
    Institute for Enzyme Research and Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53726, USA
    Biochemistry 47:798-803. 2008
  3. ncbi Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases
    Brian G Miller
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706 1544, USA
    Biochemistry 43:6387-92. 2004
  4. ncbi Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases
    Brian G Miller
    Department of Biochemistry, University of Wisconsin, Madison 53706 1544, USA
    Biochemistry 44:10776-83. 2005
  5. ncbi Divergent evolution of function in the ROK sugar kinase superfamily: role of enzyme loops in substrate specificity
    Mioara Larion
    Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, Florida 32306 4390, USA
    Biochemistry 46:13564-72. 2007
  6. ncbi The mutability of enzyme active-site shape determinants
    Brian G Miller
    Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, Florida 32306 4390, USA
    Protein Sci 16:1965-8. 2007
  7. ncbi OMP decarboxylase--An enigma persists
    Brian P Callahan
    Division of Infectious Disease, Wadsworth Center NYS DOH, Albany, NY 12202, USA
    Bioorg Chem 35:465-9. 2007
  8. ncbi A metabolic bypass of the triosephosphate isomerase reaction
    Kevin K Desai
    Department of Chemistry and Biochemistry, 217 Dittmer Laboratory of Chemistry, Florida State University, Tallahassee, Florida 32306 4390, USA
    Biochemistry 47:7983-5. 2008

Collaborators

Detail Information

Publications8

  1. ncbi Catalytic proficiency: the unusual case of OMP decarboxylase
    Brian G Miller
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706 1544, USA
    Annu Rev Biochem 71:847-85. 2002
    ..Very large connectivity effects are indicated by the results of experiments testing how transition state stabilization is affected by the truncation of binding determinants of the substrate and the active site...
  2. ncbi Carbon isotope effect study on orotidine 5'-monophosphate decarboxylase: support for an anionic intermediate
    Jeremy L Van Vleet
    Institute for Enzyme Research and Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53726, USA
    Biochemistry 47:798-803. 2008
    ..The isotope effect for the decarboxylation of the slow substrate 2'-deoxy-OMP produced a intrinsic isotope effect of nearly 1.0461...
  3. ncbi Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases
    Brian G Miller
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706 1544, USA
    Biochemistry 43:6387-92. 2004
    ..Our findings suggest that modern genomes harbor a wealth of latent enzyme activities and that extant metabolic pathways are equivocal, in contrast to their usual depiction...
  4. ncbi Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases
    Brian G Miller
    Department of Biochemistry, University of Wisconsin, Madison 53706 1544, USA
    Biochemistry 44:10776-83. 2005
    ....
  5. ncbi Divergent evolution of function in the ROK sugar kinase superfamily: role of enzyme loops in substrate specificity
    Mioara Larion
    Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, Florida 32306 4390, USA
    Biochemistry 46:13564-72. 2007
    ..This finding is consistent with an evolutionary process that includes the formation of intermediates possessing relaxed substrate specificities during the initial steps of enzyme functional divergence...
  6. ncbi The mutability of enzyme active-site shape determinants
    Brian G Miller
    Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, Florida 32306 4390, USA
    Protein Sci 16:1965-8. 2007
    ..These findings establish non-hydrogen bonding shape determinants as highly appealing targets for widespread substitution during efforts to redesign the catalytic properties of natural enzymes...
  7. ncbi OMP decarboxylase--An enigma persists
    Brian P Callahan
    Division of Infectious Disease, Wadsworth Center NYS DOH, Albany, NY 12202, USA
    Bioorg Chem 35:465-9. 2007
    ..In this perspective, we provide a summary of the reaction pathways under consideration for ODCase, highlight the supporting and refuting data, and suggest experiments designed to further test each of the candidate pathways...
  8. ncbi A metabolic bypass of the triosephosphate isomerase reaction
    Kevin K Desai
    Department of Chemistry and Biochemistry, 217 Dittmer Laboratory of Chemistry, Florida State University, Tallahassee, Florida 32306 4390, USA
    Biochemistry 47:7983-5. 2008
    ..This transformation provides an alternate pathway to the formation of dihydroxyacetone phosphate...