B L Miller

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A case study of an emerging visual artist with frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Anli Liu
    University of California San Francisco, CA 94143, USA
    Neurocase 15:235-47. 2009
  2. pmc TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 8:19. 2013
  3. ncbi request reprint Neuroanatomy of the self: evidence from patients with frontotemporal dementia
    B L Miller
    Department of Neurology, UCSF School of Medicine, San Francisco, CA 94117, USA
    Neurology 57:817-21. 2001
  4. ncbi request reprint Portraits of artists: emergence of visual creativity in dementia
    Bruce L Miller
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Arch Neurol 61:842-4. 2004
  5. ncbi request reprint Frontotemporal dementia and semantic dementia: anatomic variations on the same disease or distinctive entities?
    Bruce L Miller
    Department of Neurology, UCSF School of Medicine, San Francisco, CA 94143 1207, USA
    Alzheimer Dis Assoc Disord 21:S19-22. 2007
  6. pmc Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    E C Mormino
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Brain 132:1310-23. 2009
  7. pmc Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration
    G D Rabinovici
    Memory and Aging Center, University of California, San Francisco, California 94143, USA
    Am J Alzheimers Dis Other Demen 22:474-88. 2007
  8. pmc Of brain and bone: the unusual case of Dr. A
    J Narvid
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143, USA
    Neurocase 15:190-205. 2009
  9. ncbi request reprint Cognitive and motor assessment in autopsy-proven corticobasal degeneration
    R Murray
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neurology 68:1274-83. 2007
  10. ncbi request reprint Performance in specific language tasks correlates with regional volume changes in progressive aphasia
    Serena Amici
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA
    Cogn Behav Neurol 20:203-11. 2007

Research Grants

Detail Information

Publications162 found, 100 shown here

  1. pmc A case study of an emerging visual artist with frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Anli Liu
    University of California San Francisco, CA 94143, USA
    Neurocase 15:235-47. 2009
    ..Multiple examples of the patient's art are depicted throughout all stages of his illness, and the possible cognitive, behavioral, and neurologic correlates of his new-onset visual artistry are discussed...
  2. pmc TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 8:19. 2013
    ..With this in mind we set out to assess the genetic association of the Alzheimer's disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative disorders...
  3. ncbi request reprint Neuroanatomy of the self: evidence from patients with frontotemporal dementia
    B L Miller
    Department of Neurology, UCSF School of Medicine, San Francisco, CA 94117, USA
    Neurology 57:817-21. 2001
    ....
  4. ncbi request reprint Portraits of artists: emergence of visual creativity in dementia
    Bruce L Miller
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Arch Neurol 61:842-4. 2004
    ..Art in the context of dementia provides a unique window into the cognitive processes of various brain regions and an opportunity for rehabilitation...
  5. ncbi request reprint Frontotemporal dementia and semantic dementia: anatomic variations on the same disease or distinctive entities?
    Bruce L Miller
    Department of Neurology, UCSF School of Medicine, San Francisco, CA 94143 1207, USA
    Alzheimer Dis Assoc Disord 21:S19-22. 2007
    ..This paper discusses the major pertinent findings, and the implications of classifying the disease on the basis of atrophy versus genetic or molecular mechanisms...
  6. pmc Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    E C Mormino
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Brain 132:1310-23. 2009
    ..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy...
  7. pmc Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration
    G D Rabinovici
    Memory and Aging Center, University of California, San Francisco, California 94143, USA
    Am J Alzheimers Dis Other Demen 22:474-88. 2007
    ..001, uncorrected). These findings suggest that AD and FTLD are anatomically distinct, with degeneration of a posterior parietal network in AD and degeneration of a paralimbic fronto-insular-striatal network in FTLD...
  8. pmc Of brain and bone: the unusual case of Dr. A
    J Narvid
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143, USA
    Neurocase 15:190-205. 2009
    ..This case provides new evidence regarding the neural basis of social cognition and suggests a possible genetic link between bone disease and FTD...
  9. ncbi request reprint Cognitive and motor assessment in autopsy-proven corticobasal degeneration
    R Murray
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neurology 68:1274-83. 2007
    ..To investigate the clinical features of autopsy-proven corticobasal degeneration (CBD)...
  10. ncbi request reprint Performance in specific language tasks correlates with regional volume changes in progressive aphasia
    Serena Amici
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA
    Cogn Behav Neurol 20:203-11. 2007
    ..Patterns of language impairment have long been used clinically to localize brain damage in stroke patients. The same approach might be useful in the differential diagnosis of progressive aphasia owing to neurodegenerative disease...
  11. ncbi request reprint Novel applications of social-personality measures to the study of dementia
    P Mychack
    University of California, San Francisco, Memory and Aging Center, Department of Neurology, San Francisco, CA 94143 1207, USA
    Neurocase 7:131-43. 2001
    ....
  12. pmc Higher atrophy rate of entorhinal cortex than hippocampus in AD
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neurology 62:422-7. 2004
    ....
  13. pmc Emotional reactivity and emotion recognition in frontotemporal lobar degeneration
    K H Werner
    Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    Neurology 69:148-55. 2007
    ....
  14. ncbi request reprint Hemispheric dominance for emotions, empathy and social behaviour: evidence from right and left handers with frontotemporal dementia
    R J Perry
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143, USA
    Neurocase 7:145-60. 2001
    ..The other left hander showed the opposite pattern of deficits, suggesting a novel presentation of anomalous dominance with reversed hemispheric specialization of semantic memory and emotional processing...
  15. pmc Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI
    A T Du
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, USA
    Neurology 67:1215-20. 2006
    ....
  16. ncbi request reprint Behavioral features in semantic dementia vs other forms of progressive aphasias
    H J Rosen
    University of California at San Francisco Department of Neurology, San Francisco, CA 94143 1207, USA
    Neurology 67:1752-6. 2006
    ..To compare the behavioral profiles in different variants of primary progressive aphasia (PPA)...
  17. pmc Conflict monitoring in early frontotemporal dementia
    C E Krueger
    Memory and Aging Center, UCSF Department of Neurology, San Francisco, CA, USA
    Neurology 73:349-55. 2009
    ..The current study examined cognitive control in patients with bvFTD who otherwise seemed cognitively normal...
  18. ncbi request reprint Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia
    J D Woolley
    Memory and Aging Center, Department of Neurology, University of California San Francisco, 1779 Turk St, San Francisco, CA 94115, USA
    Neurology 69:1424-33. 2007
    ..However, the role of these areas in determining feeding disturbances in neurologic patients remains uncertain...
  19. ncbi request reprint From progressive nonfluent aphasia to corticobasal syndrome: a case report of corticobasal degeneration
    R Sanchez-Valle
    UCSF Memory and Aging Center, San Francisco, California 94143 1207, USA
    Neurocase 12:355-9. 2006
    ..This case demonstrates the clinical overlap between frontotemporal lobar degeneration and CBD. In this case, early motor speech impairment predicted earlier and more accurately than CBS the presence of underlying tau-pathology and CBD...
  20. pmc The natural history of temporal variant frontotemporal dementia
    W W Seeley
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 1207, USA
    Neurology 64:1384-90. 2005
    ..Left temporal atrophy has been linked to loss of semantic knowledge, whereas behavioral symptoms dominate the right temporal variant...
  21. ncbi request reprint The effects of executive and behavioral dysfunction on the course of ALS
    R K Olney
    ALS Treatment and Research Center, University of California, San Francisco, San Francisco, CA, USA
    Neurology 65:1774-7. 2005
    ..To determine whether patients with ALS-frontotemporal lobar dementia (FTLD) have a shorter survival and are less compliant with recommended treatments than those with ALS who have normal executive and behavioral function (classic ALS)...
  22. pmc Atrophy rates of entorhinal cortex in AD and normal aging
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    Neurology 60:481-6. 2003
    ..To explore the atrophy rate of entorhinal cortex (ERC) in AD and normal aging and assess the value of rate measurement of ERC atrophy for classifying subjects with AD from cognitively normal (CN) control subjects...
  23. pmc Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration
    E J Kim
    Memory and Aging Center, and Department of Neurology, University of California, San Francisco, San Francisco, California 94117, USA
    J Neurol Neurosurg Psychiatry 78:1375-8. 2007
    ..Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo...
  24. pmc Reading disorders in primary progressive aphasia: a behavioral and neuroimaging study
    S M Brambati
    Department of Neurology, UCSF, San Francisco, CA 94143 1207, United States
    Neuropsychologia 47:1893-900. 2009
    ..These results suggest that exception and pseudo-word reading not only rely upon different language mechanisms selectively damaged in PPA, but also that these processes are sustained by separate brain structures...
  25. pmc Atrophy progression in semantic dementia with asymmetric temporal involvement: a tensor-based morphometry study
    S M Brambati
    Memory Aging Center, UCSF Department of Neurology, San Francisco, CA 94143, USA
    Neurobiol Aging 30:103-11. 2009
    ..These results identified the anatomic substrates of the previously reported clinical evolution of LTLV and RTLV into a unique 'merged' clinical syndrome characterized by semantic and behavioral deficits and bilateral temporal atrophy...
  26. ncbi request reprint Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia
    D H Geschwind
    Department of Neurology, University of California at Los Angeles School of Medicine, 90095 1769, USA
    Ann Neurol 50:741-6. 2001
    ....
  27. pmc Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment
    Judy Pa
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Ann Neurol 65:414-23. 2009
    ..The goal of the study was to compare clinical and neuroimaging characteristics of two single-domain MCI subgroups: amnestic MCI and dysexecutive MCI...
  28. pmc COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures
    E D Gennatas
    Memory and Aging Center, Department of Neurology, University of California San Francisco, CA, USA
    Neurology 78:1663-9. 2012
    ..We sought to determine whether the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene influences neurodegeneration within dopamine-innervated brain regions...
  29. ncbi request reprint Impact of apolipoprotein E epsilon4 and vascular disease on brain morphology in men from the NHLBI twin study
    C DeCarli
    Department of Neurology, University of Kansas, Kansas City, MO 66160, USA
    Stroke 30:1548-53. 1999
    ..Since age-related brain atrophy and the extent of white matter hyperintensities (WMH) share similar risk factors, we examined the combined effect of ApoE4 and history of vascular disease on brain volume, WMH, and MRI evidence of stroke...
  30. pmc Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairment
    A L Boxer
    Memory and Aging Center, Department of Neurology, University of California at San Francisco, 94143 1207, USA
    Neurology 61:1485-91. 2003
    ..To explore the structural neuroimaging correlates of visual constructive impairment in patients with mild to moderate Alzheimer disease (AD)...
  31. ncbi request reprint Anatomical correlates of early mutism in progressive nonfluent aphasia
    M L Gorno-Tempini
    UCSF Department of Neurology, Memory and Aging Center, 350 Parnassus Ave, Suite 800, Box 1207, San Francisco, CA 94143 1207, USA
    Neurology 67:1849-51. 2006
    ..Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA...
  32. ncbi request reprint Functional correlates of musical and visual ability in frontotemporal dementia
    B L Miller
    Department of Neurology, University of California at San Francisco School of Medicine, USA
    Br J Psychiatry 176:458-63. 2000
    ..The emergence of new skills in the setting of dementia suggests that loss of function in one brain area can release new functions elsewhere...
  33. ncbi request reprint Frontotemporal dementia progresses to death faster than Alzheimer disease
    E D Roberson
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
    Neurology 65:719-25. 2005
    ..Frontotemporal lobar degeneration (FTLD) is a common cause of non-Alzheimer dementia, but its natural history and the factors related to mortality in affected patients are not well understood...
  34. ncbi request reprint Frontotemporal dementia versus vascular dementia: differential features on mental status examination
    M M Cherrier
    Department of Neurology, University of California, Los Angeles School of Medicine, USA
    J Am Geriatr Soc 45:579-83. 1997
    ..The purpose of this study was to elucidate distinct cognitive profiles of a large group of FTD and VaD patients on a brief, clinical mental status examination...
  35. pmc Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients
    L L Chao
    Magnetic Resonance Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 116R, San Francisco, CA 94121, USA
    Neurology 64:282-9. 2005
    ..Because NAA is considered a marker of neuronal integrity, reduced medial temporal and parietal lobe NAA could be an early indication of dementia-related pathology in elderly individuals...
  36. ncbi request reprint Behavioral differences between frontotemporal dementia and Alzheimer's disease: a comparison on the BEHAVE-AD rating scale
    M F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    Int Psychogeriatr 10:155-62. 1998
    ..The assessment of neuropsychiatric symptoms with a standardized scale or inventory can help distinguish dementia patients with FTD and AD...
  37. ncbi request reprint Relational integration and executive function in Alzheimer's disease
    James A Waltz
    Departjment of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Neuropsychology 18:296-305. 2004
    ....
  38. ncbi request reprint Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease
    A L Boxer
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Neurology 69:283-90. 2007
    ..To compare the in vivo uptake of two amyloid-binding PET agents, PIB and FDDNP, in human subjects with a prion protein (PrP) gene (PRNP) mutation that produces a clinical syndrome similar to Alzheimer disease (AD)...
  39. ncbi request reprint Andersen-Tawil syndrome: definition of a neurocognitive phenotype
    G Yoon
    Department of Pediatrics, Division of Medical Genetics, University of California, San Francisco 94158, USA
    Neurology 66:1703-10. 2006
    ..It is characterized by periodic paralysis, cardiac arrhythmias, and distinctive features; the effect of KCNJ2 mutations on the CNS has never been studied...
  40. ncbi request reprint Predictors of brain morphology for the men of the NHLBI twin study
    C DeCarli
    Department of Neurology, University of Kansas, Kansas City, USA
    Stroke 30:529-36. 1999
    ..We extend these findings by examining the relationship between midlife cerebrovascular risk factors and later-life differences in brain atrophy, amount of abnormal white matter, and stroke on MRI...
  41. pmc Pleasurable emotional response to music: a case of neurodegenerative generalized auditory agnosia
    Brandy R Matthews
    Department of Neurology, Indiana University School of Medicine, Regenstrief Health Center 6th Floor, 1050 Wishard Blvd, Indianapolis, IN 46202 2859, USA
    Neurocase 15:248-59. 2009
    ..The implications of this case for the evolving understanding of music perception, music misperception, music memory, and music-associated emotion are discussed...
  42. pmc The neural basis of surface dyslexia in semantic dementia
    Stephen M Wilson
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94143 1207, USA
    Brain 132:71-86. 2009
    ....
  43. ncbi request reprint Acquired extroversion associated with bitemporal variant of frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California Los Angeles, Los Angeles, CA 90073, USA
    J Neuropsychiatry Clin Neurosci 18:100-7. 2006
    ..FTD can be a vehicle for unraveling the basis of personality characteristics such as the introversion/extroversion dimension...
  44. pmc Do tests of executive functioning predict ability to downregulate emotions spontaneously and when instructed to suppress?
    Anett Gyurak
    Institute of Personality and Social Research, Department of Psychology, University of California, Berkeley, California 94720 5050, USA
    Cogn Affect Behav Neurosci 9:144-52. 2009
    ....
  45. pmc Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia
    Federica Agosta
    Memory and Aging Center, Department of Neurology, University of California, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:2018-22. 2009
    ..The atrophy patterns in epsilon4 carriers may indicate that they are at greater risk for clinical progression...
  46. ncbi request reprint White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy
    An Tao Du
    Magnetic Resonance Unit 114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurobiol Aging 26:553-9. 2005
    ..Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy...
  47. pmc Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD
    G D Rabinovici
    UCSF Memory and Aging Center, San Francisco, CA 94143, USA
    Neurology 77:2034-42. 2011
    ..To compare the diagnostic performance of PET with the amyloid ligand Pittsburgh compound B (PiB-PET) to fluorodeoxyglucose (FDG-PET) in discriminating between Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD)...
  48. pmc Clinical syndromes associated with posterior atrophy: early age at onset AD spectrum
    R Migliaccio
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Neurology 73:1571-8. 2009
    ..We compared PCA and LPA to each other and to an age-matched group of patients with early age at onset of Alzheimer disease (EO-AD). We hypothesized that these 3 syndromes are part of a single clinical and biologic continuum...
  49. ncbi request reprint A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD
    J L Chang
    Department of Neurology, University of California San Francisco, CA, USA
    Neurology 65:75-80. 2005
    ..To investigate the patterns of MRI brain atrophy in patients with ALS with and without clinically evident frontotemporal lobar dementia (FTLD) using voxel-based morphometry (VBM)...
  50. pmc Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria
    L L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Neurobiol Aging 31:368-77. 2010
    ....
  51. pmc The logopenic/phonological variant of primary progressive aphasia
    M L Gorno-Tempini
    UCSF Memory and Aging Center, University of California, San Francisco, CA 94143, USA
    Neurology 71:1227-34. 2008
    ..A "logopenic" variant (LPA) has also been proposed, but its cognitive and anatomic profile is less defined. The aim of this study was to establish the cognitive and anatomic features of LPA...
  52. pmc Fear conditioning in frontotemporal lobar degeneration and Alzheimer's disease
    M Hoefer
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 1207, USA
    Brain 131:1646-57. 2008
    ..Further study of FC in humans and animal models of dementia could provide a valuable window into these symptoms...
  53. pmc Race/ethnic differences in AD survival in US Alzheimer's Disease Centers
    K M Mehta
    Division of Geriatrics, University of California, San Francisco, 4150 Clement St, Box 181G, San Francisco, CA 94121, USA
    Neurology 70:1163-70. 2008
    ..We examined whether nonwhite AD patients (African American, Latino, Asian, American Indian) had different rates of survival compared with white AD patients...
  54. ncbi request reprint Variations in regional SPECT hypoperfusion and clinical features in frontotemporal dementia
    A M McMurtray
    Department of Neurology, University of California, Los Angeles, CA, USA
    Neurology 66:517-22. 2006
    ..To characterize the presenting clinical features for frontotemporal dementia (FTD) and contrast them with the degree of frontal and temporal hypoperfusion on SPECT imaging...
  55. pmc Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias
    P Vitali
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94143 1207, USA
    Neurology 76:1711-9. 2011
    ..No studies, however, have demonstrated how MRI can distinguish CJD from nonprion causes of rapidly progressive dementia (npRPD). We sought to determine the diagnostic accuracy of MRI for CJD compared to a cohort of npRPD subjects...
  56. ncbi request reprint Behavioral changes in frontotemporal dementia with Parkinsonism
    Catherine E Pace-Savitsky
    University of California, San Francisco, San Francisco, California, USA
    Adv Neurol 96:187-96. 2005
  57. pmc Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
    Juan Zhou
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Brain 133:1352-67. 2010
    ..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring...
  58. pmc Gene expression study on peripheral blood identifies progranulin mutations
    Giovanni Coppola
    Department of Neurology, Program in Neurogenetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Ann Neurol 64:92-6. 2008
    ..This proof-of-principle report supports the use of gene quantification as diagnostic screen for PGRN mutations and suggests a potential role for progranulin in Alzheimer's disease...
  59. pmc Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease
    Siobhan Garbutt
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Brain 131:1268-81. 2008
    ..These data suggest that oculomotor assessment may aid in the diagnosis of FTLD and related disorders...
  60. pmc Classification of primary progressive aphasia and its variants
    M L Gorno-Tempini
    Memory and Aging Center, Department of Neurology, UCSF, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143 1207, USA
    Neurology 76:1006-14. 2011
    ..Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations...
  61. ncbi request reprint Tau mutations in frontotemporal dementia
    K C Wilhelmsen
    Department of Neurology, University of California, San Francisco, Calif 94110, USA
    Dement Geriatr Cogn Disord 10:88-92. 1999
    ..These mutations only account for a small fraction of cases of FTD that are either sporadic or that contain only a few affected relatives...
  62. pmc Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
    Y Zhang
    MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurology 68:13-9. 2007
    ..However, it is unclear whether these abnormalities also impact the cingulum fibers, which connect the medial temporal lobe and the posterior cingulate regions...
  63. pmc Behavioral disorders in the frontal and temporal variants of frontotemporal dementia
    W Liu
    Department of Neurology, University of California at San Francisco, USA
    Neurology 62:742-8. 2004
    ..To compare the behavioral features and to investigate the neuroanatomic correlates of behavioral dysfunction in anatomically defined temporal and frontal variants of frontotemporal dementia (tvFTD and fvFTD)...
  64. ncbi request reprint Spatial cognition and the human navigation network in AD and MCI
    A R deIpolyi
    Gladstone Institute of Neurological Disease, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Neurology 69:986-97. 2007
    ..We characterized navigation in AD and mild cognitive impairment (MCI) to test the hypothesis that navigation disability reflects selective impairments in spatial cognition and relates to atrophy of specific brain regions...
  65. ncbi request reprint Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study
    C DeCarli
    Department of Neurology, University of California at Davis, 4860 Y St, Suite 3700, Sacramento, CA 95817, USA
    Arch Neurol 58:643-7. 2001
    ..To evaluate the relative risk (RR) of mild cognitive impairment (MCI) associated with cerebrovascular risk factors and cerebrovascular-related brain changes...
  66. pmc Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year
    D S Knopman
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Neurology 72:1843-9. 2009
    ..Because there is only limited longitudinal imaging data currently available, we measured the rate of change over 1 year of whole brain volume (WBV) and ventricular volume (VV) in patients with FTLD...
  67. pmc Association of GSK3B with Alzheimer disease and frontotemporal dementia
    Barbara A J Schaffer
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 2506 Gonda, 695 Charles E Young Dr S, Los Angeles, CA 90095 1761, USA
    Arch Neurol 65:1368-74. 2008
    ..As a known tau kinase, GSK3B is a promising candidate gene in the remaining cases of FTD and in AD, for which tau mutations have not been found...
  68. pmc Development of methodology for conducting clinical trials in frontotemporal lobar degeneration
    David S Knopman
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Brain 131:2957-68. 2008
    ..There are several candidate outcome measures -- including the FTLD-CDR and the cognitive composites -- that could be used in clinical trials across the spectrum of FTLD...
  69. pmc Emotion regulation deficits in frontotemporal lobar degeneration and Alzheimer's disease
    Madeleine S Goodkind
    Department of Psychology, University of California, Berkeley, 3210 Tolman Hall, 1650, Berkeley, CA 94720 1650, USA
    Psychol Aging 25:30-7. 2010
    ..These findings illuminate specific problems that these patients have in the emotional realm...
  70. ncbi request reprint Accuracy of the clinical evaluation for frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    Arch Neurol 64:830-5. 2007
    ..Without a definitive clinical test, the early diagnosis of frontotemporal dementia (FTD) can be difficult...
  71. pmc Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Neurology 58:1635-41. 2002
    ..To determine the effects of subcortical ischemic vascular dementia (SIVD) and AD on entorhinal cortex (ERC) and hippocampus...
  72. pmc Self awareness and personality change in dementia
    K P Rankin
    University of California San Francisco Memory and Aging Center, CA 94143 1207, USA
    J Neurol Neurosurg Psychiatry 76:632-9. 2005
    ..However, self awareness of personality has not been quantified in these patient groups...
  73. ncbi request reprint Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment
    A L Boxer
    Memory and Aging Center, Department of Neurology, UCSF, San Francisco, CA 94143 1207, USA
    Neurology 64:1431-4. 2005
    ..These findings suggest that homocysteine-related cognitive impairment may be partially reversible...
  74. ncbi request reprint TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, 2 Gibson, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1449-54. 2007
    ..TDP-43 is a major ubiquitinated disease protein in the pathologic condition of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)...
  75. ncbi request reprint The scale for emotional blunting in patients with frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    Neurocase 12:242-6. 2006
    ..5% for FTD. These findings suggest that the SEB may be a good instrument for the early detection and quantification of emotional blunting in patient with FTD...
  76. ncbi request reprint Stereotypical movements and frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Mov Disord 20:742-5. 2005
    ....
  77. pmc Concordance and discordance between brain perfusion and atrophy in frontotemporal dementia
    Soichiro Shimizu
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Brain Imaging Behav 4:46-54. 2010
    ..Detection of discordance between brain perfusion and structure in FTD might aid diagnosis and staging of the disease...
  78. ncbi request reprint Anatomical correlates of sentence comprehension and verbal working memory in neurodegenerative disease
    Serena Amici
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94143 1207, USA
    J Neurosci 27:6282-90. 2007
    ..This study reconciles two opposing views, which hold that sentence comprehension and vWM rely on either the same or different anatomical resources...
  79. ncbi request reprint A neurocomputational model of analogical reasoning and its breakdown in frontotemporal lobar degeneration
    Robert G Morrison
    Department of Psychology, University of California, Los Angelesm 90095 1563, USA
    J Cogn Neurosci 16:260-71. 2004
    ..Using the "Learning and Inference with Schemas and Analogies" model, we provide a specific account of how such deficits may arise within neural networks supporting analogical problem solving...
  80. ncbi request reprint Creativity and dementia: emerging diagnostic and treatment methods for Alzheimer's disease
    Jeffrey L Cummings
    UCLA Alzheimer s Disease Research Center, University of California, Los Angeles, CA, USA
    CNS Spectr 13:1-20; quiz 22. 2008
    ..Debra Cherry, PhD, discusses the advocacy needs of Alzheimer's disease patients and their caregivers. In addition, Patricia Utermohlen, MA, provides a testimonial of the impact of Alzheimer's disease on an accomplished artist...
  81. pmc Standardised measurement of self-awareness deficits in FTD and AD
    Craig Williamson
    Department of Neurology, University of California, San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Box 1207, Suite 905, San Francisco, CA 94143 1207, USA
    J Neurol Neurosurg Psychiatry 81:140-5. 2010
    ..Here, the authors introduce a new method that allows objective quantification of an individual's awareness of their cognitive abilities and relies upon objective bedside testing...
  82. pmc Multicenter validation of a bedside antisaccade task as a measure of executive function
    J Hellmuth
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA
    Neurology 78:1824-31. 2012
    ..To create and validate a simple, standardized version of the antisaccade (AS) task that requires no specialized equipment for use as a measure of executive function in multicenter clinical studies...
  83. ncbi request reprint Andersen-Tawil syndrome: prospective cohort analysis and expansion of the phenotype
    G Yoon
    Department of Pediatrics, Division of Medical Genetics, University of California, San Francisco, California 94143 0748, USA
    Am J Med Genet A 140:312-21. 2006
    ..Detailed anthropometric, neurological, and cardiac evaluations were performed. Using this approach, we identified novel skeletal and dental findings and proposed additional diagnostic criteria for ATS dysmorphology...
  84. ncbi request reprint Comparison of family histories in FTLD subtypes and related tauopathies
    J S Goldman
    Memory and Aging Center, University of California, San Francisco, CA 94117, USA
    Neurology 65:1817-9. 2005
    ..FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks...
  85. ncbi request reprint Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, 350 Parnassus Avenue, Suite 800, San Francisco, CA 94143 1207, USA
    Neurology 58:1608-15. 2002
    ..To assess the ability of the current diagnostic criteria for frontotemporal lobar degeneration (FTLD) to differentiate FTLD from AD...
  86. pmc Functional neuroimaging and presenting psychiatric features in frontotemporal dementia
    M F Mendez
    Department of Neurology, UCLA, Los Angeles, California, USA
    J Neurol Neurosurg Psychiatry 77:4-7. 2006
    ..Behavioural disturbances include psychiatric features. Whether patients with FTD present with psychiatric features varies with the initial neuroanatomical variability of FTD...
  87. ncbi request reprint The influence of right frontotemporal dysfunction on social behavior in frontotemporal dementia
    P Mychack
    Department of Neurology, University of California at San Francisco School of Medicine, USA
    Neurology 56:S11-5. 2001
    ....
  88. ncbi request reprint Neuroimaging in the diagnosis of frontotemporal dementia
    B L Miller
    Department of Neurology, UCSF Mt Zion Hospital, San Francisco, Calif 94115, USA
    Dement Geriatr Cogn Disord 10:71-4. 1999
    ..This study confirms that neuroimaging is sensitive to the frontotemporal degeneration associated with FTD. Additionally, it suggests that this is often asymmetric in the relative involvement of these brain regions...
  89. pmc Semantic dementia and persisting Wernicke's aphasia: linguistic and anatomical profiles
    J M Ogar
    Memory Aging Center, UCSF Department of Neurology, San Francisco, CA, United States
    Brain Lang 117:28-33. 2011
    ....
  90. pmc Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 61:358-64. 2003
    ....
  91. ncbi request reprint Patterns of brain atrophy in frontotemporal dementia and semantic dementia
    H J Rosen
    Department of Neurology, UCSF Memory and Aging Center, Univeristy of California, San Francisco, 94143 1207, USA
    Neurology 58:198-208. 2002
    ..To identify and compare the patterns of cerebral atrophy associated with two clinical variants of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (FTD) and semantic dementia (SemD)...
  92. pmc Brain atrophy associated with baseline and longitudinal measures of cognition
    V A Cardenas
    San Francisco Veterans Affairs Medical Center, USA
    Neurobiol Aging 32:572-80. 2011
    ..These findings suggest that baseline volumes of prefrontal and temporal regions may underlie continuing cognitive decline due to aging, pathology, or both in non-demented elderly individuals...
  93. pmc TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia
    J D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, UK
    Neurology 75:2204-11. 2010
    ..We sought to describe the antemortem clinical and neuroimaging features among patients with frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions (FTLD-TDP)...
  94. pmc Visual search patterns in semantic dementia show paradoxical facilitation of binding processes
    Indre V Viskontas
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, 350 Parnassus Ave, Ste 905, San Francisco, CA 94143, USA
    Neuropsychologia 49:468-78. 2011
    ....
  95. pmc Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative disease
    Katherine L Possin
    Department of Neurology, University of California San Francisco, San Francisco, California, USA
    J Int Neuropsychol Soc 15:354-64. 2009
    ..These data underscore the importance of right lateral PFC in behavioral monitoring and highlight the potential of RV error assessment for identifying patients with damage to this region...
  96. pmc Neuroimaging in dementia
    Maria Carmela Tartaglia
    University of California, San Francisco Memory and Aging Center, San Francisco, California 94143, USA
    Neurotherapeutics 8:82-92. 2011
    ..Structural and functional imaging modalities contribute to the diagnosis and understanding of the different dementias...
  97. pmc Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia
    William W Seeley
    UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143 1207, USA
    Arch Neurol 65:249-55. 2008
    ..Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the frontal lobes, but the sites of earliest injury remain unclear...
  98. pmc Spontaneous social behaviors discriminate behavioral dementias from psychiatric disorders and other dementias
    Katherine P Rankin
    Department of Neurology, University of California, San Francisco 94143 1207, USA
    J Clin Psychiatry 69:60-73. 2008
    ..The object of this study was to improve screening for behavioral dementias in primary care and mental health settings by quantifying spontaneous social behaviors specific to FTLD...
  99. pmc The diagnostic challenge of psychiatric symptoms in neurodegenerative disease: rates of and risk factors for prior psychiatric diagnosis in patients with early neurodegenerative disease
    Josh D Woolley
    Langley Porter, Department of Psychiatry, University of California, San Francisco, USA
    J Clin Psychiatry 72:126-33. 2011
    ..To identify rates of and risk factors for psychiatric diagnosis preceding the diagnosis of neurodegenerative disease...
  100. pmc Seizures in corticobasal degeneration: a case report
    Vanja C Douglas
    University of California Department of Neurology Box 0114 400 Parnassus Ave, 8th Floor Neurology Clinic San Franciso, CA 94143 0114, USA
    Neurocase 15:352-6. 2009
    ..Thus, the occurrence of seizures in a patient with dementia should not exclude the diagnosis of CBD...
  101. pmc 'The quicksand of forgetfulness': semantic dementia in One hundred years of solitude
    Katya Rascovsky
    Memory and Aging Center, UCSF Department of Neurology, San Francisco, CA 94143 1207, USA
    Brain 132:2609-16. 2009
    ..The novel also provides an inspiring and human account of one town's fight against 'the quicksand of forgetfulness'...

Research Grants5

  1. Multidisciplinary fellowship in dementia research
    Bruce Miller; Fiscal Year: 2007
    ..The goal is to produce clinician-researchers with a well-developed research focus who can understand the significance of findings in other disciplines and incorporate these findings into their own research. ..
  2. Frontotemporal Dementia: Genes, Images and Emotions
    Bruce Miller; Fiscal Year: 2007
    ..Trojanowski and Lee). The Clinical and Administrative Core will also interact extensively with the Data Management and Biostatistics Core (Dr. Fox) for data management, data quality, and data analysis functions. ..