Research Topics
Species | B L MillerSummaryAffiliation: University of California Country: USA Publications
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Publications
A case study of an emerging visual artist with frontotemporal lobar degeneration and amyotrophic lateral sclerosisAnli Liu
University of California San Francisco, CA 94143, USA
Neurocase 15:235-47. 2009..Multiple examples of the patient's art are depicted throughout all stages of his illness, and the possible cognitive, behavioral, and neurologic correlates of his new-onset visual artistry are discussed...
Portraits of artists: emergence of visual creativity in dementiaBruce L Miller
Department of Neurology, University of California, San Francisco, CA 94143, USA
Arch Neurol 61:842-4. 2004..Art in the context of dementia provides a unique window into the cognitive processes of various brain regions and an opportunity for rehabilitation...- Frontotemporal dementia and semantic dementia: anatomic variations on the same disease or distinctive entities?Bruce L Miller
Department of Neurology, UCSF School of Medicine, San Francisco, CA 94143 1207, USA
Alzheimer Dis Assoc Disord 21:S19-22. 2007..This paper discusses the major pertinent findings, and the implications of classifying the disease on the basis of atrophy versus genetic or molecular mechanisms... - Neuroanatomy of the self: evidence from patients with frontotemporal dementiaB L Miller
Department of Neurology, UCSF School of Medicine, San Francisco, CA 94117, USA
Neurology 57:817-21. 2001.... - Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degenerationG D Rabinovici
Memory and Aging Center, University of California, San Francisco, California 94143, USA
Am J Alzheimers Dis Other Demen 22:474-88. 2007..001, uncorrected). These findings suggest that AD and FTLD are anatomically distinct, with degeneration of a posterior parietal network in AD and degeneration of a paralimbic fronto-insular-striatal network in FTLD... - Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjectsE C Mormino
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Brain 132:1310-23. 2009..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy... - Cognitive and motor assessment in autopsy-proven corticobasal degenerationR Murray
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Neurology 68:1274-83. 2007..To investigate the clinical features of autopsy-proven corticobasal degeneration (CBD)... - Of brain and bone: the unusual case of Dr. AJ Narvid
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143, USA
Neurocase 15:190-205. 2009..This case provides new evidence regarding the neural basis of social cognition and suggests a possible genetic link between bone disease and FTD... - Performance in specific language tasks correlates with regional volume changes in progressive aphasiaSerena Amici
Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA
Cogn Behav Neurol 20:203-11. 2007..Patterns of language impairment have long been used clinically to localize brain damage in stroke patients. The same approach might be useful in the differential diagnosis of progressive aphasia owing to neurodegenerative disease... - Higher atrophy rate of entorhinal cortex than hippocampus in ADA T Du
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Neurology 62:422-7. 2004..CONCLUSION: The finding in AD that the atrophy rate in the entorhinal cortex is higher than in the hippocampus is consistent with the view that AD pathology begins in the entorhinal cortex... - Hemispheric dominance for emotions, empathy and social behaviour: evidence from right and left handers with frontotemporal dementiaR J Perry
Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143, USA
Neurocase 7:145-60. 2001..The other left hander showed the opposite pattern of deficits, suggesting a novel presentation of anomalous dominance with reversed hemispheric specialization of semantic memory and emotional processing... - Novel applications of social-personality measures to the study of dementiaP Mychack
University of California, San Francisco, Memory and Aging Center, Department of Neurology, San Francisco, CA 94143 1207, USA
Neurocase 7:131-43. 2001.... - Emotional reactivity and emotion recognition in frontotemporal lobar degenerationK H Werner
Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
Neurology 69:148-55. 2007.... - Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRIA T Du
Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, USA
Neurology 67:1215-20. 2006.... - Conflict monitoring in early frontotemporal dementiaC E Krueger
Memory and Aging Center, UCSF Department of Neurology, San Francisco, CA, USA
Neurology 73:349-55. 2009..The current study examined cognitive control in patients with bvFTD who otherwise seemed cognitively normal... - Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementiaJ D Woolley
Memory and Aging Center, Department of Neurology, University of California San Francisco, 1779 Turk St, San Francisco, CA 94115, USA
Neurology 69:1424-33. 2007..However, the role of these areas in determining feeding disturbances in neurologic patients remains uncertain... - Behavioral features in semantic dementia vs other forms of progressive aphasiasH J Rosen
University of California at San Francisco Department of Neurology, San Francisco, CA 94143 1207, USA
Neurology 67:1752-6. 2006..To compare the behavioral profiles in different variants of primary progressive aphasia (PPA)... - The effects of executive and behavioral dysfunction on the course of ALSR K Olney
ALS Treatment and Research Center, University of California, San Francisco, San Francisco, CA, USA
Neurology 65:1774-7. 2005..To determine whether patients with ALS-frontotemporal lobar dementia (FTLD) have a shorter survival and are less compliant with recommended treatments than those with ALS who have normal executive and behavioral function (classic ALS)... - Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degenerationE J Kim
Memory and Aging Center, and Department of Neurology, University of California, San Francisco, San Francisco, California 94117, USA
J Neurol Neurosurg Psychiatry 78:1375-8. 2007..Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo... - The natural history of temporal variant frontotemporal dementiaW W Seeley
Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 1207, USA
Neurology 64:1384-90. 2005..Left temporal atrophy has been linked to loss of semantic knowledge, whereas behavioral symptoms dominate the right temporal variant... - Atrophy rates of entorhinal cortex in AD and normal agingA T Du
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
Neurology 60:481-6. 2003..93. CONCLUSION: ERC volume loss over time may be a better indicator for AD than cross-sectional measurements... - From progressive nonfluent aphasia to corticobasal syndrome: a case report of corticobasal degenerationR Sanchez-Valle
UCSF Memory and Aging Center, San Francisco, California 94143 1207, USA
Neurocase 12:355-9. 2006..This case demonstrates the clinical overlap between frontotemporal lobar degeneration and CBD. In this case, early motor speech impairment predicted earlier and more accurately than CBS the presence of underlying tau-pathology and CBD... - Atrophy progression in semantic dementia with asymmetric temporal involvement: a tensor-based morphometry studyS M Brambati
Memory Aging Center, UCSF Department of Neurology, San Francisco, CA 94143, USA
Neurobiol Aging 30:103-11. 2009..These results identified the anatomic substrates of the previously reported clinical evolution of LTLV and RTLV into a unique 'merged' clinical syndrome characterized by semantic and behavioral deficits and bilateral temporal atrophy... - Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementiaD H Geschwind
Department of Neurology, University of California at Los Angeles School of Medicine, 90095 1769, USA
Ann Neurol 50:741-6. 2001.... - Reading disorders in primary progressive aphasia: a behavioral and neuroimaging studyS M Brambati
Department of Neurology, UCSF, San Francisco, CA 94143 1207, United States
Neuropsychologia 47:1893-900. 2009..These results suggest that exception and pseudo-word reading not only rely upon different language mechanisms selectively damaged in PPA, but also that these processes are sustained by separate brain structures... - Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairmentJudy Pa
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
Ann Neurol 65:414-23. 2009..The goal of the study was to compare clinical and neuroimaging characteristics of two single-domain MCI subgroups: amnestic MCI and dysexecutive MCI... - COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structuresE D Gennatas
Memory and Aging Center, Department of Neurology, University of California San Francisco, CA, USA
Neurology 78:1663-9. 2012..We sought to determine whether the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene influences neurodegeneration within dopamine-innervated brain regions... - Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patientsL L Chao
Magnetic Resonance Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 116R, San Francisco, CA 94121, USA
Neurology 64:282-9. 2005..Because NAA is considered a marker of neuronal integrity, reduced medial temporal and parietal lobe NAA could be an early indication of dementia-related pathology in elderly individuals... - Behavioral differences between frontotemporal dementia and Alzheimer's disease: a comparison on the BEHAVE-AD rating scaleM F Mendez
Department of Neurology, University of California at Los Angeles, USA
Int Psychogeriatr 10:155-62. 1998..The assessment of neuropsychiatric symptoms with a standardized scale or inventory can help distinguish dementia patients with FTD and AD... - Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairmentA L Boxer
Memory and Aging Center, Department of Neurology, University of California at San Francisco, 94143 1207, USA
Neurology 61:1485-91. 2003..To explore the structural neuroimaging correlates of visual constructive impairment in patients with mild to moderate Alzheimer disease (AD)... - Impact of apolipoprotein E epsilon4 and vascular disease on brain morphology in men from the NHLBI twin studyC DeCarli
Department of Neurology, University of Kansas, Kansas City, MO 66160, USA
Stroke 30:1548-53. 1999..Since age-related brain atrophy and the extent of white matter hyperintensities (WMH) share similar risk factors, we examined the combined effect of ApoE4 and history of vascular disease on brain volume, WMH, and MRI evidence of stroke... - Frontotemporal dementia progresses to death faster than Alzheimer diseaseE D Roberson
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
Neurology 65:719-25. 2005..Frontotemporal lobar degeneration (FTLD) is a common cause of non-Alzheimer dementia, but its natural history and the factors related to mortality in affected patients are not well understood... - Functional correlates of musical and visual ability in frontotemporal dementiaB L Miller
Department of Neurology, University of California at San Francisco School of Medicine, USA
Br J Psychiatry 176:458-63. 2000..The emergence of new skills in the setting of dementia suggests that loss of function in one brain area can release new functions elsewhere... - Frontotemporal dementia versus vascular dementia: differential features on mental status examinationM M Cherrier
Department of Neurology, University of California, Los Angeles School of Medicine, USA
J Am Geriatr Soc 45:579-83. 1997..The purpose of this study was to elucidate distinct cognitive profiles of a large group of FTD and VaD patients on a brief, clinical mental status examination... - Anatomical correlates of early mutism in progressive nonfluent aphasiaM L Gorno-Tempini
UCSF Department of Neurology, Memory and Aging Center, 350 Parnassus Ave, Suite 800, Box 1207, San Francisco, CA 94143 1207, USA
Neurology 67:1849-51. 2006..Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA... - Relational integration and executive function in Alzheimer's diseaseJames A Waltz
Departjment of Psychology, University of California, Los Angeles, CA 90095-1563, USA
Neuropsychology 18:296-305. 2004.... - Andersen-Tawil syndrome: definition of a neurocognitive phenotypeG Yoon
Department of Pediatrics, Division of Medical Genetics, University of California, San Francisco 94158, USA
Neurology 66:1703-10. 2006..056) and 23.4 points for mathematics (95% CI -42.53, -4.22; p = 0.017). CONCLUSION: Mutations in KCNJ2 are associated with a distinct neurocognitive phenotype, characterized by deficits in executive function and abstract reasoning... - Amyloid imaging in distinguishing atypical prion disease from Alzheimer diseaseA L Boxer
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Neurology 69:283-90. 2007..To compare the in vivo uptake of two amyloid-binding PET agents, PIB and FDDNP, in human subjects with a prion protein (PrP) gene (PRNP) mutation that produces a clinical syndrome similar to Alzheimer disease (AD)... - Predictors of brain morphology for the men of the NHLBI twin studyC DeCarli
Department of Neurology, University of Kansas, Kansas City, USA
Stroke 30:529-36. 1999..We extend these findings by examining the relationship between midlife cerebrovascular risk factors and later-life differences in brain atrophy, amount of abnormal white matter, and stroke on MRI... - Acquired extroversion associated with bitemporal variant of frontotemporal dementiaMario F Mendez
Department of Neurology, University of California Los Angeles, Los Angeles, CA 90073, USA
J Neuropsychiatry Clin Neurosci 18:100-7. 2006..FTD can be a vehicle for unraveling the basis of personality characteristics such as the introversion/extroversion dimension... - Do tests of executive functioning predict ability to downregulate emotions spontaneously and when instructed to suppress?Anett Gyurak
Institute of Personality and Social Research, Department of Psychology, University of California, Berkeley, California 94720 5050, USA
Cogn Affect Behav Neurosci 9:144-52. 2009.... - White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophyAn-Tao Du
Magnetic Resonance Unit (114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Neurobiol Aging 26:553-9. 2005..Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy... - Pleasurable emotional response to music: a case of neurodegenerative generalized auditory agnosiaBrandy R Matthews
Department of Neurology, Indiana University School of Medicine, Regenstrief Health Center 6th Floor, 1050 Wishard Blvd, Indianapolis, IN 46202 2859, USA
Neurocase 15:248-59. 2009..The implications of this case for the evolving understanding of music perception, music misperception, music memory, and music-associated emotion are discussed... - Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementiaFederica Agosta
Memory and Aging Center, Department of Neurology, University of California, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:2018-22. 2009..The atrophy patterns in epsilon4 carriers may indicate that they are at greater risk for clinical progression... - The neural basis of surface dyslexia in semantic dementiaStephen M Wilson
Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94143 1207, USA
Brain 132:71-86. 2009.... - Amyloid vs FDG-PET in the differential diagnosis of AD and FTLDG D Rabinovici
UCSF Memory and Aging Center, San Francisco, CA 94143, USA
Neurology 77:2034-42. 2011..To compare the diagnostic performance of PET with the amyloid ligand Pittsburgh compound B (PiB-PET) to fluorodeoxyglucose (FDG-PET) in discriminating between Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD)... - A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLDJ L Chang
Department of Neurology, University of California San Francisco, CA, USA
Neurology 65:75-80. 2005..This finding supports the idea of a clinical and anatomic continuum between ALS and frontotemporal lobar degeneration... - Fear conditioning in frontotemporal lobar degeneration and Alzheimer's diseaseM Hoefer
Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 1207, USA
Brain 131:1646-57. 2008..Further study of FC in humans and animal models of dementia could provide a valuable window into these symptoms... - Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementiasP Vitali
Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94143 1207, USA
Neurology 76:1711-9. 2011..No studies, however, have demonstrated how MRI can distinguish CJD from nonprion causes of rapidly progressive dementia (npRPD). We sought to determine the diagnostic accuracy of MRI for CJD compared to a cohort of npRPD subjects... - Variations in regional SPECT hypoperfusion and clinical features in frontotemporal dementiaA M McMurtray
Department of Neurology, University of California, Los Angeles, CA, USA
Neurology 66:517-22. 2006..Nonetheless, patients with FTD can initially present with further regional differences in clinical diagnostic features, such as apathy with bifrontal hypoperfusion and hypomania-like behaviors with anterior temporal involvement... - Race/ethnic differences in AD survival in US Alzheimer's Disease CentersK M Mehta
Division of Geriatrics, University of California, San Francisco, 4150 Clement St, Box 181G, San Francisco, CA 94121, USA
Neurology 70:1163-70. 2008..We examined whether nonwhite AD patients (African American, Latino, Asian, American Indian) had different rates of survival compared with white AD patients... - Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteriaL L Chao
Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA 94121, USA
Neurobiol Aging 31:368-77. 2010.... - Clinical syndromes associated with posterior atrophy: early age at onset AD spectrumR Migliaccio
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Neurology 73:1571-8. 2009..We compared PCA and LPA to each other and to an age-matched group of patients with early age at onset of Alzheimer disease (EO-AD). We hypothesized that these 3 syndromes are part of a single clinical and biologic continuum... - The logopenic/phonological variant of primary progressive aphasiaM L Gorno-Tempini
UCSF Memory and Aging Center, University of California, San Francisco, CA 94143, USA
Neurology 71:1227-34. 2008..A "logopenic" variant (LPA) has also been proposed, but its cognitive and anatomic profile is less defined. The aim of this study was to establish the cognitive and anatomic features of LPA... - Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's diseaseSiobhan Garbutt
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Brain 131:1268-81. 2008..These data suggest that oculomotor assessment may aid in the diagnosis of FTLD and related disorders... - Gene expression study on peripheral blood identifies progranulin mutationsGiovanni Coppola
Department of Neurology, Program in Neurogenetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Ann Neurol 64:92-6. 2008..This proof-of-principle report supports the use of gene quantification as diagnostic screen for PGRN mutations and suggests a potential role for progranulin in Alzheimer's disease... - Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's diseaseJuan Zhou
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
Brain 133:1352-67. 2010..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring... - Behavioral changes in frontotemporal dementia with ParkinsonismCatherine E Pace-Savitsky
University of California, San Francisco, San Francisco, California, USA
Adv Neurol 96:187-96. 2005 - Spatial cognition and the human navigation network in AD and MCIA R deIpolyi
Gladstone Institute of Neurological Disease, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Neurology 69:986-97. 2007..We characterized navigation in AD and mild cognitive impairment (MCI) to test the hypothesis that navigation disability reflects selective impairments in spatial cognition and relates to atrophy of specific brain regions... - Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer diseaseY Zhang
MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Neurology 68:13-9. 2007..However, it is unclear whether these abnormalities also impact the cingulum fibers, which connect the medial temporal lobe and the posterior cingulate regions... - Tau mutations in frontotemporal dementiaK C Wilhelmsen
Department of Neurology, University of California, San Francisco, Calif 94110, USA
Dement Geriatr Cogn Disord 10:88-92. 1999..These mutations only account for a small fraction of cases of FTD that are either sporadic or that contain only a few affected relatives... - Behavioral disorders in the frontal and temporal variants of frontotemporal dementiaW Liu
Department of Neurology, University of California at San Francisco, USA
Neurology 62:742-8. 2004..CONCLUSION: FvFTD and tvFTD show many similarities in behavior, which appear to be associated with damage to right frontal and temporal structures... - Classification of primary progressive aphasia and its variantsM L Gorno-Tempini
Memory and Aging Center, Department of Neurology, UCSF, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143 1207, USA
Neurology 76:1006-14. 2011..Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations... - Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 yearD S Knopman
Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Neurology 72:1843-9. 2009..Because there is only limited longitudinal imaging data currently available, we measured the rate of change over 1 year of whole brain volume (WBV) and ventricular volume (VV) in patients with FTLD... - Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin StudyC DeCarli
Department of Neurology, University of California at Davis, 4860 Y St, Suite 3700, Sacramento, CA 95817, USA
Arch Neurol 58:643-7. 2001..To evaluate the relative risk (RR) of mild cognitive impairment (MCI) associated with cerebrovascular risk factors and cerebrovascular-related brain changes... - Development of methodology for conducting clinical trials in frontotemporal lobar degenerationDavid S Knopman
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Brain 131:2957-68. 2008..There are several candidate outcome measures -- including the FTLD-CDR and the cognitive composites -- that could be used in clinical trials across the spectrum of FTLD... - Association of GSK3B with Alzheimer disease and frontotemporal dementiaBarbara A J Schaffer
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 2506 Gonda, 695 Charles E Young Dr S, Los Angeles, CA 90095 1761, USA
Arch Neurol 65:1368-74. 2008..As a known tau kinase, GSK3B is a promising candidate gene in the remaining cases of FTD and in AD, for which tau mutations have not been found... - Emotion regulation deficits in frontotemporal lobar degeneration and Alzheimer's diseaseMadeleine S Goodkind
Department of Psychology, University of California, Berkeley, 3210 Tolman Hall, 1650, Berkeley, CA 94720 1650, USA
Psychol Aging 25:30-7. 2010..These findings illuminate specific problems that these patients have in the emotional realm... - Accuracy of the clinical evaluation for frontotemporal dementiaMario F Mendez
Department of Neurology, University of California at Los Angeles, USA
Arch Neurol 64:830-5. 2007..Without a definitive clinical test, the early diagnosis of frontotemporal dementia (FTD) can be difficult... - Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatmentA L Boxer
Memory and Aging Center, Department of Neurology, UCSF, San Francisco, CA 94143 1207, USA
Neurology 64:1431-4. 2005..These findings suggest that homocysteine-related cognitive impairment may be partially reversible... - Self awareness and personality change in dementiaK P Rankin
University of California San Francisco Memory and Aging Center, CA 94143 1207, USA
J Neurol Neurosurg Psychiatry 76:632-9. 2005..However, self awareness of personality has not been quantified in these patient groups... - Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampusA T Du
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Neurology 58:1635-41. 2002..CONCLUSIONS: The entorhinal cortex and hippocampus are less affected by subcortical ischemic vascular dementia than by AD... - Standardised measurement of self-awareness deficits in FTD and ADCraig Williamson
Department of Neurology, University of California, San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Box 1207, Suite 905, San Francisco, CA 94143 1207, USA
J Neurol Neurosurg Psychiatry 81:140-5. 2010..Here, the authors introduce a new method that allows objective quantification of an individual's awareness of their cognitive abilities and relies upon objective bedside testing... - Anatomical correlates of sentence comprehension and verbal working memory in neurodegenerative diseaseSerena Amici
Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94143 1207, USA
J Neurosci 27:6282-90. 2007..This study reconciles two opposing views, which hold that sentence comprehension and vWM rely on either the same or different anatomical resources... - The scale for emotional blunting in patients with frontotemporal dementiaMario F Mendez
Department of Neurology, University of California at Los Angeles, USA
Neurocase 12:242-6. 2006..5% for FTD. These findings suggest that the SEB may be a good instrument for the early detection and quantification of emotional blunting in patient with FTD... - Concordance and discordance between brain perfusion and atrophy in frontotemporal dementiaSoichiro Shimizu
Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
Brain Imaging Behav 4:46-54. 2010..Detection of discordance between brain perfusion and structure in FTD might aid diagnosis and staging of the disease... - A neurocomputational model of analogical reasoning and its breakdown in frontotemporal lobar degenerationRobert G Morrison
Department of Psychology, University of California, Los Angelesm 90095 1563, USA
J Cogn Neurosci 16:260-71. 2004..Using the "Learning and Inference with Schemas and Analogies" model, we provide a specific account of how such deficits may arise within neural networks supporting analogical problem solving... - Stereotypical movements and frontotemporal dementiaMario F Mendez
Department of Neurology, University of California at Los Angeles, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Mov Disord 20:742-5. 2005.... - Creativity and dementia: emerging diagnostic and treatment methods for Alzheimer's diseaseJeffrey L Cummings
UCLA Alzheimer s Disease Research Center, University of California, Los Angeles, CA, USA
CNS Spectr 13:1-20; quiz 22. 2008..Debra Cherry, PhD, discusses the advocacy needs of Alzheimer's disease patients and their caregivers. In addition, Patricia Utermohlen, MA, provides a testimonial of the impact of Alzheimer's disease on an accomplished artist... - TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusionsMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, 2 Gibson, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
Arch Neurol 64:1449-54. 2007..TDP-43 is a major ubiquitinated disease protein in the pathologic condition of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)... - Multicenter validation of a bedside antisaccade task as a measure of executive functionJ Hellmuth
Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA
Neurology 78:1824-31. 2012..To create and validate a simple, standardized version of the antisaccade (AS) task that requires no specialized equipment for use as a measure of executive function in multicenter clinical studies... - Functional neuroimaging and presenting psychiatric features in frontotemporal dementiaM F Mendez
Department of Neurology, UCLA, Los Angeles, California, USA
J Neurol Neurosurg Psychiatry 77:4-7. 2006..Behavioural disturbances include psychiatric features. Whether patients with FTD present with psychiatric features varies with the initial neuroanatomical variability of FTD... - Comparison of family histories in FTLD subtypes and related tauopathiesJ S Goldman
Memory and Aging Center, University of California, San Francisco, CA 94117, USA
Neurology 65:1817-9. 2005..FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks... - Andersen-Tawil syndrome: prospective cohort analysis and expansion of the phenotypeG Yoon
Department of Pediatrics, Division of Medical Genetics, University of California, San Francisco, California 94143 0748, USA
Am J Med Genet A 140:312-21. 2006..Detailed anthropometric, neurological, and cardiac evaluations were performed. Using this approach, we identified novel skeletal and dental findings and proposed additional diagnostic criteria for ATS dysmorphology... - Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from ADHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, 350 Parnassus Avenue, Suite 800, San Francisco, CA 94143 1207, USA
Neurology 58:1608-15. 2002..To assess the ability of the current diagnostic criteria for frontotemporal lobar degeneration (FTLD) to differentiate FTLD from AD... - Neuroimaging in the diagnosis of frontotemporal dementiaB L Miller
Department of Neurology, UCSF Mt Zion Hospital, San Francisco, Calif 94115, USA
Dement Geriatr Cogn Disord 10:71-4. 1999..This study confirms that neuroimaging is sensitive to the frontotemporal degeneration associated with FTD. Additionally, it suggests that this is often asymmetric in the relative involvement of these brain regions... - The influence of right frontotemporal dysfunction on social behavior in frontotemporal dementiaP Mychack
Department of Neurology, University of California at San Francisco School of Medicine, USA
Neurology 56:S11-5. 2001.... - Brain atrophy associated with baseline and longitudinal measures of cognitionV A Cardenas
San Francisco Veterans Affairs Medical Center, USA
Neurobiol Aging 32:572-80. 2011..These findings suggest that baseline volumes of prefrontal and temporal regions may underlie continuing cognitive decline due to aging, pathology, or both in non-demented elderly individuals... - Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and ADN Schuff
Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
Neurology 61:358-64. 2003.... - Semantic dementia and persisting Wernicke's aphasia: linguistic and anatomical profilesJ M Ogar
Memory Aging Center, UCSF Department of Neurology, San Francisco, CA, United States
Brain Lang 117:28-33. 2011.... - Patterns of brain atrophy in frontotemporal dementia and semantic dementiaH J Rosen
Department of Neurology, UCSF Memory and Aging Center, Univeristy of California, San Francisco, 94143 1207, USA
Neurology 58:198-208. 2002..To identify and compare the patterns of cerebral atrophy associated with two clinical variants of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (FTD) and semantic dementia (SemD)... - TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementiaJ D Rohrer
Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, UK
Neurology 75:2204-11. 2010..We sought to describe the antemortem clinical and neuroimaging features among patients with frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions (FTLD-TDP)... - Frontotemporal lobar degeneration: demographic characteristics of 353 patientsJulene K Johnson
Department of Neurology, Memory and Aging Center, University of California, San Francisco, 94117, USA
Arch Neurol 62:925-30. 2005..The publication of consensus criteria for FTLD, however, prompted systematic studies. The criteria categorize FTLD into 3 subgroups: frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia... - Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative diseaseKatherine L Possin
Department of Neurology, University of California San Francisco, San Francisco, California, USA
J Int Neuropsychol Soc 15:354-64. 2009..These data underscore the importance of right lateral PFC in behavioral monitoring and highlight the potential of RV error assessment for identifying patients with damage to this region... - Patterns of cognitive and emotional empathy in frontotemporal lobar degenerationKatherine P Rankin
Memory and Aging Center, University of California San Francisco, California 94145 1203, USA
Cogn Behav Neurol 18:28-36. 2005..To examine the relationship between empathy and cognition in frontotemporal lobar degeneration (FTLD)... - Neuropsychological and functional measures of severity in Alzheimer disease, frontotemporal dementia, and semantic dementiaHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, San Francisco, California 94143 1207, USA
Alzheimer Dis Assoc Disord 18:202-7. 2004..Thus, in FTD the CDR reveals functional impairments in a wide variety of domains that are more severe than those seen in AD or SD patients with an equivalent Mini-Mental State Examination... - When sporadic disease is not sporadic: the potential for genetic etiologyJill S Goldman
University of California, Memory and Aging Center, San Francisco 94143 1207, USA
Arch Neurol 61:213-6. 2004..Approximately 2% of Alzheimer disease cases and 10% to 15% of prion disease cases are due to mutations in autosomal dominant genes. Mutations have been found in patients without family histories of neurological disease... - Cognition and anatomy in three variants of primary progressive aphasiaMaria Luisa Gorno-Tempini
Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143, USA
Ann Neurol 55:335-46. 2004..Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes... - Rapidly progressive dementiaMichael D Geschwind
University of California San Francisco Memory and Aging Center, Department of Neurology, San Francisco, CA 94143 1207, USA
Ann Neurol 64:97-108. 2008.... - Abeta amyloid and glucose metabolism in three variants of primary progressive aphasiaGil D Rabinovici
Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
Ann Neurol 64:388-401. 2008.... - Non-Alzheimer's disease dementias: anatomic, clinical, and molecular correlatesCraig E Hou
Department of Neurology, University of California at San Francisco, USA
Can J Psychiatry 49:164-71. 2004..We also discuss the pharmacologic treatment of these disorders...
Research Grants
- Multidisciplinary fellowship in dementia researchBruce Miller; Fiscal Year: 2007..The goal is to produce clinician-researchers with a well-developed research focus who can understand the significance of findings in other disciplines and incorporate these findings into their own research. ..
- Frontotemporal Dementia: Genes, Images and EmotionsBruce Miller; Fiscal Year: 2007..Trojanowski and Lee). The Clinical and Administrative Core will also interact extensively with the Data Management and Biostatistics Core (Dr. Fox) for data management, data quality, and data analysis functions. ..