R Miledi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Ricardo Miledi and the calcium hypothesis of neurotransmitter release
    Jade Ming Jeng
    Department of Neurobiology and Behavior, University of California, Irvine 92697 4292, USA
    Nat Rev Neurosci 3:71-6. 2002
  2. pmc Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes
    Agenor Limon
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Proc Natl Acad Sci U S A 105:10973-7. 2008
  3. pmc Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes
    Ricardo Miledi
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 99:13238-42. 2002
  4. ncbi request reprint Effects of the antibiotic gentamicin on nicotinic acetylcholine receptors
    Mascia Amici
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Neuropharmacology 49:627-37. 2005
  5. ncbi request reprint Analysis of free ACh and 5-HT in milk from four different species and their bioactivity on 5-HT3 and nACh receptors
    Jose Luis Gallegos-Perez
    Department of Neurobiology and Behavior, University of California, 2205 McGaugh Hall, Irvine, CA 92697, USA
    Food Funct 5:1489-94. 2014
  6. pmc Microtransplantation of functional receptors and channels from the Alzheimer's brain to frog oocytes
    R Miledi
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Proc Natl Acad Sci U S A 101:1760-3. 2004
  7. pmc Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy
    D Ragozzino
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 102:15219-23. 2005
  8. pmc Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory
    E Palma
    Istituto Pasteur, Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, 00185 Rome, Italy
    Proc Natl Acad Sci U S A 103:8465-8. 2006
  9. pmc BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes
    E Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 102:1667-72. 2005
  10. ncbi request reprint Inhibition of nicotinic acetylcholine receptors by bicuculline
    A Demuro
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4550, USA
    Neuropharmacology 41:854-61. 2001

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Ricardo Miledi and the calcium hypothesis of neurotransmitter release
    Jade Ming Jeng
    Department of Neurobiology and Behavior, University of California, Irvine 92697 4292, USA
    Nat Rev Neurosci 3:71-6. 2002
    ..Here I discuss aspects of Miledi's research that helped to establish the requirement of presynaptic calcium for neurotransmitter release, from his earliest scientific studies to his classic experiments in the squid giant synapse...
  2. pmc Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes
    Agenor Limon
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Proc Natl Acad Sci U S A 105:10973-7. 2008
    ....
  3. pmc Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes
    Ricardo Miledi
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 99:13238-42. 2002
    ....
  4. ncbi request reprint Effects of the antibiotic gentamicin on nicotinic acetylcholine receptors
    Mascia Amici
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Neuropharmacology 49:627-37. 2005
    ..This data helps to better understand the action of gentamicin on muscle and nervous tissues, providing mechanistic insights that could eventually lead to improving the medical use of aminoglycosides...
  5. ncbi request reprint Analysis of free ACh and 5-HT in milk from four different species and their bioactivity on 5-HT3 and nACh receptors
    Jose Luis Gallegos-Perez
    Department of Neurobiology and Behavior, University of California, 2205 McGaugh Hall, Irvine, CA 92697, USA
    Food Funct 5:1489-94. 2014
    ..This work is a first step to elucidate whether 5-HT and ACh, at the concentrations present in the milk, can be associated to a direct function in the GI. ..
  6. pmc Microtransplantation of functional receptors and channels from the Alzheimer's brain to frog oocytes
    R Miledi
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Proc Natl Acad Sci U S A 101:1760-3. 2004
    ..This knowledge may help in understanding the basis of Alzheimer's disease and also help in developing new treatments...
  7. pmc Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy
    D Ragozzino
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 102:15219-23. 2005
    ....
  8. pmc Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory
    E Palma
    Istituto Pasteur, Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, 00185 Rome, Italy
    Proc Natl Acad Sci U S A 103:8465-8. 2006
    ....
  9. pmc BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes
    E Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 102:1667-72. 2005
    ....
  10. ncbi request reprint Inhibition of nicotinic acetylcholine receptors by bicuculline
    A Demuro
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4550, USA
    Neuropharmacology 41:854-61. 2001
    ..All this suggests that bicuculline may serve as a lead molecule to design new anticholinergic substances...
  11. pmc Antagonistic action of pitrazepin on human and rat GABA(A) receptors
    A Demuro
    Department of Psychobiology, University of California, Irvine 92697 4550, USA
    Br J Pharmacol 127:57-64. 1999
    ..Moreover, pitrazepin did not antagonize the potentiation of GABA-currents by flunitrazepam. All this suggests that pitrazepin does not affect the GABA receptor-chloride channel by interacting with the benzodiazepine receptor site...
  12. ncbi request reprint Effects of atypical antipsychotics on vertebrate neuromuscular transmission
    Q T Nguyen
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, Irvine, USA
    Neuropharmacology 42:670-6. 2002
    ....
  13. ncbi request reprint Properties of neuronal alpha7 mutant nicotinic acetylcholine receptors gated by bicuculline
    Raffaella Tonini
    Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Piazzale A Moro 5, I 00185 Rome, Italy
    Neuropharmacology 44:765-71. 2003
    ..Therefore, the gating kinetics of both L248T and L247R-C189S-C190S receptor-channels change when BIC is replaced by ACh; and we conclude that both ACh and BIC activate mutant alpha7 receptors with different patterns of activation...
  14. doi request reprint Microtransplantation of ligand-gated receptor-channels from fresh or frozen nervous tissue into Xenopus oocytes: a potent tool for expanding functional information
    F Eusebi
    Dipartimento di Fisiologia e Farmacologia Centro di Eccellenza BEMM, Universita di Roma Sapienza, Piazzale A Moro 5, I00185 Roma, Italy
    Prog Neurobiol 88:32-40. 2009
    ..This review focuses on recently obtained information and on some new lines of biological research using receptor microtransplantation into oocytes...
  15. pmc The chemokine growth-related gene product beta protects rat cerebellar granule cells from apoptotic cell death through alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors
    C Limatola
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, 00161 Rome, Italy
    Proc Natl Acad Sci U S A 97:6197-201. 2000
    ..Our data demonstrate that GRObeta is neurotrophic for cerebellar granule cells, and that this activity depends on AMPA receptors...
  16. pmc Expression of gamma-aminobutyric acid rho 1 and rho 1 Delta 450 as gene fusions with the green fluorescent protein
    A Martinez-Torres
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 98:1947-51. 2001
    ..Thus, rho 1- and rho 1 Delta 450-GFP fusions provide a powerful tool to visualize the traffic of GABA type C receptors...
  17. ncbi request reprint Inhibition of skeletal muscle nicotinic receptors by the atypical antipsychotic clozapine
    Q T Nguyen
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Neuropharmacology 42:662-9. 2002
    ..These results suggest that clozapine antagonizes muscle nicotinic receptors by blocking open channels, and possibly also by another mechanism which still remains to be investigated...
  18. ncbi request reprint A Windows software package to record from voltage-clamped Xenopus oocytes
    Q T Nguyen
    Department of Psychobiology, University of California at Irvine 92715, USA
    J Neurosci Methods 61:213-9. 1995
    ..The last program, NicView, is designed to analyze records taken with NicScope and NicPulse. The present paper will discuss several issues regarding the design of these programs, and will give a brief description of each application...
  19. doi request reprint Functional impact of serial deletions at the C-terminus of the human GABArho1 receptor
    Jorge Mauricio Reyes-Ruiz
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, McGaugh Hall 1109, University of California Irvine, Irvine, CA 92697 4550, USA
    Biochim Biophys Acta 1798:1002-7. 2010
    ..A comparative study is presented of some electrophysiological and pharmacological properties of the deletion mutants that were able to generate GABA currents...
  20. pmc Some properties of human neuronal alpha 7 nicotinic acetylcholine receptors fused to the green fluorescent protein
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, P le A Moro 5, I00185 Roma, Italy
    Proc Natl Acad Sci U S A 99:3950-5. 2002
    ..We also conclude that fused genes do not necessarily recapitulate all of the properties of the original receptors. This fact must be borne close in mind whenever reporter genes are attached to proteins...
  21. pmc Phosphatase inhibitors remove the run-down of gamma-aminobutyric acid type A receptors in the human epileptic brain
    E Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza di Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 101:10183-8. 2004
    ..Blockage of phosphatases stabilizes the TLE GABA(A) receptors and strengthens GABAergic inhibition. It may be that this process can be targeted to develop new treatments for intractable epilepsy...
  22. pmc Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors
    J García-Colunga
    Department of Psychobiology, University of California, Irvine 92717 4550, USA
    Proc Natl Acad Sci U S A 92:2919-23. 1995
    ..These effects may help to better understand brain functions as well as the mode of action of the many serotonergic agents that are used in medical practice...
  23. pmc Properties of glutamate receptors of Alzheimer's disease brain transplanted to frog oocytes
    Annalisa Bernareggi
    Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 4550, USA
    Proc Natl Acad Sci U S A 104:2956-60. 2007
    ..That knowledge may help to decipher the etiology of the diseases and also to develop new treatments...
  24. pmc Properties of GluR3 receptors tagged with GFP at the amino or carboxyl terminus
    Agenor Limon
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Proc Natl Acad Sci U S A 104:15526-30. 2007
    ..However, the effects of different sites of tag insertion on receptor characteristics must be taken into account in assessing the roles played by these receptor proteins...
  25. pmc GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors
    Eleonora Palma
    Dipartimento di Fisiologia Umana e Farmacologia Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 104:20944-8. 2007
    ..Our findings point to the rundown of GABA(A) receptors as a hallmark of TLE and suggest that modulating tonic and phasic mTLE GABA(A) receptor activity may represent a useful therapeutic approach to the disease...
  26. ncbi request reprint Serotonin antagonizes the human neuronal alpha7 nicotinic acetylcholine receptor and becomes an agonist after L248T alpha7 mutation
    S Fucile
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Viale Regina Elena 324, I 00161 Rome, Italy
    Neuroscience 110:169-79. 2002
    ....
  27. ncbi request reprint Ectoenzymatic breakdown of diadenosine polyphosphates by Xenopus laevis oocytes
    J S Aguilar
    Department of Neurobiology and Behavior, University of California, Irvine, USA
    Eur J Biochem 268:1289-97. 2001
    ..Results indicate that, whereas the Ap(n)A-cleaving ectoenzyme appears to be located mainly in the oocyte, ectoenzymes involved in the dephosphorylation of mononucleotide moieties are located mainly in the follicular cell layer...
  28. pmc Functional expression in frog oocytes of human rho 1 receptors produced in Saccharomyces cerevisiae
    Alejandro Martinez-Martinez
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, McGaugh Hall 1115, Irvine, CA 92697 4550, USA
    Proc Natl Acad Sci U S A 101:682-6. 2004
    ..These results show that yeast may be useful to produce complete functional ionotropic receptors suitable for structural analysis...
  29. ncbi request reprint Indole- and indoline-based kainate analogues with antagonist activity at ionotropic glutamate receptors
    Xiaohong Shou
    Department of Chemistry, University of California, Irvine, CA 92697, USA
    Bioorg Med Chem Lett 15:3942-7. 2005
    ....
  30. pmc The single-channel properties of human acetylcholine alpha 7 receptors are altered by fusing alpha 7 to the green fluorescent protein
    Sergio Fucile
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, P le A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 99:3956-61. 2002
    ..All this evidence shows that GFP-tagging can alter importantly receptor kinetics, a fact that has to be taken into account whenever tagged proteins are used to study their function...
  31. pmc Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors
    Cristina Roseti
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza di Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, I 00185 Rome, Italy
    Proc Natl Acad Sci U S A 105:15118-23. 2008
    ..Our findings strongly suggest that cortical A2-A3 receptors alter the stability of GABA(A) receptors, which could offer therapeutic opportunities...
  32. doi request reprint Mammalian AT2 receptors expressed in Xenopus laevis oocytes couple to endogenous chloride channels and stimulate germinal vesicle break down
    Rosalina Reyes
    Department of Neurobiology and Behavior, University of California, Irvine, CA, USA
    Cell Physiol Biochem 24:45-52. 2009
    ..A comparative analysis was performed of the properties of cloned AT1 and AT2 receptors and their ability to induce ion currents and oocyte maturation...
  33. pmc Expression of functional receptors by the human gamma-aminobutyric acid A gamma 2 subunit
    Ataulfo Martinez-Torres
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behavior, University of California, McGaugh Hall 1115, Irvine, CA 92697 4550, USA
    Proc Natl Acad Sci U S A 101:3220-3. 2004
    ....
  34. pmc Abnormal GABAA receptors from the human epileptic hippocampal subiculum microtransplanted to Xenopus oocytes
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 102:2514-8. 2005
    ..This abnormal behavior of the subiculum GABAA receptors may contribute to epileptogenesis...
  35. ncbi request reprint A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism
    Ataulfo Martinez-Torres
    Laboratorio de Neurobiología Celular y Molecular, Instituto de Neurobiologia, Campus Universidad Nacional Autónoma de México UNAM Juriquilla, Queretaro, Mexico
    Arch Med Res 35:194-8. 2004
    ..These receptors are highly expressed in vertebrate retina, where they may play a unique role due to their unusual biophysical and pharmacologic characteristics...
  36. pmc Ricardo Miledi and the foundations of synaptic and extra-synaptic neurotransmitter receptor physiology
    Fabrizio Eusebi
    Dipartimento di Fisiologia Umana and Farmacologia, Centro di Eccellenza BEMM, Universita di Roma Sapienza, Italy
    J Physiol 581:890-2. 2007
  37. ncbi request reprint Brain distribution and molecular cloning of the bovine GABA rho1 receptor
    Abraham Rosas-Arellano
    Instituto de Neurobiologia, Laboratorio de Neurobiología Molecular y Celular II, Universidad Nacional Autonoma de Mexico, Km 15 5 Carretera a San Luis Potosí 76001 Juriquilla, Queretaro, Mexico
    Neurosci Res 57:347-53. 2007
    ..8. The results confirm the presence of GABA(C) receptor mRNAs in several areas of the mammalian brain and show that some of these areas express functional GABA rho1 receptors that have the classic GABA(C) receptor characteristics...
  38. ncbi request reprint The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation
    Eleonora Palma
    Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Roma, Italy
    Epilepsia 48:1842-9. 2007
    ..Experiments were designed to investigate whether the antiepileptic drug, levetiracetam (LEV), which is used as an adjunctive treatment for medically intractable MTLE, counteracts the GABAA receptor run-down...
  39. ncbi request reprint Cloning and functional expression of the bovine GABA(C) rho2 subunit. Molecular evidence of a widespread distribution in the CNS
    Ariel Lopez-Chavez
    Instituto de Neurobiologia, Universidad Nacional Autónoma de México Campus Juriquilla, AP1 1141 Querétaro, Mexico
    Neurosci Res 53:421-7. 2005
    ....
  40. pmc Microtransplantation of membranes from cultured cells to Xenopus oocytes: a method to study neurotransmitter receptors embedded in native lipids
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, I 00185 Rome, Italy
    Proc Natl Acad Sci U S A 100:2896-900. 2003
    ..All this makes the Xenopus oocyte a powerful tool for detailed investigations of receptors and other proteins expressed in the membrane of cultured cells...
  41. pmc Expression of Caenorhabditis elegans neurotransmitter receptors and ion channels in Xenopus oocytes
    Ataulfo Martinez-Torres
    Instituto de Neurobiologia, Universidad Nacional Autónoma de México Campus Juriquilla, Querétaro AP1 1141, Mexico
    Proc Natl Acad Sci U S A 103:5120-4. 2006
    ....
  42. ncbi request reprint Microtransplantation of neurotransmitter receptors from cells to Xenopus oocyte membranes: new procedure for ion channel studies
    Ricardo Miledi
    Instituto de Neurobiologia, Campus UNAM Juriquilla, Mexico
    Methods Mol Biol 322:347-55. 2006
    ....
  43. pmc Expression of human epileptic temporal lobe neurotransmitter receptors in Xenopus oocytes: An innovative approach to study epilepsy
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Piazzale A Moro 5, Italy
    Proc Natl Acad Sci U S A 99:15078-83. 2002
    ..Our findings are in accord with the concept that both a depression of GABA inhibition and a dysfunction of the KAI-receptor system maintain a high neuronal excitability that results in epileptic seizures...
  44. ncbi request reprint Membrane currents elicited by angiotensin II in astrocytes from the rat corpus callosum
    Marcelino Montiel-Herrera
    Instituto de Neurobiologia Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro, Mexico
    Glia 53:366-71. 2006
    ..c) 2005 Wiley-Liss, Inc...
  45. doi request reprint Some effects of the venom of the Chilean spider Latrodectus mactans on endogenous ion-currents of Xenopus laevis oocytes
    Jorge Parodi
    Laboratorio de Neurociencias CEBIOR, Departamento de Ciencias Preclinicas, Facultad de Medicina, Universidad de La Frontera, Av Francisco Salazar 01145, P O Box 54 D, Temuco, Chile
    Biochem Biophys Res Commun 375:571-5. 2008
    ..Consistent with the electrophysiological evidence we detected the expression of the mRNA coding for xKv1.1 in the oocytes...
  46. doi request reprint Developmental expression of glycine receptor subunits in rat cerebellum
    Guadalupe García-Alcocer
    Facultad de Quimica, Universidad Autonoma de Queretaro, Centro Universitario, Queretaro, Mexico
    Int J Dev Neurosci 26:319-22. 2008
    ..The alpha1 subunit was expressed at a low level and was also found in the white matter. The function of these receptors in neuronal and glial plasma membranes in early postnatal development remains to be determined...
  47. doi request reprint Expression of GABArho subunits during rat cerebellum development
    Carmen Mejia
    Instituto de Neurobiologia, Departamento de Neurobiología Molecular y Celular, Universidad Nacional Autónoma de México Campus Juriquilla, Boulevar Universitario 3001, Queretaro, 76230, Mexico
    Neurosci Lett 432:1-6. 2008
    ..The expression of GABA(C) receptors in the cerebellum adds a new dimension to the regulation of GABAergic neurotransmission and suggests further experiments to determine their functional consequences...
  48. ncbi request reprint Inhibition of neuronal nicotinic acetylcholine receptors by La(3+)
    Francisco J Rangel-González
    Centro de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Apartado Postal 1 1141, Juriquilla, Queretaro 76001, Mexico
    Eur J Pharmacol 441:15-21. 2002
    ..From these results we conclude that La(3+) regulates nicotinic receptors, reversibly and noncompetitively, presumably by inhibiting allosterically the receptor through interactions at an external domain of the receptor complex...
  49. ncbi request reprint The product of the gene GEF1 of Saccharomyces cerevisiae transports Cl- across the plasma membrane
    Angelica Lopez-Rodriguez
    Instituto de Neurobiologia, Departamento de Neurobiología Molecular y Celular, Universidad Nacional Autónoma de México Campus Juriquilla, Queretaro, Mexico
    FEMS Yeast Res 7:1218-29. 2007
    ..However, the mechanism of activation of the channel has yet to be defined...
  50. ncbi request reprint Effects of clomipramine on neuronal nicotinic acetylcholine receptors
    Hector E Lopez-Valdes
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Apartado Postal 1 1141, Juriquilla, 76001, Queretaro, Mexico
    Eur J Pharmacol 444:13-9. 2002
    ..The actions of clomipramine on neuronal nicotinic acetylcholine receptors may play an important role in the treatment of mental depression and other mood disorders...
  51. ncbi request reprint Potassium currents in primary cultured astrocytes from the rat corpus callosum
    Daniel Reyes-Haro
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro, 76230, Mexico
    J Neurocytol 34:411-20. 2005
    ..These results may help to understand better the roles of voltage-activated K(+)-currents in astrocytes from the rat CC in particular and glial cells in general...
  52. pmc Internalization and recycling of 5-HT2A receptors activated by serotonin and protein kinase C-mediated mechanisms
    Samarjit Bhattacharyya
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560065, India
    Proc Natl Acad Sci U S A 99:14470-5. 2002
    ..This study reveals a role for PKC in receptor internalization and also shows that 5-HT(2A) receptors are recycled...