Research Topics
| David MiklowitzSummaryAffiliation: University of Colorado Country: USA Publications
Research Grants
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Detail Information
Publications
Prevention of bipolar disorder in at-risk children: theoretical assumptions and empirical foundationsDavid J Miklowitz
Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309, USA
Dev Psychopathol 20:881-97. 2008..This model attempts to address the multiple interactions of psychosocial and biological risk factors in the onset and course of bipolar disorder...
A randomized study of family-focused psychoeducation and pharmacotherapy in the outpatient management of bipolar disorderDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, USA
Arch Gen Psychiatry 60:904-12. 2003..This study was performed to determine whether combining family-focused therapy (FFT) with pharmacotherapy during a postepisode interval enhances patients' mood stability during maintenance treatment...- Life stress and the course of early-onset bipolar disorderEunice Y Kim
University of Colorado, Boulder, CO, USA
J Affect Disord 99:37-44. 2007..This study examined whether levels of life stress predict levels of mood symptoms among bipolar adolescents participating in a treatment development study of family-focused psychoeducation and pharmacotherapy... - The role and impact of psychotherapy in the management of bipolar disorderMichael W Otto
Department of Psychology, Center for Anxiety and Related Disorders, Boston University, 648 Beacon St, 6th Floor, Boston, MA 02215-2013, USA
CNS Spectr 9:27-32. 2004..The available evidence suggests that interventions delivered in individual, group, or family settings, can provide significant benefit to patients undergoing pharmacotherapy for bipolar disorder... - Early-onset bipolar disorder: a family treatment perspectiveDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Dev Psychopathol 18:1247-65. 2006..Future research should focus on clarifying the developmental pathways to early-onset bipolar disorder and the role of protective factors and preventative psychosocial interventions in delaying the first onset of the disorder... - Family-focused treatment of the suicidal bipolar patientDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Bipolar Disord 8:640-51. 2006..This article describes the application of family-focused therapy (FFT) as an adjunct to pharmacotherapy in the management of suicidal ideation and behavior among bipolar patients... - A review of evidence-based psychosocial interventions for bipolar disorderDavid J Miklowitz
Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
J Clin Psychiatry 67:28-33. 2006..This article discusses each of these interventions and summarizes the evidence for their efficacy in randomized trials. Recommendations for implementing psychosocial interventions in clinical practice are also given... - The longitudinal course of bipolar disorder as revealed through weekly text messaging: a feasibility studyJedediah M Bopp
Department of Psychology, University of Colorado, Boulder, CO, USA
Bipolar Disord 12:327-34. 2010.... - Behavioral activation, inhibition and mood symptoms in early-onset bipolar disorderAdrine Biuckians
Department of Psychology, University of Colorado at Boulder, CO 80309 0345, USA
J Affect Disord 97:71-6. 2007..The secondary aim was to investigate whether self-reported BIS levels were associated with self-reported anxiety symptoms... - An update on the role of psychotherapy in the management of bipolar disorderDavid J Miklowitz
Department of Psychology, Muenzinger Building, University of Colorado, Boulder, CO 80309 0345, USA
Curr Psychiatry Rep 8:498-503. 2006.... - Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement ProgramDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Arch Gen Psychiatry 64:419-26. 2007..Psychosocial interventions have been shown to enhance pharmacotherapy outcomes in bipolar disorder... - The psychopathology and treatment of bipolar disorderDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, Colorado 80309 0345, USA
Annu Rev Clin Psychol 2:199-235. 2006..Much remains to be clarified about the interactive contributions of genetic, neurobiological, and psychosocial factors to the course of the disorder, and the moderators and mediators of treatment effects... - Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trialDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Am J Psychiatry 164:1340-7. 2007..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode... - Common and specific elements of psychosocial treatments for bipolar disorder: a survey of clinicians participating in randomized trialsDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
J Psychiatr Pract 14:77-85. 2008..We investigated whether different forms of psychotherapy consisted of overlapping versus modality-specific ingredients... - Family-focused treatment for adolescents with bipolar disorder: results of a 2-year randomized trialDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Arch Gen Psychiatry 65:1053-61. 2008..Family interventions have been found to hasten episode recovery and delay recurrences among adults with bipolar disorder... - Adjunctive psychotherapy for bipolar disorder: state of the evidenceDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Am J Psychiatry 165:1408-19. 2008..This article reviews randomized trials of adjunctive psychotherapy for bipolar disorder... 
Expressed emotion moderates the effects of family-focused treatment for bipolar adolescentsDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309, USA
J Am Acad Child Adolesc Psychiatry 48:643-51. 2009....- Psychosocial treatments for bipolar disorder: cost-effectiveness, mediating mechanisms, and future directionsDavid J Miklowitz
Departments of Psychology and Psychiatry, University of Colorado, Boulder and Denver, CO 80309 0345, USA
Bipolar Disord 11:110-22. 2009..Randomized trials of adjunctive psychotherapy for bipolar disorder are reviewed, in tandem with discussion of cost-effectiveness, mediating mechanisms, and moderators of effects... - Family functioning among adolescents with bipolar disorderAimee E Sullivan
Department of Psychology, University of Colorado, Boulder CO 80309, USA
J Fam Psychol 24:60-7. 2010..Family adaptability, cohesion, and conflict may be important targets for family treatments administered during the postepisode phases of early onset bipolar disorder... - Psychotherapy, symptom outcomes, and role functioning over one year among patients with bipolar disorderDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Psychiatr Serv 57:959-65. 2006..A one-year naturalistic-prospective design was used to examine the association between psychotherapy use and the symptomatic and functional outcomes of patients with bipolar disorder... - The role of family systems in severe and recurrent psychiatric disorders: a developmental psychopathology viewDavid J Miklowitz
Department of Psychology, Muenzinger Building, University of Colorado, Boulder, CO 80309 0345, USA
Dev Psychopathol 16:667-88. 2004..Future research should elucidate mediating and moderating variables in the pathways from EE to patients' outcomes, and the conditions under which family treatments bring about favorable outcomes of psychiatric disorder... - Family-focused treatment for adolescents with bipolar disorderDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
J Affect Disord 82:S113-28. 2004..The adult version of FFT has been shown to be effective in forestalling relapses in two randomized clinical trials involving bipolar adults... - Expressed emotion as a predictor of outcome among bipolar patients undergoing family therapyEunice Y Kim
Department of Psychology, University of Colorado, Campus Box 345, Boulder, CO 80309 0345, USA
J Affect Disord 82:343-52. 2004..However, few studies have examined whether levels of EE predict the course of illness for patients engaged in psychosocial interventions... - Perceived criticism from family members as a predictor of the one-year course of bipolar disorderDavid J Miklowitz
Department of Psychology, Muenzinger Bldg, University of Colorado, Boulder, CO 80309 0345, USA
Psychiatry Res 136:101-11. 2005..Results indicate that a brief rating of subjective distress in response to familial criticism is a useful prognostic device and may aid in planning psychosocial interventions for patients with bipolar disorder... - Integrated family and individual therapy for bipolar disorder: results of a treatment development studyDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder 80309, USA
J Clin Psychiatry 64:182-91. 2003..This study concerned a new psychosocial approach - integrated family and individual therapy (IFIT) - that synthesizes family psychoeducational sessions with individual sessions of interpersonal and social rhythm therapy... - The comorbidity of bipolar disorder and axis II personality disorders: prevalence and clinical correlatesElizabeth L George
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Bipolar Disord 5:115-22. 2003..The few studies that do exist suggest that axis II pathology complicates the diagnosis and course of bipolar disorder. This study examined the prevalence of axis II disorder in bipolar patients who were clinically remitted... - Childhood mania, attention deficit hyperactivity disorder and conduct disorder: a critical review of diagnostic dilemmasEunice Y Kim
Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309, USA
Bipolar Disord 4:215-25. 2002..We review the literature on the extent to which these disorders can be reliably differentiated, and describe the diagnostic confusion that may be the result of features common to both classes of disorders... - Expressed emotion attitudes and individual psychopathology among the relatives of bipolar patientsTina R Goldstein
Department of Psychology, University of Colorado at Boulder, Muenzinger Psychology Building, Campus Box 345, Boulder, Colorado 80309 0345, USA
Fam Process 41:645-57. 2002..The findings are discussed with reference to explanations for the genesis of high-EE attitudes... - Clinicians' fidelity to a manual-based family treatment as a predictor of the one-year course of bipolar disorderAmy Weisman
Department of Psychology, University of Miami, P O Box 248185, Coral Gables, FL 33124 2070, USA
Fam Process 41:123-31. 2002..Study implications are discussed... - Observed emotional involvement and overinvolvement in families of patients with bipolar disorderSteffany J Fredman
Department of Psychology, University of North Carolina at Chapel Hill, NC 27599, USA
J Fam Psychol 22:71-9. 2008.... - Psychosocial intervention development for the prevention and treatment of depression: promoting innovation and increasing accessSteven D Hollon
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
Biol Psychiatry 52:610-30. 2002.... - Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BDJoseph F Goldberg
Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut, USA
Am J Psychiatry 164:1348-55. 2007..However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs... - Current suicide ideation and prior suicide attempts of bipolar patients as influences on caregiver burdenCheryl A Chessick
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
Suicide Life Threat Behav 37:482-91. 2007..Levels of depression in caregivers varied with whether the caregiver was a spouse or a parent, and whether patients had a history of suicide attempts, current suicidal ideation, or both... - The prospective course of rapid-cycling bipolar disorder: findings from the STEP-BDChristopher D Schneck
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80220, USA
Am J Psychiatry 165:370-7; quiz 410. 2008..In a naturalistic follow-up of adult bipolar patients, the authors examined the contributions of demographic, phenomenological, and clinical variables, including antidepressant use, to prospectively observed mood episode frequency... - Lamotrigine treatment of bipolar disorder: data from the first 500 patients in STEP-BDLauren B Marangell
Mood Disorders Program, Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
Bipolar Disord 6:139-43. 2004..To describe the frequency and correlates of lamotrigine therapy among the first 500 patients enrolled into the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study... - Perceived stigma and depression among caregivers of patients with bipolar disorderDeborah A Perlick
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Br J Psychiatry 190:535-6. 2007..Results suggest that caregivers' perceptions of stigma may negatively affect their mental health by reducing their coping effectiveness... - Correlates of high expressed emotion attitudes among parents of bipolar adolescentsAllison L Coville
Bates College, USA
J Clin Psychol 64:438-49. 2008..We encourage prospective investigations of the developmental correlates of parental EE attitudes in larger, more heterogeneous samples of bipolar adolescents and children... - Caregiver burden and health in bipolar disorder: a cluster analytic approachDeborah A Perlick
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10019, USA
J Nerv Ment Dis 196:484-91. 2008..Cluster analysis is a promising method for identifying subgroups of caregivers with different stress and coping profiles associated with different health-related outcomes... - Classifying episodes in schizophrenia and bipolar disorder: criteria for relapse and remission applied to recent-onset samplesKeith H Nuechterlein
UCLA Department of Psychiatry and Biobehavioral Sciences, 300 UCLA Medical Plaza, Room 2251, Los Angeles, CA 90095 6968, United States
Psychiatry Res 144:153-66. 2006.... - Family-focused treatment versus individual treatment for bipolar disorder: results of a randomized clinical trialMargaret M Rea
Department of Psychiatry, University of California, Los Angeles, USA
J Consult Clin Psychol 71:482-92. 2003..Results suggest that family psychoeducational treatment is a useful adjunct to pharmacotherapy in decreasing the risk of relapse and hospitalization frequently associated with bipolar disorder... - Validity of the distinction between primary and secondary substance use disorder in patients with bipolar disorder: data from the first 1000 STEP-BD participantsMark D Fossey
Department of Psychiatry, University of Oklahoma College of Medicine Tulsa, Tulsa, Oklahoma 74135, USA
Am J Addict 15:138-43. 2006..The primary/secondary distinction for SUD is not valid when variations in the age of onset of the non-SUD are linked to course characteristics... - Prevalence and correlates of burden among caregivers of patients with bipolar disorder enrolled in the Systematic Treatment Enhancement Program for Bipolar DisorderDeborah A Perlick
Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
Bipolar Disord 9:262-73. 2007.... - Family-focused treatment for bipolar disorder in adults and youthChad D Morris
University of Colorado at Denver and Health Sciences Center, Denver, CO 80220, USA
J Clin Psychol 63:433-45. 2007..Controlled trials indicate that FFT is an efficacious adjunct to pharmacotherapy for patients with bipolar disorder. We describe its recent application to early onset bipolar patients and include a clinical vignette... - Care satisfaction, hope, and life functioning among adults with bipolar disorder: data from the first 1000 participants in the Systematic Treatment Enhancement ProgramChad D Morris
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80220, USA
Compr Psychiatry 46:98-104. 2005..This prospective study examined the longitudinal relationships between patients' satisfaction with care, levels of hope, and life functioning in the first 1000 patients to enter STEP-BD... - Social skills knowledge and performance among adolescents with bipolar disorderTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
Bipolar Disord 8:350-61. 2006..This study investigated social skills deficits among adolescents with bipolar disorder... - Modeling costs and burden of informal caregiving for persons with bipolar disorderNancy Wolff
Center for Mental Health Services and Criminal Justice Research, Rutgers University, 30 College Avenue, New Brunswick, NJ 08901, USA
J Ment Health Policy Econ 9:99-110. 2006..While a vast literature demonstrates this connection, the cost and financial burden of informal caregiving has received considerably less research attention, especially as it-pertains to bipolar disorder... - Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)Roy H Perlis
Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
Am J Psychiatry 163:217-24. 2006..The authors looked for the features associated with risk of recurrence... - Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 yearsLauren B Marangell
Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and the Department of Veterans Affairs, VISN 16 MIRECC, Houston, TX 77030, USA
Bipolar Disord 8:566-75. 2006.... - Demographic and diagnostic characteristics of the first 1000 patients enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)Jane N Kogan
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Bipolar Disord 6:460-9. 2004..The current report provides a context for interpreting studies resulting from STEP-BD by summarizing the baseline demographic and diagnostic characteristics of the first 1000 enrolled... - Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement ProgramChristopher D Schneck
Department of Psychiatry, University of Colorado Health Sciences Center, 4455 East 12th Ave, Box A011 15, Denver, CO 80220, USA
Am J Psychiatry 161:1902-8. 2004..This study compared demographic and phenomenological variables between bipolar patients with and without rapid cycling as a function of bipolar I versus bipolar II status... - Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidoneAndrew A Nierenberg
Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
Am J Psychiatry 163:210-6. 2006..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone... - Factors associated with stigma among caregivers of patients with bipolar disorder in the STEP-BD studyJodi M Gonzalez
Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
Psychiatr Serv 58:41-8. 2007..Little is known about the factors contributing to mental illness stigma among caregivers of people with bipolar disorder... - Treatment characteristics and illness burden among European Americans, African Americans, and Latinos in the first 2,000 patients of the systematic treatment enhancement program for bipolar disorderJodi M Gonzalez
University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Psychopharmacol Bull 40:31-46. 2007..This study compared illness characteristics, treatment history, and overall functioning in a sample of European American, African American, and Latino patients with bipolar disorder... - Are antidepressants associated with new-onset suicidality in bipolar disorder? A prospective study of participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)Mark S Bauer
Providence Veterans Affairs Medical Center and the Department of Psychiatry and Human Behavior, Brown University, VAMC 116R, 830 Chalkstone Avenue, Providence, R I 02908 4799, USA
J Clin Psychiatry 67:48-55. 2006..However, few data are available to inform the suicidality risk assessment of antidepressant use specifically in bipolar disorder... - Child- and family-focused cognitive-behavioral therapy for pediatric bipolar disorder: development and preliminary resultsMani N Pavuluri
University of Illinois at Chicago, USA
J Am Acad Child Adolesc Psychiatry 43:528-37. 2004..a biological theory of excessive reactivity, and (3). the role of environmental stressors in outcome. CFF-CBT actively engages parents and children over 12 hour-long sessions... - Contributors to suicidal ideation among bipolar patients with and without a history of suicide attemptsMichael H Allen
University of Colorado Health Science Center, University North Pavilion, 4455 East 12th Avenue, Denver, CO, USA
Suicide Life Threat Behav 35:671-80. 2005..Bipolar patients with suicidal ideation may benefit from different treatment strategies depending on their prior attempt status... - Prevalence and correlates of tobacco use in bipolar disorder: data from the first 2000 participants in the Systematic Treatment Enhancement ProgramJeanette A Waxmonsky
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80220, USA
Gen Hosp Psychiatry 27:321-8. 2005..We predicted that poorly controlled manic, depressed and mixed states, and the presence of psychotic symptoms, would be associated with a greater prevalence of smoking among patients with bipolar disorder... - Serotonin gene polymorphisms and bipolar I disorder: focus on the serotonin transporterHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, U S A
Ann Med 37:590-602. 2005..Our analyses do not support association between SLC6A4 and BDI families. Further studies using sub-groups of BDI are worthwhile... - Toward a life span developmental psychopathology perspective on bipolar disorderDavid J Miklowitz
Dev Psychopathol 18:935-8. 2006 - Effectiveness of adjunctive antidepressant treatment for bipolar depressionGary S Sachs
Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
N Engl J Med 356:1711-22. 2007..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania... - Psychosocial service utilization by patients with bipolar disorders: data from the first 500 participants in the Systematic Treatment Enhancement ProgramAnna Lembke
Stanford University School of Medicine, CA, USA
J Psychiatr Pract 10:81-7. 2004..Potential moderators, such as insurance status and availability of care, should be examined in future studies...
Research Grants
- Family-Focused Psychoeducation for Bipolar AdolescentsDavid Miklowitz; Fiscal Year: 2003..Secondary analyses will examine the impact of FFT-A on parents' mood states and subjective distress, and on other hypothesized mediating mechanisms: family expressed emotion, family interactional behavior, and social rhythm stability. ..
- Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar DisorderDavid Miklowitz; Fiscal Year: 2007....
- Family-Focused Treatment for Bipolar AdolescentsDavid Miklowitz; Fiscal Year: 2007..At the study's completion, we will have obtained a knowledge base to help develop a best practice model of treatment for BP adolescents that integrates family-focused problem-solving with psychopharmacology. ..
- Family-Focused Treatment for Bipolar AdolescentsDavid Miklowitz; Fiscal Year: 2009..At the study's completion, we will have obtained a knowledge base to help develop a best practice model of treatment for BP adolescents that integrates family-focused problem-solving with psychopharmacology. ..