HANNA KATRI ANNIKKI MIKKOLA

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development
    Michael A Teitell
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles, 90095, USA
    Pediatr Res 59:33R-9R. 2006
  2. ncbi request reprint The journey of developing hematopoietic stem cells
    Hanna K A Mikkola
    Department of Molecular, Cell and Developmental Biology, Jonsson Comprehensive Cancer Center, Institute for Stem Cell Biology and Medicine, University of California, Los Angeles, CA 90095, USA
    Development 133:3733-44. 2006
  3. pmc Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability
    Mattias Magnusson
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e53912. 2013
  4. doi request reprint Hematopoietic stem cells in transit--where's the niche?
    Mattias Magnusson
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 2:302-4. 2008
  5. ncbi request reprint The hematopoietic stem cell and its niche: a comparative view
    Julian A Martinez-Agosto
    Department of Human Genetics and Department of Pediatrics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:3044-60. 2007
  6. pmc Placenta as a newly identified source of hematopoietic stem cells
    Lydia K Lee
    Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Curr Opin Hematol 17:313-8. 2010
  7. doi request reprint Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells
    Tae Sub Park
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA, USA
    Stem Cells 27:783-95. 2009
  8. pmc The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation
    Katrin E Rhodes
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 2:252-63. 2008
  9. pmc Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis
    Christos Gekas
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Blood 113:3461-71. 2009
  10. ncbi request reprint Isolation and visualization of mouse placental hematopoietic stem cells
    Christos Gekas
    University of California Los Angeles, Los Angeles, California, USA
    Curr Protoc Stem Cell Biol . 2008

Research Grants

Collaborators

  • Michael Teitell
  • Xinmin Li
  • Stuart H Orkin
  • Volker Hartenstein
  • Mervin Yoder
  • S K Kurdistani
  • William E Lowry
  • Hanno Hock
  • Yanling Wang
  • Christos Gekas
  • Mattias Magnusson
  • Katrin E Rhodes
  • Ben Van Handel
  • Lydia K Lee
  • Tae Sub Park
  • Julian A Martinez-Agosto
  • Thorsten M Schlaeger
  • Melissa Romero
  • Rajkumar Sasidharan
  • Andy Huang
  • Sacha L Prashad
  • Pamela Saarikoski
  • Maria I Sierra
  • Masaya Ueno
  • Anne E Conway
  • Scott Armstrong
  • Matteo Pellegrini
  • Encarnacion Montecino-Rodriguez
  • Hildur Helgadottir
  • Roberto Ferrari
  • Zoran Galic
  • Kathrin Plath
  • Amander T Clark
  • Laura Richter
  • Anne Lindgren
  • Laurraine M Gereige
  • Eric Olson
  • Rhonda Bassel-Duby
  • Andrei V Krivtsov
  • Benjamin J van Handel
  • Simon Conway
  • Cameron S Francis
  • David N Chan
  • Christopher T Lux
  • Utpal Banerjee
  • Hildur B Helgadottir
  • Francoise Dieterlen-Lievre

Detail Information

Publications16

  1. ncbi request reprint Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development
    Michael A Teitell
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles, 90095, USA
    Pediatr Res 59:33R-9R. 2006
    ....
  2. ncbi request reprint The journey of developing hematopoietic stem cells
    Hanna K A Mikkola
    Department of Molecular, Cell and Developmental Biology, Jonsson Comprehensive Cancer Center, Institute for Stem Cell Biology and Medicine, University of California, Los Angeles, CA 90095, USA
    Development 133:3733-44. 2006
    ..Elucidating the interactions between developing HSCs and their niches should facilitate the generation and expansion of HSCs in vitro to exploit their clinical potential...
  3. pmc Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability
    Mattias Magnusson
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e53912. 2013
    ....
  4. doi request reprint Hematopoietic stem cells in transit--where's the niche?
    Mattias Magnusson
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 2:302-4. 2008
    ..An improved understanding of Egr1 targets may lead to better strategies to expand populations of HSCs ex vivo for therapeutic applications...
  5. ncbi request reprint The hematopoietic stem cell and its niche: a comparative view
    Julian A Martinez-Agosto
    Department of Human Genetics and Department of Pediatrics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:3044-60. 2007
    ....
  6. pmc Placenta as a newly identified source of hematopoietic stem cells
    Lydia K Lee
    Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Curr Opin Hematol 17:313-8. 2010
    ..Given that the placenta has been recently unveiled as a major hematopoietic organ that supports HSC development, the purpose of this review is to present current advances in defining the origin and regulation of placental HSCs...
  7. doi request reprint Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells
    Tae Sub Park
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA, USA
    Stem Cells 27:783-95. 2009
    ....
  8. pmc The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation
    Katrin E Rhodes
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 2:252-63. 2008
    ..These data suggest that, in addition to providing a niche for a large pool of HSCs prior to liver colonization, the placenta is a true site of HSC generation...
  9. pmc Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis
    Christos Gekas
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Blood 113:3461-71. 2009
    ..In summary, this work identifies Mef2C as an integral member of hematopoietic transcription factors with distinct upstream regulatory mechanisms and functional requirements in megakaryocyte and B-lymphoid lineages...
  10. ncbi request reprint Isolation and visualization of mouse placental hematopoietic stem cells
    Christos Gekas
    University of California Los Angeles, Los Angeles, California, USA
    Curr Protoc Stem Cell Biol . 2008
    ..It also contains a method for immunohistochemical analysis of placenta tissue sections to visualize developing HSCs in the placenta...
  11. ncbi request reprint The placenta is a niche for hematopoietic stem cells
    Christos Gekas
    Department of Pediatric Oncology, Dana Farber Cancer Institute and, Childrens Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 8:365-75. 2005
    ..Importantly, the placental HSC pool is not explained by rare circulating HSCs, which appear later. These data support an important, but unappreciated, role for the placenta in establishing the mammalian definitive hematopoietic system...
  12. ncbi request reprint Placenta as a site for hematopoietic stem cell development
    Hanna K A Mikkola
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Children s Hospital, Boston, Mass 02115, USA
    Exp Hematol 33:1048-54. 2005
    ....
  13. ncbi request reprint Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo
    Hanna K A Mikkola
    Department of Hematology Oncology, Children s Hospital, Boston, MA, USA
    Blood 101:508-16. 2003
    ..Although CD41 is commonly referred to as megakaryocyte-platelet integrin in adult hematopoiesis, these results implicate a wider role for CD41 during murine ontogeny...
  14. ncbi request reprint Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
    Hanna K A Mikkola
    Department of Pediatric Oncology, Children s Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Nature 421:547-51. 2003
    ..These findings contrast with lineage choice mechanisms, in which the identity of haematopoietic lineages requires continuous transcription factor expression...
  15. ncbi request reprint Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development
    Thorsten M Schlaeger
    Division of Hematology Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 105:3871-4. 2005
    ..These results indicate that the SCL-dependent phase of HSC development ends before Tie2Cre-mediated gene ablation becomes effective...
  16. ncbi request reprint The search for the hemangioblast
    Hanna K A Mikkola
    Dana Farber Cancer Institute and Children s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    J Hematother Stem Cell Res 11:9-17. 2002

Research Grants3

  1. Placenta as a novel site for hematopoietic stem cells
    Hanna Mikkola; Fiscal Year: 2005
    ..abstract_text> ..
  2. PDGF-B signaling in fetal hematopoietic stem cell microenvironments
    Hanna Mikkola; Fiscal Year: 2009
    ..These studies will begin to unravel unique molecular cues utilized in fetal hematopoietic stem cell niches that may ultimately allow us to improve the methods for culturing hematopoietic stem/progenitor cells for therapeutic purposes. ..
  3. PDGF-B signaling in fetal hematopoietic stem cell microenvironments
    HANNA KATRI ANNIKKI MIKKOLA; Fiscal Year: 2010
    ..These studies will begin to unravel unique molecular cues utilized in fetal hematopoietic stem cell niches that may ultimately allow us to improve the methods for culturing hematopoietic stem/progenitor cells for therapeutic purposes. ..