Mark E Mikkelsen

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Use of therapeutic hypothermia after in-hospital cardiac arrest
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 41:1385-95. 2013
  2. pmc Lower serum endocan levels are associated with the development of acute lung injury after major trauma
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 27:522.e11-7. 2012
  3. pmc The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, 836 W Gates Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 185:1307-15. 2012
  4. pmc Factors associated with nonadherence to early goal-directed therapy in the ED
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    Chest 138:551-8. 2010
  5. ncbi request reprint Emergency extracorporeal life support for asphyxic status asthmaticus
    Mark E Mikkelsen
    Division of Pulmonary, Allergy, and Critical Care, Hospital of the University of Pennsylvania, 836 W Gates Pavilion, Philadelphia, PA 19104, USA
    Respir Care 52:1525-9. 2007
  6. doi request reprint Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:1670-7. 2009
  7. doi request reprint Cognitive, mood and quality of life impairments in a select population of ARDS survivors
    Mark E Mikkelsen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Respirology 14:76-82. 2009
  8. pmc Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    ASAIO J 55:47-52. 2009
  9. ncbi request reprint Potential reasons why physicians underuse lung-protective ventilation: a retrospective cohort study using physician documentation
    Mark E Mikkelsen
    Division of Pulmonary, Allergy, and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Respir Care 53:455-61. 2008
  10. pmc Out-of-hospital characteristics and care of patients with severe sepsis: a cohort study
    Christopher W Seymour
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98104, USA
    J Crit Care 25:553-62. 2010

Detail Information

Publications20

  1. doi request reprint Use of therapeutic hypothermia after in-hospital cardiac arrest
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 41:1385-95. 2013
    ..We aimed to determine the use of therapeutic hypothermia for adult in-hospital cardiac arrest, whether use has increased over time, and to identify factors associated with its use...
  2. pmc Lower serum endocan levels are associated with the development of acute lung injury after major trauma
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 27:522.e11-7. 2012
    ..We tested the association of serum endocan levels with subsequent development of ALI after major trauma...
  3. pmc The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, 836 W Gates Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 185:1307-15. 2012
    ..Cognitive and psychiatric morbidity is common and potentially modifiable after acute lung injury (ALI). However, practical measures of neuropsychological function for use in multicenter trials are lacking...
  4. pmc Factors associated with nonadherence to early goal-directed therapy in the ED
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    Chest 138:551-8. 2010
    ..EGDT appears to be underused, even in centers with formalized protocols. The aim of our study was to identify factors associated with not initiating EGDT in the ED...
  5. ncbi request reprint Emergency extracorporeal life support for asphyxic status asthmaticus
    Mark E Mikkelsen
    Division of Pulmonary, Allergy, and Critical Care, Hospital of the University of Pennsylvania, 836 W Gates Pavilion, Philadelphia, PA 19104, USA
    Respir Care 52:1525-9. 2007
    ....
  6. doi request reprint Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:1670-7. 2009
    ..e., refractory hypotension)...
  7. doi request reprint Cognitive, mood and quality of life impairments in a select population of ARDS survivors
    Mark E Mikkelsen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Respirology 14:76-82. 2009
    ..This study investigated associations between cognitive impairment, mood disorders and quality of life in a select group of ARDS survivors...
  8. pmc Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    ASAIO J 55:47-52. 2009
    ....
  9. ncbi request reprint Potential reasons why physicians underuse lung-protective ventilation: a retrospective cohort study using physician documentation
    Mark E Mikkelsen
    Division of Pulmonary, Allergy, and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Respir Care 53:455-61. 2008
    ..Physicians often fail to use lung-protective ventilation (LPV) in patients with acute lung injury...
  10. pmc Out-of-hospital characteristics and care of patients with severe sepsis: a cohort study
    Christopher W Seymour
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98104, USA
    J Crit Care 25:553-62. 2010
    ....
  11. doi request reprint Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department
    David F Gaieski
    Department of Emergency Medicine, Division of Pulmonary, Allergy, and Critical Care, the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 38:1045-53. 2010
    ..To study the association between time to antibiotic administration and survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department...
  12. pmc The epidemiology of acute respiratory distress syndrome in patients presenting to the emergency department with severe sepsis
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Pulmonary and Allergy Associates, Morristown, New Jersey, and Morristown Medical Center, Morristown, New Jersey Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology, Columbia University Medical Center, New York, New York and Department of Emergency Medicine, Medstar Washington Hospital Center, Washington, DC, and Georgetown University School of Medicine, Washington, DC
    Shock 40:375-81. 2013
    ..To date, no study has directly examined the epidemiology of ARDS in severe sepsis from the earliest presentation to the health care system, the emergency department (ED)...
  13. doi request reprint Emergency department lactate is associated with mortality in older adults admitted with and without infections
    Daniel A del Portal
    University of Pennsylvania School of Medicine, Department of Emergency Medicine, Philadelphia, PA, USA
    Acad Emerg Med 17:260-8. 2010
    ..This study investigates whether serum lactate values measured in the ED are associated with mortality in older patients admitted to the hospital, both with and without infections...
  14. pmc Severe sepsis cohorts derived from claims-based strategies appear to be biased toward a more severely ill patient population
    Stacey Ann Whittaker
    School of Medicine, University of Pennsylvania, Pulmonary, Allergy, and Critical Care Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 41:945-53. 2013
    ..We compared the sensitivity of two code abstraction methods in identifying severe sepsis cases using a severe sepsis registry...
  15. pmc A randomized trial of nighttime physician staffing in an intensive care unit
    Meeta Prasad Kerlin
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    N Engl J Med 368:2201-9. 2013
    ..Increasing numbers of intensive care units (ICUs) are adopting the practice of nighttime intensivist staffing despite the lack of experimental evidence of its effectiveness...
  16. ncbi request reprint Elevation in serum lactate at the time of febrile neutropenia (FN) in hemodynamically-stable patients with hematologic malignancies (HM) is associated with the development of septic shock within 48 hours
    Anthony R Mato
    John Theurer Cancer Center, Lymphoma Division, Hackensack University Medical Center, Hackensack, NJ, USA
    Cancer Biol Ther 9:585-9. 2010
    ..This study was designed to determine whether serum lactate, measured at the time of FN, is associated with the development of septic shock in hospitalized hematologic malignancy (HM) patients...
  17. ncbi request reprint Can we optimize long-term outcomes in acute respiratory distress syndrome by targeting normoxemia?
    Mark E Mikkelsen
    1 Pulmonary, Allergy, and Critical Care Division, Department of Medicine
    Ann Am Thorac Soc 11:613-8. 2014
    ..We conclude with a proposal to consider resetting the target range for arterial oxygenation higher (85-110 mm Hg) as a potential strategy to improve the long-term outcomes of ARDS survivors. ..
  18. doi request reprint The association of body mass index with time to target temperature and outcomes following post-arrest targeted temperature management
    Marion Leary
    Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States Electronic address
    Resuscitation 85:244-7. 2014
    ..It is unclear to what extent body mass index (BMI) is associated with the time to reach target temperature and subsequent clinical outcomes...
  19. doi request reprint Out-of-hospital fluid in severe sepsis: effect on early resuscitation in the emergency department
    Christopher W Seymour
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington, USA
    Prehosp Emerg Care 14:145-52. 2010
    ..Early identification and treatment of patients with severe sepsis improves outcome, yet the role of out-of-hospital intravenous (IV) fluid is unknown...
  20. doi request reprint A systematic review to inform institutional decisions about the use of extracorporeal membrane oxygenation during the H1N1 influenza pandemic
    Matthew D Mitchell
    Center for Evidence Based Practice, University of Pennsylvania Health System, Philadelphia, PA, USA
    Crit Care Med 38:1398-404. 2010
    ....