John C Middlebrooks

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Auditory cortical images of cochlear-implant stimuli: dependence on electrode configuration
    Julie Arenberg Bierer
    Kresge Hearing Research Institute Department of Otorhinolaryngology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurophysiol 87:478-92. 2002
  2. pmc Auditory prosthesis with a penetrating nerve array
    John C Middlebrooks
    Kresge Hearing Research Institute, Department of Otorhinolaryngology, University of Michigan, Ann Arbor, MI 48109 0506, USA
    J Assoc Res Otolaryngol 8:258-79. 2007
  3. ncbi request reprint Cochlear implants: the view from the brain
    John C Middlebrooks
    Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109 0506, USA
    Curr Opin Neurobiol 15:488-93. 2005
  4. pmc Auditory cortex phase locking to amplitude-modulated cochlear implant pulse trains
    John C Middlebrooks
    Kresge Hearing Research Institute, Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    J Neurophysiol 100:76-91. 2008
  5. pmc Cochlear-implant high pulse rate and narrow electrode configuration impair transmission of temporal information to the auditory cortex
    John C Middlebrooks
    Department of Otolaryngology Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
    J Neurophysiol 100:92-107. 2008
  6. doi request reprint Intraneural stimulation for auditory prosthesis: modiolar trunk and intracranial stimulation sites
    John C Middlebrooks
    Kresge Hearing Research Institute, Department of Otolaryngology and Biomedical Engineering, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109 5506, USA
    Hear Res 242:52-63. 2008
  7. ncbi request reprint Spatial sensitivity in the dorsal zone (area DZ) of cat auditory cortex
    G Christopher Stecker
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA
    J Neurophysiol 94:1267-80. 2005
  8. ncbi request reprint Effects of cochlear-implant pulse rate and inter-channel timing on channel interactions and thresholds
    John C Middlebrooks
    Kresge Hearing Research Institute, Department of Otorhinolaryngology, University of Michigan Medical School, 1301 E Ann St, Ann Arbor, Michigan 48109 0506, USA
    J Acoust Soc Am 116:452-68. 2004
  9. ncbi request reprint Cortical neurons that localize sounds
    John C Middlebrooks
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109 0506, USA
    Neuroscientist 8:73-83. 2002
  10. ncbi request reprint Auditory cortical images of cochlear-implant stimuli: coding of stimulus channel and current level
    John C Middlebrooks
    Kresge Hearing Research Institute Department of Otorhinolaryngology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurophysiol 87:493-507. 2002

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Auditory cortical images of cochlear-implant stimuli: dependence on electrode configuration
    Julie Arenberg Bierer
    Kresge Hearing Research Institute Department of Otorhinolaryngology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurophysiol 87:478-92. 2002
    ..Electrode configurations that produced compact cortical images (e.g., TP and BP + 0) showed the greatest range of thresholds within each cortical image and the largest dynamic range at cortical sites removed from the most sensitive site...
  2. pmc Auditory prosthesis with a penetrating nerve array
    John C Middlebrooks
    Kresge Hearing Research Institute, Department of Otorhinolaryngology, University of Michigan, Ann Arbor, MI 48109 0506, USA
    J Assoc Res Otolaryngol 8:258-79. 2007
    ..The results suggest that if an intraneural stimulating array were incorporated into an auditory prosthesis system for humans, it could offer substantial improvement in hearing replacement compared to contemporary cochlear implants...
  3. ncbi request reprint Cochlear implants: the view from the brain
    John C Middlebrooks
    Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109 0506, USA
    Curr Opin Neurobiol 15:488-93. 2005
    ..In turn, the cochlear implant can be exploited as an experimental tool for examining central hearing mechanisms isolated from the effects of cochlear mechanics and transduction...
  4. pmc Auditory cortex phase locking to amplitude-modulated cochlear implant pulse trains
    John C Middlebrooks
    Kresge Hearing Research Institute, Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    J Neurophysiol 100:76-91. 2008
    ..The results show that cortical neurons can phase lock to modulated electrical pulse trains across the range of modulation frequencies and depths presented by cochlear implant speech processors...
  5. pmc Cochlear-implant high pulse rate and narrow electrode configuration impair transmission of temporal information to the auditory cortex
    John C Middlebrooks
    Department of Otolaryngology Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
    J Neurophysiol 100:92-107. 2008
    ..Results from this animal model suggest explanations for the failure of high pulse rates and/or bipolar electrode configurations to produce hoped-for improvements in speech reception...
  6. doi request reprint Intraneural stimulation for auditory prosthesis: modiolar trunk and intracranial stimulation sites
    John C Middlebrooks
    Kresge Hearing Research Institute, Department of Otolaryngology and Biomedical Engineering, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109 5506, USA
    Hear Res 242:52-63. 2008
    ..The intracranial site differed in that there was greater between-animal variation in tonotopic patterns. We discuss the implications of these results for possible improvements in hearing prosthesis for human subjects...
  7. ncbi request reprint Spatial sensitivity in the dorsal zone (area DZ) of cat auditory cortex
    G Christopher Stecker
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA
    J Neurophysiol 94:1267-80. 2005
    ....
  8. ncbi request reprint Effects of cochlear-implant pulse rate and inter-channel timing on channel interactions and thresholds
    John C Middlebrooks
    Kresge Hearing Research Institute, Department of Otorhinolaryngology, University of Michigan Medical School, 1301 E Ann St, Ann Arbor, Michigan 48109 0506, USA
    J Acoust Soc Am 116:452-68. 2004
    ..Thresholds for various paired-pulse stimuli, pulse rates, and pulse-train durations were measured to test possible mechanisms of temporal integration...
  9. ncbi request reprint Cortical neurons that localize sounds
    John C Middlebrooks
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109 0506, USA
    Neuroscientist 8:73-83. 2002
    ....
  10. ncbi request reprint Auditory cortical images of cochlear-implant stimuli: coding of stimulus channel and current level
    John C Middlebrooks
    Kresge Hearing Research Institute Department of Otorhinolaryngology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurophysiol 87:493-507. 2002
    ..These results suggest that the choice of the optimal electrode configuration for use by human cochlear-prosthesis users would depend on the particular demands of the speech-processing strategy that is to be employed...
  11. pmc Spatial sensitivity of neurons in the anterior, posterior, and primary fields of cat auditory cortex
    Ian A Harrington
    Central Systems Laboratory, Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109 0506, USA
    Hear Res 240:22-41. 2008
    ....
  12. ncbi request reprint Representation of auditory space by cortical neurons in awake cats
    Brian J Mickey
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurosci 23:8649-63. 2003
    ..For the vast majority of units, receptive fields showed no significant change with the cat's head position or level of participation in the auditory task...
  13. pmc Auditory temporal acuity probed with cochlear implant stimulation and cortical recording
    Alana E Kirby
    Department of Otolaryngology Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
    J Neurophysiol 103:531-42. 2010
    ..These results indicate that gap detection and modulation detection are mediated by two separate neural mechanisms...
  14. ncbi request reprint Sensitivity of auditory cortical neurons to the locations of leading and lagging sounds
    Brian J Mickey
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
    J Neurophysiol 94:979-89. 2005
    ..Unlike listeners, however, transmission of information about the lagging location remained low, even at ISDs of 12-16 ms...
  15. pmc Detection of pulse trains in the electrically stimulated cochlea: effects of cochlear health
    Bryan E Pfingst
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 5616, USA
    J Acoust Soc Am 130:3954-68. 2011
    ..The amount of multipulse integration was correlated with the health of the implanted cochlea with implications for perception of more complex prosthetic stimuli...
  16. pmc Location coding by opponent neural populations in the auditory cortex
    G Christopher Stecker
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 3:e78. 2005
    ....
  17. ncbi request reprint Spatial sensitivity in field PAF of cat auditory cortex
    G Christopher Stecker
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurophysiol 89:2889-903. 2003
    ..The latter finding suggests more accurate population coding of space in PAF, made possible by a more diverse population of neural response types...
  18. pmc Specialization for sound localization in fields A1, DZ, and PAF of cat auditory cortex
    Chen Chung Lee
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    J Assoc Res Otolaryngol 14:61-82. 2013
    ..Spatial preferences of area A1 neurons were intermediate between those of DZ and PAF, sharpening as needed for localization tasks...
  19. ncbi request reprint Distributed coding of sound locations in the auditory cortex
    G Christopher Stecker
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
    Biol Cybern 89:341-9. 2003
    ....
  20. ncbi request reprint Cortical representation of auditory space: information-bearing features of spike patterns
    Shigeto Furukawa
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurophysiol 87:1749-62. 2002
    ..The results indicate that any complete model of the cortical representation of auditory space must incorporate the temporal characteristics of neuronal response patterns...
  21. pmc Auditory cortex spatial sensitivity sharpens during task performance
    Chen Chung Lee
    Kresge Hearing Research Institute, Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Nat Neurosci 14:108-14. 2011
    ..5-h test sessions. Sharpening resulted primarily from increased suppression of responses to sounds at least-preferred locations. That and an observed increase in latencies suggest an important role of inhibitory mechanisms...
  22. pmc Selective electrical stimulation of the auditory nerve activates a pathway specialized for high temporal acuity
    John C Middlebrooks
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 30:1937-46. 2010
    ..Frequency-specific stimulation of that pathway by intraneural stimulation might improve temporal acuity in human users of a future auditory prosthesis, which in turn might improve musical pitch perception and speech reception in noise...
  23. pmc Cortical responses to cochlear implant stimulation: channel interactions
    Julie Arenberg Bierer
    Kresge Hearing Research Institute, Department of Otorhinolaryngology, University of Michigan, Ann Arbor, MI 48109 0506, USA
    J Assoc Res Otolaryngol 5:32-48. 2004
    ..Channel interactions were greater for closer electrode spacing. The results have implications for design of speech processors for cochlear implants...
  24. ncbi request reprint Vertical-plane sound localization probed with ripple-spectrum noise
    Ewan A Macpherson
    Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, Michigan 48109 0506, USA
    J Acoust Soc Am 114:430-45. 2003
    ..The low spectral-frequency limit suggests that broad-scale spectral variation is discounted, even though components at this scale are among those contributing the most to the shapes of directional transfer functions...
  25. ncbi request reprint Human sound localization at near-threshold levels
    Andrew T Sabin
    Central Systems Laboratory, Kresge Hearing Research Institute, 1301 E Ann Street, Ann Arbor, MI 48109 0506, USA
    Hear Res 199:124-34. 2005
    ....
  26. ncbi request reprint Listener weighting of cues for lateral angle: the duplex theory of sound localization revisited
    Ewan A Macpherson
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109 0506, USA
    J Acoust Soc Am 111:2219-36. 2002
    ..For wideband stimuli, the ITD weight was greater than or equal to that given to ILD. Manipulations of monaural spectral cues and the interaural level spectrum had little influence on lateral angle judgements...
  27. doi request reprint Sound localization deficits during reversible deactivation of primary auditory cortex and/or the dorsal zone
    Shveta Malhotra
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    J Neurophysiol 99:1628-42. 2008
    ....
  28. ncbi request reprint Hearing phantoms. Focus on "Spectral cues explain illusory elevation effects with stereo sounds in cats"
    John C Middlebrooks
    J Neurophysiol 90:1. 2003
  29. pmc Cochlear implant electrode configuration effects on activation threshold and tonotopic selectivity
    Russell L Snyder
    Department of Otolaryngology HNS, Box 0526, U490, University of California, San Francisco, CA 94143 0526, USA
    Hear Res 235:23-38. 2008
    ..As the spacing of bipolar electrodes was increased (separations >1mm), the activity patterns became broader and evoked patterns with two distinct threshold minima, one associated with each contact...
  30. ncbi request reprint Auditory space processing: here, there or everywhere?
    John C Middlebrooks
    Nat Neurosci 5:824-6. 2002
  31. ncbi request reprint Auditory cortex cheers the overture and listens through the finale
    John C Middlebrooks
    Nat Neurosci 8:851-2. 2005
  32. ncbi request reprint The acquisitive auditory cortex
    John C Middlebrooks
    Nat Neurosci 6:1122-3. 2003
  33. pmc Topographic spread of inferior colliculus activation in response to acoustic and intracochlear electric stimulation
    Russell L Snyder
    Epstein Laboratory, Department of Otolaryngology, University of California, San Francisco, CA 94143 0526, USA
    J Assoc Res Otolaryngol 5:305-22. 2004
    ..Bipolar stimulation with longitudinally oriented VP electrodes produced broad activation that tended to broaden as the separation between electrodes increased...