Research Topics
| John C MiddlebrooksSummaryAffiliation: University of Michigan Country: USA Publications
| Collaborators
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Detail Information
Publications
Auditory cortical images of cochlear-implant stimuli: dependence on electrode configurationJulie Arenberg Bierer
Kresge Hearing Research Institute (Department of Otorhinolaryngology) and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109-0506, USA
J Neurophysiol 87:478-92. 2002..Electrode configurations that produced compact cortical images (e.g., TP and BP + 0) showed the greatest range of thresholds within each cortical image and the largest dynamic range at cortical sites removed from the most sensitive site...
Auditory prosthesis with a penetrating nerve arrayJohn C Middlebrooks
Kresge Hearing Research Institute, Department of Otorhinolaryngology, University of Michigan, Ann Arbor, MI 48109 0506, USA
J Assoc Res Otolaryngol 8:258-79. 2007..The results suggest that if an intraneural stimulating array were incorporated into an auditory prosthesis system for humans, it could offer substantial improvement in hearing replacement compared to contemporary cochlear implants...- Cochlear implants: the view from the brainJohn C Middlebrooks
Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109 0506, USA
Curr Opin Neurobiol 15:488-93. 2005..In turn, the cochlear implant can be exploited as an experimental tool for examining central hearing mechanisms isolated from the effects of cochlear mechanics and transduction... - Auditory cortex phase locking to amplitude-modulated cochlear implant pulse trainsJohn C Middlebrooks
Kresge Hearing Research Institute, Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
J Neurophysiol 100:76-91. 2008..The results show that cortical neurons can phase lock to modulated electrical pulse trains across the range of modulation frequencies and depths presented by cochlear implant speech processors... - Cochlear-implant high pulse rate and narrow electrode configuration impair transmission of temporal information to the auditory cortexJohn C Middlebrooks
Department of Otolaryngology Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
J Neurophysiol 100:92-107. 2008..Results from this animal model suggest explanations for the failure of high pulse rates and/or bipolar electrode configurations to produce hoped-for improvements in speech reception... 
Intraneural stimulation for auditory prosthesis: modiolar trunk and intracranial stimulation sitesJohn C Middlebrooks
Kresge Hearing Research Institute, Department of Otolaryngology and Biomedical Engineering, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109 5506, USA
Hear Res 242:52-63. 2008..The intracranial site differed in that there was greater between-animal variation in tonotopic patterns. We discuss the implications of these results for possible improvements in hearing prosthesis for human subjects...- Spatial sensitivity in the dorsal zone (area DZ) of cat auditory cortexG Christopher Stecker
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA
J Neurophysiol 94:1267-80. 2005.... - Effects of cochlear-implant pulse rate and inter-channel timing on channel interactions and thresholdsJohn C Middlebrooks
Kresge Hearing Research Institute, Department of Otorhinolaryngology, University of Michigan Medical School, 1301 E Ann St, Ann Arbor, Michigan 48109 0506, USA
J Acoust Soc Am 116:452-68. 2004..Thresholds for various paired-pulse stimuli, pulse rates, and pulse-train durations were measured to test possible mechanisms of temporal integration... - Cortical neurons that localize soundsJohn C Middlebrooks
Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109 0506, USA
Neuroscientist 8:73-83. 2002.... - Auditory cortical images of cochlear-implant stimuli: coding of stimulus channel and current levelJohn C Middlebrooks
Kresge Hearing Research Institute Department of Otorhinolaryngology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
J Neurophysiol 87:493-507. 2002..These results suggest that the choice of the optimal electrode configuration for use by human cochlear-prosthesis users would depend on the particular demands of the speech-processing strategy that is to be employed... - Spatial sensitivity of neurons in the anterior, posterior, and primary fields of cat auditory cortexIan A Harrington
Central Systems Laboratory, Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109 0506, USA
Hear Res 240:22-41. 2008.... - Representation of auditory space by cortical neurons in awake catsBrian J Mickey
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0506, USA
J Neurosci 23:8649-63. 2003..For the vast majority of units, receptive fields showed no significant change with the cat's head position or level of participation in the auditory task... - Auditory temporal acuity probed with cochlear implant stimulation and cortical recordingAlana E Kirby
Department of Otolaryngology Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
J Neurophysiol 103:531-42. 2010..These results indicate that gap detection and modulation detection are mediated by two separate neural mechanisms... - Sensitivity of auditory cortical neurons to the locations of leading and lagging soundsBrian J Mickey
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109-0506, USA
J Neurophysiol 94:979-89. 2005..Unlike listeners, however, transmission of information about the lagging location remained low, even at ISDs of 12-16 ms... - Detection of pulse trains in the electrically stimulated cochlea: effects of cochlear healthBryan E Pfingst
Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 5616, USA
J Acoust Soc Am 130:3954-68. 2011..The amount of multipulse integration was correlated with the health of the implanted cochlea with implications for perception of more complex prosthetic stimuli... - Location coding by opponent neural populations in the auditory cortexG Christopher Stecker
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
PLoS Biol 3:e78. 2005.... - Spatial sensitivity in field PAF of cat auditory cortexG Christopher Stecker
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
J Neurophysiol 89:2889-903. 2003..The latter finding suggests more accurate population coding of space in PAF, made possible by a more diverse population of neural response types... - Distributed coding of sound locations in the auditory cortexG Christopher Stecker
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
Biol Cybern 89:341-9. 2003.... - Cortical representation of auditory space: information-bearing features of spike patternsShigeto Furukawa
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
J Neurophysiol 87:1749-62. 2002..The results indicate that any complete model of the cortical representation of auditory space must incorporate the temporal characteristics of neuronal response patterns... - Auditory cortex spatial sensitivity sharpens during task performanceChen Chung Lee
Kresge Hearing Research Institute, Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
Nat Neurosci 14:108-14. 2011..5-h test sessions. Sharpening resulted primarily from increased suppression of responses to sounds at least-preferred locations. That and an observed increase in latencies suggest an important role of inhibitory mechanisms... - Selective electrical stimulation of the auditory nerve activates a pathway specialized for high temporal acuityJohn C Middlebrooks
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 30:1937-46. 2010..Frequency-specific stimulation of that pathway by intraneural stimulation might improve temporal acuity in human users of a future auditory prosthesis, which in turn might improve musical pitch perception and speech reception in noise... - Cortical responses to cochlear implant stimulation: channel interactionsJulie Arenberg Bierer
Kresge Hearing Research Institute, Department of Otorhinolaryngology, University of Michigan, Ann Arbor, MI 48109-0506, USA
J Assoc Res Otolaryngol 5:32-48. 2004..Channel interactions were greater for closer electrode spacing. The results have implications for design of speech processors for cochlear implants... - Human sound localization at near-threshold levelsAndrew T Sabin
Central Systems Laboratory, Kresge Hearing Research Institute, 1301 E. Ann Street, Ann Arbor, MI 48109-0506, USA
Hear Res 199:124-34. 2005.... - Vertical-plane sound localization probed with ripple-spectrum noiseEwan A Macpherson
Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, Michigan 48109 0506, USA
J Acoust Soc Am 114:430-45. 2003..The low spectral-frequency limit suggests that broad-scale spectral variation is discounted, even though components at this scale are among those contributing the most to the shapes of directional transfer functions... - Listener weighting of cues for lateral angle: the duplex theory of sound localization revisitedEwan A Macpherson
Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109 0506, USA
J Acoust Soc Am 111:2219-36. 2002..For wideband stimuli, the ITD weight was greater than or equal to that given to ILD. Manipulations of monaural spectral cues and the interaural level spectrum had little influence on lateral angle judgements... - Specialization for sound localization in fields A1, DZ, and PAF of cat auditory cortexChen Chung Lee
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
J Assoc Res Otolaryngol 14:61-82. 2013..Spatial preferences of area A1 neurons were intermediate between those of DZ and PAF, sharpening as needed for localization tasks... - Sound localization deficits during reversible deactivation of primary auditory cortex and/or the dorsal zoneShveta Malhotra
Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
J Neurophysiol 99:1628-42. 2008.... - Hearing phantoms. Focus on "Spectral cues explain illusory elevation effects with stereo sounds in cats"John C Middlebrooks
J Neurophysiol 90:1. 2003 - Cochlear implant electrode configuration effects on activation threshold and tonotopic selectivityRussell L Snyder
Department of Otolaryngology HNS, Box 0526, U490, University of California, San Francisco, CA 94143 0526, USA
Hear Res 235:23-38. 2008..As the spacing of bipolar electrodes was increased (separations >1mm), the activity patterns became broader and evoked patterns with two distinct threshold minima, one associated with each contact... - Auditory space processing: here, there or everywhere?John C Middlebrooks
Nat Neurosci 5:824-6. 2002 - Auditory cortex cheers the overture and listens through the finaleJohn C Middlebrooks
Nat Neurosci 8:851-2. 2005 - The acquisitive auditory cortexJohn C Middlebrooks
Nat Neurosci 6:1122-3. 2003 - Topographic spread of inferior colliculus activation in response to acoustic and intracochlear electric stimulationRussell L Snyder
Epstein Laboratory, Department of Otolaryngology, University of California, San Francisco, CA 94143 0526, USA
J Assoc Res Otolaryngol 5:305-22. 2004..Bipolar stimulation with longitudinally oriented VP electrodes produced broad activation that tended to broaden as the separation between electrodes increased...