Aaron W Michels

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Targeting the trimolecular complex
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Court, MS A140, Aurora, CO 80045, USA Electronic address
    Clin Immunol 149:339-44. 2013
  2. pmc Targeting the trimolecular complex: the pathway towards type 1 diabetes prevention
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Diabetes Technol Ther 15:S2-8-S2-12. 2013
  3. pmc Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 187:5921-30. 2011
  4. doi request reprint Autoimmune polyendocrine syndrome type 1 (APS-1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS-2)
    A W Michels
    Department of Medicine, Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, Aurora, Colorado 80045, United States
    J Intern Med 265:530-40. 2009
  5. pmc Immunologic endocrine disorders
    Aaron W Michels
    Department of Medicine, Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Allergy Clin Immunol 125:S226-37. 2010
  6. doi request reprint The anti-insulin trimolecular complex in type 1 diabetes
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 17:329-34. 2010
  7. doi request reprint 2011 Update: antigen-specific therapy in type 1 diabetes
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 18:235-40. 2011
  8. pmc Immune intervention in type 1 diabetes
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Semin Immunol 23:214-9. 2011
  9. doi request reprint Autoimmune polyglandular syndromes
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Court, MS B140, PO Box 6511, Aurora, CO 80045, USA
    Nat Rev Endocrinol 6:270-7. 2010

Detail Information

Publications9

  1. pmc Targeting the trimolecular complex
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Court, MS A140, Aurora, CO 80045, USA Electronic address
    Clin Immunol 149:339-44. 2013
    ..This review focuses on the components of the anti-insulin trimolecular complex, registers of insulin peptide binding to 'diabetogenic' MHC class II molecules, and therapies targeting each component of the trimolecular complex. ..
  2. pmc Targeting the trimolecular complex: the pathway towards type 1 diabetes prevention
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Diabetes Technol Ther 15:S2-8-S2-12. 2013
    ..It is our belief that targeting this complex with safe and specific therapies will lead to the prevention of type 1 diabetes and an improved understanding as to why diabetes develops...
  3. pmc Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 187:5921-30. 2011
    ..These studies present a novel method for identifying small molecules capable of both stimulating and inhibiting T cell responses, with potentially therapeutic applications...
  4. doi request reprint Autoimmune polyendocrine syndrome type 1 (APS-1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS-2)
    A W Michels
    Department of Medicine, Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, Aurora, Colorado 80045, United States
    J Intern Med 265:530-40. 2009
    ..With continued basic and clinical research, therapies aimed at treating the underlying autoimmunity and disease prevention should become possible...
  5. pmc Immunologic endocrine disorders
    Aaron W Michels
    Department of Medicine, Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Allergy Clin Immunol 125:S226-37. 2010
    ..As a result, there are now iatrogenic autoimmune disorders arising from the treatment of chronic viral infections and malignancies...
  6. doi request reprint The anti-insulin trimolecular complex in type 1 diabetes
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 17:329-34. 2010
    ..Description of the immunologic components needed for autoimmune diabetes...
  7. doi request reprint 2011 Update: antigen-specific therapy in type 1 diabetes
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 18:235-40. 2011
    ..To update on the clinical trials using antigen-specific therapies in autoimmune diabetes...
  8. pmc Immune intervention in type 1 diabetes
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Semin Immunol 23:214-9. 2011
    ..This review focuses on immune intervention for the prevention and amelioration of human T1D with a focus on potential immune suppressive, antigen specific and environmental therapies...
  9. doi request reprint Autoimmune polyglandular syndromes
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Court, MS B140, PO Box 6511, Aurora, CO 80045, USA
    Nat Rev Endocrinol 6:270-7. 2010
    ..This Review discusses the genetic basis of APS-1, APS-2 and IPEX syndrome, with an emphasis on the mechanisms of autoimmunity and presents currently available therapies to treat their underlying autoimmune disorders...