Carmen Z Michaylira
Affiliation: University of North Carolina
- Haplotype insufficiency for suppressor of cytokine signaling-2 enhances intestinal growth and promotes polyp formation in growth hormone-transgenic miceCarmen Z Michaylira
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 27599 7545, USA
Endocrinology 147:1632-41. 2006..Small variations in SOCS2 expression levels may significantly influence the outcome of therapeutic GH or acromegaly in intestine...
- Suppressor of cytokine signaling-2: a growth hormone-inducible inhibitor of intestinal epithelial cell proliferationMegan E Miller
Department of Nutrition, University of North Carolina at Chapel Hill, 27599 7545, USA
Gastroenterology 127:570-81. 2004..These studies test the hypothesis that GH induces a suppressor of cytokine signaling (SOCS), which inhibits intestinal epithelial cell (IEC) proliferation...
- Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cellsShira Fruchtman
Dept of Cell and Molecular Physiology, CB 7545, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7545, USA
Am J Physiol Gastrointest Liver Physiol 289:G342-50. 2005....
- Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivoCarmen Z Michaylira
CB 7545, Dept of Cell and Molecular Physiology, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
Am J Physiol Gastrointest Liver Physiol 291:G472-81. 2006..We conclude that SOCS2 normally limits basal and IGF-I- and EGF-induced intestinal growth in vivo and has novel inhibitory effects on the IGF-IR tyrosine kinase pathway in intestinal epithelial cells...
- IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanismsMunenori Takaoka
Gastroengerology Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 6:534-40. 2007..In aggregate, these data suggest that IGFBP-3 contributes to esophageal tumor development and progression through IGF-dependent and independent mechanisms...