George K Michalopoulos

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process
    Uma R Chandran
    Departmental of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    BMC Cancer 7:64. 2007
  2. pmc Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donors
    Uma R Chandran
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15232, USA
    BMC Cancer 5:45. 2005
  3. pmc Histological organization in hepatocyte organoid cultures
    G K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 159:1877-87. 2001
  4. pmc Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas
    George K Michalopoulos
    University of Pittsburgh, Department of Pathology, School of Medicine, S 410 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Pathol 176:2-13. 2010
  5. pmc HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Gene Expr 11:55-75. 2003
  6. pmc Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15102, USA
    Hepatology 36:278-83. 2002
  7. pmc Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly
    Vasiliki Gkretsi
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 48:1932-41. 2008
  8. pmc Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis
    Shashikiran Donthamsetty
    University of Pittsburgh School of Medicine, Department of Pathology, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e74625. 2013
  9. ncbi request reprint Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis
    Vasiliki Gkretsi
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 45:1025-34. 2007
  10. pmc Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase
    Udayan Apte
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 50:844-51. 2009

Collaborators

Detail Information

Publications75

  1. pmc Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process
    Uma R Chandran
    Departmental of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    BMC Cancer 7:64. 2007
    ..Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets...
  2. pmc Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donors
    Uma R Chandran
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15232, USA
    BMC Cancer 5:45. 2005
    ..However, normal appearing prostate tissue from tumor free organ donors represents an alterative source of baseline tissue for differential expression studies...
  3. pmc Histological organization in hepatocyte organoid cultures
    G K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 159:1877-87. 2001
    ....
  4. pmc Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas
    George K Michalopoulos
    University of Pittsburgh, Department of Pathology, School of Medicine, S 410 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Pathol 176:2-13. 2010
    ..The review also aims to provide insights into the ways by which current concepts of liver regeneration can provide understanding regarding malfunction of the regenerative process in liver diseases, such as acute liver failure...
  5. pmc HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Gene Expr 11:55-75. 2003
    ..The results underscore the usefulness of the organoid cultures for generating information on histogenesis, which cannot be obtained by other culture or whole animal models...
  6. pmc Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15102, USA
    Hepatology 36:278-83. 2002
    ..Since the only DPPIV cells inoculated in the cultures were hepatocytes, this finding demonstrates that, in the conditions of the organoid cultures, hepatocytes do undergo phenotypic transition to biliary epithelial cells...
  7. pmc Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly
    Vasiliki Gkretsi
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 48:1932-41. 2008
    ..After the proliferative stage, however, the previous trends are reversed resulting in a super-differentiated phenotype in the ILK-deficient livers...
  8. pmc Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis
    Shashikiran Donthamsetty
    University of Pittsburgh School of Medicine, Department of Pathology, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e74625. 2013
    ..Decreased levels of Rsu-1, a partner for PINCH and a protein often deleted in human liver cancer, may play an important role in the development of the observed phenotype. ..
  9. ncbi request reprint Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis
    Vasiliki Gkretsi
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 45:1025-34. 2007
    ....
  10. pmc Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase
    Udayan Apte
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 50:844-51. 2009
    ..This is the first evidence of a defect leading to impaired termination of regeneration and excessive accumulation of liver weight following partial hepatectomy...
  11. ncbi request reprint Beta-catenin is temporally regulated during normal liver development
    Amanda Micsenyi
    Department of Pathology, University of Pittsburgh, School of Medicine, PA 15261, USA
    Gastroenterology 126:1134-46. 2004
    ..beta-Catenin, a key component of the Wnt pathway, plays an important role in unregulated liver growth in liver tumors, in regulated growth during liver regeneration, and in ex vivo embryonic liver cultures...
  12. pmc RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats
    Shirish Paranjpe
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Pathol 176:2669-81. 2010
    ..The data indicate that although the MET and EGFR pathways are similar, the contributions made by MET and EGFR are unique and are not compensated by each other or other cytokines...
  13. pmc Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver
    Xinping Tan
    Department of Pathology, University of Pittsburgh, School of Medicine, Pennsylvania 15261, USA
    Gastroenterology 129:285-302. 2005
    ..Wnt/beta-catenin activation is observed in normal liver development, regeneration, and liver cancer. Our aim was to elucidate the regulation and mechanism of this pathway in liver...
  14. ncbi request reprint Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
    Satdarshan P S Monga
    Division of Cellular and Molecular Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Cancer Res 62:2064-71. 2002
    ..Part of the multifunctionality of HGF might be attributable to nuclear beta-catenin and the resulting target gene expression...
  15. ncbi request reprint Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Cell Physiol 207:261-70. 2006
    ..These findings disclose a cross-talk between the COX-2/PGE(2)/EP(1) and EGFR/c-Met signaling pathways that coordinately regulate human HCC cell invasion...
  16. pmc Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression
    Yu Chen Han
    Departments of Pathology and Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cancer Res 70:4375-84. 2010
    ..We conclude that ILK interaction with MCM7 and MCM7 phosphorylation may be a critical event in ITGA7 signaling pathway, leading to tumor suppression...
  17. pmc Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas
    Jian Hua Luo
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hepatology 44:1012-24. 2006
    ..In conclusion, a set of specific genes and areas of genomic instability are found across the board in liver neoplasia...
  18. pmc Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo
    Vishakha S Bhave
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 54:1360-70. 2011
    ..REST inhibition results in down-regulation of reprogramming factor expression, increased apoptosis, decreased proliferation, and cell death. The reprogramming factors are also up-regulated after 70% partial hepatectomy in vivo...
  19. pmc Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice
    Bowen Liu
    Division of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 52:1060-7. 2010
    ..6-fold), beta-catenin (1.7-fold), transforming growth factor beta type I (3.1-fold), nodal (1.8-fold), and yes-associated protein (1.4-fold). Changes after hepatectomy included decreased expression in several cell cycle-related genes...
  20. ncbi request reprint Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma
    Baoguo Ren
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    J Natl Cancer Inst 99:868-80. 2007
    ..Integrins are the major adhesive molecules in mammalian cells. Each integrin subtype plays a unique role in cell differentiation and embryo development. However, integrin involvement in carcinogenesis has not been well defined...
  21. pmc Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium
    Pallavi B Limaye
    Department of Pathology, School of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 47:1702-13. 2008
    ..Most of the HGF+EGF target genes were altered by LY294002...
  22. ncbi request reprint Wnt impacts growth and differentiation in ex vivo liver development
    Sunny Z Hussain
    Department of Pediatric Gastroenterology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Exp Cell Res 292:157-69. 2004
    ..The addition of insulin to the combination of HGF and Wnt provided no growth or differentiation advantage. Our results indicate usefulness of Wnt and HGF in hepatocyte cultures and suggest their balance during normal liver development...
  23. pmc Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference
    Shirish Paranjpe
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 45:1471-7. 2007
    ..The active form of caspase 3 was seen to increase in ShMet-treated rats. The TUNEL assay indicated a slight increase in apoptosis in ShMet-treated rats compared with that in controls...
  24. doi request reprint Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice
    Chih Wen Lin
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 54:620-30. 2011
    ..Expression of cell cycle-related genes in the TG mice was also decreased compared to the WT mice...
  25. pmc Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation
    Bowen Liu
    Department of Pathology, University of Pittsburgh School of Medicine, S 410 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Pathol 175:717-24. 2009
    ..Co-immunoprecipitation validated the interaction of GPC3 and CD81. Our results indicate that GPC3 may be a negative regulator of liver regeneration and hepatocyte proliferation, and that this regulation may involve CD81...
  26. pmc Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene
    Shashikiran Donthamsetty
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 53:587-95. 2011
    ..The prolonged proliferative response in the ILK/liver-/- mice seems to be due to sustained induction of CAR leading to sustained induction of c-Myc, which is known to be a key mediator of TCPOPOP-CAR induced direct liver hyperplasia...
  27. ncbi request reprint Lack of Fas antagonism by Met in human fatty liver disease
    Chunbin Zou
    Department of Pathology, School of Medicine, University of Pittsburgh, S411A Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, Pennsylvania 15261, USA
    Nat Med 13:1078-85. 2007
    ..Using mouse models of FLD, we show that synthetic YLGA peptide tempers hepatocyte apoptosis and liver damage and therefore has therapeutic potential...
  28. pmc Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex
    Vishakha S Bhave
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Pathol 183:153-9. 2013
    ..Overall, our data suggest that GPC3 down-regulates cell proliferation by binding to HH and down-regulating the HH signaling pathway and binding with CD81, thus making it unavailable to bind to Hhex and causing its nuclear translocation...
  29. pmc Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation
    Michael A Nalesnik
    Department of Pathology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15241, USA
    Am J Pathol 180:1495-508. 2012
    ....
  30. ncbi request reprint Conditional deletion of beta-catenin reveals its role in liver growth and regeneration
    Xinping Tan
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Gastroenterology 131:1561-72. 2006
    ..The Wnt/beta-catenin pathway plays a role in liver growth and development. To address this conclusively, we used a conditional knockout approach to delete beta-catenin in the liver...
  31. doi request reprint Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development
    Xinping Tan
    Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Hepatology 47:1667-79. 2008
    ..While the stem cell assays demonstrated no intrinsic defect in hematopoiesis, distorted hepatic architecture and deficient hepatocyte compartments resulted in defective endothelial cell organization leading to overall fetal pallor...
  32. pmc Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy
    Kari Nejak-Bowen
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e59836. 2013
    ....
  33. pmc Promotion of Fas-mediated apoptosis in Type II cells by high doses of hepatocyte growth factor bypasses the mitochondrial requirement
    Yongge Zhao
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Cell Physiol 213:556-63. 2007
    ..These findings indicate that high doses of HGF could be used to promote apoptosis in Type II cells bypassing the requirement for mitochondria activation...
  34. pmc Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 41:535-44. 2005
    ..In conclusion, our results show that hepatocytes can function as facultative stem cells and rescue the biliary epithelium during repair from injury when its proliferative capacity is being compromised...
  35. ncbi request reprint Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis
    Jing Leng
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 38:756-68. 2003
    ..01). In conclusion, our results suggest the involvement of COX-2-dependent and -independent mechanisms in celecoxib-mediated HCC cell apoptosis...
  36. pmc Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation
    Vasiliki Gkretsi
    Department of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biochem Biophys Res Commun 353:638-43. 2007
    ..Our results show that ILK and cell-matrix adhesion proteins play an important role in the process of matrix-induced hepatocyte differentiation...
  37. pmc Liver regeneration: alternative epithelial pathways
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Biochem Cell Biol 43:173-9. 2011
    ..Mechanistic analysis of these pathways has implications for liver biology and for potential therapeutic modalities in human liver disease...
  38. pmc Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling
    Myrto Giannopoulou
    Department of Pathology, University of PittsburghSchool of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 173:30-41. 2008
    ..These observations suggest that HGF is a potent anti-inflammatory cytokine that inhibits renal inflammation by disrupting NF-kappaB signaling and may be a promising therapeutic agent for progressive renal diseases...
  39. pmc Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development
    Pallavi B Limaye
    Department of Pathology, Division of Transplantation Pathology, Montefiore University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Lab Invest 88:865-72. 2008
    ....
  40. pmc Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR
    Aaron W Bell
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 44:186-94. 2006
    ....
  41. pmc Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation
    Jing Lin Xia
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 168:1500-12. 2006
    ..HGF abolished the phenotypic conversion of biliary epithelial cells induced by TGF-beta1. These results suggest that HGF ameliorates hepatic biliary fibrosis in part by blocking bile duct epithelial to mesenchymal transition...
  42. pmc Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cell Physiol 216:486-97. 2008
    ..Taken together, these observations demonstrate a novel alpha(1)-AR-mediated Stat3 activation that involves G(q/11), Src, and EGFR in hepatic cells...
  43. pmc Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver failure
    Alex Hattoum
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hum Pathol 44:743-9. 2013
    ..Cell proliferation was overall suppressed in regenerative clusters. Transdifferentiation of biliary and progenitor cells appears to be regulated by a complex interaction of signals promoting and arresting growth...
  44. pmc Liver regeneration
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Cell Physiol 213:286-300. 2007
    ..In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other...
  45. ncbi request reprint Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification
    Satdarshan P S Monga
    Department of Cellular and Molecular Pathology, S421 BST, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Gastroenterology 124:202-16. 2003
    ..The aim of this study was to investigate the role of beta-catenin, a key component of the Wnt pathway, in liver development as well as its normal distribution in developing liver...
  46. pmc Gliotoxin-induced changes in rat liver regeneration after partial hepatectomy
    Kari N Nejak-Bowen
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Liver Int 33:1044-55. 2013
    ....
  47. pmc Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli
    Callie A Norris
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e96053. 2014
    ..These findings have wide ranging ramifications regarding how we currently interpret a variety of in vivo and in vitro biological models involving elements of IL-6 signaling and the hepatic acute phase response. ..
  48. doi request reprint Principles of liver regeneration and growth homeostasis
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Compr Physiol 3:485-513. 2013
    ..The complex challenges of the liver toward body homeostasis are thus always preserved by complex but unfailing responses involving orchestrated signaling and affecting growth and differentiation of all hepatic cell types...
  49. pmc Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis
    Hong Min Ni
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 52:338-48. 2010
    ..However, Bid/Bax double deletion in hepatocytes did not further augment the defect, which suggested that Bid and Bax worked by the same regulatory mechanism in [Ca(2+)](ER) control...
  50. ncbi request reprint Flexible lineage specifications of adult hepatic cells, associated molecular pathways, and their relationship to liver cancer
    George K Michalopoulos
    Department of Pathology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Cell Transplant 15:S67-8. 2006
    ..In addition, hepatocytes can revert to primitive progenitor cell types and express gene profiles that appear as characteristic "signatures" in hepatocellular carcinomas...
  51. ncbi request reprint HGF, MET, and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhotic and normal liver
    Karen E Schoedel
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Mod Pathol 16:14-21. 2003
    ..Furthermore, matrix turnover appears to be a more prominent feature of fibrolamellar hepatocellular carcinoma. These findings provide insight into the behavioral differences between hepatocellular carcinoma and the fibrolamellar variant...
  52. pmc A mouse model of accelerated liver aging caused by a defect in DNA repair
    Siobhán Q Gregg
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hepatology 55:609-21. 2012
    ..There was a highly significant correlation in genome-wide transcriptional changes between old WT and 16-week-old, but not 5-week-old, Ercc1(-/Δ) mice, emphasizing that the Ercc1(-/Δ) mice acquire an aging profile in early adulthood...
  53. ncbi request reprint A mechanism of cell survival: sequestration of Fas by the HGF receptor Met
    Xue Wang
    Department of Pathology, Division of Cellular and Molecular Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Cell 9:411-21. 2002
    ..Our results describe a direct link between growth factor tyrosine kinase receptors and death receptors to establish a novel paradigm in growth regulation...
  54. pmc Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice
    Shashikiran Donthamsetty
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Comp Hepatol 10:11. 2011
    ..abstract:..
  55. ncbi request reprint PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway
    Chang Han
    Department of Pathology, Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 38:167-77. 2003
    ....
  56. ncbi request reprint Gene expression analysis of human soft tissue leiomyosarcomas
    Baoguo Ren
    Department of Pathology, University of Pittsburgh School of Medicine, PA 15361, USA
    Hum Pathol 34:549-58. 2003
    ....
  57. ncbi request reprint Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells
    M Jo
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 275:8806-11. 2000
    ..This cross-talk between c-Met and EGFR may have significant implications for altered growth control in tumorigenesis...
  58. ncbi request reprint Expression of HGF and cMet in the developing and adult brain
    C L Achim
    University of Pittsburgh School of Medicine, Department of Pathology, PA 15213, USA
    Brain Res Dev Brain Res 102:299-303. 1997
    ..Segregation of HGF predominantly in the hippocampal CA3-4 and cMet in CA1 supports the hypothesis that HGF may mediate important neurotrophic functions in both developing and adult brains...
  59. ncbi request reprint Comparative genomic hybridization of hepatocellular carcinoma: correlation with fluorescence in situ hybridization in paraffin-embedded tissue
    U N Rao
    Department of Pathology, Presbyterian University Hospital, University of Pittsburgh Medical Center, PA 15213, USA
    Mol Diagn 6:27-37. 2001
    ..Chromosome 7 involvement is reported to be less frequent...
  60. pmc Development of a chemically defined medium and discovery of new mitogenic growth factors for mouse hepatocytes: mitogenic effects of FGF1/2 and PDGF
    William C Bowen
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e95487. 2014
    ..These results demonstrate unanticipated fundamental differences in growth biology of hepatocytes between the two rodent species...
  61. pmc Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation
    Pallavi B Limaye
    Department of Pathology, School of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Comp Hepatol 9:9. 2010
    ....
  62. ncbi request reprint Activation of LXRs prevents bile acid toxicity and cholestasis in female mice
    Hirdesh Uppal
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hepatology 45:422-32. 2007
    ..Conclusion: We propose that LXRs have evolved to have the dual functions of maintaining cholesterol and bile acid homeostasis by increasing cholesterol catabolism and, at the same time, preventing toxicity from bile acid accumulation...
  63. pmc Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation
    Zahida Khan
    University of Pittsburgh School of Medicine, Cellular and Molecular Pathology, Pittsburgh, PA 15261, USA
    Am J Pathol 169:1251-69. 2006
    ..In conclusion, these studies establish the peroxisome as a highly relevant site of subcellular localization and function for the endogenous HIF pathway in hepatocytes...
  64. pmc Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa
    Peter Pediaditakis
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
    J Biol Chem 277:14109-15. 2002
    ..This suggests mandatory maintenance of a steric interaction of the N domain and the first kringle domain for HGF/NK1 to act as an agonist for rat hepatocyte growth but is not required by full-length HGF/SF...
  65. ncbi request reprint Liver regeneration
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15241, USA
    Adv Biochem Eng Biotechnol 93:101-34. 2005
    ..All of this complex phenomenology occurs while the liver continues to provide all the metabolic support required to sustain life of the organism...
  66. pmc Protection from acute cellular injury using Sleeping Beauty mediated telomerase gene transfer
    Joon Seok Song
    University of Pittsburgh Medical Center, Division of Transplantation Pathology, Pittsburgh, PA 15213, USA
    Biochem Biophys Res Commun 363:253-6. 2007
    ..In summary, SB transposon mediated telomerase gene transfer may have a protective effect against t-BH, CCl(4), or d-GalN induced acute cellular injury, and this results suggested SB-mediated telomerase therapy for tissue engineering...
  67. pmc The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat
    P Pediaditakis
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 34:688-93. 2001
    ..The use of radiolabeled HGF/SF showed that during the first 3 hours, HGF/SF is used in part from hepatic stores. Furthermore, during the first 3 hours after PHX, only active two-chain HGF/SF is seen in the plasma...
  68. ncbi request reprint Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor
    Y Liu
    Department of Pathology, School of Medicine, University of Pittsburgh, PA 15261
    Biochim Biophys Acta 1216:299-303. 1993
    ..Our results suggest the existence of evolutionary pressure to conserve the distinct structure, and presumably the biological functions, of HGF...
  69. ncbi request reprint Structural and functional characterization of the mouse hepatocyte growth factor gene promoter
    Y Liu
    Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania 15261
    J Biol Chem 269:4152-60. 1994
    ..Our findings revealed a complex pattern of transcriptional regulation of the mouse HGF gene expression...
  70. pmc Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration
    S P Monga
    Department of Pathology, University of Pittsburgh, School of Medicine, PA, USA
    Hepatology 33:1098-109. 2001
    ..Furthermore, these changes might also be intended to negatively regulate cell-cell adhesion for structural reorganization during the process of liver regeneration...
  71. pmc Cationic colloidal silica membrane perturbation as a means of examining changes at the sinusoidal surface during liver regeneration
    D B Stolz
    Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Pathol 155:1487-98. 1999
    ..They also show considerable modulation of surface components that may regulate angiogenic processes at the end stage of liver regeneration during the reformation of sinusoids...
  72. ncbi request reprint The mouse hepatocyte growth factor-encoding gene: structural organization and evolutionary conservation
    Y Liu
    Department of Pathology, School of Medicine, University of Pittsburgh, PA 15261
    Gene 144:179-87. 1994
    ..Our current results on mouse HGF structure provide basic and detailed information to carry out further manipulation, such as gene targeting...
  73. pmc Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth
    J Yang
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 33:848-59. 2001
    ..Our results also indicate that long-term expression of human HGF in mice markedly activates growth-related signal transduction events, promotes cell proliferation, and leads to liver and overall body growth in whole adult animals...
  74. pmc Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration
    Christoph Kohler
    Department of Internal Medicine, University of Halle, Halle, Germany
    Hepatology 39:1056-65. 2004
    ..In conclusion, Notch/Jagged signaling pathway is activated during liver regeneration and is potentially contributing to signals affecting cell growth and differentiation...
  75. pmc Liver regeneration, growth factors, and amphiregulin
    George K Michalopoulos
    Gastroenterology 128:503-6. 2005