PETER A MICHAELY

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Crystal structure of a 12 ANK repeat stack from human ankyrinR
    Peter Michaely
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235 9039, USA
    EMBO J 21:6387-96. 2002
  2. pmc Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR
    Peter Michaely
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    EMBO J 26:3273-82. 2007
  3. pmc Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia
    Christopher Jones
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 117:165-74. 2007
  4. pmc The epidermal growth factor homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562, and H586
    Zhenze Zhao
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9039, USA
    J Biol Chem 283:26528-37. 2008
  5. pmc The role of calcium in lipoprotein release by the low-density lipoprotein receptor
    Zhenze Zhao
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Biochemistry 48:7313-24. 2009
  6. ncbi request reprint The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits
    Peter Michaely
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 279:34023-31. 2004
  7. ncbi request reprint The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits
    Rita Garuti
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8591, USA
    J Biol Chem 280:40996-1004. 2005

Research Grants

Collaborators

Detail Information

Publications8

  1. pmc Crystal structure of a 12 ANK repeat stack from human ankyrinR
    Peter Michaely
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235 9039, USA
    EMBO J 21:6387-96. 2002
    ....
  2. pmc Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR
    Peter Michaely
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    EMBO J 26:3273-82. 2007
    ..Together, these experiments demonstrate that the LDLR has a very low-density lipoprotein (VLDL)-induced, FDNPVY-independent internalization mechanism...
  3. pmc Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia
    Christopher Jones
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 117:165-74. 2007
    ..The preservation of VLDL remnant clearance attenuates the phenotype of ARH and likely contributes to greater responsiveness to statins in ARH compared with FH...
  4. pmc The epidermal growth factor homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562, and H586
    Zhenze Zhao
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9039, USA
    J Biol Chem 283:26528-37. 2008
    ..We propose that H190, H562, and H586 are part of an allosteric mechanism that drives lipoprotein release...
  5. pmc The role of calcium in lipoprotein release by the low-density lipoprotein receptor
    Zhenze Zhao
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Biochemistry 48:7313-24. 2009
    ..We propose that endosomes use both the acid-dependent and calcium-dependent release mechanisms to drive lipoprotein release and that the acid-dependent process is only required for LDL release...
  6. ncbi request reprint The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits
    Peter Michaely
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 279:34023-31. 2004
    ....
  7. ncbi request reprint The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits
    Rita Garuti
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8591, USA
    J Biol Chem 280:40996-1004. 2005
    ..These results demonstrate that ARH must bind the LDLR tail and either clathrin or AP-2 to promote receptor clustering and internalization of LDL...

Research Grants7

  1. Characterization of the Role of ARH on LDLR Function
    Peter Michaely; Fiscal Year: 2006
    ..The characterization of the function of ARH and its associated proteins in lipoprotein uptake by LDLR may clarify our understanding of the clearance process. ..
  2. Characterization of the Role of ARH on LDLR Function
    Peter Michaely; Fiscal Year: 2007
    ..The characterization of the function of ARH and its associated proteins in lipoprotein uptake by LDLR may clarify our understanding of the clearance process. ..
  3. Characterization of the Role of ARH on LDLR Function
    Peter Michaely; Fiscal Year: 2009
    ..The characterization of the function of ARH and its associated proteins in lipoprotein uptake by LDLR may clarify our understanding of the clearance process. ..
  4. Characterization of the Role of ARH on LDLR Function
    Peter Michaely; Fiscal Year: 2009
    ..The characterization of the function of ARH and its associated proteins in lipoprotein uptake by LDLR may clarify our understanding of the clearance process. ..
  5. Characterization of the Role of ARH on LDLR Function
    Peter Michaely; Fiscal Year: 2009
    ..The characterization of the function of ARH and its associated proteins in lipoprotein uptake by LDLR may clarify our understanding of the clearance process. ..
  6. Characterization of the Role of ARH on LDLR Function
    PETER A MICHAELY; Fiscal Year: 2010
    ..The characterization of the function of ARH and its associated proteins in lipoprotein uptake by LDLR may clarify our understanding of the clearance process. ..