M L Michaelis

Summary

Affiliation: University of Kansas
Country: USA

Publications

  1. ncbi request reprint {beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents
    M L Michaelis
    Department of Pharmacology and Toxicology, 1251 Wescoe Hall Dr, 5064 Malott Hall, University of Kansas, Lawrence, KS 66045, USA
    J Pharmacol Exp Ther 312:659-68. 2005
  2. pmc Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress
    Xinkun Wang
    Higuchi Biosciences Center, University of Kansas, Lawrence, KS 66047, USA
    BMC Neurosci 10:12. 2009
  3. ncbi request reprint Ongoing in vivo studies with cytoskeletal drugs in tau transgenic mice
    Mary L Michaelis
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, 1241 Wescoe Hall Dr, Lawrence, KS 66045, USA
    Curr Alzheimer Res 3:215-9. 2006
  4. ncbi request reprint Cytoskeletal integrity as a drug target
    M L Michaelis
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
    Curr Alzheimer Res 2:227-9. 2005
  5. ncbi request reprint Drugs targeting Alzheimer's disease: some things old and some things new
    Mary L Michaelis
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045 7582, USA
    J Pharmacol Exp Ther 304:897-904. 2003
  6. ncbi request reprint Tau neurofibrillary pathology and microtubule stability
    Mary L Michaelis
    Department of Pharmacology and Toxicology, University of Kansas, Malott Hall 5064, 1251 Wescoe Hall Drive, Lawrence, KS 66045 7582, USA
    J Mol Neurosci 19:289-93. 2002
  7. ncbi request reprint Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons
    Guibin Li
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence 66045, USA
    J Neurochem 84:347-62. 2003
  8. ncbi request reprint beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton
    Kathleen I Seyb
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
    J Mol Neurosci 28:111-23. 2006
  9. pmc Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform
    K I Seyb
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, USA
    J Biomol Screen 13:870-8. 2008
  10. ncbi request reprint p35/Cyclin-dependent kinase 5 is required for protection against beta-amyloid-induced cell death but not tau phosphorylation by ceramide
    Kathleen I Seyb
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
    J Mol Neurosci 31:23-35. 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint {beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents
    M L Michaelis
    Department of Pharmacology and Toxicology, 1251 Wescoe Hall Dr, 5064 Malott Hall, University of Kansas, Lawrence, KS 66045, USA
    J Pharmacol Exp Ther 312:659-68. 2005
    ....
  2. pmc Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress
    Xinkun Wang
    Higuchi Biosciences Center, University of Kansas, Lawrence, KS 66047, USA
    BMC Neurosci 10:12. 2009
    ..The purpose of this study was to identify endogenous factors that predispose vulnerable neurons to OS by employing genomic and biochemical approaches...
  3. ncbi request reprint Ongoing in vivo studies with cytoskeletal drugs in tau transgenic mice
    Mary L Michaelis
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, 1241 Wescoe Hall Dr, Lawrence, KS 66045, USA
    Curr Alzheimer Res 3:215-9. 2006
    ..A study is ongoing with free-fed mice to determine if the drug interventions do have any beneficial effects in these mutant mice...
  4. ncbi request reprint Cytoskeletal integrity as a drug target
    M L Michaelis
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
    Curr Alzheimer Res 2:227-9. 2005
    ..In vivo proof-of-concept studies in animal models will require the development of agents that can protect cytoskeletal integrity and also cross the blood brain barrier...
  5. ncbi request reprint Drugs targeting Alzheimer's disease: some things old and some things new
    Mary L Michaelis
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045 7582, USA
    J Pharmacol Exp Ther 304:897-904. 2003
    ..Nevertheless, the pace of recent research clearly supports optimism that slowing progression of AD will soon be possible...
  6. ncbi request reprint Tau neurofibrillary pathology and microtubule stability
    Mary L Michaelis
    Department of Pharmacology and Toxicology, University of Kansas, Malott Hall 5064, 1251 Wescoe Hall Drive, Lawrence, KS 66045 7582, USA
    J Mol Neurosci 19:289-93. 2002
    ..Thus the cytoskeletal network may serve as a biosensor of cellular well-being...
  7. ncbi request reprint Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons
    Guibin Li
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence 66045, USA
    J Neurochem 84:347-62. 2003
    ..These results suggest that MT-stabilizing agents may provide a therapeutic approach to decrease Abeta toxicity and neurofibrillary pathology in AD and other tauopathies...
  8. ncbi request reprint beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton
    Kathleen I Seyb
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
    J Mol Neurosci 28:111-23. 2006
    ....
  9. pmc Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform
    K I Seyb
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, USA
    J Biomol Screen 13:870-8. 2008
    ..In fact, of the compounds that inhibited calpain activation by Abeta with IC(50) values of <10 microM and showed little or no toxicity at concentrations up to 30 microM, none inhibit the calpain enzyme directly...
  10. ncbi request reprint p35/Cyclin-dependent kinase 5 is required for protection against beta-amyloid-induced cell death but not tau phosphorylation by ceramide
    Kathleen I Seyb
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
    J Mol Neurosci 31:23-35. 2007
    ..However, ceramide blocked tau hyperphosphorylation potentially via inhibition of glycogen synthase kinase-3beta. These data suggest that ceramide can regulate A beta cell toxicity in a p35/cdk5-dependent manner...
  11. ncbi request reprint Single-molecule characterization of the dynamics of calmodulin bound to oxidatively modified plasma-membrane Ca2+-ATPase
    Kenneth D Osborn
    Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA
    Biochemistry 44:11074-81. 2005
    ..Enhanced proteolysis was observed for PMCA upon binding CaM or ATP. In contrast, proteolysis was partially blocked for oxidatively modified PMCA, even in the presence of ATP...
  12. ncbi request reprint Oxidative inactivation of purified plasma membrane Ca2+-ATPase by hydrogen peroxide and protection by calmodulin
    Asma Zaidi
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045, USA
    Biochemistry 42:12001-10. 2003
    ..Preincubation of PMCA with CaM protected the enzyme from undergoing this conformational change...
  13. ncbi request reprint Overcoming the blood-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors
    Antonie Rice
    Department of Pharmaceutical Chemistry, University of Kansas, 226 Simons, 2095 Constant Avenue, Lawrence, KS 66047, USA
    J Mol Neurosci 20:339-43. 2003
    ..e., a taxane that may reach and treat therapeutic targets in the CNS...
  14. ncbi request reprint Amyloid peptide toxicity and microtubule-stabilizing drugs
    Mary L Michaelis
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence 66045, USA
    J Mol Neurosci 19:101-5. 2002
    ..A small number of neuroprotective compounds appear to have potential to enter the brain and thus might be tested to see if they slow progression of neurodegeneration in an appropriate animal model of Alzheimer's disease...
  15. ncbi request reprint Antisense oligonucleotide suppression of Na(+)/Ca(2+) exchanger activity in primary neurons from rat brain
    N S Ranciat-McComb
    Department of Pharmacology and Toxicology, 5064 Malott Hall, and Center for Neurobiology and Immunology Research, University of Kansas, Lawrence, KS 66045, USA
    Neurosci Lett 294:13-6. 2000
    ..These results suggest that NCX plays a significant role in maintaining neuronal Ca(2+) homeostasis and in restoring baseline Ca(2+) levels following depolarization...
  16. ncbi request reprint Theoretically predicted structures of plasma membrane Ca(2+)-ATPase and their susceptibilities to oxidation
    Gerald H Lushington
    Molecular Graphics and Modeling Laboratory, University of Kansas, 1251 Wescoe Hall Dr, Lawrence, KS 66045, USA
    J Mol Graph Model 24:175-85. 2005
    ..The resulting model complex has permitted us to identify three amino acids whose solvent accessibility is greatly reduced by the C20W dissociation: Tyr 589, Met 622, and Met 831...
  17. ncbi request reprint Age-related decrease in brain synaptic membrane Ca2+-ATPase in F344/BNF1 rats
    A Zaidi
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence 66045, USA
    Neurobiol Aging 19:487-95. 1998
    ....
  18. ncbi request reprint A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity
    Sabah Ansar
    Department of Pharmacology and Toxicology, The University of Kansas, Malott 5064, 1251 Wescoe Hall Drive, Lawrence, KS 66045 7563, USA
    Bioorg Med Chem Lett 17:1984-90. 2007
    ..Taken together, these data establish A4, a C-terminal inhibitor of Hsp90, as a potent lead for the development of a novel class of compounds to treat Alzheimer's disease...
  19. pmc Effects of paraquat-induced oxidative stress on the neuronal plasma membrane Ca(2+)-ATPase
    Asma Zaidi
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA
    Free Radic Biol Med 47:1507-14. 2009
    ..Our findings suggest that PMCA is a sensitive target of oxidative stress in primary neurons. Inactivation of this Ca(2+) transporter under prolonged oxidative stress could alter neuronal Ca(2+) signaling...
  20. ncbi request reprint Effects of reactive oxygen species on brain synaptic plasma membrane Ca(2+)-ATPase
    A Zaidi
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence 66045, USA
    Free Radic Biol Med 27:810-21. 1999
    ..The PMCA appears to be very sensitive to inhibition by ROS and hence may be a target of oxidative stress in the aging brain. Reduction in its activity may contribute to age-related alterations in neuronal [Ca2+]i regulation...
  21. ncbi request reprint Partitioning of the plasma membrane Ca2+-ATPase into lipid rafts in primary neurons: effects of cholesterol depletion
    Lei Jiang
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045, USA
    J Neurochem 102:378-88. 2007
    ..We propose that association of PMCA with rafts represents a novel mechanism for its regulation and, consequently, of Ca(2+) signaling in the central nervous system...
  22. pmc Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability
    Xiaodong Bao
    Higuchi Biosciences Center, Department of Pharmacology and Toxicology, and Life Span Studies Institute, University of Kansas, Lawrence, KS 66047, USA
    J Neurosci 29:13929-44. 2009
    ..The Glud1 mouse might be a useful model for the effects of lifelong excess synaptic Glu release on CNS neurons and for age-associated neurodegenerative processes...
  23. ncbi request reprint Selective dendrite-targeting of mRNAs of NR1 splice variants without exon 5: identification of a cis-acting sequence and isolation of sequence-binding proteins
    Ranu Pal
    Department of Pharmacology and Toxicology and the Center for Neurobiology and Immunology Research, University of Kansas, Lawrence, KS 66045, USA
    Brain Res 994:1-18. 2003
    ..We concluded that the 24-base sequence in 5'-UTR of ex5(-) mRNA functioned as a cis-acting, dendrite-targeting element recognized selectively by two microsome proteins...
  24. pmc Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line
    Yuanming Lu
    The Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045 7563, USA
    Bioorg Med Chem 17:1709-15. 2009
    ..The results suggest that novobiocin analogues may provide novel leads for the development of neuroprotective drugs...
  25. ncbi request reprint RNA--induced silencing of the plasma membrane Ca2+-ATPase 2 in neuronal cells: effects on Ca2+ homeostasis and cell viability
    Denzyl Fernandes
    Gene Logic, Inc, Cambridge, Massachusetts, USA
    J Neurochem 102:454-65. 2007
    ..Our results indicate that a loss of PMCA such as occurs in aging brain likely leads to subtle disruptions in normal Ca(2+) signaling and enhanced susceptibility to stresses that can alter the regulation of Ca(2+) homeostasis...
  26. ncbi request reprint Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers
    David Butler
    Department of Pharmaceutical Sciences and the Neurosciences Program, University of Connecticut, Storrs, CT 06269 3092, USA
    Eur J Pharmacol 562:20-7. 2007
    ..They also suggest that microtubule-stabilizing drugs can be used to slow or halt the progressive synaptic deterioration linked to Alzheimer-type pathogenesis...
  27. ncbi request reprint Proteomic analysis of protein nitration in rat cerebellum: effect of biological aging
    Giridharan Gokulrangan
    Department of Pharmaceutical Chemistry, University of Lawrence, Kansas 66047, USA
    J Neurochem 100:1494-504. 2007
    ....