Yubin Miao

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. pmc 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide analogues for melanoma imaging
    Yubin Miao
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Bioconjug Chem 19:539-47. 2008
  2. pmc 203Pb-labeled alpha-melanocyte-stimulating hormone peptide as an imaging probe for melanoma detection
    Yubin Miao
    Department of Dermatology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Nucl Med 49:823-9. 2008
  3. pmc Peptide-targeted radionuclide therapy for melanoma
    Yubin Miao
    College of Pharmacy, University of New Mexico, 2502 Marble NE, MSC09 5360, Albuquerque, NM 87131, USA
    Crit Rev Oncol Hematol 67:213-28. 2008
  4. ncbi request reprint Alpha-melanocyte stimulating hormone peptide-targeted melanoma imaging
    Yubin Miao
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Front Biosci 12:4514-24. 2007
  5. ncbi request reprint Reducing renal uptake of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues
    Yubin Miao
    Department of Internal Medicine, University of Missouri Columbia, Columbia, MO 65211, USA
    Nucl Med Biol 33:723-33. 2006
  6. pmc Reduction of the ring size of radiolabeled lactam bridge-cyclized alpha-MSH peptide, resulting in enhanced melanoma uptake
    Haixun Guo
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Nucl Med 51:418-26. 2010
  7. pmc Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide
    Haixun Guo
    College of Pharmacy, Cancer Research Treatment Center, Department of Cell Biology and Physiology, Department of Pathology, Department of Dermatology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Bioconjug Chem 20:2162-8. 2009
  8. ncbi request reprint Evaluation of the human melanoma targeting properties of radiolabeled alpha-melanocyte stimulating hormone peptide analogues
    Yubin Miao
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Bioconjug Chem 14:1177-84. 2003
  9. ncbi request reprint Therapeutic efficacy of a 188Re-labeled alpha-melanocyte-stimulating hormone peptide analog in murine and human melanoma-bearing mouse models
    Yubin Miao
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    J Nucl Med 46:121-9. 2005
  10. pmc Metastatic melanoma imaging with an (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptide
    Haixun Guo
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Nucl Med Biol 36:267-76. 2009

Collaborators

Detail Information

Publications40

  1. pmc 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide analogues for melanoma imaging
    Yubin Miao
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Bioconjug Chem 19:539-47. 2008
    ....
  2. pmc 203Pb-labeled alpha-melanocyte-stimulating hormone peptide as an imaging probe for melanoma detection
    Yubin Miao
    Department of Dermatology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Nucl Med 49:823-9. 2008
    ..The purpose of this study was to evaluate the potential of (203)Pb-DOTA-Re(Arg(11))CCMSH as a matched-pair SPECT agent for (212)Pb-DOTA-Re(Arg(11))CCMSH...
  3. pmc Peptide-targeted radionuclide therapy for melanoma
    Yubin Miao
    College of Pharmacy, University of New Mexico, 2502 Marble NE, MSC09 5360, Albuquerque, NM 87131, USA
    Crit Rev Oncol Hematol 67:213-28. 2008
    ..The lack of effective treatments for metastatic melanoma and end-stage disease underscores the necessity to develop and implement new treatment strategies, such as peptide-targeted radionuclide therapy...
  4. ncbi request reprint Alpha-melanocyte stimulating hormone peptide-targeted melanoma imaging
    Yubin Miao
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Front Biosci 12:4514-24. 2007
    ..This review highlights the strategies being used to design alpha-MSH peptide radiopharmaceuticals to target MC1 receptors and some recent developments of radiolabeled alpha-MSH peptide analogues for melanoma imaging...
  5. ncbi request reprint Reducing renal uptake of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues
    Yubin Miao
    Department of Internal Medicine, University of Missouri Columbia, Columbia, MO 65211, USA
    Nucl Med Biol 33:723-33. 2006
    ....
  6. pmc Reduction of the ring size of radiolabeled lactam bridge-cyclized alpha-MSH peptide, resulting in enhanced melanoma uptake
    Haixun Guo
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Nucl Med 51:418-26. 2010
    ..The purpose of this study was to examine the profound effect of the ring size of the radiolabeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone (alpha-MSH) peptide on its melanoma-targeting properties...
  7. pmc Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide
    Haixun Guo
    College of Pharmacy, Cancer Research Treatment Center, Department of Cell Biology and Physiology, Department of Pathology, Department of Dermatology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Bioconjug Chem 20:2162-8. 2009
    ....
  8. ncbi request reprint Evaluation of the human melanoma targeting properties of radiolabeled alpha-melanocyte stimulating hormone peptide analogues
    Yubin Miao
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Bioconjug Chem 14:1177-84. 2003
    ..Moreover, the biodistribution properties of (188)Re-(Arg(11))CCMSH and (188)Re-CCMSH highlight their potential as therapeutic agents for human melanoma...
  9. ncbi request reprint Therapeutic efficacy of a 188Re-labeled alpha-melanocyte-stimulating hormone peptide analog in murine and human melanoma-bearing mouse models
    Yubin Miao
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    J Nucl Med 46:121-9. 2005
    ..The purpose of this study was to examine the therapeutic efficacy of (188)Re-(Arg(11))[Cys(3,4,10),d-Phe(7)]alpha-melanocyte-stimulating hormone(3-13) (CCMSH) in the B16/F1 murine melanoma- and TXM13 human melanoma-bearing mouse models...
  10. pmc Metastatic melanoma imaging with an (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptide
    Haixun Guo
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Nucl Med Biol 36:267-76. 2009
    ....
  11. pmc Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide
    Jianquan Yang
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Bioorg Med Chem 18:6695-700. 2010
    ....
  12. pmc Design and evaluation of new Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptides for melanoma imaging
    Haixun Guo
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Mol Pharm 10:1400-8. 2013
    ..Overall, high melanoma uptake coupled with fast urinary clearance of (99m)Tc(EDDA)-HYNIC-GGNle-CycMSH(hex) highlighted its potential for metastatic melanoma detection in the future...
  13. ncbi request reprint Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues
    Zhen Cheng
    Department of Chemistry, 125 Chemistry Building, University of Missouri Columbia, Columbia, MO 65211, USA
    J Med Chem 45:3048-56. 2002
    ..13 +/- 1.47% ID/g for (111)In-10 at 4 h pi. Complex 6 showed high melanoma uptake and lower kidney uptake than the corresponding Lys(11) analogues, supporting 6 for further investigations as a potential therapeutic radiopharmaceutical...
  14. ncbi request reprint Melanoma therapy via peptide-targeted {alpha}-radiation
    Yubin Miao
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Clin Cancer Res 11:5616-21. 2005
    ..This high linear energy transfer overcomes radiation-resistant tumor cells and oxygen effects resulting in potentially high therapeutic indices in tumors such as melanoma...
  15. ncbi request reprint In vivo evaluation of 188Re-labeled alpha-melanocyte stimulating hormone peptide analogs for melanoma therapy
    Yubin Miao
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Int J Cancer 101:480-7. 2002
    ..Improved tumor uptake and reduced kidney retention of 188Re-(Arg(11))CCMSH will facilitate targeted irradiation of melanoma tumors while minimizing the dose to the kidneys...
  16. ncbi request reprint Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model
    Yubin Miao
    College of Pharmacy, University of New Mexico, Albuquerque, NM, USA
    Cancer Biother Radiopharm 22:333-41. 2007
    ..The aim of this study was to examine the therapeutic efficacy of (177)Lu-DOTA-Re(Arg(11))CCMSH in the B16/F1 murine melanoma-bearing mouse model...
  17. pmc Effects of Amino Acids on Melanoma Targeting and Clearance Properties of Tc-99m-Labeled Arg-X-Asp-Conjugated α-Melanocyte Stimulating Hormone Peptides
    Adam M Flook
    College of Pharmacy, Cancer Research and Treatment Center, Department of Dermatology, University of New Mexico, Albuquerque, New Mexico, 87131, United States
    J Med Chem 56:8793-802. 2013
    ..It is desirable to reduce the renal uptake of (99m)Tc-RSD-Lys-(Arg(11))CCMSH to facilitate its potential therapeutic application. ..
  18. pmc Effects of the amino acid linkers on the melanoma-targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-MSH peptides
    Haixun Guo
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Nucl Med 52:608-16. 2011
    ....
  19. pmc Evaluation of a novel Arg-Gly-Asp-conjugated α-melanocyte stimulating hormone hybrid peptide for potential melanoma therapy
    Jianquan Yang
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
    Bioconjug Chem 20:1634-42. 2009
    ..The purpose of this study was to determine whether Arg-Gly-Asp (RGD)-conjugated α-melanocyte stimulating hormone (α-MSH) hybrid peptide could be employed to target melanocortin-1 (MC1) receptor for potential melanoma therapy...
  20. ncbi request reprint 99mTc- and 111In-labeled alpha-melanocyte-stimulating hormone peptides as imaging probes for primary and pulmonary metastatic melanoma detection
    Yubin Miao
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, USA
    J Nucl Med 48:73-80. 2007
    ....
  21. pmc Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides
    Haixun Guo
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Bioorg Med Chem Lett 23:5484-7. 2013
    ..The cellular and biological results provided an insight into the design of new GnRH peptides in the future...
  22. pmc Gallium-67-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide for primary and metastatic melanoma imaging
    Haixun Guo
    College of Pharmacy, Cancer Research Treatment Center, and Department of Dermatology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Bioconjug Chem 20:2356-63. 2009
    ..67Ga-DOTA-GlyGlu-CycMSH exhibited favorable melanoma targeting and imaging properties, highlighting its potential as an effective imaging probe for early detection of primary and metastatic melanoma...
  23. ncbi request reprint Tumor-targeting properties of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues in a murine melanoma model
    Yubin Miao
    Department of Internal Medicine, University of Missouri Columbia, 65211, USA
    Nucl Med Biol 32:485-93. 2005
    ..The purpose of this study was to compare the tumor-targeting properties of (90)Y-DOTA-Re(Arg(11))CCMSH and (177)Lu-DOTA-Re(Arg(11))CCMSH in a murine melanoma mouse model...
  24. pmc Melanoma targeting property of a Lu-177-labeled lactam bridge-cyclized alpha-MSH peptide
    Haixun Guo
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Bioorg Med Chem Lett 23:2319-23. 2013
    ..Overall, high melanoma uptake coupled with fast urinary clearance of (177)Lu-DOTA-GGNle-CycMSHhex underscored its potential for melanoma treatment in the future...
  25. pmc Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide
    Jianquan Yang
    2502 Marble NE, MSC09 5360, College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Bioorg Med Chem Lett 24:195-8. 2014
    ..5, 2, 4 and 24h post-injection, respectively. Flank B16/F1 melanoma lesions were clearly imaged at 2h post-injection using (99m)Tc-RAD-Arg-(Arg(11))CCMSH as an imaging probe. ..
  26. pmc Structural modification on the Lys linker enhanced tumor to kidney uptake ratios of 99mTc-labeled RGD-conjugated α-MSH hybrid peptides
    Jianquan Yang
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States
    Mol Pharm 9:1418-24. 2012
    ..A dramatically enhanced tumor-to-kidney uptake ratio of (99m)Tc-RGD-(Arg(11))CCMSH suggests that (188)Re-RGD-(Arg(11))CCMSH may behave in a similar fashion warranting future evaluation for melanoma treatment...
  27. pmc Substitution of Gly with Ala enhanced the melanoma uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide
    Jianquan Yang
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Bioorg Med Chem Lett 22:1541-5. 2012
    ....
  28. pmc Technetium-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptides for human melanoma imaging
    Jianquan Yang
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Nucl Med Biol 37:873-83. 2010
    ....
  29. pmc A novel indium-111-labeled gonadotropin-releasing hormone peptide for human prostate cancer imaging
    Haixun Guo
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Bioorg Med Chem Lett 21:5184-7. 2011
    ..The successful imaging of DU145 human prostate cancer-xenografted tumor lesions using (111)In-DOTA-Ahx-(d-Lys(6)-GnRH1) highlighted its potential as a novel imaging probe for human prostate cancer imaging...
  30. pmc Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides
    Haixun Guo
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States
    Bioconjug Chem 22:1682-9. 2011
    ..The successful imaging of MDA-MB-231 human breast cancer-xenografted tumor lesions using (111)In-DOTA-Ahx-(D-Lys(6)-GnRH1) suggested its potential as a novel imaging probe for human breast cancer imaging...
  31. ncbi request reprint Alpha-melanocyte-stimulating hormone peptide analogs labeled with technetium-99m and indium-111 for malignant melanoma targeting
    Jianqing Chen
    Department of Biochemistry, University of Missouri, Columbia, Missouri, USA
    Cancer 94:1196-201. 2002
    ....
  32. ncbi request reprint Melanoma imaging with pretargeted bivalent bacteriophage
    Jessica R Newton
    Department of Biochemistry, University of Missouri, Columbia, Missouri, USA
    J Nucl Med 48:429-36. 2007
    ..This study provides proof of principle for the use of phage displaying multiple melanocortin-1 receptor-homing peptides for the pretargeting and subsequent imaging of murine melanomas in vivo...
  33. pmc Introduction of d-Phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides
    Jie Lu
    College of Pharmacy, University of New Mexico, 2502 Marble NE, MSC09 5360, Albuquerque, NM 87131, United States
    Bioorg Med Chem Lett 24:725-30. 2014
    ....
  34. pmc Gallium-67-labeled lactam bridge-cyclized alpha-MSH peptides with enhanced melanoma uptake and reduced renal uptake
    Haixun Guo
    College of Pharmacy, Cancer Research and Treatment Center, Department of Dermatology, University of New Mexico, Albuquerque, New Mexico 87131, United States
    Bioconjug Chem 23:1341-8. 2012
    ..5, 2, and 24 h postinjection. High melanoma uptake coupled with low renal uptake highlighted the potential of (67)Ga-NOTA-GGNle-CycMSHhex for melanoma imaging and therapy. ..
  35. pmc Evaluation of New Tc-99m-Labeled Arg-X-Asp-Conjugated α-Melanocyte Stimulating Hormone Peptides for Melanoma Imaging
    Adam M Flook
    College of Pharmacy, Cancer Research and Treatment Center, and Department of Dermatology, University of New Mexico, Albuquerque, New Mexico 87131, United States
    Mol Pharm 10:3417-24. 2013
    ..However, high renal uptake of (99m)Tc-RTD-Lys-(Arg(11))CCMSH and (99m)Tc-RVD-Lys-(Arg(11))CCMSH need to be reduced to facilitate their future applications. ..
  36. pmc Cu-64-labeled lactam bridge-cyclized α-MSH peptides for PET imaging of melanoma
    Haixun Guo
    College of Pharmacy, Cancer Research and Treatment Center, and Department of Dermatology, University of New Mexico, Albuquerque, New Mexico 87131, United States
    Mol Pharm 9:2322-30. 2012
    ..High melanoma uptake coupled with low accumulation in nontarget organs suggested (64)Cu-NOTA-GGNle-CycMSH(hex) as a lead radiolabeled peptide for melanoma imaging and therapy...
  37. pmc A heterodimeric [RGD-Glu-[(64)Cu-NO2A]-6-Ahx-RM2] αvβ3/GRPr-targeting antagonist radiotracer for PET imaging of prostate tumors
    Kubra Durkan
    Research Division, Harry S Truman Memorial Veterans Hospital, Columbia, MO 65201, USA Department of Radiology, University of Missouri School of Medicine, Columbia, MO 65211, USA Department of Nuclear Applications, Ege University, 35100, Bornova, Izmir, Turkey Electronic address
    Nucl Med Biol 41:133-9. 2014
    ....
  38. pmc Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma
    Lihui Wei
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 34:945-53. 2007
    ..This encouraged us to investigate DOTA-ReCCMSH(Arg11) labeled with another beta+-emitting radionuclide, 68Ga...
  39. ncbi request reprint Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized alpha-MSH peptide analog using a cross-bridged cyclam chelator
    Lihui Wei
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology and the Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 48:64-72. 2007
    ..The goal of this study was to conjugate CBTE2A to the alpha-MSH targeting ReCCMSH(Arg(11)) peptide for labeling to (64)Cu and to investigate whether the increased metal-chelate stability with CBTE2A would improve imaging quality...
  40. ncbi request reprint Imaging of melanoma using 64Cu- and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of alpha-MSH
    Paul McQuade
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology and the Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 48:2985-92. 2005
    ..The data obtained suggests that DOTA-ReCCMSH(Arg(11)), when labeled with beta(+)-emitting radionuclides, has the potential for early detection of malignant melanoma by exploiting the sensitivity and high resolution of PET...