J M Miano

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Expression and chromosomal mapping of the mouse smooth muscle calponin gene
    J M Miano
    Center for Cardiovascular Research, University of Rochester Medical Center, New York 14642, USA
    Mamm Genome 12:187-91. 2001
  2. ncbi request reprint Expression of human smooth muscle calponin in transgenic mice revealed with a bacterial artificial chromosome
    Joseph M Miano
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Physiol Heart Circ Physiol 282:H1793-803. 2002
  3. ncbi request reprint Serum response factor-dependent regulation of the smooth muscle calponin gene
    J M Miano
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 275:9814-22. 2000
  4. ncbi request reprint Gene structure and chromosomal mapping of the rat smooth muscle calponin gene
    M A Nobrega
    Department of Physiology, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee 53226, USA
    Mamm Genome 11:115-9. 2000
  5. ncbi request reprint Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells
    J Chen
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 276:34175-81. 2001
  6. ncbi request reprint Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene
    J M Miano
    Medical College of Wisconsin, Department of Physiology, Milwaukee 53226, USA
    Gene 197:215-24. 1997
  7. ncbi request reprint Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells
    H Ou
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, NY, USA
    Circ Res 87:881-7. 2000
  8. ncbi request reprint Localized adenovirus-mediated gene transfer into vascular smooth muscle in the hamster cheek pouch
    M D Frame
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Microcirculation 8:403-13. 2001
  9. ncbi request reprint all-Trans-retinoic acid reduces neointimal formation and promotes favorable geometric remodeling of the rat carotid artery after balloon withdrawal injury
    J M Miano
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Circulation 98:1219-27. 1998
  10. ncbi request reprint Mapping of the rat SM22 gene to chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy
    G Koike
    Medical College of Wisconsin, Department of Physiology, Milwaukee 53226 0509, USA
    Mamm Genome 9:76-7. 1998

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Expression and chromosomal mapping of the mouse smooth muscle calponin gene
    J M Miano
    Center for Cardiovascular Research, University of Rochester Medical Center, New York 14642, USA
    Mamm Genome 12:187-91. 2001
    ..These results are the first to show reversible expression of Cnn1 and demonstrate the utility of the BC3H1 muscle cell line as a model system for the further characterization of Cnn1 gene regulation...
  2. ncbi request reprint Expression of human smooth muscle calponin in transgenic mice revealed with a bacterial artificial chromosome
    Joseph M Miano
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Physiol Heart Circ Physiol 282:H1793-803. 2002
    ..These BAC mice represent a new model system in which to systematically assess regulatory elements governing SM-Calp transcription in vivo...
  3. ncbi request reprint Serum response factor-dependent regulation of the smooth muscle calponin gene
    J M Miano
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 275:9814-22. 2000
    ..These results demonstrate an important role for intronic CArG boxes and the SRF protein in the transcriptional control of smooth muscle calponin in vitro...
  4. ncbi request reprint Gene structure and chromosomal mapping of the rat smooth muscle calponin gene
    M A Nobrega
    Department of Physiology, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee 53226, USA
    Mamm Genome 11:115-9. 2000
    ..These studies provide additional information relating to the control of CnnI gene expression and provide a platform to begin assessing the potential linkage of CnnI to spontaneous and experimental disease phenotypes in rats...
  5. ncbi request reprint Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells
    J Chen
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 276:34175-81. 2001
    ..Radiation hybrid mapping studies placed the rat RISC locus on chromosome 10q. These studies reveal a novel retinoid-inducible protease whose activity may be involved in vascular wall and kidney homeostasis...
  6. ncbi request reprint Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene
    J M Miano
    Medical College of Wisconsin, Department of Physiology, Milwaukee 53226, USA
    Gene 197:215-24. 1997
    ..Finally, the localization of SMCC to a defined genomic interval will facilitate an analysis of its potential as a candidate gene for disease phenotypes mapping to 19p13.2...
  7. ncbi request reprint Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells
    H Ou
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, NY, USA
    Circ Res 87:881-7. 2000
    ..atRA-mediated apoptosis in SMCs seems to require the participation of active tTG, suggesting a potential mechanistic link between this retinoid-inducible gene and programmed cell death...
  8. ncbi request reprint Localized adenovirus-mediated gene transfer into vascular smooth muscle in the hamster cheek pouch
    M D Frame
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Microcirculation 8:403-13. 2001
    ..Our purpose was to develop a method for adenovirus delivery to the hamster cheek pouch to experimentally target gene transfer in tissue used for microvascular studies...
  9. ncbi request reprint all-Trans-retinoic acid reduces neointimal formation and promotes favorable geometric remodeling of the rat carotid artery after balloon withdrawal injury
    J M Miano
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Circulation 98:1219-27. 1998
    ..In this report, we have initiated studies to examine the hypothesis that atRA limits neointimal formation after experimental vascular injury...
  10. ncbi request reprint Mapping of the rat SM22 gene to chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy
    G Koike
    Medical College of Wisconsin, Department of Physiology, Milwaukee 53226 0509, USA
    Mamm Genome 9:76-7. 1998
  11. pmc Restricted inactivation of serum response factor to the cardiovascular system
    Joseph M Miano
    Center for Cardiovascular Research, Aab Institute of Biomedical Sciences, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 101:17132-7. 2004
    ..These results suggest a vital role for SRF in contractile/cytoskeletal architecture necessary for the proper assembly and function of cardiomyocytes and vascular SMC...
  12. ncbi request reprint AKAP12alpha, an atypical serum response factor-dependent target gene
    Jeffrey W Streb
    Center for Cardiovascular Research in the Aab Institute of Biomedical Sciences, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 280:4125-34. 2005
    ..Furthermore, we provide new insight into the role of flanking sequences in determining sensitivity to SRF-myocardin activity...
  13. ncbi request reprint Neurovascular pathways and Alzheimer amyloid beta-peptide
    Berislav V Zlokovic
    Frank R Smith Laboratories for Neuroscience and Neurosurgical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Brain Pathol 15:78-83. 2005
    ..We suggest that there is a link between neurovascular dysfunction and elevated brain Abeta which provides a new scenario for therapeutic interventions to control Alzheimer mental deterioration...
  14. pmc Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation
    Xiaochun Long
    The Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 104:16570-5. 2007
    ....
  15. ncbi request reprint Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo
    Ping Qiu
    Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA
    Circ Res 97:983-91. 2005
    ..This is the first demonstration that Myocd can act as a transcriptional coactivator of the smooth muscle regulatory network in a CArG box-independent manner...
  16. pmc Defining the mammalian CArGome
    Qiang Sun
    Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Genome Res 16:197-207. 2006
    ..We suggest one function of SRF is that of an ancient master regulator of the actin cytoskeleton...
  17. ncbi request reprint Contribution of serum response factor and myocardin to transcriptional regulation of smoothelins
    Sander S M Rensen
    Department of Genetics and Cell Biology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Cardiovasc Res 70:136-45. 2006
    ..Serum response factor (SRF) and myocardin are essential for contractile SMC differentiation. We evaluated the contribution of SRF/myocardin to transcriptional regulation of smoothelins...
  18. pmc Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype
    Nienwen Chow
    Socratech Research Laboratories L L C, Department of Neurosurgery, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 104:823-8. 2007
    ..Thus, SRF-MYOCD overexpression in small cerebral arteries appears to initiate independently of Abeta a pathogenic pathway mediating arterial hypercontractility and CBF dysregulation, which are associated with Alzheimer's dementia...
  19. ncbi request reprint Remote control of gene expression
    Xiaochun Long
    Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 282:15941-5. 2007
    ..This review summarizes current approaches to characterize remote control of gene expression in transgenic mice and inherent limitations for accurately interpreting the essential nature of CRM activity...
  20. doi request reprint Expression and comparative genomics of two serum response factor genes in zebrafish
    Jody L Davis
    Department of Biological Sciences, State University of New York College at Brockport, Brockport, NY, USA
    Int J Dev Biol 52:389-96. 2008
    ....
  21. ncbi request reprint Channeling to myocardin
    Joseph M Miano
    Circ Res 95:340-2. 2004
  22. ncbi request reprint Mammalian smooth muscle differentiation: origins, markers and transcriptional control
    Joseph M Miano
    Center for Cardiovascular Research, Box 679, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Results Probl Cell Differ 38:39-59. 2002
  23. ncbi request reprint Cardiac-specific gene expression: a HANDful of factors
    Joseph M Miano
    J Mol Cell Cardiol 34:1287-91. 2002
  24. ncbi request reprint Myocardin: a component of a molecular switch for smooth muscle differentiation
    Jiyuan Chen
    Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Mol Cell Cardiol 34:1345-56. 2002
    ..Results reveal the expression of several SMC markers concomitant with a lower growth potential. Collectively, these studies suggest that myocardin is an important component of a molecular switch for the SMC differentiation program...
  25. ncbi request reprint Serum response factor: toggling between disparate programs of gene expression
    Joseph M Miano
    Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, NY 14642, Rochester, USA
    J Mol Cell Cardiol 35:577-93. 2003
    ..The purpose of this review is to summarize the history and progress made in SRF research with emphasis on the role this transcription factor plays in facilitating a program of SMC-restricted gene expression...
  26. doi request reprint SRF'ing the actin cytoskeleton with no destrin
    Joseph M Miano
    Physiol Genomics 34:6-8. 2008
  27. pmc Myocardin is sufficient for a smooth muscle-like contractile phenotype
    Xiaochun Long
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 211 Bailey Road, Rochester, New York 14586, USA
    Arterioscler Thromb Vasc Biol 28:1505-10. 2008
    ..Here, we sought to ascertain whether Myocd-mediated gene expression confers a structural and physiological cardiac or SMC phenotype...
  28. ncbi request reprint Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels
    Miao Jiang
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 94:167-74. 2004
    ..We conclude that Ad-SM22-4A1 drives a smooth muscle-specific functional expression of CYP4A1 and demonstrates increased angiogenesis, presumably via increased production of 20-HETE...
  29. ncbi request reprint Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP
    D Kyle Hogarth
    Section of Pulmonary and Critical Care Medicine, Dept of Medicine, University of Chicago, 5841 S Maryland Avenue, MC 6076, Chicago, IL 60637, USA
    Am J Physiol Cell Physiol 287:C449-56. 2004
    ..Transformation of VSMC by high doses of ATP can be prevented and even reversed by inhibition of PKA activity...
  30. ncbi request reprint Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus
    Joseph M Miano
    Cardiovascular Research Institute, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 292:C70-81. 2007
    ..This review summarizes the recent genomic and genetic analyses of CArG-SRF that support its role as an ancient, master regulator of the actin cytoskeleton and contractile machinery...
  31. ncbi request reprint Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival
    David J Nagel
    Cardiovascular Research Institute, University of Rochester, New York, USA
    Circ Res 98:777-84. 2006
    ..These suggest that nuclear PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis...
  32. pmc Deck of CArGs
    Joseph M Miano
    Circ Res 103:13-5. 2008
  33. ncbi request reprint HDAC7 supports vascular integrity
    Joseph M Miano
    Nat Med 12:997-8. 2006
  34. ncbi request reprint Fishing for function in zebrafish
    Joseph M Miano
    Circ Res 98:723-6. 2006
  35. ncbi request reprint Tissue expression of the novel serine carboxypeptidase Scpep1
    Ting Hein D Lee
    Cardiovascular Research Institute, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 679, Rochester, NY 14642, USA
    J Histochem Cytochem 54:701-11. 2006
    ..The highly specific Scpep1 antibody characterized herein provides a necessary reagent for elucidating Scpep1 function...
  36. ncbi request reprint Cross-species sequence analysis reveals multiple charged residue-rich domains that regulate nuclear/cytoplasmic partitioning and membrane localization of a kinase anchoring protein 12 (SSeCKS/Gravin)
    Jeffrey W Streb
    Center for Cardiovascular Research in the Aab Institute of Biomedical Sciences, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 280:28007-14. 2005
    ..Our data suggest that AKAP12 localization is regulated by a hierarchy of targeting domains and that the localization of AKAP12-assembled signaling complexes may be dynamically regulated...
  37. ncbi request reprint Angiotensin II: a devious activator of mineralocorticoid receptor-dependent gene expression
    Burns C Blaxall
    Circ Res 96:610-1. 2005
  38. ncbi request reprint Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles
    Jeffrey W Streb
    Center for Cardiovascular Research in the Aab Institute of Biomedical Sciences, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 279:56014-23. 2004
    ..Our results demonstrate heretofore unrecognized complexity within the AKAP12 locus and suggest a mechanism for genetic control of signaling specificity through distinct regulation of alternately targeted anchoring protein isoforms...
  39. ncbi request reprint Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells
    Toru Aizawa
    University of Rochester, Center for Cardiovascular Research, 601 Elmwood Ave, Box 679, Rochester, NY 14642, USA
    Circ Res 93:406-13. 2003
    ..These results suggest that SNAP and CNP exert inhibitory effects on NF-kappaB-dependent transcription by activation of PKA via cGMP-dependent inhibition of PDE3 activity. Therefore, PDE3 is a novel mediator of inflammation in VSMCs...
  40. ncbi request reprint Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration
    Jiyuan Chen
    Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 679, Rochester, New York 14642, USA
    Mol Ther 8:220-9. 2003
    ..These data demonstrate that Ad-mda7 exhibits selectivity in apoptosis induction and growth suppression in an atypical SMC line, raising new questions pertaining to heterogeneity in SMC death susceptibility...
  41. ncbi request reprint Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA
    Amanda Davis
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC 6076, Chicago, IL 60637, USA
    Cell Signal 15:597-604. 2003
    ..These data demonstrate that (i) PKA negatively regulates SRF activity and (ii) ET1 and ATP stimulate opposing pathways, whose balance determines the net activity of SRF...