Research Topics
Genomes and Genes | J M MianoSummaryAffiliation: University of Rochester Country: USA Publications
| Collaborators
|
Detail Information
Publications
Expression and chromosomal mapping of the mouse smooth muscle calponin geneJ M Miano
Center for Cardiovascular Research, University of Rochester Medical Center, New York 14642, USA
Mamm Genome 12:187-91. 2001..These results are the first to show reversible expression of Cnn1 and demonstrate the utility of the BC3H1 muscle cell line as a model system for the further characterization of Cnn1 gene regulation...- Expression of human smooth muscle calponin in transgenic mice revealed with a bacterial artificial chromosomeJoseph M Miano
Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Am J Physiol Heart Circ Physiol 282:H1793-803. 2002..These BAC mice represent a new model system in which to systematically assess regulatory elements governing SM-Calp transcription in vivo... - Serum response factor-dependent regulation of the smooth muscle calponin geneJ M Miano
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Biol Chem 275:9814-22. 2000..These results demonstrate an important role for intronic CArG boxes and the SRF protein in the transcriptional control of smooth muscle calponin in vitro... - Gene structure and chromosomal mapping of the rat smooth muscle calponin geneM A Nobrega
Department of Physiology, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee 53226, USA
Mamm Genome 11:115-9. 2000..These studies provide additional information relating to the control of CnnI gene expression and provide a platform to begin assessing the potential linkage of CnnI to spontaneous and experimental disease phenotypes in rats... - Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cellsJ Chen
Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 276:34175-81. 2001..Radiation hybrid mapping studies placed the rat RISC locus on chromosome 10q. These studies reveal a novel retinoid-inducible protease whose activity may be involved in vascular wall and kidney homeostasis... - Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin geneJ M Miano
Medical College of Wisconsin, Department of Physiology, Milwaukee 53226, USA
Gene 197:215-24. 1997..Finally, the localization of SMCC to a defined genomic interval will facilitate an analysis of its potential as a candidate gene for disease phenotypes mapping to 19p13.2... - Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cellsH Ou
Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, NY, USA
Circ Res 87:881-7. 2000..atRA-mediated apoptosis in SMCs seems to require the participation of active tTG, suggesting a potential mechanistic link between this retinoid-inducible gene and programmed cell death... - Localized adenovirus-mediated gene transfer into vascular smooth muscle in the hamster cheek pouchM D Frame
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Microcirculation 8:403-13. 2001..Our purpose was to develop a method for adenovirus delivery to the hamster cheek pouch to experimentally target gene transfer in tissue used for microvascular studies... - all-Trans-retinoic acid reduces neointimal formation and promotes favorable geometric remodeling of the rat carotid artery after balloon withdrawal injuryJ M Miano
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Circulation 98:1219-27. 1998..In this report, we have initiated studies to examine the hypothesis that atRA limits neointimal formation after experimental vascular injury... - Mapping of the rat SM22 gene to chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophyG Koike
Medical College of Wisconsin, Department of Physiology, Milwaukee 53226-0509, USA
Mamm Genome 9:76-7. 1998 
Restricted inactivation of serum response factor to the cardiovascular systemJoseph M Miano
Center for Cardiovascular Research, Aab Institute of Biomedical Sciences, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 101:17132-7. 2004..These results suggest a vital role for SRF in contractile/cytoskeletal architecture necessary for the proper assembly and function of cardiomyocytes and vascular SMC...- AKAP12alpha, an atypical serum response factor-dependent target geneJeffrey W Streb
Center for Cardiovascular Research in the Aab Institute of Biomedical Sciences, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Biol Chem 280:4125-34. 2005..Furthermore, we provide new insight into the role of flanking sequences in determining sensitivity to SRF-myocardin activity... - Neurovascular pathways and Alzheimer amyloid beta-peptideBerislav V Zlokovic
Frank R Smith Laboratories for Neuroscience and Neurosurgical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
Brain Pathol 15:78-83. 2005..We suggest that there is a link between neurovascular dysfunction and elevated brain Abeta which provides a new scenario for therapeutic interventions to control Alzheimer mental deterioration... - Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiationXiaochun Long
The Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 104:16570-5. 2007.... - Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivoPing Qiu
Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA
Circ Res 97:983-91. 2005..This is the first demonstration that Myocd can act as a transcriptional coactivator of the smooth muscle regulatory network in a CArG box-independent manner... - Defining the mammalian CArGomeQiang Sun
Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, NY 14642, USA
Genome Res 16:197-207. 2006..We suggest one function of SRF is that of an ancient master regulator of the actin cytoskeleton... - Contribution of serum response factor and myocardin to transcriptional regulation of smoothelinsSander S M Rensen
Department of Genetics and Cell Biology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
Cardiovasc Res 70:136-45. 2006..Our data show a role for SRF/myocardin in regulating smoothelin-A whereas the higher smoothelin-B expression appears to be SRF/myocardin-independent... - Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotypeNienwen Chow
Socratech Research Laboratories L L C, Department of Neurosurgery, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 104:823-8. 2007..Thus, SRF-MYOCD overexpression in small cerebral arteries appears to initiate independently of Abeta a pathogenic pathway mediating arterial hypercontractility and CBF dysregulation, which are associated with Alzheimer's dementia... - Remote control of gene expressionXiaochun Long
Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Biol Chem 282:15941-5. 2007..This review summarizes current approaches to characterize remote control of gene expression in transgenic mice and inherent limitations for accurately interpreting the essential nature of CRM activity... 
Expression and comparative genomics of two serum response factor genes in zebrafishJody L Davis
Department of Biological Sciences, State University of New York College at Brockport, Brockport, NY, USA
Int J Dev Biol 52:389-96. 2008....- Channeling to myocardinJoseph M Miano
Circ Res 95:340-2. 2004 - Mammalian smooth muscle differentiation: origins, markers and transcriptional controlJoseph M Miano
Center for Cardiovascular Research, Box 679, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Results Probl Cell Differ 38:39-59. 2002 - Cardiac-specific gene expression: a HANDful of factorsJoseph M Miano
J Mol Cell Cardiol 34:1287-91. 2002 - Myocardin: a component of a molecular switch for smooth muscle differentiationJiyuan Chen
Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Mol Cell Cardiol 34:1345-56. 2002..Results reveal the expression of several SMC markers concomitant with a lower growth potential. Collectively, these studies suggest that myocardin is an important component of a molecular switch for the SMC differentiation program... - Serum response factor: toggling between disparate programs of gene expressionJoseph M Miano
Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, NY 14642, Rochester, USA
J Mol Cell Cardiol 35:577-93. 2003..The purpose of this review is to summarize the history and progress made in SRF research with emphasis on the role this transcription factor plays in facilitating a program of SMC-restricted gene expression... - SRF'ing the actin cytoskeleton with no destrinJoseph M Miano
Physiol Genomics 34:6-8. 2008 - Myocardin is sufficient for a smooth muscle-like contractile phenotypeXiaochun Long
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 211 Bailey Road, Rochester, New York 14586, USA
Arterioscler Thromb Vasc Biol 28:1505-10. 2008..Here, we sought to ascertain whether Myocd-mediated gene expression confers a structural and physiological cardiac or SMC phenotype... - Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvesselsMiao Jiang
Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
Circ Res 94:167-74. 2004..We conclude that Ad-SM22-4A1 drives a smooth muscle-specific functional expression of CYP4A1 and demonstrates increased angiogenesis, presumably via increased production of 20-HETE... - Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATPD Kyle Hogarth
Section of Pulmonary and Critical Care Medicine, Dept. of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC 6076, Chicago, IL 60637, USA
Am J Physiol Cell Physiol 287:C449-56. 2004..Transformation of VSMC by high doses of ATP can be prevented and even reversed by inhibition of PKA activity... - Serum response factor: master regulator of the actin cytoskeleton and contractile apparatusJoseph M Miano
Cardiovascular Research Institute, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
Am J Physiol Cell Physiol 292:C70-81. 2007..This review summarizes the recent genomic and genetic analyses of CArG-SRF that support its role as an ancient, master regulator of the actin cytoskeleton and contractile machinery... - Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survivalDavid J Nagel
Cardiovascular Research Institute, University of Rochester, New York, USA
Circ Res 98:777-84. 2006..These suggest that nuclear PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis... - Deck of CArGsJoseph M Miano
Circ Res 103:13-5. 2008 - HDAC7 supports vascular integrityJoseph M Miano
Nat Med 12:997-8. 2006 - Fishing for function in zebrafishJoseph M Miano
Circ Res 98:723-6. 2006 - Tissue expression of the novel serine carboxypeptidase Scpep1Ting Hein D Lee
Cardiovascular Research Institute, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 679, Rochester, NY 14642, USA
J Histochem Cytochem 54:701-11. 2006..The highly specific Scpep1 antibody characterized herein provides a necessary reagent for elucidating Scpep1 function... - Cross-species sequence analysis reveals multiple charged residue-rich domains that regulate nuclear/cytoplasmic partitioning and membrane localization of a kinase anchoring protein 12 (SSeCKS/Gravin)Jeffrey W Streb
Center for Cardiovascular Research in the Aab Institute of Biomedical Sciences, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Biol Chem 280:28007-14. 2005..Our data suggest that AKAP12 localization is regulated by a hierarchy of targeting domains and that the localization of AKAP12-assembled signaling complexes may be dynamically regulated... - Angiotensin II: a devious activator of mineralocorticoid receptor-dependent gene expressionBurns C Blaxall
Circ Res 96:610-1. 2005 - Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profilesJeffrey W Streb
Center for Cardiovascular Research in the Aab Institute of Biomedical Sciences, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Biol Chem 279:56014-23. 2004..Our results demonstrate heretofore unrecognized complexity within the AKAP12 locus and suggest a mechanism for genetic control of signaling specificity through distinct regulation of alternately targeted anchoring protein isoforms... - Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cellsToru Aizawa
University of Rochester, Center for Cardiovascular Research, 601 Elmwood Ave, Box 679, Rochester, NY 14642, USA
Circ Res 93:406-13. 2003..These results suggest that SNAP and CNP exert inhibitory effects on NF-kappaB-dependent transcription by activation of PKA via cGMP-dependent inhibition of PDE3 activity. Therefore, PDE3 is a novel mediator of inflammation in VSMCs... - Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migrationJiyuan Chen
Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 679, Rochester, New York 14642, USA
Mol Ther 8:220-9. 2003..These data demonstrate that Ad-mda7 exhibits selectivity in apoptosis induction and growth suppression in an atypical SMC line, raising new questions pertaining to heterogeneity in SMC death susceptibility... - Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKAAmanda Davis
Section of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Chicago, 5841 S. Maryland Avenue, MC 6076, Chicago, IL 60637, USA
Cell Signal 15:597-604. 2003..These data demonstrate that (i) PKA negatively regulates SRF activity and (ii) ET1 and ATP stimulate opposing pathways, whose balance determines the net activity of SRF...