Research Topics
| D J MeyerhoffSummaryAffiliation: University of California Country: USA Publications
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Publications
Proton magnetization transfer of metabolites in human brainD J Meyerhoff
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center and Department of Radiology, University of California San Francisco, San Francisco, California, USA
Magn Reson Med 42:417-20. 1999..The findings are interpreted to reflect possible magnetization transfer between pools of creatine-containing metabolites with different molecular mobility. Magn Reson Med 42:417-420, 1999...
Smoking comorbidity in alcoholism: neurobiological and neurocognitive consequencesDieter J Meyerhoff
Department of Radiology, University of California at San Francisco, San Francisco, California, USA
Alcohol Clin Exp Res 30:253-64. 2006....
Health risks of chronic moderate and heavy alcohol consumption: how much is too much?Dieter J Meyerhoff
Department of Radiology, University of California, San Francisco, 94121, USA
Alcohol Clin Exp Res 29:1334-40. 2005....
Effects of heavy drinking, binge drinking, and family history of alcoholism on regional brain metabolitesD J Meyerhoff
Department of Radiology, University of California San Francisco, San Francisco, California, USA
Alcohol Clin Exp Res 28:650-61. 2004....
Cortical metabolite alterations in abstinent cocaine and cocaine/alcohol-dependent subjects: proton magnetic resonance spectroscopic imagingD J Meyerhoff
Magnetic Resonance Unit, University of California San Francisco, San Francisco, CA, USA
Addict Biol 4:405-19. 1999....
Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patientsD J Meyerhoff
Department of Veterans Affairs Medical Center, Department of Radiology, University of California San Francisco, 94121, USA
Neurology 52:995-1003. 1999....
Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imagingS Mackay
Magnetic Resonance Spectroscopy Unit, Department of Veterans Affairs Medical Center, San Francisco, USA
Arch Neurol 53:167-74. 1996..Our findings in subjects with SIVD are consistent with higher levels of creatine-containing metabolites and/or lower levels of NAA in frontal white matter...
Brain metabolite concentrations and neurocognition during short-term recovery from alcohol dependence: Preliminary evidence of the effects of concurrent chronic cigarette smokingTimothy C Durazzo
San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA
Alcohol Clin Exp Res 30:539-51. 2006..However, the potential effects of chronic cigarette smoking on the recovery of alcohol-induced brain injury have not been studied...
Deep gray matter structures in HIV infection: a proton MR spectroscopic studyD J Meyerhoff
Department of Radiology, University of California, San Francisco, USA
AJNR Am J Neuroradiol 17:973-8. 1996..The trends toward increased Cho/Cr are consistent with histopathologic findings of infiltration of subcortical gray matter structures with foamy macrophages, microglia, and lymphocytes, or possibly with gliosis...
Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapyV A Cardenas
University of California, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
J Neurovirol 15:324-33. 2009..Therefore, HIV+ individuals on ART should be monitored for cognitive decline, and treatments that reduce ongoing neurological injury should be considered...
Effects of chronic alcohol consumption on the broad phospholipid signal in human brain: an in vivo 31P MRS studyM R Estilaei
Department of Radiology, MR Unit DVA Medical Center, University of California San Francisco, 94121, USA
Alcohol Clin Exp Res 25:89-97. 2001..The observed smaller broad signal component in these relatively young heavy drinkers is a sensitive measure of white matter phospholipid damage...
Tract-Based Spatial Statistics (TBSS) of diffusion tensor imaging data in alcohol dependence: abnormalities of the motivational neurocircuitryPing Hong Yeh
Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, San Francisco, CA 94121, USA
Psychiatry Res 173:22-30. 2009..These abnormalities in fiber connections could be partially responsible for deficiencies in executive functions, behavioral regulation, and impulse control commonly described in alcohol dependence...
Brain atrophy in HIV infection is more strongly associated with CDC clinical stage than with cognitive impairmentV Di Sclafani
Department of Psychiatry, University of California, San Francisco 94121, USA
J Int Neuropsychol Soc 3:276-87. 1997..These results suggest that MRI-detectable brain atrophy secondary to HIV infection is not the primary substrate underlying the progressive NP impairment in HIV disease...
Effects of chronic alcohol abuse and HIV infection on brain phosphorus metabolitesD J Meyerhoff
Department of Veterans Affairs Medical Center, Magnetic Resonance Spectroscopy Unit, San Francisco, CA 94121, USA
Alcohol Clin Exp Res 19:685-92. 1995..These findings suggest altered brain phospholipid metabolites and energy metabolites with alcohol abuse and HIV infection. They demonstrate that the adverse metabolic effects of HIV on the brain are augmented by chronic alcohol abuse...
Quantitative brain MRI in alcohol dependence: preliminary evidence for effects of concurrent chronic cigarette smoking on regional brain volumesS Gazdzinski
Department of Radiology and the Department of Psychiatry, University of California San Francisco, San Francisco, California 94121, USA
Alcohol Clin Exp Res 29:1484-95. 2005..Although cigarette smoking is common among alcohol-dependent individuals, previous research did not account for the potential effects of chronic smoking on regional brain volumes in alcoholism...
Alzheimer disease and subcortical ischemic vascular dementia: evaluation by combining MR imaging segmentation and H-1 MR spectroscopic imagingS Mackay
Department of Veterans Affairs DVA Medical Center, Magnetic Resonance Spectroscopy Unit, San Francisco, CA 94121, USA
Radiology 198:537-45. 1996..Combined studies allowed more accurate discrimination between AD and control subjects than either study alone...
Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysisB J Soher
Department of Radiology, University of California San Francisco, MR Unit 114M, DVA Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
Magn Reson Imaging 18:1159-65. 2000..This approach was applied to data from optimized PRESS-SI and multi-slice spin-echo SI acquisitions, for which sample spectra and metabolite images are shown...
Heavy alcohol consumption in individuals with HIV infection: effects on neuropsychological performanceJohannes C Rothlind
Mental Health Service, DVA Veterans Affairs Medical Center, San Francisco, CA 94121, USA
J Int Neuropsychol Soc 11:70-83. 2005....
BMI and neuronal integrity in healthy, cognitively normal elderly: a proton magnetic resonance spectroscopy studyStefan Gazdzinski
Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, San Francisco, California, USA
Obesity (Silver Spring) 18:743-8. 2010..Future studies need to evaluate whether these metabolite abnormalities are involved in the development and maintenance of weight problems...
N-acetylaspartate as a marker of neuronal injury in neurodegenerative diseaseNorbert Schuff
Magnetic Resonance Unit VA Medical Center, Department of Radiology, University of California, San Francisco, CA 94121, USA
Adv Exp Med Biol 576:241-62; discussion 361-3. 2006
Effects of abstinence from alcohol on the broad phospholipid signal in human brain: an in vivo 31P magnetic resonance spectroscopy studyM R Estilaei
MR Unit DVA Medical Center, Department of Radiology, University of California San Francisco, 94121, USA
Alcohol Clin Exp Res 25:1213-20. 2001..But the results also suggest a persistent abnormality in the nature and/or physical properties of white matter phospholipids in long-term abstinent alcoholics...
Cerebral white matter recovery in abstinent alcoholics--a multimodality magnetic resonance studyStefan Gazdzinski
Centre for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Centre, San Francisco, USA
Brain 133:1043-53. 2010....
Effects of brain membranes on 1H nuclear magnetic resonance signal intensity of ethanol in vitroV Govindaraju
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Alcohol Alcohol 32:671-81. 1997..These results provide a mechanism for decreased NMR visibility of ethanol in brain, and suggest that chronic exposure to ethanol produces membrane changes which result in increased NMR visibility...
Effects of abstinence on the brain: quantitative magnetic resonance imaging and magnetic resonance spectroscopic imaging in chronic alcohol abuseV A Cardenas
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, The Department of Radiology, University of California San Francisco, San Francisco, California 94121, USA
Alcohol Clin Exp Res 25:1673-82. 2001..Proton MR spectroscopic measures, as applied in this cross-sectional study, were largely ineffective in revealing metabolic effects of abstinence on the alcohol-damaged brain...
A detailed analysis of localized J-difference GABA editing: theoretical and experimental study at 4 TL G Kaiser
Northern California Institute for Research and Education, San Francisco, CA, USA
NMR Biomed 21:22-32. 2008..The numerical simulations presented in this study should facilitate both implementation of the more efficient acquisition and quantification process of J-coupled systems...
In-vivo investigation of the human cingulum bundle using the optimization of MR diffusion spectrum imagingMarzieh Nezamzadeh
Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Eur J Radiol 75:e29-36. 2010..This optimized DSI setting should be useful for detecting alterations along the cingulum bundle in Alzheimer disease and related neurodegenerative disorders...
Chronic cigarette smoking and heavy drinking in human immunodeficiency virus: consequences for neurocognition and brain morphologyTimothy C Durazzo
Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, USA
Alcohol 41:489-501. 2007..Overall, the findings suggested that the direct and/or indirect effects of chronic cigarette smoking created an additional burden on the integrity of brain neurobiology and neurocognition in this cohort of HIV-positive heavy drinkers...
Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholicsStefan Gazdzinski
Magnetic Resonance Unit, San Francisco Veterans Administration Medical Center, San Francisco, CA 94121, United States
Psychiatry Res 162:133-45. 2008..These data may also have implications for other conditions with established MTL involvement and significant smoking co-morbidity, such as schizophrenia-spectrum and mood disorders...
Are treated alcoholics representative of the entire population with alcohol use disorders? A magnetic resonance study of brain injuryStefan Gazdzinski
Center for Imaging of Neurodegenerative Diseases CIND, Veterans Administration Medical Center, San Francisco, CA 94121, USA
Alcohol 42:67-76. 2008....
Body mass index and magnetic resonance markers of brain integrity in adultsStefan Gazdzinski
Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
Ann Neurol 63:652-7. 2008....
Proton magnetic resonance spectroscopy in alcohol use disorders: a potential new endophenotype?Dieter J Meyerhoff
University of California San Francisco, VA Medical Center San Francisco, Center for Imaging of Neurodegenerative Diseases, San Francisco, California 94121, USA
Alcohol Clin Exp Res 32:1146-58. 2008..Current effort is directed at defining new classification schemes for alcohol use disorders (AUD) based on genetic/biological, physiological, and behavioral endophenotypes...
Measures of learning, memory and processing speed accurately predict smoking status in short-term abstinent treatment-seeking alcohol-dependent individualsTimothy C Durazzo
Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA, USA
Alcohol Alcohol 45:507-13. 2010..The primary goal of this study was to identify which measures commonly used to assess neurocognition in AUDs accurately predict smoking status of individuals seeking treatment of alcohol dependence...
Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatmentTimothy C Durazzo
Department of Radiology and Biomedical Imaging, University of California San Francisco, 94121, USA
Alcohol 44:201-10. 2010..The significantly decreased frontal GM perfusion in resumers compared with both abstainers and nsLD across the assessment interval suggests premorbid and/or acquired neurobiological abnormalities of the frontal GM in resumers...
Effects of low-level exposure to sarin and cyclosarin during the 1991 Gulf War on brain function and brain structure in US veteransLinda L Chao
Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 114 M, San Francisco, CA 94121, USA
Neurotoxicology 31:493-501. 2010..The goal of the current study is to determine the generalizability of these findings in another cohort of GW veterans with suspected GB/GF exposure...
Metabolite levels in the brain reward pathway discriminate those who remain abstinent from those who resume hazardous alcohol consumption after treatment for alcohol dependenceTimothy C Durazzo
Center for Imaging of Neurodegenerative Diseases 114M, San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA
J Stud Alcohol Drugs 71:278-89. 2010..This study compared baseline metabolite levels in components of the brain reward system among individuals who remained abstinent and those who resumed hazardous alcohol consumption after treatment for alcohol dependence...
Combined neuroimaging, neurocognitive and psychiatric factors to predict alcohol consumption following treatment for alcohol dependenceTimothy C Durazzo
Center for Imaging of Neurodegenerative Disease 114M, San Francisco Veterans Administration Medical Center, and Department of Radiology, University of California, 4150 Clement St, San Francisco CA 94121, USA
Alcohol Alcohol 43:683-91. 2008..This study examined the ability of multimodality magnetic resonance, neurocognitive, psychiatric and demographic, to predict alcohol consumption after treatment for AUD...
The impact of chronic cigarette smoking on recovery from cortical gray matter perfusion deficits in alcohol dependence: longitudinal arterial spin labeling MRIAnderson Mon
Department of Radiology, Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, University of California, San Francisco, California 94121, USA
Alcohol Clin Exp Res 33:1314-21. 2009..However, no longitudinal magnetic resonance imaging (MRI) studies of cerebral perfusion changes during abstinence from alcohol have been reported...
The relationships of sociodemographic factors, medical, psychiatric, and substance-misuse co-morbidities to neurocognition in short-term abstinent alcohol-dependent individualsTimothy C Durazzo
Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA 94121, USA
Alcohol 42:439-49. 2008..The study of participants who demonstrate common co-morbidities observed in AUD is necessary to fully understand how AUD, as a clinical syndrome, affects neurocognition, brain neurobiology, and their changes with extended abstinence...
Hierarchical linear modeling (HLM) of longitudinal brain structural and cognitive changes in alcohol-dependent individuals during sobrietyPing Hong Yeh
Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, United States Northern California Institute for Research and Education, USA
Drug Alcohol Depend 91:195-204. 2007....
The neurobiological and neurocognitive consequences of chronic cigarette smoking in alcohol use disordersTimothy C Durazzo
Department of Veterans Administration Medical Center, Center for Imaging of Neurodegenerative Disease, CA 94121, USA
Alcohol Alcohol 42:174-85. 2007....
Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholismTimothy C Durazzo
Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Front Biosci 12:4079-100. 2007..Consideration of the potential separate and interactive effects of chronic smoking and alcohol use disorders may have significant implications for pharmacological and behavioral treatment interventions...
Abnormal CNV in chronic heavy drinkersLinda L Chao
Magnetic Resonance Unit, 116R San Francisco VA Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
Clin Neurophysiol 114:2081-95. 2003..We used the contingent negative variation (CNV), a slow negative shift in the human electroencephalogram, to investigate the effects of heavy chronic alcohol use on frontal lobe function...
Abnormal contingent negative variation in HIV patients receiving antiretroviral therapyLinda L Chao
Magnetic Resonance Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 116R, San Francisco, CA 94121, USA
Neuroreport 14:2111-5. 2003..However, the benefits of antiretroviral therapy on immune function appear to facilitate neurocognitive performance...
Cigarette smoking exacerbates chronic alcohol-induced brain damage: a preliminary metabolite imaging studyTimothy C Durazzo
San Francisco Veterans Administration Medical Center, MRS Unit 114M, 4150 Clement St, San Francisco, CA 94121, USA
Alcohol Clin Exp Res 28:1849-60. 2004..Nevertheless, previous research has typically not accounted for the potential independent or compounding effects of cigarette smoking on alcohol-induced brain injury and neurocognition...
Using automated morphometry to detect associations between ERP latency and structural brain MRI in normal adultsValerie A Cardenas
Magnetic Resonance Unit, San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA
Hum Brain Mapp 25:317-27. 2005..These results imply that the WM connectivity between generators influences P3b latency more than the generators themselves do...
Temporal dynamics and determinants of whole brain tissue volume changes during recovery from alcohol dependenceStefan Gazdzinski
Department of Veterans Affairs Medical Center San Francisco, San Francisco, CA 94121, USA
Drug Alcohol Depend 78:263-73. 2005..Previous quantitative measurements of brain volumes in alcohol dependent individuals performed after several weeks of abstinence likely underestimated the full extent of chronic alcohol-associated brain shrinkage...
Sensitive and fast T1 mapping based on two inversion recovery images and a reference imageGeon Ho Jahng
University of California San Francisco, 4150 Clement Street, 114M San Francisco, California 94121, USA
Med Phys 32:1524-8. 2005..The proposed method should be useful for clinical studies because the T1 maps can be obtained within a few seconds...
Chronic active heavy drinking and family history of problem drinking modulate regional brain tissue volumesValerie A Cardenas
University of California, San Francisco and San Francisco VA Medical Center, 4150 Clement St, San Francisco CA 94121, USA
Psychiatry Res 138:115-30. 2005..Community-dwelling heavy drinkers who are not in alcoholism treatment have dose-related gray matter volume losses, and family history of problem drinking ameliorates some structural consequences of heavy drinking...
A comparison of neurocognitive function in nonsmoking and chronically smoking short-term abstinent alcoholicsTimothy C Durazzo
San Francisco Veterans Administration Medical Center, Center for Imaging of Neurodegenerative Disease, San Francisco, CA 94116, USA
Alcohol 39:1-11. 2006....
Non-treatment-seeking heavy drinkers: effects of chronic cigarette smoking on brain structureTimothy C Durazzo
Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
Drug Alcohol Depend 87:76-82. 2007....
Deformation-based morphometry of brain changes in alcohol dependence and abstinenceValerie A Cardenas
Center for the Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, Department of Radiology, University of California, San Francisco, NCIRE, CA 94121, USA
Neuroimage 34:879-87. 2007..Abstinence-associated tissue volume gains are significant in focal parts of the fronto-ponto-cerebellar circuit that is adversely affected by heavy drinking...
Chronic smoking is associated with differential neurocognitive recovery in abstinent alcoholic patients: a preliminary investigationTimothy C Durazzo
San Francisco Veterans Administration Medical Center, San Francisco, CA 94121, USA
Alcohol Clin Exp Res 31:1114-27. 2007..However, previous studies investigating neurocognitive recovery in abstinent alcoholic patients did not specifically consider the potential effects of chronic cigarette smoking...
Chronic cigarette smoking: implications for neurocognition and brain neurobiologyTimothy C Durazzo
Department of Radiology and Biomedical Imaging, University of California, 505 Parnassus Avenue, M 391, San Francisco, CA 94143, USA
Int J Environ Res Public Health 7:3760-91. 2010..Longitudinal studies are needed to determine if the smoking-related neurobiological and neurocognitive abnormalities increase over time and/or show recovery with sustained smoking cessation...
A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysisPatricia Lani Lee
NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02111, USA
J Magn Reson Imaging 17:625-33. 2003....
Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individualsA Mon
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
Genes Brain Behav 12:98-107. 2013..The findings suggest that functionally significant brain tissue volume recovery during abstinence from alcohol is influenced by BDNF genotype...
Effects of alcohol and HIV infection on the central nervous systemD J Meyerhoff
Department of Radiology, Department of Veterans' Affairs Medical Center, University of California San Francisco, San Francisco, California, USA
Alcohol Res Health 25:288-98. 2001....
Cortical gray matter loss in treatment-naïve alcohol dependent individualsG Fein
Neurobehavioral Research, Inc, Corte Madera, California, USA
Alcohol Clin Exp Res 26:558-64. 2002..Nevertheless, we suggest that most of the reports of the central nervous system consequences of alcoholism may not accurately describe the majority of alcoholic-dependent individuals...
Indirect imaging of ethanol via magnetization transfer at high and low magnetic fieldsMohammad R Estilaei
MR Unit DVA Medical Center, Department of Radiology, University of California-San Francisco, 4150 Clement Street 114M, San Francisco, CA 94121, USA
Magn Reson Med 49:755-9. 2003..In human brain at physiologically relevant brain EtOH concentrations, water signal reductions were measurable when saturating the EtOH resonance. Strengths and limitations of indirectly imaging brain EtOH are discussed...
Prefrontal cortical volume reduction associated with frontal cortex function deficit in 6-week abstinent crack-cocaine dependent menGeorge Fein
Neurobehavioral Research Inc, 201 Tamal Vista Boulevard, Corte Madera, CA 94925, USA
Drug Alcohol Depend 68:87-93. 2002..Our goal was to test the a priori hypothesis of prefrontal cortical volume reduction, along with associated impairments in frontal mediated functions, and to look for differences between the Cr and CrA groups...
Magnetic resonance detects brainstem changes in chronic, active heavy drinkersCourtnay W Bloomer
University of Pennsylvania-Presbyterian Medical Center, Philadelphia, PA 19104, USA
Psychiatry Res 132:209-18. 2004..The results also indicate that the midsagittal MRI brainstem area is an easily determined and reliable indicator of brainstem volume...
Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificityRobert H Paul
Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
J Neuropsychiatry Clin Neurosci 19:283-92. 2007..Prospective studies are needed to elucidate the evolution of these changes in the setting of antiretroviral therapy...
Regional patterns of brain metabolites in AIDS dementia complexConstantin T Yiannoutsos
Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202, USA
Neuroimage 23:928-35. 2004..We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age...
