Affiliation: University of California
- Roger Sperry and his chemoaffinity hypothesisR L Meyer
Developmental and Cell Biology, University of California, Irvine 92697 2275, USA
Neuropsychologia 36:957-80. 1998..The origins of this hypothesis, the controversies that surrounded it for several decades and its eventual acceptance, are discussed in this article...
- Large-scale synaptic errors during map formation by regeneration optic axons in the goldfishR L Meyer
Department of Developmental and Cell Biology, University of California, Irvine 92717, USA
J Comp Neurol 409:299-312. 1999..Synaptic rearrangement is a major feature of targeting in this system and may be required for the regeneration of a retinotopic projection...
- The neurite-promoting effect of laminin is mediated by different mechanisms in embryonic and adult regenerating mouse optic axons in vitroC A Bates
Developmental and Cell Biology, University of California, Irvine 92727, USA
Dev Biol 181:91-101. 1997..These findings suggest that there are intrinsic differences between embryonic and adult optic fibers that may have implications for regenerative failure in the central nervous system of adult mammals ...
- Regenerating optic fibers correct large-scale errors by random growth: evidence from in vivo imagingA J Dawson
Department of Developmental and Cell Biology, University of California at Irvine, Irvine, California 92697, USA
J Comp Neurol 434:40-55. 2001..In contrast, large errors along the anterior-posterior axis corresponding to nasal-temporal retina were rare and there was no differential behavior that distinguished these fibers...
- Increased NCAM-180 immunoreactivity and maintenance of L1 immunoreactivity in injured optic fibers of adult miceC G Becker
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-2275, USA
Exp Neurol 169:438-48. 2001..The capacity of optic fibers to show increased NCAM-180 immunoreactivity and maintain L1 expression after a lesion may explain why these fibers exhibit relatively good potential for regeneration...
- Immunohistochemical localization of CNTFRalpha in adult mouse retina and optic nerve following intraorbital nerve crush: evidence for the axonal loss of a trophic factor receptor after injuryJill A Miotke
Department of Developmental and Cell Biology, University of California at Irvine, Irvine, California 92697 2305, USA
J Comp Neurol 500:384-400. 2007..It is suggested that the loss of CNTFRalpha from axons renders RGCs unresponsive to CNTF, thereby contributing to regenerative failure and death, while its appearance on glia may promote glial scarring...
- Spontaneous retinal activity is tonic and does not drive tectal activity during activity-dependent refinement in regenerationBradley J Kolls
Department of Developmental and Cell Biology, University of California, Irvine, California 92697, USA
J Neurosci 22:2626-36. 2002..The implications of these results for the role of presynaptic activity in refinement are considered...
- Axonal rearrangement without reexpression of a growth associated marker: evidence from the compression of the retinotectal system in adult goldfishKeyuan Si
School of Life Sciences, Lanzhou University, Lanzhou, 730000, PRC, China
Restor Neurol Neurosci 25:535-47. 2007..Growing axons express a number of proteins associated with axonal growth which are thought to be critical for regeneration and sprouting. Whether these proteins are expressed during injury-induced axonal remodeling is tested in this paper...
- Axonal protein synthesis and degradation are necessary for efficient growth cone regenerationPoonam Verma
Cambridge University Centre for Brain Repair, Cambridge CB2 2PY, United Kingdom
J Neurosci 25:331-42. 2005..Collectively, these findings suggest that local protein synthesis and degradation, controlled by various TOR-, p38 MAPK-, and caspase-dependent pathways, underlie growth cone initiation after axotomy...
- Growth dynamics and morphology of regenerating optic fibers in tectum are altered by injury conditions: an in vivo imaging study in goldfishAmy J Dawson
Department of Development and Cell Biology, University of California at Irvine, Irvine, CA 92697 2305, USA
Exp Neurol 210:592-601. 2008..The morphology and behavior of the deflected fibers suggest they were impaired in their capacity to grow to their correct targets...
- Synaptic Homeostasis in the Visual SystemRONALD MEYER; Fiscal Year: 2004..These studies will document and analyze a new form of synaptic plasticity that may not only be important for normal function but might also underlie functional recovery following neuronal injury and disease. ..
- Reinnervation following sparse regenerationRONALD MEYER; Fiscal Year: 2006..The formation of the low density projection will be analyzed by anatomical, in vivo imaging and electrophysiological methods. ..