Nuala J Meyer

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Future clinical applications of genomics for acute respiratory distress syndrome
    Nuala J Meyer
    Department of Medicine Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA Electronic address
    Lancet Respir Med 1:793-803. 2013
  2. doi request reprint Genetic heterogeneity and risk of acute respiratory distress syndrome
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Semin Respir Crit Care Med 34:459-74. 2013
  3. pmc IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 187:950-9. 2013
  4. pmc SNP-set analysis replicates acute lung injury genetic risk factors
    Nuala J Meyer
    Department of Medicine Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania, 3600 Spruce Street, 874 Maloney, Philadelphia, PA 19104, USA
    BMC Med Genet 13:52. 2012
  5. pmc Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma
    Melanie Rushefski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, USA
    BMC Med Genet 12:77. 2011
  6. pmc ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 183:1344-53. 2011
  7. pmc Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction
    Joshua M Diamond
    1 Pulmonary, Allergy, and Critical Care Division
    Am J Respir Crit Care Med 189:567-75. 2014
  8. pmc Variation in PTX3 is associated with primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, 3400 Spruce St, 8 West Gates, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 186:546-52. 2012
  9. pmc The epidemiology of acute respiratory distress syndrome in patients presenting to the emergency department with severe sepsis
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Pulmonary and Allergy Associates, Morristown, New Jersey, and Morristown Medical Center, Morristown, New Jersey Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology, Columbia University Medical Center, New York, New York and Department of Emergency Medicine, Medstar Washington Hospital Center, Washington, DC, and Georgetown University School of Medicine, Washington, DC
    Shock 40:375-81. 2013
  10. pmc Elevated plasma angiopoietin-2 levels and primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    PLoS ONE 7:e51932. 2012

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Future clinical applications of genomics for acute respiratory distress syndrome
    Nuala J Meyer
    Department of Medicine Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA Electronic address
    Lancet Respir Med 1:793-803. 2013
    ....
  2. doi request reprint Genetic heterogeneity and risk of acute respiratory distress syndrome
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Semin Respir Crit Care Med 34:459-74. 2013
    ..The genetic risk for ARDS seems to vary both by ancestry and by the subtype of ARDS, suggesting that both factors may be valid considerations in clinical trial design. ..
  3. pmc IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 187:950-9. 2013
    ..Acute respiratory distress syndrome (ARDS) behaves as a complex genetic trait, yet knowledge of genetic susceptibility factors remains incomplete...
  4. pmc SNP-set analysis replicates acute lung injury genetic risk factors
    Nuala J Meyer
    Department of Medicine Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania, 3600 Spruce Street, 874 Maloney, Philadelphia, PA 19104, USA
    BMC Med Genet 13:52. 2012
    ..We used a gene - based replication strategy to test the reproducibility of prior acute lung injury (ALI) candidate gene associations...
  5. pmc Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma
    Melanie Rushefski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, USA
    BMC Med Genet 12:77. 2011
    ..Little is known about genetic variation within the PRDX6 gene and its association with acute lung injury (ALI). In this study we sequenced the PRDX6 gene to uncover common variants, and tested association with ALI following major trauma...
  6. pmc ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 183:1344-53. 2011
    ..Acute lung injury (ALI) acts as a complex genetic trait, yet its genetic risk factors remain incompletely understood. Large-scale genotyping has not previously been reported for ALI...
  7. pmc Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction
    Joshua M Diamond
    1 Pulmonary, Allergy, and Critical Care Division
    Am J Respir Crit Care Med 189:567-75. 2014
    ..The evaluation of the role of recipient genetic variation in PGD has thus far been limited to single, candidate gene analyses...
  8. pmc Variation in PTX3 is associated with primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, 3400 Spruce St, 8 West Gates, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 186:546-52. 2012
    ..Elevated long pentraxin-3 (PTX3) levels are associated with the development of primary graft dysfunction (PGD) after lung transplantation. Abnormalities in innate immunity, mediated by PTX3 release, may play a role in PGD pathogenesis...
  9. pmc The epidemiology of acute respiratory distress syndrome in patients presenting to the emergency department with severe sepsis
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Pulmonary and Allergy Associates, Morristown, New Jersey, and Morristown Medical Center, Morristown, New Jersey Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology, Columbia University Medical Center, New York, New York and Department of Emergency Medicine, Medstar Washington Hospital Center, Washington, DC, and Georgetown University School of Medicine, Washington, DC
    Shock 40:375-81. 2013
    ..To date, no study has directly examined the epidemiology of ARDS in severe sepsis from the earliest presentation to the health care system, the emergency department (ED)...
  10. pmc Elevated plasma angiopoietin-2 levels and primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    PLoS ONE 7:e51932. 2012
    ..Angiopoietin-2 serves as a partial antagonist to the Tie-2 receptor and induces increased endothelial permeability. We hypothesized that elevated Ang2 levels would be associated with development of PGD...
  11. ncbi request reprint Heterogeneous phenotypes of acute respiratory distress syndrome after major trauma
    John P Reilly
    1 Division of Pulmonary, Allergy, and Critical Care, Department of Medicine
    Ann Am Thorac Soc 11:728-36. 2014
    ..Lung injury biomarkers suggest a dominant alveolar-capillary barrier injury pattern in this phenotype. ..
  12. pmc African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients
    Michael G S Shashaty
    Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 27:496-504. 2012
    ..Acute kidney injury (AKI) is a common source of morbidity after trauma. We sought to determine novel risk factors for AKI, by Acute Kidney Injury Network (AKIN) criteria, in critically ill trauma patients...
  13. pmc The association of early transfusion with acute lung injury in patients with severe injury
    Daniel N Holena
    Division of Traumatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Trauma Acute Care Surg 73:825-31. 2012
    ..We hypothesized that the relationship between PRBC delivery and ALI risk varies through time after injury...
  14. ncbi request reprint A multibiomarker-based outcome risk stratification model for adult septic shock*
    Hector R Wong
    1Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 3Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 4Intensive Care Units, Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland 5Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 6University of British Columbia, Vancouver, BC, Canada 7Critical Care Research Laboratories, Centre for Heart Lung Innovation, St Paul s Hospital, Vancouver, BC, Canada 8Department of Intensive Care Medicine, Tampere University Hospital, Tampere, Finland 9Department of Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland 10Department of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA
    Crit Care Med 42:781-9. 2014
    ..Investigators advocate that interventional trials in septic shock require effective outcome risk stratification. We derived and tested a multibiomarker-based approach to estimate mortality risk in adults with septic shock...
  15. pmc Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e28268. 2012
    ..This study supports the feasibility of future multi-center GWA investigations of ALI risk, and identifies PPFIA1 as a potential functional candidate ALI risk gene for future research...
  16. pmc Lower serum endocan levels are associated with the development of acute lung injury after major trauma
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 27:522.e11-7. 2012
    ..We tested the association of serum endocan levels with subsequent development of ALI after major trauma...