David S Metzger

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Human immunodeficiency virus prevention and the potential of drug abuse treatment
    David S Metzger
    University of Pennsylvania Veteran s Affairs Medical Center, Center for Studies of Addiction, Philadelphia, Pennsylvania 19104, USA
    Clin Infect Dis 37:S451-6. 2003
  2. pmc HIV prevention among injection drug users: the need for integrated models
    David S Metzger
    University of Pennsylvania VA Medical Center, Center for Studies of Addiction, Philadelphia, PA 19104, USA
    J Urban Health 80:iii59-66. 2003
  3. doi request reprint The glucocorticoid antagonist RU-486 suppresses HIV infectivity and replication
    Tami D Benton
    Children s Hospital of Philadelphia Research Institute, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Neuropsychiatry Clin Neurosci 25:51-7. 2013
  4. ncbi request reprint Naltrexone inhibits alcohol-mediated enhancement of HIV infection of T lymphocytes
    Xu Wang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Leukoc Biol 79:1166-72. 2006
  5. pmc Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection
    Xu Wang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 113:671-4. 2009
  6. pmc Selective serotonin reuptake inhibitor suppression of HIV infectivity and replication
    Tami Benton
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Psychosom Med 72:925-32. 2010
  7. pmc Behind the cascade: analyzing spatial patterns along the HIV care continuum
    Michael G Eberhart
    AIDS Activities Coordinating Office, Philadelphia Department of Public Health, Philadelphia, PA Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA Philadelphia Veterans Affairs Center for Health Equity Research and Promotion, Philadelphia, PA University of Pennsylvania School of Design, Philadelphia, PA Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, and Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA and Treatment Research Institute, Philadelphia, PA
    J Acquir Immune Defic Syndr 64:S42-51. 2013
  8. pmc Drug treatment as HIV prevention: expanding treatment options
    David S Metzger
    HIV AIDS Prevention Research Division, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
    Curr HIV/AIDS Rep 7:220-5. 2010
  9. pmc Morphine withdrawal enhances hepatitis C virus replicon expression
    Chuan qing Wang
    Department of Pediatrics, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, and the Department of Psychiatry, University of Pennsylvania School of Medicine, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Am J Pathol 167:1333-40. 2005
  10. pmc Effects of behavioral stress reduction Transcendental Meditation intervention in persons with HIV
    Sumedha Chhatre
    a Department of Psychiatry, HIV AIDS Prevention Research Division, University of Pennsylvania, Philadelphia, PA, USA
    AIDS Care 25:1291-7. 2013

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Human immunodeficiency virus prevention and the potential of drug abuse treatment
    David S Metzger
    University of Pennsylvania Veteran s Affairs Medical Center, Center for Studies of Addiction, Philadelphia, Pennsylvania 19104, USA
    Clin Infect Dis 37:S451-6. 2003
    ....
  2. pmc HIV prevention among injection drug users: the need for integrated models
    David S Metzger
    University of Pennsylvania VA Medical Center, Center for Studies of Addiction, Philadelphia, PA 19104, USA
    J Urban Health 80:iii59-66. 2003
    ....
  3. doi request reprint The glucocorticoid antagonist RU-486 suppresses HIV infectivity and replication
    Tami D Benton
    Children s Hospital of Philadelphia Research Institute, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Neuropsychiatry Clin Neurosci 25:51-7. 2013
    ..Thus, glucocorticoid antagonism may suppress HIV infectivity and replication ex vivo. Studies to determine the role of glucocorticoid antagonists in the host defense against HIV should be performed...
  4. ncbi request reprint Naltrexone inhibits alcohol-mediated enhancement of HIV infection of T lymphocytes
    Xu Wang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Leukoc Biol 79:1166-72. 2006
    ..These findings suggest a biological mechanism for the potential therapeutic benefit of naltrexone in treating HIV-infected alcoholics...
  5. pmc Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection
    Xu Wang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 113:671-4. 2009
    ..These findings provide compelling and direct evidence at the molecular level to support the notion that intracellular anti-HIV-1 miRNA-mediated innate immunity may have a key role in protecting monocytes/macrophages from HIV-1 infection...
  6. pmc Selective serotonin reuptake inhibitor suppression of HIV infectivity and replication
    Tami Benton
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Psychosom Med 72:925-32. 2010
    ..Depression has been associated with suppression of natural killer cells and CD8(+) lymphocytes, key regulators of HIV infection...
  7. pmc Behind the cascade: analyzing spatial patterns along the HIV care continuum
    Michael G Eberhart
    AIDS Activities Coordinating Office, Philadelphia Department of Public Health, Philadelphia, PA Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA Philadelphia Veterans Affairs Center for Health Equity Research and Promotion, Philadelphia, PA University of Pennsylvania School of Design, Philadelphia, PA Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, and Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA and Treatment Research Institute, Philadelphia, PA
    J Acquir Immune Defic Syndr 64:S42-51. 2013
    ..Spatial analysis may be useful for monitoring HIV care by identifying geographic areas with poor outcomes...
  8. pmc Drug treatment as HIV prevention: expanding treatment options
    David S Metzger
    HIV AIDS Prevention Research Division, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
    Curr HIV/AIDS Rep 7:220-5. 2010
    ..While important challenges remain in maximizing its impact, the scientific literature provides strong evidence of the efficacy of drug treatment as an HIV prevention strategy...
  9. pmc Morphine withdrawal enhances hepatitis C virus replicon expression
    Chuan qing Wang
    Department of Pediatrics, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, and the Department of Psychiatry, University of Pennsylvania School of Medicine, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Am J Pathol 167:1333-40. 2005
    ..These in vitro observations support the concept that opioid abuse favors HCV persistence in hepatic cells by suppressing IFN-alpha-mediated intracellular innate immunity and contributes to the development of chronic HCV infection...
  10. pmc Effects of behavioral stress reduction Transcendental Meditation intervention in persons with HIV
    Sumedha Chhatre
    a Department of Psychiatry, HIV AIDS Prevention Research Division, University of Pennsylvania, Philadelphia, PA, USA
    AIDS Care 25:1291-7. 2013
    ..TM stress reduction intervention in community dwelling adults with HIV is viable and can enhance health-related quality of life. Further research with large sample and longer follow-up is needed to validate our results...
  11. pmc Drug treatment as HIV prevention: a research update
    David S Metzger
    HIV AIDS Prevention Research Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 55:S32-6. 2010
    ..Although there are challenges to implementing drug treatment programs for maximum impact, the scientific literature leaves no doubt about the effectiveness of drug treatment as an HIV prevention strategy...
  12. pmc Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users
    Li Ye
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 5:e9602. 2010
    ..We thus investigated the in vivo impact of heroin use or heroin use plus HCV infection on the CD56(+) T cell frequency and function...
  13. ncbi request reprint Childhood sexual and physical abuse histories, PTSD, depression, and HIV risk outcomes in women injection drug users: a potential mediating pathway
    Rosalyn E Plotzker
    Center for the Studies of Addiction, HIV Prevention Division, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Addict 16:431-8. 2007
    ..01) and drug (p < 0.03) risk. After PTSD/depression adjustment, CSA was no longer associated with sexual or drug risk. These results suggest that women IDUs' CSA-to-risk path is mediated by PTSD/depression...
  14. pmc Selectively willing and conditionally able: HIV vaccine trial participation among women at "high risk" of HIV infection
    Chelsea D Voytek
    HIV AIDS Prevention Research Division, University of Pennsylvania, 3535 Market Street, Suite 4000, Philadelphia, PA 19104, USA
    Vaccine 29:6130-5. 2011
    ..Further research is needed regarding structural factors which influence personal agency and individuals' thinking about research participation...
  15. pmc Homelessness and HIV risk behaviors among injection drug users
    Stephen Metraux
    Graduate Program in Health Policy, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104 4495, USA
    J Urban Health 81:618-29. 2004
    ....
  16. pmc Increased plasmacytoid dendritic cell maturation and natural killer cell activation in HIV-1 exposed, uninfected intravenous drug users
    Costin Tomescu
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    AIDS 24:2151-60. 2010
    ..However, the exact mechanism contributing to NK activation in HIV-1 exposed, uninfected intravenous drug users (EU-IDU) remains to be elucidated...
  17. pmc Alcohol suppresses IL-2-induced CC chemokine production by natural killer cells
    Ting Zhang
    Department of Pediatrics, Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, PA 19104, USA
    Alcohol Clin Exp Res 29:1559-67. 2005
    ..We investigated whether alcohol impairs NK cell function, particularly production of CC chemokines induced by interleukin (IL)-2, the natural ligands for CCR5 receptor...
  18. doi request reprint Examining racial disparities in HIV: lessons from sexually transmitted infections research
    Julie Kraut-Becher
    HIV AIDS Prevention Research Division, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Acquir Immune Defic Syndr 47:S20-7. 2008
    ..Conversely, an emphasis on the interactions of several factors is more likely to produce effective public health interventions and reductions in HIV transmission...
  19. doi request reprint The first national scientific meeting of the Social and Behavioral Science Research Network
    Michael B Blank
    Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 47:S1-4. 2008
  20. pmc Morphine enhances HIV infection of neonatal macrophages
    Yuan Li
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, U S A
    Pediatr Res 54:282-8. 2003
    ..Thus, morphine, most likely through alteration of beta-chemokines and CCR5 receptor expression, enhances the susceptibility of neonatal MDM to HIV infection, and may have a cofactor role in perinatal HIV transmission and infection...
  21. ncbi request reprint Alcohol potentiates hepatitis C virus replicon expression
    Ting Zhang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hepatology 38:57-65. 2003
    ..Thus, alcohol may play an important role in vivo as a cofactor in HCV disease progression and compromise IFN-alpha-based therapy against HCV infection...
  22. pmc Alcohol potentiates HIV-1 infection of human blood mononuclear phagocytes
    Xu Wang
    Division of Immunologic and Infectious Disease, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, Pennsylvania 19104, USA
    Alcohol Clin Exp Res 26:1880-6. 2002
    ..The mechanisms by which alcohol affects the function of human immune cells that are the targets for HIV are unknown...
  23. ncbi request reprint A randomized trial of audio computer and in-person interview to assess HIV risk among drug and alcohol users in Rio De Janeiro, Brazil
    Anna Azevedo Simoes
    Health Department of the State Government of Rio de Janeiro, Rio de Janeiro, Brazil
    J Subst Abuse Treat 30:237-43. 2006
    ..ACASI seems to be a key resource in improving the reporting of sensitive data in Brazil, as it has been in prior international studies...
  24. ncbi request reprint Randomized, controlled evaluation of a prototype informed consent process for HIV vaccine efficacy trials
    Anne S Coletti
    Family Health International, Research Triangle Park, North Carolina, USA
    J Acquir Immune Defic Syndr 32:161-9. 2003
    ..It is recommended that the prototype informed consent process be adopted for future HIV vaccine efficacy trials as well as for clinical trials in other research areas...
  25. ncbi request reprint Decreasing international HIV transmission: the role of expanding access to opioid agonist therapies for injection drug users
    Lynn E Sullivan
    Yale University School of Medicine, New Haven, CT 06520 8025, USA
    Addiction 100:150-8. 2005
    ..To examine the role of expanded access to opioid agonist treatment as a means to decrease international HIV transmission...
  26. doi request reprint Future directions for HIV prevention research: charting a prevention science research agenda
    Ralph J Diclemente
    Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    J Acquir Immune Defic Syndr 47:S47-8. 2008
  27. ncbi request reprint Acceptability of audio computer-assisted self-interview (ACASI) among substance abusers seeking treatment in Rio de Janeiro, Brazil
    Anna Azevedo Simoes
    Health Department of the State Government of Rio de Janeiro, Brazil
    Drug Alcohol Depend 82:S103-7. 2006
    ..The findings extend our understanding of the role of the ACASI method by suggesting the utility of this approach in assessing HIV risk among low-to middle-income drug users in a cultural setting quite different from previous studies...