Research Topics
| David MetzgerSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
Childhood sexual and physical abuse histories, PTSD, depression, and HIV risk outcomes in women injection drug users: a potential mediating pathwayRosalyn E Plotzker
Center for the Studies of Addiction, HIV Prevention Division, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
Am J Addict 16:431-8. 2007..01) and drug (p < 0.03) risk. After PTSD/depression adjustment, CSA was no longer associated with sexual or drug risk. These results suggest that women IDUs' CSA-to-risk path is mediated by PTSD/depression...
Examining racial disparities in HIV: lessons from sexually transmitted infections researchJulie Kraut-Becher
HIV AIDS Prevention Research Division, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
J Acquir Immune Defic Syndr 47:S20-7. 2008..Conversely, an emphasis on the interactions of several factors is more likely to produce effective public health interventions and reductions in HIV transmission...
Drug treatment as HIV prevention: a research updateDavid S Metzger
HIV AIDS Prevention Research Division, University of Pennsylvania, Philadelphia, PA 19104, USA
J Acquir Immune Defic Syndr 55:S32-6. 2010..Although there are challenges to implementing drug treatment programs for maximum impact, the scientific literature leaves no doubt about the effectiveness of drug treatment as an HIV prevention strategy...- Drug treatment as HIV prevention: expanding treatment optionsDavid S Metzger
HIV AIDS Prevention Research Division, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
Curr HIV/AIDS Rep 7:220-5. 2010..While important challenges remain in maximizing its impact, the scientific literature provides strong evidence of the efficacy of drug treatment as an HIV prevention strategy... - HIV prevention among injection drug users: the need for integrated modelsDavid S Metzger
University of Pennsylvania VA Medical Center, Center for Studies of Addiction, Philadelphia, PA 19104, USA
J Urban Health 80:iii59-66. 2003.... - Human immunodeficiency virus prevention and the potential of drug abuse treatmentDavid S Metzger
University of Pennsylvania Veteran s Affairs Medical Center, Center for Studies of Addiction, Philadelphia, Pennsylvania 19104, USA
Clin Infect Dis 37:S451-6. 2003.... - The first national scientific meeting of the Social and Behavioral Science Research NetworkMichael B Blank
Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Acquir Immune Defic Syndr 47:S1-4. 2008 - Rapid assessment of existing HIV prevention programming in a community mental health centerPhyllis L Solomon
University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
J Prev Interv Community 33:137-51. 2007..But overall, formalized training on HIV prevention by case managers is extremely rare. Case managers felt that other providers, such as doctors or nurses, were more appropriate to deliver an HIV prevention intervention... - Selective serotonin reuptake inhibitor and substance P antagonist enhancement of natural killer cell innate immunity in human immunodeficiency virus/acquired immunodeficiency syndromeDwight L Evans
Department of Psychiatry, Joseph J Stokes Research Institute of The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Biol Psychiatry 63:899-905. 2008..This study examines the potential role of three underlying regulatory systems that have been under investigation in central nervous system research as well as immune and viral research: serotonin, neurokinin, and glucocorticoid systems... - Homelessness and HIV risk behaviors among injection drug usersStephen Metraux
Graduate Program in Health Policy, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104 4495, USA
J Urban Health 81:618-29. 2004.... - Sociodemographic and behavioral characteristics associated with timeliness and retention in a 6-month follow-up study of high-risk injection drug usersAntoine Messiah
Center for the Studies of Addiction, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Epidemiol 157:930-9. 2003..None of the drug-related behaviors that increase the risk of human immunodeficiency virus infection was associated with timeliness or retention, suggesting that the study might be minimally biased... - Effects of an intensive street-level police intervention on syringe exchange program use in Philadelphia, PACorey S Davis
BS, University of Pennsylvania, Center for the Study of Addiction, HIV AIDS Prevention Research Division, 3535 Market Street, Suite 4058, Philadelphia, PA 19104 3309, USA
Am J Public Health 95:233-6. 2005..Declines in use among Black and male participants were much more pronounced than decreases among White and female participants... - Effect of GB virus C viremia on HIV acquisition and HIV set-pointGregory P Bisson
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
AIDS 19:1910-2. 2005..32; 95% confidence interval 0.6-2.6). Pre-existing GBV-C viremia at the time of HIV acquisition was also not associated with lower plasma HIV-RNA levels... - Naltrexone inhibits alcohol-mediated enhancement of HIV infection of T lymphocytesXu Wang
Division of Allergy and Immunology, Joseph Stokes Jr. Research Institute at the Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
J Leukoc Biol 79:1166-72. 2006..These findings suggest a biological mechanism for the potential therapeutic benefit of naltrexone in treating HIV-infected alcoholics... - Alcohol potentiates hepatitis C virus replicon expressionTing Zhang
Division of Allergy and Immunology, Joseph Stokes Jr. Research Institute at the Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hepatology 38:57-65. 2003..Thus, alcohol may play an important role in vivo as a cofactor in HCV disease progression and compromise IFN-alpha-based therapy against HCV infection... - Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infectionXu Wang
Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Blood 113:671-4. 2009..These findings provide compelling and direct evidence at the molecular level to support the notion that intracellular anti-HIV-1 miRNA-mediated innate immunity may have a key role in protecting monocytes/macrophages from HIV-1 infection... - Alcohol suppresses IL-2-induced CC chemokine production by natural killer cellsTing Zhang
Department of Pediatrics, Division of Allergy and Immunology, Joseph Stokes Jr. Research Institute at the Children's Hospital of Philadelphia, PA 19104, USA
Alcohol Clin Exp Res 29:1559-67. 2005..Thus, by inhibiting NK cell-mediated innate immunity against HIV, alcohol consumption may have a cofactor role in the immunopathogenesis of HIV disease... - Morphine enhances HIV infection of neonatal macrophagesYuan Li
Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, U.S.A
Pediatr Res 54:282-8. 2003..Thus, morphine, most likely through alteration of beta-chemokines and CCR5 receptor expression, enhances the susceptibility of neonatal MDM to HIV infection, and may have a cofactor role in perinatal HIV transmission and infection... - A randomized trial of audio computer and in-person interview to assess HIV risk among drug and alcohol users in Rio De Janeiro, BrazilAnna Azevedo Simoes
Health Department of the State Government of Rio de Janeiro, Rio de Janeiro, Brazil
J Subst Abuse Treat 30:237-43. 2006..ACASI seems to be a key resource in improving the reporting of sensitive data in Brazil, as it has been in prior international studies... - Decreasing international HIV transmission: the role of expanding access to opioid agonist therapies for injection drug usersLynn E Sullivan
Yale University School of Medicine, New Haven, CT 06520 8025, USA
Addiction 100:150-8. 2005..To examine the role of expanded access to opioid agonist treatment as a means to decrease international HIV transmission... - Future directions for HIV prevention research: charting a prevention science research agendaRalph J Diclemente
Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
J Acquir Immune Defic Syndr 47:S47-8. 2008 - Acceptability of audio computer-assisted self-interview (ACASI) among substance abusers seeking treatment in Rio de Janeiro, BrazilAnna Azevedo Simoes
Health Department of the State Government of Rio de Janeiro, Brazil
Drug Alcohol Depend 82:S103-7. 2006..The findings extend our understanding of the role of the ACASI method by suggesting the utility of this approach in assessing HIV risk among low-to middle-income drug users in a cultural setting quite different from previous studies... - Randomized, controlled evaluation of a prototype informed consent process for HIV vaccine efficacy trialsAnne S Coletti
Family Health International, Research Triangle Park, North Carolina, USA
J Acquir Immune Defic Syndr 32:161-9. 2003..It is recommended that the prototype informed consent process be adopted for future HIV vaccine efficacy trials as well as for clinical trials in other research areas... - Alcohol potentiates HIV-1 infection of human blood mononuclear phagocytesXu Wang
Division of Immunologic and Infectious Disease, Joseph Stokes Jr Research Institute at the Children's Hospital of Philadelphia, Department of Pediatrics, Pennsylvania 19104, USA
Alcohol Clin Exp Res 26:1880-6. 2002....
Research Grants
- Penn prevention clinical trials unitDavid Metzger; Fiscal Year: 2007..Members of this CAB have a long history of participation in prevention research through the conduct of community and participant education initiatives and service on numerous protocol teams. ADMINISTRATIVE COMPONENT: ..
- HIV PREVENTION TRIAL UNITDavid Metzger; Fiscal Year: 2006..Thus, an additional aim of our group is to be active participants in three of the PTN science working groups-Microbicides, Behavioral Intervention, and Substance Related Transmission. ..
- Efficacy of Drug-HIV counseling among IDU at Methadone clinics in JakartaDavid S Metzger; Fiscal Year: 2010..Adhi Nurhidayat,MD during his NIDA INVEST Fellowship at University of Pennsylvania when he spent time with David Metzger, PhD and George Woody, MD...