David Metzger

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Childhood sexual and physical abuse histories, PTSD, depression, and HIV risk outcomes in women injection drug users: a potential mediating pathway
    Rosalyn E Plotzker
    Center for the Studies of Addiction, HIV Prevention Division, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Addict 16:431-8. 2007
  2. doi request reprint Examining racial disparities in HIV: lessons from sexually transmitted infections research
    Julie Kraut-Becher
    HIV AIDS Prevention Research Division, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Acquir Immune Defic Syndr 47:S20-7. 2008
  3. pmc Drug treatment as HIV prevention: a research update
    David S Metzger
    HIV AIDS Prevention Research Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 55:S32-6. 2010
  4. pmc Drug treatment as HIV prevention: expanding treatment options
    David S Metzger
    HIV AIDS Prevention Research Division, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
    Curr HIV/AIDS Rep 7:220-5. 2010
  5. ncbi request reprint Human immunodeficiency virus prevention and the potential of drug abuse treatment
    David S Metzger
    University of Pennsylvania Veteran s Affairs Medical Center, Center for Studies of Addiction, Philadelphia, Pennsylvania 19104, USA
    Clin Infect Dis 37:S451-6. 2003
  6. pmc HIV prevention among injection drug users: the need for integrated models
    David S Metzger
    University of Pennsylvania VA Medical Center, Center for Studies of Addiction, Philadelphia, PA 19104, USA
    J Urban Health 80:iii59-66. 2003
  7. doi request reprint The first national scientific meeting of the Social and Behavioral Science Research Network
    Michael B Blank
    Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 47:S1-4. 2008
  8. ncbi request reprint Rapid assessment of existing HIV prevention programming in a community mental health center
    Phyllis L Solomon
    University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
    J Prev Interv Community 33:137-51. 2007
  9. pmc Selective serotonin reuptake inhibitor and substance P antagonist enhancement of natural killer cell innate immunity in human immunodeficiency virus/acquired immunodeficiency syndrome
    Dwight L Evans
    Department of Psychiatry, Joseph J Stokes Research Institute of The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 63:899-905. 2008
  10. pmc Homelessness and HIV risk behaviors among injection drug users
    Stephen Metraux
    Graduate Program in Health Policy, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104 4495, USA
    J Urban Health 81:618-29. 2004

Research Grants

  1. Penn prevention clinical trials unit
    David Metzger; Fiscal Year: 2007
  2. HIV PREVENTION TRIAL UNIT
    David Metzger; Fiscal Year: 2006
  3. Efficacy of Drug-HIV counseling among IDU at Methadone clinics in Jakarta
    David S Metzger; Fiscal Year: 2010

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Childhood sexual and physical abuse histories, PTSD, depression, and HIV risk outcomes in women injection drug users: a potential mediating pathway
    Rosalyn E Plotzker
    Center for the Studies of Addiction, HIV Prevention Division, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Addict 16:431-8. 2007
    ..01) and drug (p < 0.03) risk. After PTSD/depression adjustment, CSA was no longer associated with sexual or drug risk. These results suggest that women IDUs' CSA-to-risk path is mediated by PTSD/depression...
  2. doi request reprint Examining racial disparities in HIV: lessons from sexually transmitted infections research
    Julie Kraut-Becher
    HIV AIDS Prevention Research Division, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Acquir Immune Defic Syndr 47:S20-7. 2008
    ..Conversely, an emphasis on the interactions of several factors is more likely to produce effective public health interventions and reductions in HIV transmission...
  3. pmc Drug treatment as HIV prevention: a research update
    David S Metzger
    HIV AIDS Prevention Research Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 55:S32-6. 2010
    ..Although there are challenges to implementing drug treatment programs for maximum impact, the scientific literature leaves no doubt about the effectiveness of drug treatment as an HIV prevention strategy...
  4. pmc Drug treatment as HIV prevention: expanding treatment options
    David S Metzger
    HIV AIDS Prevention Research Division, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
    Curr HIV/AIDS Rep 7:220-5. 2010
    ..While important challenges remain in maximizing its impact, the scientific literature provides strong evidence of the efficacy of drug treatment as an HIV prevention strategy...
  5. ncbi request reprint Human immunodeficiency virus prevention and the potential of drug abuse treatment
    David S Metzger
    University of Pennsylvania Veteran s Affairs Medical Center, Center for Studies of Addiction, Philadelphia, Pennsylvania 19104, USA
    Clin Infect Dis 37:S451-6. 2003
    ....
  6. pmc HIV prevention among injection drug users: the need for integrated models
    David S Metzger
    University of Pennsylvania VA Medical Center, Center for Studies of Addiction, Philadelphia, PA 19104, USA
    J Urban Health 80:iii59-66. 2003
    ....
  7. doi request reprint The first national scientific meeting of the Social and Behavioral Science Research Network
    Michael B Blank
    Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 47:S1-4. 2008
  8. ncbi request reprint Rapid assessment of existing HIV prevention programming in a community mental health center
    Phyllis L Solomon
    University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
    J Prev Interv Community 33:137-51. 2007
    ..But overall, formalized training on HIV prevention by case managers is extremely rare. Case managers felt that other providers, such as doctors or nurses, were more appropriate to deliver an HIV prevention intervention...
  9. pmc Selective serotonin reuptake inhibitor and substance P antagonist enhancement of natural killer cell innate immunity in human immunodeficiency virus/acquired immunodeficiency syndrome
    Dwight L Evans
    Department of Psychiatry, Joseph J Stokes Research Institute of The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 63:899-905. 2008
    ..This study examines the potential role of three underlying regulatory systems that have been under investigation in central nervous system research as well as immune and viral research: serotonin, neurokinin, and glucocorticoid systems...
  10. pmc Homelessness and HIV risk behaviors among injection drug users
    Stephen Metraux
    Graduate Program in Health Policy, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104 4495, USA
    J Urban Health 81:618-29. 2004
    ....
  11. doi request reprint Racial disparities in HIV prevalence and risk behaviors among injection drug users and members of their risk networks
    Chyvette Williams
    School of Public Health, University of Illinois, Chicago, IL, USA
    J Acquir Immune Defic Syndr 63:S90-4. 2013
    ..Understanding racial disparities in HIV is a critical challenge; yet, risk behaviors alone do not explain observed disparities in infection rates...
  12. pmc Effects of an intensive street-level police intervention on syringe exchange program use in Philadelphia, PA
    Corey S Davis
    BS, University of Pennsylvania, Center for the Study of Addiction, HIV AIDS Prevention Research Division, 3535 Market Street, Suite 4058, Philadelphia, PA 19104 3309, USA
    Am J Public Health 95:233-6. 2005
    ..Declines in use among Black and male participants were much more pronounced than decreases among White and female participants...
  13. ncbi request reprint Effect of GB virus C viremia on HIV acquisition and HIV set-point
    Gregory P Bisson
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    AIDS 19:1910-2. 2005
    ..32; 95% confidence interval 0.6-2.6). Pre-existing GBV-C viremia at the time of HIV acquisition was also not associated with lower plasma HIV-RNA levels...
  14. ncbi request reprint Sociodemographic and behavioral characteristics associated with timeliness and retention in a 6-month follow-up study of high-risk injection drug users
    Antoine Messiah
    Center for the Studies of Addiction, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Epidemiol 157:930-9. 2003
    ..None of the drug-related behaviors that increase the risk of human immunodeficiency virus infection was associated with timeliness or retention, suggesting that the study might be minimally biased...
  15. ncbi request reprint Naltrexone inhibits alcohol-mediated enhancement of HIV infection of T lymphocytes
    Xu Wang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Leukoc Biol 79:1166-72. 2006
    ..These findings suggest a biological mechanism for the potential therapeutic benefit of naltrexone in treating HIV-infected alcoholics...
  16. ncbi request reprint Alcohol potentiates hepatitis C virus replicon expression
    Ting Zhang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hepatology 38:57-65. 2003
    ..Thus, alcohol may play an important role in vivo as a cofactor in HCV disease progression and compromise IFN-alpha-based therapy against HCV infection...
  17. ncbi request reprint Alcohol suppresses IL-2-induced CC chemokine production by natural killer cells
    Ting Zhang
    Department of Pediatrics, Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, PA 19104, USA
    Alcohol Clin Exp Res 29:1559-67. 2005
    ..We investigated whether alcohol impairs NK cell function, particularly production of CC chemokines induced by interleukin (IL)-2, the natural ligands for CCR5 receptor...
  18. ncbi request reprint Morphine enhances HIV infection of neonatal macrophages
    Yuan Li
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, U S A
    Pediatr Res 54:282-8. 2003
    ..Thus, morphine, most likely through alteration of beta-chemokines and CCR5 receptor expression, enhances the susceptibility of neonatal MDM to HIV infection, and may have a cofactor role in perinatal HIV transmission and infection...
  19. pmc Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection
    Xu Wang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 113:671-4. 2009
    ..These findings provide compelling and direct evidence at the molecular level to support the notion that intracellular anti-HIV-1 miRNA-mediated innate immunity may have a key role in protecting monocytes/macrophages from HIV-1 infection...
  20. ncbi request reprint A randomized trial of audio computer and in-person interview to assess HIV risk among drug and alcohol users in Rio De Janeiro, Brazil
    Anna Azevedo Simoes
    Health Department of the State Government of Rio de Janeiro, Rio de Janeiro, Brazil
    J Subst Abuse Treat 30:237-43. 2006
    ..ACASI seems to be a key resource in improving the reporting of sensitive data in Brazil, as it has been in prior international studies...
  21. ncbi request reprint Randomized, controlled evaluation of a prototype informed consent process for HIV vaccine efficacy trials
    Anne S Coletti
    Family Health International, Research Triangle Park, North Carolina, USA
    J Acquir Immune Defic Syndr 32:161-9. 2003
    ..It is recommended that the prototype informed consent process be adopted for future HIV vaccine efficacy trials as well as for clinical trials in other research areas...
  22. doi request reprint Future directions for HIV prevention research: charting a prevention science research agenda
    Ralph J Diclemente
    Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    J Acquir Immune Defic Syndr 47:S47-8. 2008
  23. ncbi request reprint Acceptability of audio computer-assisted self-interview (ACASI) among substance abusers seeking treatment in Rio de Janeiro, Brazil
    Anna Azevedo Simoes
    Health Department of the State Government of Rio de Janeiro, Brazil
    Drug Alcohol Depend 82:S103-7. 2006
    ..The findings extend our understanding of the role of the ACASI method by suggesting the utility of this approach in assessing HIV risk among low-to middle-income drug users in a cultural setting quite different from previous studies...
  24. ncbi request reprint Decreasing international HIV transmission: the role of expanding access to opioid agonist therapies for injection drug users
    Lynn E Sullivan
    Yale University School of Medicine, New Haven, CT 06520 8025, USA
    Addiction 100:150-8. 2005
    ..To examine the role of expanded access to opioid agonist treatment as a means to decrease international HIV transmission...
  25. ncbi request reprint Alcohol potentiates HIV-1 infection of human blood mononuclear phagocytes
    Xu Wang
    Division of Immunologic and Infectious Disease, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, Pennsylvania 19104, USA
    Alcohol Clin Exp Res 26:1880-6. 2002
    ..The mechanisms by which alcohol affects the function of human immune cells that are the targets for HIV are unknown...

Research Grants6

  1. Penn prevention clinical trials unit
    David Metzger; Fiscal Year: 2007
    ..Members of this CAB have a long history of participation in prevention research through the conduct of community and participant education initiatives and service on numerous protocol teams. ADMINISTRATIVE COMPONENT: ..
  2. HIV PREVENTION TRIAL UNIT
    David Metzger; Fiscal Year: 2006
    ..Thus, an additional aim of our group is to be active participants in three of the PTN science working groups-Microbicides, Behavioral Intervention, and Substance Related Transmission. ..
  3. Efficacy of Drug-HIV counseling among IDU at Methadone clinics in Jakarta
    David S Metzger; Fiscal Year: 2010
    ..Adhi Nurhidayat,MD during his NIDA INVEST Fellowship at University of Pennsylvania when he spent time with David Metzger, PhD and George Woody, MD...