David E Metzger

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation
    David E Metzger
    Institute for Regenerative Medicine, Institute for Diabetes Obesity and Metabolism, Epigenetics Program, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1056 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Development 139:1447-56. 2012
  2. pmc Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions
    David E Metzger
    Institute for Regenerative Medicine, Institute for Diabetes Obesity and Metabolism, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
    Diabetes 63:1804-16. 2014

Detail Information

Publications2

  1. pmc The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation
    David E Metzger
    Institute for Regenerative Medicine, Institute for Diabetes Obesity and Metabolism, Epigenetics Program, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1056 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Development 139:1447-56. 2012
    ....
  2. pmc Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions
    David E Metzger
    Institute for Regenerative Medicine, Institute for Diabetes Obesity and Metabolism, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
    Diabetes 63:1804-16. 2014
    ..Overall, we find that Grg3 and Grg1 establish a monohormonal β-cell identity, and Groucho family members may be useful tools or markers for making functional β-cells. ..