JOSHUA P contact METLAY

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Unintended consequences of a quality measure for acute bronchitis
    Serena Roth
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Am J Manag Care 18:e217-24. 2012
  2. pmc Serotype emergence and genotype distribution among macrolide-resistant invasive Streptococcus pneumoniae isolates in the postconjugate vaccine (PCV-7) era
    Zhenying Liu
    Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Antimicrob Agents Chemother 56:743-50. 2012
  3. pmc Exposure to children as a risk factor for bacteremic pneumococcal disease: changes in the post-conjugate vaccine era
    Joshua P Metlay
    Department of Medicine, University of Pennsylvania School of Medicine, 712 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104, USA
    Arch Intern Med 170:725-31. 2010
  4. pmc Patient reported receipt of medication instructions for warfarin is associated with reduced risk of serious bleeding events
    Joshua P Metlay
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Gen Intern Med 23:1589-94. 2008
  5. ncbi request reprint Antibiotic treatment of acute respiratory infections in acute care settings
    Ralph Gonzales
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA 94118, USA
    Acad Emerg Med 13:288-94. 2006
  6. pmc Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis
    Carolyn V Gould
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Antimicrob Agents Chemother 51:3225-9. 2007
  7. doi request reprint Antibiotic prescriptions are associated with increased patient satisfaction with emergency department visits for acute respiratory tract infections
    Cordelia R Stearns
    Center for Health Equity Research and Promotion, VA Medical Center, Philadelphia, PA, USA
    Acad Emerg Med 16:934-41. 2009
  8. doi request reprint How long does it take to "rule out" bacteremia in children with central venous catheters?
    Samir S Shah
    Children s Hospital of Philadelphia, Division of Infectious Diseases, Room 1526, North Campus, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 121:135-41. 2008
  9. doi request reprint Patient attitudes regarding participation in studies of antimicrobial resistance
    Pam Tolomeo
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 29:155-9. 2008
  10. ncbi request reprint Clinical and public health implications of macrolide-resistant Streptococcus pneumoniae
    R C Moellering
    Beth Israel Deaconess Medical Center, Department of Medicine, Boston, MA 02215, USA
    J Chemother 14:42-56. 2002

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Unintended consequences of a quality measure for acute bronchitis
    Serena Roth
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Am J Manag Care 18:e217-24. 2012
    ..0)...
  2. pmc Serotype emergence and genotype distribution among macrolide-resistant invasive Streptococcus pneumoniae isolates in the postconjugate vaccine (PCV-7) era
    Zhenying Liu
    Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Antimicrob Agents Chemother 56:743-50. 2012
    ..In contrast, erythromycin-resistant isolates within the 15A serotype consisted of clonally identical or closely related isolates...
  3. pmc Exposure to children as a risk factor for bacteremic pneumococcal disease: changes in the post-conjugate vaccine era
    Joshua P Metlay
    Department of Medicine, University of Pennsylvania School of Medicine, 712 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104, USA
    Arch Intern Med 170:725-31. 2010
    ..We examined recent trends in serotypes responsible for disease and current risk factors among adults...
  4. pmc Patient reported receipt of medication instructions for warfarin is associated with reduced risk of serious bleeding events
    Joshua P Metlay
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Gen Intern Med 23:1589-94. 2008
    ..Adverse drug events are an important cause of preventable hospitalizations...
  5. ncbi request reprint Antibiotic treatment of acute respiratory infections in acute care settings
    Ralph Gonzales
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA 94118, USA
    Acad Emerg Med 13:288-94. 2006
    ..To examine the patterns of antibiotic use for acute respiratory tract infections (ARIs) in acute care settings...
  6. pmc Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis
    Carolyn V Gould
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Antimicrob Agents Chemother 51:3225-9. 2007
    ....
  7. doi request reprint Antibiotic prescriptions are associated with increased patient satisfaction with emergency department visits for acute respiratory tract infections
    Cordelia R Stearns
    Center for Health Equity Research and Promotion, VA Medical Center, Philadelphia, PA, USA
    Acad Emerg Med 16:934-41. 2009
    ....
  8. doi request reprint How long does it take to "rule out" bacteremia in children with central venous catheters?
    Samir S Shah
    Children s Hospital of Philadelphia, Division of Infectious Diseases, Room 1526, North Campus, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 121:135-41. 2008
    ....
  9. doi request reprint Patient attitudes regarding participation in studies of antimicrobial resistance
    Pam Tolomeo
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 29:155-9. 2008
    ..However, participation rates have been low in studies that involve fecal sampling. Attitudes toward such studies among potential study participants have not been assessed...
  10. ncbi request reprint Clinical and public health implications of macrolide-resistant Streptococcus pneumoniae
    R C Moellering
    Beth Israel Deaconess Medical Center, Department of Medicine, Boston, MA 02215, USA
    J Chemother 14:42-56. 2002
    ..Further studies are required to monitor and control macrolide resistance and evaluate settings in which macrolide treatment failures are occurring, and new therapeutic interventions are needed...
  11. pmc Risk factors for nonadherence to warfarin: results from the IN-RANGE study
    Alec B Platt
    Department of Medicine, University of Pennsylvania School of Medicine, PA, USA
    Pharmacoepidemiol Drug Saf 17:853-60. 2008
    ..Warfarin is widely used to prevent stroke and venous thromboembolism despite its narrow therapeutic window. Warfarin nonadherence is a substantial problem, but risk factors have not been well elucidated...
  12. doi request reprint Treatment and outcomes for patients with bacteremic pneumococcal pneumonia
    Catherine M Berjohn
    Drexel School of Public Health, Philadelphia, PA, USA
    Medicine (Baltimore) 87:160-6. 2008
    ..Current patterns of drug resistance did not lead to delays in administration of active antimicrobial therapy...
  13. pmc Duration of outpatient fecal colonization due to Escherichia coli Isolates with decreased susceptibility to fluoroquinolones: longitudinal study of patients recently discharged from the hospital
    Ebbing Lautenbach
    University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Antimicrob Agents Chemother 50:3939-43. 2006
    ..07) but was not associated with other resistance mechanisms, demographics, or antibiotic use...
  14. pmc Effect of communication errors during calls to an antimicrobial stewardship program
    Darren R Linkin
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Infect Control Hosp Epidemiol 28:1374-81. 2007
    ....
  15. ncbi request reprint Cluster-randomized trial to improve antibiotic use for adults with acute respiratory infections treated in emergency departments
    Joshua P Metlay
    Center for Health Equity Research and Promotion, VA Medical Center, Philadelphia, PA, USA
    Ann Emerg Med 50:221-30. 2007
    ..We evaluate the effectiveness of an educational program in hospital emergency departments (EDs) targeting reduction in antibiotic overuse for acute respiratory tract infections...
  16. ncbi request reprint The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Stephen E Kimmel
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Intern Med 167:229-35. 2007
    ..Warfarin sodium is a highly efficacious drug, but proper levels of anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient adherence on anticoagulation control...
  17. ncbi request reprint Pay for performance for antibiotic timing in pneumonia: caveat emptor
    Jesse M Pines
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, USA
    Jt Comm J Qual Patient Saf 32:531-5. 2006
    ....
  18. ncbi request reprint The impact of emergency department crowding measures on time to antibiotics for patients with community-acquired pneumonia
    Jesse M Pines
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Emerg Med 50:510-6. 2007
    ..We seek to determine the impact of emergency department (ED) crowding on delays in antibiotic administration for patients with community-acquired pneumonia...
  19. ncbi request reprint Emergency department operational changes in response to pay-for-performance and antibiotic timing in pneumonia
    Jesse M Pines
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Acad Emerg Med 14:545-8. 2007
    ....
  20. pmc Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Epidemiol 60:911-8. 2007
    ..A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis...
  21. doi request reprint Adverse events associated with prolonged antibiotic use
    Sharon B Meropol
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:523-32. 2008
    ....
  22. pmc The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients
    Ebbing Lautenbach
    Divisions of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Clin Infect Dis 51:280-5. 2010
    ..Fluoroquinolones are the most commonly prescribed antimicrobials. The epidemiology of fecal colonization with Escherichia coli demonstrating reduced susceptibility to fluoroquinolones remains unclear...
  23. doi request reprint Social capital and glucose control
    Judith A Long
    Philadelphia Veterans Affairs Center for Health Equity Research and Promotion, 1201 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Community Health 35:519-26. 2010
    ..No other measure of social capital was associated with HbA1c. In this study of black veterans with diabetes we observed that living in neighborhoods where people work together is associated with better glucose control...
  24. pmc Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Alec B Platt
    MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Chest 137:883-9. 2010
    ..Currently, no comprehensive screening tool exists to help providers assess the risk of nonadherence at the time of initiation of warfarin therapy...
  25. pmc Reduced antibiotic prescribing for acute respiratory infections in adults and children
    Sharon B Meropol
    Center for Clinical Epidemiology and Biostatistics, Penn Center for Education and Research on Therapeutics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Br J Gen Pract 59:e321-8. 2009
    ..In the US, prescribing for acute non-specific respiratory infections (ARIs) has decreased, but broad-spectrum antibacterial prescribing has soared...
  26. ncbi request reprint Antibacterial drug resistance: implications for the treatment of patients with community-acquired pneumonia
    Joshua P Metlay
    Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    Infect Dis Clin North Am 18:777-90. 2004
    ..Whether levels of drug resistance will continue to increase or decline is unknown. Therefore,carefully designed outcomes studies likely will continue to be essential to help define optimal therapy for patients who have CAP...
  27. doi request reprint Perceived social support among adults seeking care for acute respiratory tract infections in US EDs
    Sara K Levin
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94118, USA
    Am J Emerg Med 27:582-7. 2009
    ..Social support levels among adults seeking care in the ED for acute respiratory tract infections are similar to general population cohorts, suggesting that social support is not a strong determinant of health care seeking in EDs...
  28. pmc Access to emergency care in the United States
    Brendan G Carr
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Ann Emerg Med 54:261-9. 2009
    ..Rapid access to emergency services is essential for emergency care-sensitive conditions such as acute myocardial infarction, stroke, sepsis, and major trauma. We seek to determine US population access to an emergency department (ED)...
  29. pmc Gastrointestinal tract colonization with fluoroquinolone-resistant Escherichia coli in hospitalized patients: changes over time in risk factors for resistance
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, the Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 30:18-24. 2009
    ..The objective of this study was to identify the prevalence of and risk factors for FQREC colonization among hospitalized patients...
  30. doi request reprint Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
    ..The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin...
  31. doi request reprint Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:561-71. 2008
    ..We sought to examine the validity of specific hospital discharge codes in identifying drug toxicity precipitating hospitalization, among elderly users of high-risk medications...
  32. pmc Macrolide resistance in adults with bacteremic pneumococcal pneumonia
    Joshua P Metlay
    Center for Clinical Epidemiology and Biostatistics, Philadelphia Veterans Affairs Medical Center, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Emerg Infect Dis 12:1223-30. 2006
    ..Among patients who reported taking antimicrobial agents in the 6 months preceding infection, failure to complete the course of prescribed drugs was associated with an increased probability of macrolide resistance (OR 3.4)...
  33. pmc Inaccurate communications in telephone calls to an antimicrobial stewardship program
    Darren R Linkin
    Department of Medicine, Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 27:688-94. 2006
    ....
  34. ncbi request reprint Impact of pediatric vaccination with pneumococcal conjugate vaccine on the risk of bacteremic pneumococcal pneumonia in adults
    Joshua P Metlay
    Department of Veterans Affairs, VA Medical Center, 9th Floor, Philadelphia PA 19104, USA
    Vaccine 24:468-75. 2006
    ....
  35. ncbi request reprint Assessing the suitability of intervention sites for quality improvement studies in emergency departments
    Joshua P Metlay
    Center for Health Equity Research and Promotion, VA Medical Center and University of Pennsylvania School of Medicine, Philadelphia, USA
    Acad Emerg Med 12:667-70. 2005
    ....
  36. ncbi request reprint Medication safety in older adults: home-based practice patterns
    Joshua P Metlay
    Penn Program for the Reduction in Medication Errors, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 53:976-82. 2005
    ..To identify the current state of medication-taking practices of community-dwelling older adults on high-risk medications...
  37. ncbi request reprint The validity and feasibility of saliva melatonin assessment in the elderly
    Nalaka S Gooneratne
    Division of Geriatric Medicine, School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA
    J Pineal Res 34:88-94. 2003
    ..Saliva specimens provide an economical and practical method for melatonin assessment, however, in older adults, issues such as hyposalivation and low melatonin levels limit the feasibility and validity, respectively, of saliva melatonin...
  38. ncbi request reprint Agreement between patient self-report and a Veterans Affairs national pharmacy database for identifying recent exposures to antibiotics
    Joshua P Metlay
    Philadelphia Veterans Affairs Medical Center, Division of General Internal Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, Univ of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 12:9-15. 2003
    ..The authors compared self-report with pharmacy dispensing data to determine the accuracy of self-reported antibiotic exposure...
  39. ncbi request reprint Prior antimicrobial drug exposure: a risk factor for trimethoprim-sulfamethoxazole-resistant urinary tract infections
    Joshua P Metlay
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    J Antimicrob Chemother 51:963-70. 2003
    ..We used a novel data system to identify patterns of individual antimicrobial drug exposures associated with trimethoprim-sulfamethoxazole-resistant urinary tract infections (UTIs)...
  40. ncbi request reprint Role of computerized physician order entry systems in facilitating medication errors
    Ross Koppel
    Department of Sociology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 USA
    JAMA 293:1197-203. 2005
    ..Published studies report that CPOE reduces medication errors up to 81%. Few researchers, however, have focused on the existence or types of medication errors facilitated by CPOE...
  41. pmc Test characteristics of perirectal and rectal swab compared to stool sample for detection of fluoroquinolone-resistant Escherichia coli in the gastrointestinal tract
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Antimicrob Agents Chemother 49:798-800. 2005
    ..For rectal swab, the sensitivity was 90% (95% CI, 68 to 99%) and the specificity was 100% (95% CI, 91 to 100%)...
  42. ncbi request reprint Antibiotic prescribing decisions of generalists and infectious disease specialists: thresholds for adopting new drug therapies
    Joshua P Metlay
    Center for Health Equity Research and Promotion, Department of Veterans Affairs, University of Pennsylvania, Philadelphia, USA
    Med Decis Making 22:498-505. 2002
    ..Thus, the adoption of recommendations to limit overuse of newer antibiotics may be variable across clinical settings and providers, reducing the impact of these recommendations on emerging resistance...
  43. ncbi request reprint Association between fluoroquinolone resistance and mortality in Escherichia coli and Klebsiella pneumoniae infections: the role of inadequate empirical antimicrobial therapy
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Infect Dis 41:923-9. 2005
    ..The prevalence of fluoroquinolone (FQ) resistance among Escherichia coli and Klebsiella pneumoniae has increased markedly in recent years. However, the impact of FQ resistance on mortality remains unknown...
  44. ncbi request reprint The association between emergency department crowding and hospital performance on antibiotic timing for pneumonia and percutaneous intervention for myocardial infarction
    Jesse M Pines
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Acad Emerg Med 13:873-8. 2006
    ..Antibiotics within four hours of arrival for patients with pneumonia and percutaneous intervention (PCI) within two hours for patients with acute myocardial infarction (AMI) are standard measures of emergency department (ED) quality...
  45. pmc Tensions in antibiotic prescribing: pitting social concerns against the interests of individual patients
    Joshua P Metlay
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania School of Medicine, 712 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Gen Intern Med 17:87-94. 2002
    ..However, optimal use from the perspective of the community (reserving newer agents for future use) is not always consistent with optimal use from the perspective of the individual patient (prescribing newer, broader agents)...
  46. ncbi request reprint Phenotypic and genotypic characterization of fecal Escherichia coli isolates with decreased susceptibility to fluoroquinolones: results from a large hospital-based surveillance initiative
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Infect Dis 194:79-85. 2006
    ..The prevalence of fecal colonization with Escherichia coli that has reduced susceptibility to fluoroquinolones is unknown. A detailed characterization of such isolates is limited...
  47. pmc Antimicrobial drug resistance, regulation, and research
    Joshua P Metlay
    VA Medical Center, University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania 19104, USA
    Emerg Infect Dis 12:183-90. 2006
    ..Recent consultations and collaborations between regulators, academics, and industry are welcome. Efforts to coordinate regulatory measures would benefit from greater levels of international dialogue...
  48. ncbi request reprint Update on community-acquired pneumonia: impact of antibiotic resistance on clinical outcomes
    Joshua P Metlay
    Veterans Affairs Medical Center, and Division of General Internal Medicine, Center for Clinical Epidemiology and Bistatistics, University of Pennsylvania School of Medicine, Philadelphia, 17104, USA
    Curr Opin Infect Dis 15:163-7. 2002
    ..However, as patterns of drug resistance evolve, future studies will be needed to address the continued appropriateness of current empirical treatment guidelines for these patients...
  49. pmc Changes in veterans' use of outpatient care from 1992 to 2000
    Judith A Long
    Philadelphia Veterans Affairs Center for Health Equity Research and Promotion, University of Pennsylvania s Leonard Davis Institute of Health Economics, PA 19104 6021, USA
    Am J Public Health 95:2246-51. 2005
    ..To determine whether the reorganization was associated with changes in patterns of out-patient VHA use, we sought to evaluate changes in characteristics of veterans who use VHA outpatient services between 1992 and 2000...
  50. ncbi request reprint Outcomes in lower respiratory tract infections and the impact of antimicrobial drug resistance
    Joshua P Metlay
    Veterans Affairs Medical Center and Division of General Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Clin Microbiol Infect 8:1-11. 2002
    ..Additional studies are urgently needed to assess better whether the current empiric treatment guidelines are adequate or will need to be adjusted as patterns of resistance continue to evolve...
  51. ncbi request reprint Risk factors for fluoroquinolone resistance in nosocomial Escherichia coli and Klebsiella pneumoniae infections
    Ebbing Lautenbach
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 162:2469-77. 2002
    ..Risk factors for FQ resistance in these pathogens remain unknown. Although FQs are important components of the present antimicrobial arsenal, their continued usefulness is threatened by rising FQ resistance...
  52. pmc Hospital-reported pneumococcal susceptibility to penicillin
    Joshua P Metlay
    VA Medical Center, Philadelphia, Pennsylvania, USA
    Emerg Infect Dis 10:54-9. 2004
    ..8). In addition, correlations were not significant in reported pneumococcal susceptibility to penicillin within individual hospitals during the 3 years...
  53. doi request reprint Primary early thoracoscopy and reduction in length of hospital stay and additional procedures among children with complicated pneumonia: results of a multicenter retrospective cohort study
    Samir S Shah
    Division of Infectious Diseases, The Childrens Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 162:675-81. 2008
    ....
  54. doi request reprint Availability of rapid human immunodeficiency virus testing in academic emergency departments
    Peter D Ehrenkranz
    Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania, Philadelphia, PA, USA
    Acad Emerg Med 15:144-50. 2008
    ..The study objectives were to determine the accessibility of rapid HIV testing in academic EDs, to identify factors that influence an ED's adoption of testing, and to describe current HIV testing practices...
  55. ncbi request reprint Vital-sign abnormalities as predictors of pneumonia in adults with acute cough illness
    Brendon R Nolt
    The Center for Health Equity Research and Promotion, VA Medical Center and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Am J Emerg Med 25:631-6. 2007
    ..This study examines the strength of the association between vital-sign abnormalities, advanced age, and the diagnosis of community-acquired pneumonia (CAP) in the evaluation of adults with acute cough illness...
  56. ncbi request reprint Accuracy of adult reported pneumococcal vaccination status of children
    Chris Czaja
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Ann Epidemiol 15:253-6. 2005
    ..To evaluate the accuracy of an adult's recall of children's vaccination status with the pneumococcal vaccine, the authors conducted a cross-sectional survey of adults in Philadelphia County from January to December 2003...
  57. pmc Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study
    Catherine S Parker
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Gen Intern Med 22:1254-9. 2007
    ..Patient adherence to warfarin may influence anticoagulation control; yet, adherence among warfarin users has not been rigorously studied...
  58. pmc Costs of treating children with complicated pneumonia: a comparison of primary video-assisted thoracoscopic surgery and chest tube placement
    Samir S Shah
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Pulmonol 45:71-7. 2010
    ....
  59. ncbi request reprint Testing strategies in the initial management of patients with community-acquired pneumonia
    Joshua P Metlay
    Veterans Affairs Medical Center and University of Pennsylvania School of Medicine, 9th Floor, University and Woodland Avenues, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 138:109-18. 2003
    ....
  60. doi request reprint Polymicrobial bloodstream infections among children and adolescents with central venous catheters evaluated in ambulatory care
    Kevin J Downes
    Divisions of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Infect Dis 46:387-94. 2008
    ..Bloodstream infections (BSIs) are an ever-present concern for clinicians evaluating ill-appearing pediatric patients with central venous catheters (CVCs) in the ambulatory care setting...
  61. ncbi request reprint Medication comprehension and safety in older adults
    Joshua P Metlay
    Leonard Davis Institute of Health Economics, University of Pennsylvania, and Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA
    LDI Issue Brief 14:1-4. 2008
    ..These findings may help clinicians better predict and monitor their patients' adherence to prescription drug regimens...
  62. pmc Patterns and determinants of inappropriate antibiotic use in injection drug users
    Joanna L Starrels
    Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Gen Intern Med 24:263-9. 2009
    ..Inappropriate antibiotic use contributes to the emergence and spread of drug resistant infections. Though injection drug users are at increased risk for drug resistant infections, few studies have examined antibiotic use in this population...
  63. ncbi request reprint Declining antibiotic prescriptions for upper respiratory infections, 1993-2004
    Stefan G Vanderweil
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA
    Acad Emerg Med 14:366-9. 2007
    ..To examine antibiotic prescribing trends for U.S. emergency department (ED) visits with upper respiratory tract infections (URIs) between 1993 and 2004...
  64. ncbi request reprint Impact of hospital formularies on fluoroquinolone prescribing in emergency departments
    Sherrie L Aspinall
    Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, and Unviersity of Pittsburgh School of Pharmacy, Pittsburgh, PA 15240, USA
    Am J Manag Care 13:241-8. 2007
    ..To examine factors associated with fluoroquinolone prescribing among adults receiving antibiotics for acute respiratory tract infections (ARIs) in emergency departments...
  65. ncbi request reprint Facility-level variation in antibiotic prescriptions for veterans with upper respiratory infections
    Sherrie L Aspinall
    Center for Health Equity Research and Promotion, Veterans Affairs Healthcare System, Pittsburgh, USA
    Clin Ther 27:258-62. 2005
    ..Programs have targeted individual patient and physician behaviors to reduce the use of antibiotics for upper respiratory infections (URIs), but such efforts have had limited success to date...
  66. ncbi request reprint Population antibiotic susceptibility for Streptococcus pneumoniae and treatment outcomes in common respiratory tract infections
    Jon P Furuno
    Department of Epidemiology and Preventive Medicine, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Pharmacoepidemiol Drug Saf 15:1-9. 2006
    ..pneumoniae are associated with higher risk of treatment failure in suppurative acute otitis media (AOM), acute sinusitis, and acute exacerbation of chronic bronchitis (AECB)...
  67. ncbi request reprint Tensions in antibiotic prescribing
    Joshua P Metlay
    University of Pennsylvania, USA
    LDI Issue Brief 7:1-4. 2002
    ..This Issue Brief explores one of the fundamental challenges physicians face in optimizing antibiotic use: the potential conflict between what is best for an individual patient, and what is best for society as a whole...
  68. ncbi request reprint Clinical prediction model for influenza
    Samir S Shah
    Arch Pediatr Adolesc Med 158:1018; author reply 1018. 2004
  69. ncbi request reprint Surveillance for second primary colorectal cancer after adjuvant chemotherapy: an analysis of Intergroup 0089
    Robert J Green
    The Helen and Harry Gray Cancer Institute, 1309 North Flagler Drive, West Palm Beach, FL 33401, USA
    Ann Intern Med 136:261-9. 2002
    ..It is unclear whether guidelines for colonoscopy screening in patients with polyps are appropriate for patients with previous colon cancer...
  70. ncbi request reprint Cigarette smoking among Chinese Americans and the influence of linguistic acculturation
    Steven S Fu
    Department of Veteran Affairs Medical Center, Section of General Internal Medicine, Center for Chronic Disease Outcomes Research, Minneapolis, MN 55417, USA
    Nicotine Tob Res 5:803-11. 2003
    ..Further research is needed to assess whether acculturation is associated with smoking among Chinese American women and with use of smoking cessation treatments and services by Chinese American smokers...
  71. ncbi request reprint Educational interventions to improve antibiotic use in the community: report from the International Forum on Antibiotic Resistance (IFAR) colloquium, 2002
    Roger G Finch
    Nottingham City Hospital and University of Nottingham, Nottingham, UK
    Lancet Infect Dis 4:44-53. 2004
    ..Current research aims include the application of behaviour-change models, the development and validation of prudent antibiotic prescribing standards, and the refinement of tools to assess educational interventions...

Research Grants13

  1. Risk factors for drug resistant pneumococcal bacteremia
    Joshua Metlay; Fiscal Year: 2009
    ..The proposed study will maintain our enrollment over an additional three years in order to complete six-years of active enrollment and achieve the necessary sample size for the proposed molecular and geographic analyses. ..
  2. Risk factors for drug resistant pneumococcal bacteremia
    Joshua Metlay; Fiscal Year: 2007
    ..The proposed study will maintain our enrollment over an additional three years in order to complete six-years of active enrollment and achieve the necessary sample size for the proposed molecular and geographic analyses. ..
  3. RISK FACTORS FOR DRUG RESISTANT PNEUMOCOCCAL PNEUMONIA
    Joshua Metlay; Fiscal Year: 2003
    ..Finally, a cohort study will be completed within the study design, by examining outcomes for all patients, stratifying by pneumococcal drug susceptibility and adequacy of antimicrobial drug coverage. ..
  4. Development, Implementation and Evaluation of Novel Strategies to Reduce Inapprop
    JOSHUA P contact METLAY; Fiscal Year: 2010
    ....