Christian M Metallo

Summary

Affiliation: University of California
Country: USA

Publications

  1. Grassian A, Parker S, Davidson S, Divakaruni A, Green C, Zhang X, et al. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Res. 2014;74:3317-31 pubmed publisher
    ..Lastly, IDH1-mutant cells also grew poorly as subcutaneous xenografts within a hypoxic in vivo microenvironment. Together, our results suggest therapeutic opportunities to exploit the metabolic vulnerabilities specific to IDH1 mutation. ..
  2. Badur M, Muthusamy T, Parker S, Ma S, McBrayer S, Cordes T, et al. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. Cell Rep. 2018;25:1018-1026.e4 pubmed publisher
    ..NADPH regeneration may be limiting for lipogenesis and potentially redox homeostasis in IDH1-mutant cells, highlighting critical links between cellular biosynthesis and redox metabolism. ..
  3. Wallace M, Green C, Roberts L, Lee Y, McCarville J, Sanchez Gurmaches J, et al. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol. 2018;14:1021-1031 pubmed publisher
    ..These results identify adipose tissue mmBCFA synthesis as a novel link between BCAA metabolism and lipogenesis, highlighting roles for CrAT and FASN promiscuity influencing acyl-chain diversity in the lipidome. ..
  4. Lewis C, Parker S, Fiske B, McCloskey D, Gui D, Green C, et al. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Mol Cell. 2014;55:253-63 pubmed publisher
    ..Using this system we determine the direction of serine/glycine interconversion within the mitochondria and cytosol, highlighting the ability of this approach to resolve compartmentalized reactions in intact cells. ..
  5. Parker S, Metallo C. Metabolic consequences of oncogenic IDH mutations. Pharmacol Ther. 2015;152:54-62 pubmed publisher
  6. Zhang H, Badur M, Divakaruni A, Parker S, Jäger C, Hiller K, et al. Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Rep. 2016;16:1536-1547 pubmed publisher
    ..These results demonstrate that self-renewing hPSCs can present distinct metabolic states and highlight the importance of medium nutrients on mitochondrial function and development. ..
  7. Badur M, Zhang H, Metallo C. Enzymatic passaging of human embryonic stem cells alters central carbon metabolism and glycan abundance. Biotechnol J. 2015;10:1600-11 pubmed publisher
  8. Zhao D, Badur M, Luebeck J, Magaña J, Birmingham A, Sasik R, et al. Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis. Mol Cell. 2018;69:699-708.e7 pubmed publisher
  9. Metallo C, Vander Heiden M. Understanding metabolic regulation and its influence on cell physiology. Mol Cell. 2013;49:388-98 pubmed publisher

More Information

Publications13

  1. Vacanti N, Divakaruni A, Green C, Parker S, Henry R, Ciaraldi T, et al. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell. 2014;56:425-35 pubmed publisher
    ..Thus, in contrast to inhibition of complex I or PDH, suppression of pyruvate transport induces a form of metabolic flexibility associated with the use of lipids and amino acids as catabolic and anabolic fuels. ..
  2. Cordes T, Wallace M, Michelucci A, Divakaruni A, Sapcariu S, Sousa C, et al. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016;291:14274-84 pubmed publisher
    ..This metabolic network links the innate immune response and tricarboxylic acid metabolism to function of the electron transport chain. ..
  3. Parker S, Svensson R, Divakaruni A, Lefebvre A, Murphy A, Shaw R, et al. LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng. 2017;43:208-217 pubmed publisher
    ..Together, our data implicate LKB1 as a major regulator of adaptive metabolic reprogramming and suggest synergistic pharmacological strategies for mitigating LKB1-deficient NSCLC tumor growth. ..
  4. Badur M, Metallo C. Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease. Metab Eng. 2018;45:95-108 pubmed publisher
    ..In turn, MFA approaches will increasingly help to uncover new therapeutic opportunities that enhance human health. ..