Christian M Metallo
Affiliation: University of California
- Vacanti N, Divakaruni A, Green C, Parker S, Henry R, Ciaraldi T, et al. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell. 2014;56:425-35 pubmed publisher..Thus, in contrast to inhibition of complex I or PDH, suppression of pyruvate transport induces a form of metabolic flexibility associated with the use of lipids and amino acids as catabolic and anabolic fuels. ..
- Cordes T, Wallace M, Michelucci A, Divakaruni A, Sapcariu S, Sousa C, et al. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016;291:14274-84 pubmed publisher..This metabolic network links the innate immune response and tricarboxylic acid metabolism to function of the electron transport chain. ..
- Parker S, Svensson R, Divakaruni A, Lefebvre A, Murphy A, Shaw R, et al. LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng. 2017;43:208-217 pubmed publisher..Together, our data implicate LKB1 as a major regulator of adaptive metabolic reprogramming and suggest synergistic pharmacological strategies for mitigating LKB1-deficient NSCLC tumor growth. ..
- Badur M, Metallo C. Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease. Metab Eng. 2018;45:95-108 pubmed publisher..In turn, MFA approaches will increasingly help to uncover new therapeutic opportunities that enhance human health. ..