Luisa Mestroni

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Genetics and genetic testing of dilated cardiomyopathy: a new perspective
    Luisa Mestroni
    Cardiovascular Institute, University of Colorado, Aurora, CO 80305, USA
    Discov Med 15:43-9. 2013
  2. doi request reprint Heart failure and personalized medicine
    Luisa Mestroni
    University of Colorado Cardiovascular Institute, Aurora, Colorado, USA
    J Cardiovasc Med (Hagerstown) 12:6-12. 2011
  3. doi request reprint SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism
    William P McNair
    Cardiovascular Institute, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
    J Am Coll Cardiol 57:2160-8. 2011
  4. ncbi request reprint Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy
    Matthew R G Taylor
    CU Cardiovascular Institute, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Hum Mutat 26:566-74. 2005
  5. pmc Poor prognosis of rare sarcomeric gene variants in patients with dilated cardiomyopathy
    Marco Merlo
    Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, Colorado, USA Cardiovascular Department Ospedali Riuniti, and University of Trieste, Trieste, Italy
    Clin Transl Sci 6:424-8. 2013
  6. pmc Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes
    Matthew Taylor
    Adult Medical Genetics Program and Division of Cardiology, University of Colorado Denver, Aurora, USA
    Circulation 124:876-85. 2011
  7. ncbi request reprint Danon disease presenting with dilated cardiomyopathy and a complex phenotype
    Matthew R G Taylor
    University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA
    J Hum Genet 52:830-5. 2007
  8. pmc Whole exome sequencing identifies a troponin T mutation hot spot in familial dilated cardiomyopathy
    Nzali Campbell
    Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, Colorado, United States of America
    PLoS ONE 8:e78104. 2013
  9. pmc Pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure
    Matthew R G Taylor
    University of Colorado Denver, Aurora, CO, USA
    Pharmacogenet Genomics 19:35-43. 2009
  10. pmc Cardiomyopathy, familial dilated
    Matthew R G Taylor
    University of Colorado Cardiovascular Institute and Adult Medical Genetics Program, Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Orphanet J Rare Dis 1:27. 2006

Collaborators

Detail Information

Publications19

  1. pmc Genetics and genetic testing of dilated cardiomyopathy: a new perspective
    Luisa Mestroni
    Cardiovascular Institute, University of Colorado, Aurora, CO 80305, USA
    Discov Med 15:43-9. 2013
    ..It can also guide reproductive decision-making including utilization of pre-implantation genetic diagnostic strategies...
  2. doi request reprint Heart failure and personalized medicine
    Luisa Mestroni
    University of Colorado Cardiovascular Institute, Aurora, Colorado, USA
    J Cardiovasc Med (Hagerstown) 12:6-12. 2011
    ....
  3. doi request reprint SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism
    William P McNair
    Cardiovascular Institute, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
    J Am Coll Cardiol 57:2160-8. 2011
    ..The aim of this study was to discern the role of the cardiac voltage-gated sodium ion channel SCN5A in the etiology of dilated cardiomyopathy (DCM)...
  4. ncbi request reprint Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy
    Matthew R G Taylor
    CU Cardiovascular Institute, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Hum Mutat 26:566-74. 2005
    ..The Arg690Cys mutation altered the observed LAP2alpha interaction with A-type lamins. Our finding implicates a novel nuclear lamina-associated protein in the pathogenesis of genetic forms of dilated cardiomyopathy...
  5. pmc Poor prognosis of rare sarcomeric gene variants in patients with dilated cardiomyopathy
    Marco Merlo
    Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, Colorado, USA Cardiovascular Department Ospedali Riuniti, and University of Trieste, Trieste, Italy
    Clin Transl Sci 6:424-8. 2013
    ..To address this question, we analyzed the outcome of rare sarcomeric gene variants in patients enrolled in our Familial Cardiomyopathy Registry...
  6. pmc Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes
    Matthew Taylor
    Adult Medical Genetics Program and Division of Cardiology, University of Colorado Denver, Aurora, USA
    Circulation 124:876-85. 2011
    ..We evaluated the cardiomyopathy gene titin (TTN) as a candidate ARVC gene because of its proximity to an ARVC locus at position 2q32 and the connection of the titin protein to the transitional junction at intercalated disks...
  7. ncbi request reprint Danon disease presenting with dilated cardiomyopathy and a complex phenotype
    Matthew R G Taylor
    University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA
    J Hum Genet 52:830-5. 2007
    ..Furthermore, the absence of vacuolar myopathy in biopsies from young patients may not exclude Danon disease...
  8. pmc Whole exome sequencing identifies a troponin T mutation hot spot in familial dilated cardiomyopathy
    Nzali Campbell
    Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, Colorado, United States of America
    PLoS ONE 8:e78104. 2013
    ..In conclusion, an exome sequencing strategy that includes segregation analysis using distant affected relatives within a family represents a viable diagnostic strategy in a genetically heterogeneous disease like DCM. ..
  9. pmc Pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure
    Matthew R G Taylor
    University of Colorado Denver, Aurora, CO, USA
    Pharmacogenet Genomics 19:35-43. 2009
    ..We hypothesized that variation in genes of the endothelin system mediate the clinical response to beta-blockers in heart failure...
  10. pmc Cardiomyopathy, familial dilated
    Matthew R G Taylor
    University of Colorado Cardiovascular Institute and Adult Medical Genetics Program, Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Orphanet J Rare Dis 1:27. 2006
    ..Patients with severe heart failure, severe reduction of the functional capacity and depressed left ventricular ejection fraction have a low survival rate and may require heart transplant...
  11. ncbi request reprint Analysis of genetic variations of lamin A/C gene (LMNA) by denaturing high-performance liquid chromatography
    Matthew R G Taylor
    University of Colorado Cardiovascular Institute, Denver, USA
    J Biomol Screen 9:625-8. 2004
    ..LMNA mutations are clinically relevant in at least 6 human diseases. This study provides a protocol for high-throughput LMNA analysis applicable both in the research and in the clinical diagnostic setting...
  12. ncbi request reprint SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia
    William P McNair
    University of Colorado Cardiovascular Institute, Denver, Colo, USA
    Circulation 110:2163-7. 2004
    ....
  13. ncbi request reprint Natural history of dilated cardiomyopathy due to lamin A/C gene mutations
    Matthew R G Taylor
    University of Colorado Cardiovascular Institute, Denver, Colorado 80010, USA
    J Am Coll Cardiol 41:771-80. 2003
    ..We examined the prevalence, genotype-phenotype correlation, and natural history of lamin A/C gene (LMNA) mutations in subjects with dilated cardiomyopathy (DCM)...
  14. doi request reprint Utility of cardiac magnetic resonance imaging to differentiate cardiac sarcoidosis from arrhythmogenic right ventricular cardiomyopathy
    David A Steckman
    Section of Cardiac Electrophysiology, University of Colorado, Denver, Colorado, USA
    Am J Cardiol 110:575-9. 2012
    ..The presence of mediastinal lymphadenopathy and left ventricular septal scar favors a diagnosis of CS and not ARVC. Consideration of CS should be given if these MRI findings are observed during the evaluation for possible ARVC...
  15. ncbi request reprint Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing
    Matthew R G Taylor
    Adult medical Genetics Clinic, Department of Internal Medicine, UCHSC, Aurora, Colorado 80010, USA
    Expert Rev Mol Diagn 4:99-113. 2004
    ..In this review, the clinical and molecular genetics of hypertrophic cardiomyopathy are described...
  16. ncbi request reprint Pharmacogenomics, personalized medicine, and heart failure
    Luisa Mestroni
    Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, USA
    Discov Med 11:551-61. 2011
    ....
  17. pmc Pharmacogenetics of heart failure
    Luisa Mestroni
    University of Colorado Cardiovascular Institute and Adult Medical Genetics Program, Aurora, Colorado, USA
    Curr Opin Cardiol 29:227-34. 2014
    ....
  18. ncbi request reprint Ophthalmic manifestations of Danon disease
    F Ryan Prall
    Department of Ophthalmology, University of Colorado, Aurora, Colorado, USA
    Ophthalmology 113:1010-3. 2006
    ..To describe the ophthalmic findings in patients with Danon disease, an X-linked condition causing cardiomyopathy in males and females...
  19. ncbi request reprint [Dilated cardiomyopathy: etiology, clinical criteria for diagnosis and screening of the familial form]
    Umberto Startari
    University of Colorado Cardiovascular Institute, Adult Medical Genetics Program, Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Ital Heart J Suppl 3:378-85. 2002
    ..The family screening should be followed-up every 2 to 3 years, in particular in unaffected relatives (in the absence of a molecular diagnosis), to exclude a late onset of the disease...