JIRI F MESTECKY

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Comparative Evaluation of HIV-1 Neutralization in External Secretions and Sera of HIV-1-Infected Women
    Qing Wei
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL, USA
    Open AIDS J 6:293-302. 2012
  2. pmc Antibody-mediated protection and the mucosal immune system of the genital tract: relevance to vaccine design
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, AL 35294 2170, USA
    J Reprod Immunol 85:81-5. 2010
  3. ncbi request reprint Perspectives on mucosal vaccines: is mucosal tolerance a barrier?
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 179:5633-8. 2007
  4. ncbi request reprint Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Box 1, 845 19th Street South, Birmingham, AL 35294, USA
    J Reprod Immunol 73:86-97. 2007
  5. ncbi request reprint IgA nephropathy: current views of immune complex formation
    Jiri Mestecky
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL 35294 2170, USA
    Contrib Nephrol 157:56-63. 2007
  6. pmc Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy
    J Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Kidney Blood Press Res 31:29-37. 2008
  7. doi request reprint Oral immunization: an update
    Jiri Mestecky
    Department of Microbiology and Medicine, The University of Alabama at Birmingham, AL 35294 2170, USA
    Curr Opin Gastroenterol 24:713-9. 2008
  8. pmc Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfaces
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35295 2170, USA
    Immunol Lett 124:57-62. 2009
  9. pmc Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infection
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Reprod Immunol 83:196-200. 2009
  10. ncbi request reprint Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Box 1, 845 19th Street South, Birmingham, AL 35294, USA
    J Reprod Immunol 72:1-17. 2006

Research Grants

Collaborators

Detail Information

Publications43

  1. pmc Comparative Evaluation of HIV-1 Neutralization in External Secretions and Sera of HIV-1-Infected Women
    Qing Wei
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL, USA
    Open AIDS J 6:293-302. 2012
    ....
  2. pmc Antibody-mediated protection and the mucosal immune system of the genital tract: relevance to vaccine design
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, AL 35294 2170, USA
    J Reprod Immunol 85:81-5. 2010
    ..The approaches have been explored to a limited extent in humans...
  3. ncbi request reprint Perspectives on mucosal vaccines: is mucosal tolerance a barrier?
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 179:5633-8. 2007
    ..Optimization of mucosal vaccination strategies has the potential for enhancing protective immune responses and suppressing systemic responses to autoantigens desirable for the treatment of autoimmune diseases...
  4. ncbi request reprint Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Box 1, 845 19th Street South, Birmingham, AL 35294, USA
    J Reprod Immunol 73:86-97. 2007
    ..These differences must be considered in the design of protective vaccines against infection with HIV and other agents of sexually transmitted diseases...
  5. ncbi request reprint IgA nephropathy: current views of immune complex formation
    Jiri Mestecky
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL 35294 2170, USA
    Contrib Nephrol 157:56-63. 2007
    ..Because of the molecular defect in IgA1 glycosylation and its subsequent recognition by naturally-occurring antibodies, experimental approaches that diminish or prevent formation of large immunostimulatory IC should be further explored...
  6. pmc Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy
    J Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Kidney Blood Press Res 31:29-37. 2008
    ..These findings suggest that experimental approaches that prevent the formation of large Gal-deficient IgA1-IgG IC may be applied ultimately in an immunologically mediated therapy...
  7. doi request reprint Oral immunization: an update
    Jiri Mestecky
    Department of Microbiology and Medicine, The University of Alabama at Birmingham, AL 35294 2170, USA
    Curr Opin Gastroenterol 24:713-9. 2008
    ..Here, we summarize the current status of such vaccines, with a focus on intestinal infectious diseases, describe alternative approaches, and analyze advantages and difficulties encountered with a broad implementation of these vaccines...
  8. pmc Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfaces
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35295 2170, USA
    Immunol Lett 124:57-62. 2009
    ..In embodying both adaptive and innate immune mechanisms within a single molecule, S-IgA maintains comprehensive protection of mucosal surfaces with economy of structure and function...
  9. pmc Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infection
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Reprod Immunol 83:196-200. 2009
    ..Whether humoral responses to previously or newly encountered antigens are compromised in HIV-1-infected persons is under current investigation...
  10. ncbi request reprint Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Box 1, 845 19th Street South, Birmingham, AL 35294, USA
    J Reprod Immunol 72:1-17. 2006
    ..These differences must be considered in the design of protective vaccines against infection with HIV and other agents of sexually transmitted diseases...
  11. ncbi request reprint Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individuals
    Jiri Mestecky
    Departments of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    AIDS Res Hum Retroviruses 20:972-88. 2004
    ..Therefore, in striking contrast to other mucosally encountered microbial infections, HIV-1 does not induce vigorous specific IgA responses in any body fluid examined or in ASC in peripheral blood...
  12. ncbi request reprint Immune response versus mucosal tolerance to mucosally administered antigens
    Jiri Mestecky
    Department of Microbiology BBRB 757, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294 2170, USA
    Vaccine 23:1800-3. 2005
    ..Thus, ongoing systemic responses are refractory to the induction of mucosal tolerance in humans. This finding is of considerable importance for the development of and sequence of immunization with mucosally administered vaccines...
  13. ncbi request reprint Mucosal immune system of the human genital tract
    J Mestecky
    Departments of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    J Infect Dis 179:S470-4. 1999
    ....
  14. ncbi request reprint Immunologic uniqueness of the genital tract: challenge for vaccine development
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Box 1, 845 19th Street South, Birmingham, AL 35294, USA
    Am J Reprod Immunol 53:208-14. 2005
    ..Furthermore, combined systemic and mucosal (oral, rectal, and especially intranasal) immunization may induce protective humoral responses in both the systemic and mucosal compartments of the immune system...
  15. pmc Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins
    Denise L Kothe
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Virology 360:218-34. 2007
    ....
  16. ncbi request reprint IgA-containing immune complexes in the urine of IgA nephropathy patients
    Karel Matousovic
    Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294 2170, USA
    Nephrol Dial Transplant 21:2478-84. 2006
    ..Due to damaged sieving properties of the glomerular capillary wall in IgAN, these immune complexes may appear in the urine...
  17. ncbi request reprint Neutralizing antibodies in mucosal secretions: IgG or IgA?
    Rashada Alexander
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr HIV Res 5:588-93. 2007
    ..Considering the importance of the antibody response to ascertaining the correlates of HIV immunity, as well as on vaccine research and development, this review addresses the relevant studies and their implications...
  18. ncbi request reprint Oral tolerance in humans: failure to suppress an existing immune response by oral antigen administration
    Zina Moldoveanu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Ann N Y Acad Sci 1029:299-309. 2004
    ..Therefore, some form of immunomodulation greater than that provided by oral administration of antigen alone is required in humans for suppression of an existing immune response...
  19. pmc Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity
    Hitoshi Suzuki
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 119:1668-77. 2009
    ..Collectively, these findings indicate that glycan-specific antibodies are associated with the development of IgAN and may represent a disease-specific marker and potential therapeutic target...
  20. pmc IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Semin Nephrol 28:78-87. 2008
    ..By using sophisticated analytic methods, it may be possible to define biomarkers for diagnostic purposes and identify new therapeutic targets for a future disease-specific therapy...
  21. doi request reprint Mucosal antibody responses to HIV
    Zina Moldoveanu
    University of Alabama, Birmingham, AL, USA
    Methods Mol Biol 485:333-45. 2009
    ..Finally, due to the enormous variability of Ig levels not only in various secretions, but also in the same secretion collected at different times, determinations of total Ig levels must be performed to generate meaningful results...
  22. ncbi request reprint Interactions of human mesangial cells with IgA and IgA-containing immune complexes
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Kidney Int 62:465-75. 2002
    ..The circulating immune complexes (CIC) are composed of galactose- (Gal) deficient IgA1 and IgG or IgA1 antibodies specific for the Gal-deficient IgA1; interactions of these CIC with mesangial cells (MC) were studied...
  23. ncbi request reprint Immune responses to human papillomavirus in genital tract of women with cervical cancer
    Huan H Nguyen
    Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Bevill Biomed Res Building, Room 746, Birmingham, AL 35294 2170, USA
    Gynecol Oncol 96:452-61. 2005
    ....
  24. pmc Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infection
    Zdenek Hel
    Department of Pathology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, Alabama 35294 2170, USA
    Endocr Rev 31:79-97. 2010
    ..This review summarizes current knowledge of the effects of various types of sex steroid hormones on immune processes involved in the biology of HIV-1 infection...
  25. pmc Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognition
    Milan Raska
    Department of Immunology, Palacky University in Olomouc, Olomouc 77100, Czech Republic
    J Biol Chem 285:20860-9. 2010
    ..These results indicate that gp120 glycans contribute to antibody reactivity and should be considered in HIV-1 vaccine design...
  26. pmc Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses
    Milan Raska
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Vaccine 26:1541-51. 2008
    ..7% of CD8(+) splenocytes after in vitro stimulation with HIV-1 envelope peptides. These results demonstrate that DNA vaccines targeted to tissues with high proteosynthetic activity, such as the liver, results in enhanced immune responses...
  27. ncbi request reprint Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: implications for IgA nephropathy
    Matthew B Renfrow
    UAB Biomedical FT ICR MS Laboratory, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, MCLM 570 1530 3rd AVE S, Birmingham, AL 35294 0005, USA
    Anal Bioanal Chem 389:1397-407. 2007
    ..These results suggest that future analysis of IgA1 HR from IgAN patients and normal healthy controls should be feasible...
  28. ncbi request reprint Human male genital tract secretions: both mucosal and systemic immune compartments contribute to the humoral immunity
    Zina Moldoveanu
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 175:4127-36. 2005
    ..These findings should be considered in immunization strategies to induce humoral responses against sexually transmitted infections, including HIV-1...
  29. ncbi request reprint HIV infection: first battle decides the war
    Zdenek Hel
    Department of Pathology, University of Alabama at Birmingham, 619 19th Street South, Room SW W286, Birmingham, AL 35249 7331, USA
    Trends Immunol 27:274-81. 2006
    ....
  30. ncbi request reprint Increased levels of galactose-deficient IgG in sera of HIV-1-infected individuals
    Jennifer S Moore
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    AIDS 19:381-9. 2005
    ..However, this phenomenon has not been investigated at length in human viral infections...
  31. pmc Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteins
    Jennifer S Moore
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Mol Immunol 44:2598-604. 2007
    ..Because of the heterogeneity of GalNAc-specific lectins, they should be carefully characterized with appropriate substrates before undertaking any study...
  32. pmc Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells
    Milan Raska
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mol Biol 369:69-78. 2007
    ..These data are the first evidence that human cells that lack ST6-GalNAcI can sialylate core 1 GalNAc-Ser/Thr...
  33. ncbi request reprint IgA nephropathy: a clinical overview
    Bruce A Julian
    University of Alabama at Birmingham, Department of Medicine, Birmingham, AL 35294, USA
    Contrib Nephrol 157:19-26. 2007
    ..These or other related findings may provide the necessary tools to better classify phenotypes in multiplex pedigrees and to improve monitoring of disease progression or response to therapy...
  34. ncbi request reprint IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Kidney Int 67:504-13. 2005
    ..Sera of patients with IgA nephropathy (IgAN) contain circulating immune complexes (CIC) composed of galactose-deficient IgA1 complexed with antiglycan antibodies. The role of these CIC in the pathogenesis of IgAN is not known...
  35. ncbi request reprint IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells
    Jan Novak
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL 35294, USA
    Contrib Nephrol 157:134-8. 2007
    ..In summary, we identified the neoepitopes on IgA1 responsible for formation of the pathogenic immune complexes. These studies may lead to development of noninvasive diagnostic assays and future disease-specific therapy...
  36. ncbi request reprint IgA nephropathy: characterization of IgG antibodies specific for galactose-deficient IgA1
    Hitoshi Suzuki
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL 35294 2170, USA
    Contrib Nephrol 157:129-33. 2007
    ..The immortalized cell lines will provide a stable and convenient source of IgG for molecular studies of antibodies specific to the aberrant O-glycans in IgA1...
  37. pmc Methods for evaluation of humoral immune responses in human genital tract secretions
    Jiri Mestecky
    Departments of Microbiology and Medicine, University of Alabama at Birmingham, 845 19th Street, South, Birmingham, AL 35294 2170
    Am J Reprod Immunol 65:361-7. 2011
    ..Special precautions and rigorous controls must be used in the evaluation of antibody-mediated virus neutralization in external secretions of the genital and intestinal tracts...
  38. ncbi request reprint Humoral immune responses to microbial infections in the genital tract
    Michael W Russell
    Department of Microbiology, and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, NY 14214, USA
    Microbes Infect 4:667-77. 2002
    ..Antibody responses to genital infections or to locally applied vaccines are usually modest, but alternative strategies for eliciting genital tract antibodies are being developed...
  39. ncbi request reprint Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells
    Gang Meng
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nat Med 8:150-6. 2002
    ..Our finding that CCR5+ intestinal epithelial cells select and transfer exclusively R5 viruses indicates a mechanism for the selective transmission of R5 HIV-1 in primary infection acquired through the upper gastrointestinal tract...
  40. pmc IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1
    Hitoshi Suzuki
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 118:629-39. 2008
    ..Thus, our data suggest that premature sialylation likely contributes to the aberrant IgA1 glycosylation in IgA nephropathy and may represent a new therapeutic target...
  41. ncbi request reprint Influenza virus infection of the murine uterus: a new model for antiviral immunity in the female reproductive tract
    Kathryn B Renegar
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Viral Immunol 19:613-22. 2006
    ..We believe this work to be the first direct demonstration of S-IgA-mediated antiviral uterine immunity. It provides a model for further investigation of immunity in the female reproductive tract...
  42. ncbi request reprint Peyer's patches as the inductive site for IgA responses
    Jiri Mestecky
    Division of Gastroenterology, University of Alabama at Birmingham, 703 South 19th Street, Birmingham, AL 35294, USA
    J Immunol 180:1293-4. 2008
  43. pmc Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire
    Huan H Nguyen
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    J Virol 81:9331-8. 2007
    ....

Research Grants8

  1. Familial IgA Nephropathy: Genetic and Metabolic Studies
    Jiri Mestecky; Fiscal Year: 2006
    ..abstract_text> ..
  2. PERIODONTAL DISEASE:ROLE OF ABERRANT Ig GLYCOSYLATION
    Jiri Mestecky; Fiscal Year: 2002
    ..Results of these studies will generate information concerning previously unexplored inflammatory pathways that participate in the development of PD. ..
  3. Mucosal and systemic responses in HIV vaccinees
    Jiri Mestecky; Fiscal Year: 2003
    ..abstract_text> ..
  4. PERIODONTAL DISEASE:ROLE OF ABERRANT Ig GLYCOSYLATION
    Jiri Mestecky; Fiscal Year: 2006
    ..Results of these studies will generate information concerning previously unexplored inflammatory pathways that participate in the development of PD. ..
  5. Novel VLP-Based Mucosal and Sytemic HIV Vaccines
    Jiri Mestecky; Fiscal Year: 2007
    ..Proposed studies will be executed in collaboration with external investigators from various US institutions, and the direction, approaches and generated results will be discussed with members of the Advisory Group. ..