Arturas Meskauskas

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Ribosomal protein L3: gatekeeper to the A site
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, University of Maryland, Microbiology Building, Room 2135, College Park, MD 20742, USA
    Mol Cell 25:877-88. 2007
  2. pmc Yeast ribosomal protein L10 helps coordinate tRNA movement through the large subunit
    Alexey N Petrov
    Department of Cell Biology and Molecular Genetics, University of Maryland, 2135 Microbiology Building, College Park, MD 20742, USA
    Nucleic Acids Res 36:6187-98. 2008
  3. pmc Structure/function analysis of yeast ribosomal protein L2
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, Microbiology Building Rm 2135, University of Maryland, College Park, MD, 20742, USA
    Nucleic Acids Res 36:1826-35. 2008
  4. pmc Identification of functionally important amino acids of ribosomal protein L3 by saturation mutagenesis
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, Microbiology Building Room 2135, University of Maryland, College Park, 20742, USA
    Mol Cell Biol 25:10863-74. 2005
  5. pmc Eukaryotic rpL10 drives ribosomal rotation
    Sergey O Sulima
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA, Section of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA and Department of Biotechnology and Microbiology, Vilnius University, Vilnius LT 03101, Lithuania
    Nucleic Acids Res 42:2049-63. 2014
  6. pmc Ribosome binding to a 5' translational enhancer is altered in the presence of the 3' untranslated region in cap-independent translation of turnip crinkle virus
    Vera A Stupina
    Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, MD 20742, USA
    J Virol 85:4638-53. 2011
  7. pmc Ribosomal protein L3: influence on ribosome structure and function
    Alexey Petrov
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    RNA Biol 1:59-65. 2004
  8. ncbi request reprint Enhanced purity, activity and structural integrity of yeast ribosomes purified using a general chromatographic method
    Jonathan A Leshin
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA
    RNA Biol 7:354-60. 2010
  9. pmc Ribosomal protein L3 functions as a 'rocker switch' to aid in coordinating of large subunit-associated functions in eukaryotes and Archaea
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, Microbiology Building Rm 2135, University of Maryland, College Park, MD 20742, USA
    Nucleic Acids Res 36:6175-86. 2008
  10. pmc A molecular clamp ensures allosteric coordination of peptidyltransfer and ligand binding to the ribosomal A-site
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Nucleic Acids Res 38:7800-13. 2010

Collaborators

  • Anne E Simon
  • Davide Ruggero
  • Rong Guo
  • Jonathan D Dinman
  • Vera A Stupina
  • Xuefeng Yuan
  • Michel de Messieres
  • Sergey O Sulima
  • Karen Jack
  • Jonathan A Leshin
  • Alexey N Petrov
  • Alexey Petrov
  • Stephanie Patchett
  • Jen Chien Chang
  • Arthur La Porta
  • Suna P Gulay
  • Ashton Trey Belew
  • Margarida Anjos
  • Arlen W Johnson
  • Olya Krasnykh
  • Noam Kopmar
  • Dori M Landry
  • Sunnie R Thompson
  • Sharmishtha Musalgaonkar
  • Cristian Bellodi
  • Alison M Dean
  • Rachel O Niederer
  • Rasa Rakauskaite
  • Kerong Shi
  • Bruce A Shapiro
  • Sara C Roshwalb
  • Yaroslava G Yingling
  • John C McCormack

Detail Information

Publications18

  1. pmc Ribosomal protein L3: gatekeeper to the A site
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, University of Maryland, Microbiology Building, Room 2135, College Park, MD 20742, USA
    Mol Cell 25:877-88. 2007
    ..These studies provide a basis for deeper insight into rational design of small molecule antiviral therapeutics...
  2. pmc Yeast ribosomal protein L10 helps coordinate tRNA movement through the large subunit
    Alexey N Petrov
    Department of Cell Biology and Molecular Genetics, University of Maryland, 2135 Microbiology Building, College Park, MD 20742, USA
    Nucleic Acids Res 36:6187-98. 2008
    ..The importance of L10 as a potential transducer of information through the ribosome, and of a possible role of its N-terminal domain in switching between the pre- and post-translocational states are discussed...
  3. pmc Structure/function analysis of yeast ribosomal protein L2
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, Microbiology Building Rm 2135, University of Maryland, College Park, MD, 20742, USA
    Nucleic Acids Res 36:1826-35. 2008
    ....
  4. pmc Identification of functionally important amino acids of ribosomal protein L3 by saturation mutagenesis
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, Microbiology Building Room 2135, University of Maryland, College Park, 20742, USA
    Mol Cell Biol 25:10863-74. 2005
    ..The results of these analyses are discussed with regard to how protein-rRNA interactions may affect ribosome function...
  5. pmc Eukaryotic rpL10 drives ribosomal rotation
    Sergey O Sulima
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA, Section of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA and Department of Biotechnology and Microbiology, Vilnius University, Vilnius LT 03101, Lithuania
    Nucleic Acids Res 42:2049-63. 2014
    ....
  6. pmc Ribosome binding to a 5' translational enhancer is altered in the presence of the 3' untranslated region in cap-independent translation of turnip crinkle virus
    Vera A Stupina
    Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, MD 20742, USA
    J Virol 85:4638-53. 2011
    ..This suggests that ribosomes can promote an interaction between the 5' and 3' UTRs of TCV...
  7. pmc Ribosomal protein L3: influence on ribosome structure and function
    Alexey Petrov
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    RNA Biol 1:59-65. 2004
    ..In vivo dimethylsulfate (DMS) protection studies reveal that small changes in L3 primary sequence also have significant effects on rRNA structure as far away as 100 A, supporting an allosteric model of ribosome function...
  8. ncbi request reprint Enhanced purity, activity and structural integrity of yeast ribosomes purified using a general chromatographic method
    Jonathan A Leshin
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA
    RNA Biol 7:354-60. 2010
    ..The simplicity of the method, and the enhanced purity and activity of chromatographically purified ribosome represents a significant technical advancement for the study of eukaryotic ribosomes...
  9. pmc Ribosomal protein L3 functions as a 'rocker switch' to aid in coordinating of large subunit-associated functions in eukaryotes and Archaea
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, Microbiology Building Rm 2135, University of Maryland, College Park, MD 20742, USA
    Nucleic Acids Res 36:6175-86. 2008
    ..A model is presented describing how all three domains of L3 may function together as a 'rocker switch' to coordinate the stepwise processes of translation elongation...
  10. pmc A molecular clamp ensures allosteric coordination of peptidyltransfer and ligand binding to the ribosomal A-site
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Nucleic Acids Res 38:7800-13. 2010
    ..The observation that these mutations affected translational fidelity, virus propagation and cell growth demonstrates how small structural changes at the atomic scale can propagate outward to broadly impact the biology of cell...
  11. pmc The 3' end of Turnip crinkle virus contains a highly interactive structure including a translational enhancer that is disrupted by binding to the RNA-dependent RNA polymerase
    Xuefeng Yuan
    Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, Maryland 20742, USA
    RNA 15:1849-64. 2009
    ....
  12. pmc rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells
    Karen Jack
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Mol Cell 44:660-6. 2011
    ..These findings uncover specific roles for Ψ modification in ribosome-ligand interactions that are conserved in yeast, mouse, and humans...
  13. pmc Decreased peptidyltransferase activity correlates with increased programmed -1 ribosomal frameshifting and viral maintenance defects in the yeast Saccharomyces cerevisiae
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    RNA 9:982-92. 2003
    ....
  14. pmc Evolution of a helper virus-derived, ribosome binding translational enhancer in an untranslated satellite RNA of Turnip crinkle virus
    Rong Guo
    Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, MD 20742, USA
    Virology 419:10-6. 2011
    ..These results suggest that minor changes from the original TCV sequence in satC reflect requirements other than elimination of ribosome binding...
  15. pmc Chromatographic purification of highly active yeast ribosomes
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, University of Maryland, USA
    J Vis Exp . 2011
    ..The simplicity of the method, and the enhanced purity and activity of chromatographically purified ribosome represents a significant technical advancement for the study of eukaryotic ribosomes...
  16. pmc The 3' proximal translational enhancer of Turnip crinkle virus binds to 60S ribosomal subunits
    Vera A Stupina
    Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, Maryland 20742, USA
    RNA 14:2379-93. 2008
    ..This strong correlation suggests that ribosome entry in the 3' UTR is a key function of the 3' translational enhancer of TCV and that the T-shaped element contains some tRNA-like properties...
  17. pmc Single-molecule measurements of the CCR5 mRNA unfolding pathways
    Michel de Messieres
    Department of Physics, Institute for Physical Science and Technology Biophysics Program, University of Maryland, College Park, Maryland
    Biophys J 106:244-52. 2014
    ..The dynamic ensemble of conformations that CCR5 mRNA exhibits in the single-molecule experiments may be a significant feature of the frameshifting mechanism. ..
  18. pmc Delayed rRNA processing results in significant ribosome biogenesis and functional defects
    Arturas Meskauskas
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Mol Cell Biol 23:1602-13. 2003
    ..The frameshifting defect is accentuated when the demand for ribosomes is highest, suggesting that rRNA posttranscriptional modification is the bottleneck in ribosome biogenesis...