Research Topics
| CAROLYN MERVISSummaryAffiliation: University of Louisville Country: USA Publications
Research Grants
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Detail Information
Publications
Longitudinal assessment of intellectual abilities of children with Williams syndrome: multilevel modeling of performance on the Kaufman Brief Intelligence Test-Second EditionCarolyn B Mervis
Department of Psychology and Brain Sciences, University of Louisville, KY 40292, USA
Am J Intellect Dev Disabil 117:134-55. 2012..Maternal education was significantly related to Verbal SS intercept. No significant sex differences were found. Implications for studies of genotype/phenotype correlations in WS are discussed...- Frequency of the 7q11.23 inversion polymorphism in transmitting parents of children with Williams syndrome and in the general population does not differ between North America and EuropeColleen A Morris
Department of Pediatrics, University of Nevada School of Medicine, Las Vegas, Nevada, USA
Mol Cytogenet 4:7. 2011..Results indicated that Frohnauer et al.'s data are consistent with previously reported frequencies of 7q11.23 inversion in North America and Spain in both transmitting parents and the general population... - Cognitive and behavioral characteristics of children with Williams syndrome: implications for intervention approachesCarolyn B Mervis
Department of Psychological and Brain Sciences, 317 Life Sciences Building, University of Louisville, Louisville, KY 40292, USA
Am J Med Genet C Semin Med Genet 154:229-48. 2010..Finally, we briefly discuss intervention approaches that may help children with WS to achieve their full potential... - Vocabulary abilities of children with Williams syndrome: strengths, weaknesses, and relation to visuospatial construction abilityCarolyn B Mervis
Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
J Speech Lang Hear Res 51:967-82. 2008..This project was designed to identify relative strengths and weaknesses in vocabulary ability for children with Williams syndrome (WS) and to demonstrate the importance of stringent matching criteria for cross-group comparisons... 
Language and communicative development in Williams syndromeCarolyn B Mervis
Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
Ment Retard Dev Disabil Res Rev 13:3-15. 2007..We argue that rather than being the paradigm case for the independence of language from cognition, Williams syndrome provides strong evidence of the interdependence of many aspects of language and cognition...- Methodological issues in cross-syndrome comparisons: matching procedures, sensitivity (Se), and specificity (Sp)C B Mervis
Department of Psychology, University of Louisville, KY 40292, USA
Monogr Soc Res Child Dev 64:115-30; discussion 131-9. 1999.... - Intellectual abilities and adaptive behavior of children and adolescents with Kabuki syndrome: a preliminary studyCarolyn B Mervis
Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
Am J Med Genet A 132:248-55. 2005..This pattern affected adaptive behavior as well, yielding a relative strength in Social Interaction and Communicative Skills and considerable weakness in Motor Skills and Personal Living Skills... - Methodological issues in group-matching designs: alpha levels for control variable comparisons and measurement characteristics of control and target variablesCarolyn B Mervis
Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
J Autism Dev Disord 34:7-17. 2004.... - Attentional characteristics of infants and toddlers with Williams syndrome during triadic interactionsCarolyn B Mervis
Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
Dev Neuropsychol 23:243-68. 2003.... - Adaptive behavior of 4- through 8-year-old children with Williams syndromeC B Mervis
Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
Am J Ment Retard 106:82-93. 2001..The children earned similar overall standard scores on the Vineland and the Differential Ability Scales. Interrelations among adaptive behavior, cognitive abilities, and personality characteristics are discussed... - The Williams syndrome cognitive profileC B Mervis
University of Louisville, Louisville, KY 40292, USA
Brain Cogn 44:604-28. 2000..Possible applications for the WSCP include psychoeducational evaluation and empirical research such as the search for genotype/phenotype relations in this genetically based syndrome... - Williams syndrome: 15 years of psychological researchCarolyn B Mervis
Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
Dev Neuropsychol 23:1-12. 2003..Our hope is that this issue will motivate further studies, informed by the genetic-developmental approach, on both Williams syndrome and other neurodevelopmental genetic disorders... - Expressive vocabulary ability of toddlers with Williams syndrome or Down syndrome: a comparisonC B Mervis
Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
Dev Neuropsychol 17:111-26. 2000.... - Williams syndrome: cognition, personality, and adaptive behaviorC B Mervis
Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
Ment Retard Dev Disabil Res Rev 6:148-58. 2000..The importance of operationalizations of crucial components of the behavioral phenotype for the study of genotype/phenotype correlations in Williams syndrome is stressed. MRDD Research Reviews 2000;6:148-158... - The roles of verbal short-term memory and working memory in the acquisition of grammar by children with Williams syndromeByron F Robinson
Department of Psychology, Georgia State University, Atlanta 30303, USA
Dev Neuropsychol 23:13-31. 2003..Phonological short-term memory, however, contributed independently to grammatical ability even after receptive vocabulary was taken into account... - Socio-communicative deficits in young children with Williams syndrome: performance on the Autism Diagnostic Observation ScheduleBonita P Klein-Tasman
Department of Psychology, University of Wisconsin Milwaukee, WI 53201, USA
Child Neuropsychol 13:444-67. 2007..Implications for our understanding of the socio-communicative abilities of young children with Williams syndrome and diagnostic practices regarding dual diagnosis are discussed... - Referential communication skills of children with Williams syndrome: understanding when messages are not adequateAngela E John
University of Louisville, Louisville, KY 40292, USA
Am J Intellect Dev Disabil 114:85-99. 2009.... - Overlap with the autism spectrum in young children with Williams syndromeBonita P Klein-Tasman
Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, WI 53201, USA
J Dev Behav Pediatr 30:289-99. 2009.... - Comprehension of the communicative intent behind pointing and gazing gestures by young children with Williams syndrome or Down syndromeAngela E John
Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
J Speech Lang Hear Res 53:950-60. 2010..In this study, the authors examined the ability of preschoolers with Williams syndrome (WS) or Down syndrome (DS) to infer communicative intent as expressed through gestures (pointing and eye-gaze shift)... - Neuropsychological components of intellectual disability: the contributions of immediate, working, and associative memoryJamie O Edgin
Department of Psychology, University of Denver, Denver, Colorado, USA
J Intellect Disabil Res 54:406-17. 2010..g. Down syndrome (DS) and Williams syndrome (WS)] allows us to test whether or not these dissociations may extend across cognitive domains, including PFC and hippocampal memory processes... - Sensory modulation impairments in children with Williams syndromeAngela E John
Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
Am J Med Genet C Semin Med Genet 154:266-76. 2010..Children in the high impairment group demonstrated poorer adaptive functioning, executive functioning, more problem behaviors, and more difficult temperaments than children in the low impairment group... - Longitudinal course of anxiety in children and adolescents with Williams syndromeJanet Woodruff-Borden
Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
Am J Med Genet C Semin Med Genet 154:277-90. 2010..These findings are discussed in terms of persistence of anxiety over time and the need to develop and test interventions to address the high levels of anxiety experienced by children and adolescents with WS... - Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndromeOvsanna T Leyfer
Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
Am J Med Genet B Neuropsychiatr Genet 141:615-22. 2006..The prevalence of Generalized Anxiety Disorder (GAD) increased significantly with age. These findings are another step toward defining the behavioral phenotype of WS... - Distinctive personality characteristics of 8-, 9-, and 10-year-olds with Williams syndromeBonita P Klein-Tasman
Department of Psychology, University of Wisconsin Milwaukee, 53201, USA
Dev Neuropsychol 23:269-90. 2003..The personality profiles emerging from the CBQ and MPQ provide a crucial step toward investigations of genotype/phenotype relations... - Neurobehavioral implications of habitual snoring in childrenCarolyn B Mervis
Kosair Children's Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 114:44-9. 2004..Larger studies are urgently required because current guidelines for treatment of snoring in children may require reevaluation... - Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorderCheryl R Holbrook
Kosair Children's Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 111:554-63. 2003..Furthermore, SDB can lead to mild ADHD-like behaviors that can be readily misperceived and potentially delay the diagnosis and appropriate treatment... - Genome rearrangements detected by SNP microarrays in individuals with intellectual disability referred with possible Williams syndromeAriel M Pani
Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky, United States of America
PLoS ONE 5:e12349. 2010..With the advent of microarray techniques, submicroscopic genome alterations not associated with known syndromes are emerging as a significant cause of ID and MCA... - Correlates of sleep and pediatric bipolar disorderRochelle C Mehl
Department of Pediatrics, Kosair Children's Hospital Research Institute and Division of Pediatric Sleep Medicine, University of Louisville, KY 40202, USA
Sleep 29:193-7. 2006..Prevalence rates of pediatric bipolar disorder, as assessed by the Child Behavior Checklist, are consistent with those found in the adult bipolar population... - What are theories for? Concept use throughout the continuum of dinosaur expertiseKathy E Johnson
Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
J Exp Child Psychol 87:171-200. 2004..The interaction of specific concept knowledge with broader framework theories of biology throughout the continuum of expertise is considered... - GTF2I hemizygosity implicated in mental retardation in Williams syndrome: genotype-phenotype analysis of five families with deletions in the Williams syndrome regionColleen A Morris
Department of Pediatrics, Division of Genetics, University of Nevada School of Medicine, Las Vegas, Nevada 89102, USA
Am J Med Genet A 123:45-59. 2003..Comparison of these five families with reports of other individuals with partial deletions of the WS region most strongly implicates GTF2I in the mental retardation of WS... - Neural correlates of genetically abnormal social cognition in Williams syndromeAndreas Meyer-Lindenberg
Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Nat Neurosci 8:991-3. 2005..Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior... - Neural basis of genetically determined visuospatial construction deficit in Williams syndromeAndreas Meyer-Lindenberg
Unit on Integrative Neuroimaging, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 4C101, 9000 Rockville Pike, Bethesda, MD 20892, USA
Neuron 43:623-31. 2004.... - Heat shock protein 27 gene: chromosomal and molecular location and relationship to Williams syndromeA Dean Stock
Department of Pediatrics, Division of Genetics, Laboratory of Molecular Cytogenetics, University of Nevada School of Medicine, Las Vegas 89102, USA
Am J Med Genet A 120:320-5. 2003..B363M4 was demonstrated to overlap the telomeric end of B161A02 and HSP27 may be contained partially within the telomeric end of B161A02. The possible role of HSP27 in the cognitive features of WS is discussed... - Neurobehavioral correlates of sleep-disordered breathing in childrenCarolyn B Mervis
Department of Pediatrics, Kosair Children's Hospital Research Institute and Division of Pediatric Sleep Medicine, Universtiy of Louisville, KY 40202, USA
J Sleep Res 13:165-72. 2004..Furthermore, total arousal index was negatively correlated with neurocognitive abilities, suggesting a role for sleep fragmentation in pediatric SDB-induced cognitive dysfunction... - Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviourAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, National Institute of Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, Maryland 20892-1365, USA
Nat Rev Neurosci 7:380-93. 2006.... - Functional, structural, and metabolic abnormalities of the hippocampal formation in Williams syndromeAndreas Meyer-Lindenberg
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, NIH, Department of Health and Human Services, Bethesda, MD 20892 1365, USA
J Clin Invest 115:1888-95. 2005..These data demonstrate abnormalities in HF in WS in agreement with murine models, implicate LIMK1 and CYLN2 in human hippocampal function, and suggest that hippocampal dysfunction may contribute to neurocognitive abnormalities in WS... - The common inversion of the Williams-Beuren syndrome region at 7q11.23 does not cause clinical symptomsElaine Tam
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Am J Med Genet A 146:1797-806. 2008..Whole genome analysis may reveal previously unidentified copy number variants that could contribute to syndromic features... - Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndromeStefano Marenco
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:15117-22. 2007.... - Rearrangements of the Williams-Beuren syndrome locus: molecular basis and implications for speech and language developmentLucy R Osborne
Department of Medicine, University of Toronto, Ontario, Canada
Expert Rev Mol Med 9:1-16. 2007..The spectrum and frequency of genomic rearrangements at 7q11.23 presents an exceptional opportunity to identify gene(s) directly involved in human speech and language development... - Genetic contributions to human gyrification: sulcal morphometry in Williams syndromeJ Shane Kippenhan
National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Neurosci 25:7840-6. 2005....
Research Grants
- Early Development with Williams or Down SyndromeCAROLYN MERVIS; Fiscal Year: 2007..The research will have implications both for theoretical models of the relations between language and cognition and for the design of cognitive and language intervention strategies for children with developmental disabilities. ..
- GENOTYPE/PHENOTYPE CORRELATIONS IN WILLIAMS SYNDROMECAROLYN MERVIS; Fiscal Year: 2004..An initial specific goal is to identify genes responsible for the personality characteristics of WS as well as other specific phenotype features. ..
- EARLY DEVELOPMENT: WILLIAMS OR DOWN SYNDROME CHILDRENCAROLYN MERVIS; Fiscal Year: 2003..The research will have implications both for theoretical models of the relation between language and cognition and for the design of early cognitive and language intervention for children with developmental disabilities. ..
- GENOTYPE/PHENOTYPE CORRELATIONS IN WILLIAMS SYNDROMECAROLYN MERVIS; Fiscal Year: 1999..The findings of this research will be of immediate use to physicians and to practitioners who provide educational and therapeutic services to individuals with WS and their families. ..
- GENOTYPE/PHENOTYPE CORRELATIONS IN WILLIAMS SYNDROMECAROLYN MERVIS; Fiscal Year: 2009..The findings will be of immediate use to practitioners who provide educational and therapeutic services to individuals with WS and their families. ..