CAROLYN MERVIS

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc The regulatory function of social referencing in preschoolers with Down syndrome or Williams syndrome
    Angela John Thurman
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY, 40292, USA
    J Neurodev Disord 5:2. 2013
  2. pmc Longitudinal assessment of intellectual abilities of children with Williams syndrome: multilevel modeling of performance on the Kaufman Brief Intelligence Test-Second Edition
    Carolyn B Mervis
    Department of Psychology and Brain Sciences, University of Louisville, KY 40292, USA
    Am J Intellect Dev Disabil 117:134-55. 2012
  3. pmc Frequency of the 7q11.23 inversion polymorphism in transmitting parents of children with Williams syndrome and in the general population does not differ between North America and Europe
    Colleen A Morris
    Department of Pediatrics, University of Nevada School of Medicine, Las Vegas, Nevada, USA
    Mol Cytogenet 4:7. 2011
  4. ncbi request reprint Methodological issues in cross-syndrome comparisons: matching procedures, sensitivity (Se), and specificity (Sp)
    C B Mervis
    Department of Psychology, University of Louisville, KY 40292, USA
    Monogr Soc Res Child Dev 64:115-30; discussion 131-9. 1999
  5. pmc Cognitive and behavioral characteristics of children with Williams syndrome: implications for intervention approaches
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, 317 Life Sciences Building, University of Louisville, Louisville, KY 40292, USA
    Am J Med Genet C Semin Med Genet 154:229-48. 2010
  6. ncbi request reprint Methodological issues in group-matching designs: alpha levels for control variable comparisons and measurement characteristics of control and target variables
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
    J Autism Dev Disord 34:7-17. 2004
  7. pmc Vocabulary abilities of children with Williams syndrome: strengths, weaknesses, and relation to visuospatial construction ability
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
    J Speech Lang Hear Res 51:967-82. 2008
  8. ncbi request reprint Intellectual abilities and adaptive behavior of children and adolescents with Kabuki syndrome: a preliminary study
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
    Am J Med Genet A 132:248-55. 2005
  9. ncbi request reprint Attentional characteristics of infants and toddlers with Williams syndrome during triadic interactions
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
    Dev Neuropsychol 23:243-68. 2003
  10. ncbi request reprint Williams syndrome: 15 years of psychological research
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
    Dev Neuropsychol 23:1-12. 2003

Research Grants

Collaborators

Detail Information

Publications41

  1. pmc The regulatory function of social referencing in preschoolers with Down syndrome or Williams syndrome
    Angela John Thurman
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY, 40292, USA
    J Neurodev Disord 5:2. 2013
    ..abstract:..
  2. pmc Longitudinal assessment of intellectual abilities of children with Williams syndrome: multilevel modeling of performance on the Kaufman Brief Intelligence Test-Second Edition
    Carolyn B Mervis
    Department of Psychology and Brain Sciences, University of Louisville, KY 40292, USA
    Am J Intellect Dev Disabil 117:134-55. 2012
    ..Maternal education was significantly related to Verbal SS intercept. No significant sex differences were found. Implications for studies of genotype/phenotype correlations in WS are discussed...
  3. pmc Frequency of the 7q11.23 inversion polymorphism in transmitting parents of children with Williams syndrome and in the general population does not differ between North America and Europe
    Colleen A Morris
    Department of Pediatrics, University of Nevada School of Medicine, Las Vegas, Nevada, USA
    Mol Cytogenet 4:7. 2011
    ..Results indicated that Frohnauer et al.'s data are consistent with previously reported frequencies of 7q11.23 inversion in North America and Spain in both transmitting parents and the general population...
  4. ncbi request reprint Methodological issues in cross-syndrome comparisons: matching procedures, sensitivity (Se), and specificity (Sp)
    C B Mervis
    Department of Psychology, University of Louisville, KY 40292, USA
    Monogr Soc Res Child Dev 64:115-30; discussion 131-9. 1999
    ....
  5. pmc Cognitive and behavioral characteristics of children with Williams syndrome: implications for intervention approaches
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, 317 Life Sciences Building, University of Louisville, Louisville, KY 40292, USA
    Am J Med Genet C Semin Med Genet 154:229-48. 2010
    ..Finally, we briefly discuss intervention approaches that may help children with WS to achieve their full potential...
  6. ncbi request reprint Methodological issues in group-matching designs: alpha levels for control variable comparisons and measurement characteristics of control and target variables
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
    J Autism Dev Disord 34:7-17. 2004
    ....
  7. pmc Vocabulary abilities of children with Williams syndrome: strengths, weaknesses, and relation to visuospatial construction ability
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
    J Speech Lang Hear Res 51:967-82. 2008
    ..This project was designed to identify relative strengths and weaknesses in vocabulary ability for children with Williams syndrome (WS) and to demonstrate the importance of stringent matching criteria for cross-group comparisons...
  8. ncbi request reprint Intellectual abilities and adaptive behavior of children and adolescents with Kabuki syndrome: a preliminary study
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
    Am J Med Genet A 132:248-55. 2005
    ..This pattern affected adaptive behavior as well, yielding a relative strength in Social Interaction and Communicative Skills and considerable weakness in Motor Skills and Personal Living Skills...
  9. ncbi request reprint Attentional characteristics of infants and toddlers with Williams syndrome during triadic interactions
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
    Dev Neuropsychol 23:243-68. 2003
    ....
  10. ncbi request reprint Williams syndrome: 15 years of psychological research
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
    Dev Neuropsychol 23:1-12. 2003
    ..Our hope is that this issue will motivate further studies, informed by the genetic-developmental approach, on both Williams syndrome and other neurodevelopmental genetic disorders...
  11. ncbi request reprint Language and communicative development in Williams syndrome
    Carolyn B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
    Ment Retard Dev Disabil Res Rev 13:3-15. 2007
    ..We argue that rather than being the paradigm case for the independence of language from cognition, Williams syndrome provides strong evidence of the interdependence of many aspects of language and cognition...
  12. ncbi request reprint Adaptive behavior of 4- through 8-year-old children with Williams syndrome
    C B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
    Am J Ment Retard 106:82-93. 2001
    ..The children earned similar overall standard scores on the Vineland and the Differential Ability Scales. Interrelations among adaptive behavior, cognitive abilities, and personality characteristics are discussed...
  13. ncbi request reprint The Williams syndrome cognitive profile
    C B Mervis
    University of Louisville, Louisville, KY 40292, USA
    Brain Cogn 44:604-28. 2000
    ..Possible applications for the WSCP include psychoeducational evaluation and empirical research such as the search for genotype/phenotype relations in this genetically based syndrome...
  14. ncbi request reprint Expressive vocabulary ability of toddlers with Williams syndrome or Down syndrome: a comparison
    C B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
    Dev Neuropsychol 17:111-26. 2000
    ....
  15. ncbi request reprint Williams syndrome: cognition, personality, and adaptive behavior
    C B Mervis
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
    Ment Retard Dev Disabil Res Rev 6:148-58. 2000
    ..The importance of operationalizations of crucial components of the behavioral phenotype for the study of genotype/phenotype correlations in Williams syndrome is stressed. MRDD Research Reviews 2000;6:148-158...
  16. ncbi request reprint The roles of verbal short-term memory and working memory in the acquisition of grammar by children with Williams syndrome
    Byron F Robinson
    Department of Psychology, Georgia State University, Atlanta 30303, USA
    Dev Neuropsychol 23:13-31. 2003
    ..Phonological short-term memory, however, contributed independently to grammatical ability even after receptive vocabulary was taken into account...
  17. ncbi request reprint Socio-communicative deficits in young children with Williams syndrome: performance on the Autism Diagnostic Observation Schedule
    Bonita P Klein-Tasman
    Department of Psychology, University of Wisconsin Milwaukee, WI 53201, USA
    Child Neuropsychol 13:444-67. 2007
    ..Implications for our understanding of the socio-communicative abilities of young children with Williams syndrome and diagnostic practices regarding dual diagnosis are discussed...
  18. pmc Overlap with the autism spectrum in young children with Williams syndrome
    Bonita P Klein-Tasman
    Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, WI 53201, USA
    J Dev Behav Pediatr 30:289-99. 2009
    ....
  19. pmc Sensory modulation impairments in children with Williams syndrome
    Angela E John
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
    Am J Med Genet C Semin Med Genet 154:266-76. 2010
    ..Children in the high impairment group demonstrated poorer adaptive functioning, executive functioning, more problem behaviors, and more difficult temperaments than children in the low impairment group...
  20. pmc Longitudinal course of anxiety in children and adolescents with Williams syndrome
    Janet Woodruff-Borden
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
    Am J Med Genet C Semin Med Genet 154:277-90. 2010
    ..These findings are discussed in terms of persistence of anxiety over time and the need to develop and test interventions to address the high levels of anxiety experienced by children and adolescents with WS...
  21. pmc Comprehension of the communicative intent behind pointing and gazing gestures by young children with Williams syndrome or Down syndrome
    Angela E John
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
    J Speech Lang Hear Res 53:950-60. 2010
    ..In this study, the authors examined the ability of preschoolers with Williams syndrome (WS) or Down syndrome (DS) to infer communicative intent as expressed through gestures (pointing and eye-gaze shift)...
  22. pmc Referential communication skills of children with Williams syndrome: understanding when messages are not adequate
    Angela E John
    University of Louisville, Louisville, KY 40292, USA
    Am J Intellect Dev Disabil 114:85-99. 2009
    ....
  23. pmc Neuropsychological components of intellectual disability: the contributions of immediate, working, and associative memory
    Jamie O Edgin
    Department of Psychology, University of Denver, Denver, Colorado, USA
    J Intellect Disabil Res 54:406-17. 2010
    ..g. Down syndrome (DS) and Williams syndrome (WS)] allows us to test whether or not these dissociations may extend across cognitive domains, including PFC and hippocampal memory processes...
  24. pmc Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome
    Ovsanna T Leyfer
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky 40292, USA
    Am J Med Genet B Neuropsychiatr Genet 141:615-22. 2006
    ..The prevalence of Generalized Anxiety Disorder (GAD) increased significantly with age. These findings are another step toward defining the behavioral phenotype of WS...
  25. ncbi request reprint Distinctive personality characteristics of 8-, 9-, and 10-year-olds with Williams syndrome
    Bonita P Klein-Tasman
    Department of Psychology, University of Wisconsin Milwaukee, 53201, USA
    Dev Neuropsychol 23:269-90. 2003
    ..The personality profiles emerging from the CBQ and MPQ provide a crucial step toward investigations of genotype/phenotype relations...
  26. ncbi request reprint Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorder
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 111:554-63. 2003
    ....
  27. ncbi request reprint Neurobehavioral implications of habitual snoring in children
    Louise M O'Brien
    Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 114:44-9. 2004
    ..However, PS has not been well evaluated, and it is unknown whether PS is associated with serious morbidity. This study investigated whether PS is associated with neurobehavioral deficits in children...
  28. pmc Genome rearrangements detected by SNP microarrays in individuals with intellectual disability referred with possible Williams syndrome
    Ariel M Pani
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 5:e12349. 2010
    ..With the advent of microarray techniques, submicroscopic genome alterations not associated with known syndromes are emerging as a significant cause of ID and MCA...
  29. ncbi request reprint Correlates of sleep and pediatric bipolar disorder
    Rochelle C Mehl
    Department of Pediatrics, Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, University of Louisville, KY 40202, USA
    Sleep 29:193-7. 2006
    ..To determine, based on a large community sample, the prevalence and associated sleep characteristics of children with a bipolar mood disturbance behavioral profile...
  30. ncbi request reprint What are theories for? Concept use throughout the continuum of dinosaur expertise
    Kathy E Johnson
    Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    J Exp Child Psychol 87:171-200. 2004
    ..The interaction of specific concept knowledge with broader framework theories of biology throughout the continuum of expertise is considered...
  31. ncbi request reprint GTF2I hemizygosity implicated in mental retardation in Williams syndrome: genotype-phenotype analysis of five families with deletions in the Williams syndrome region
    Colleen A Morris
    Department of Pediatrics, Division of Genetics, University of Nevada School of Medicine, Las Vegas, Nevada 89102, USA
    Am J Med Genet A 123:45-59. 2003
    ..Comparison of these five families with reports of other individuals with partial deletions of the WS region most strongly implicates GTF2I in the mental retardation of WS...
  32. ncbi request reprint Neural basis of genetically determined visuospatial construction deficit in Williams syndrome
    Andreas Meyer-Lindenberg
    Unit on Integrative Neuroimaging, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 4C101, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neuron 43:623-31. 2004
    ....
  33. ncbi request reprint Neural correlates of genetically abnormal social cognition in Williams syndrome
    Andreas Meyer-Lindenberg
    Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Neurosci 8:991-3. 2005
    ..Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior...
  34. pmc Functional, structural, and metabolic abnormalities of the hippocampal formation in Williams syndrome
    Andreas Meyer-Lindenberg
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, NIH, Department of Health and Human Services, Bethesda, MD 20892 1365, USA
    J Clin Invest 115:1888-95. 2005
    ..These data demonstrate abnormalities in HF in WS in agreement with murine models, implicate LIMK1 and CYLN2 in human hippocampal function, and suggest that hippocampal dysfunction may contribute to neurocognitive abnormalities in WS...
  35. ncbi request reprint Neurobehavioral correlates of sleep-disordered breathing in children
    Louise M O'Brien
    Department of Pediatrics, Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Universtiy of Louisville, KY 40202, USA
    J Sleep Res 13:165-72. 2004
    ..Furthermore, total arousal index was negatively correlated with neurocognitive abilities, suggesting a role for sleep fragmentation in pediatric SDB-induced cognitive dysfunction...
  36. ncbi request reprint Genetic contributions to human gyrification: sulcal morphometry in Williams syndrome
    J Shane Kippenhan
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 25:7840-6. 2005
    ....
  37. pmc The common inversion of the Williams-Beuren syndrome region at 7q11.23 does not cause clinical symptoms
    Elaine Tam
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 146:1797-806. 2008
    ..Whole genome analysis may reveal previously unidentified copy number variants that could contribute to syndromic features...
  38. pmc Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome
    Stefano Marenco
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:15117-22. 2007
    ....
  39. pmc Rearrangements of the Williams-Beuren syndrome locus: molecular basis and implications for speech and language development
    Lucy R Osborne
    Department of Medicine, University of Toronto, Ontario, Canada
    Expert Rev Mol Med 9:1-16. 2007
    ..The spectrum and frequency of genomic rearrangements at 7q11.23 presents an exceptional opportunity to identify gene(s) directly involved in human speech and language development...
  40. ncbi request reprint Heat shock protein 27 gene: chromosomal and molecular location and relationship to Williams syndrome
    A Dean Stock
    Department of Pediatrics, Division of Genetics, Laboratory of Molecular Cytogenetics, University of Nevada School of Medicine, Las Vegas 89102, USA
    Am J Med Genet A 120:320-5. 2003
    ..B363M4 was demonstrated to overlap the telomeric end of B161A02 and HSP27 may be contained partially within the telomeric end of B161A02. The possible role of HSP27 in the cognitive features of WS is discussed...
  41. ncbi request reprint Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviour
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, National Institute of Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
    Nat Rev Neurosci 7:380-93. 2006
    ....

Research Grants18

  1. Early Development with Williams or Down Syndrome
    CAROLYN MERVIS; Fiscal Year: 2007
    ..The research will have implications both for theoretical models of the relations between language and cognition and for the design of cognitive and language intervention strategies for children with developmental disabilities. ..
  2. GENOTYPE/PHENOTYPE CORRELATIONS IN WILLIAMS SYNDROME
    CAROLYN MERVIS; Fiscal Year: 2004
    ..An initial specific goal is to identify genes responsible for the personality characteristics of WS as well as other specific phenotype features. ..
  3. EARLY DEVELOPMENT: WILLIAMS OR DOWN SYNDROME CHILDREN
    CAROLYN MERVIS; Fiscal Year: 2003
    ..The research will have implications both for theoretical models of the relation between language and cognition and for the design of early cognitive and language intervention for children with developmental disabilities. ..
  4. GENOTYPE/PHENOTYPE CORRELATIONS IN WILLIAMS SYNDROME
    CAROLYN MERVIS; Fiscal Year: 1999
    ..The findings of this research will be of immediate use to physicians and to practitioners who provide educational and therapeutic services to individuals with WS and their families. ..
  5. GENOTYPE/PHENOTYPE CORRELATIONS IN WILLIAMS SYNDROME
    CAROLYN MERVIS; Fiscal Year: 2009
    ..The findings will be of immediate use to practitioners who provide educational and therapeutic services to individuals with WS and their families. ..