Matthew Merritt

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP
    Lloyd Lumata
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Phys Chem Chem Phys 15:9800-7. 2013
  2. pmc Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR
    Matthew E Merritt
    Advanced Imaging Research Center, Department of Radiology, and Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:19773-7. 2007
  3. ncbi request reprint Adiabatic JHSQC for 13C isotopomer analysis
    Matthew E Merritt
    University of Texas Southwestern Medical Center, Advanced Imaging Research Center, 2201 Inwood Road, NE 4 204, Dallas, TX 775390 8568, USA
    Magn Reson Chem 44:463-6. 2006
  4. pmc Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-
    Matthew E Merritt
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 60:1029-36. 2008
  5. pmc Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance
    Matthew E Merritt
    Advanced Imaging Research Center, Department of Molecular Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
    Proc Natl Acad Sci U S A 108:19084-9. 2011
  6. pmc Dipolar cross-relaxation modulates signal amplitudes in the (1)H NMR spectrum of hyperpolarized [(13)C]formate
    Matthew E Merritt
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
    J Magn Reson 189:280-5. 2007
  7. ncbi request reprint Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra
    Matthew Merritt
    Department of Radiology, The Mary Nell and Ralph B Rogers Magnetic Resonance Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 50:659-63. 2003
  8. pmc Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR
    Natasha Hausler
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Biochem J 394:465-73. 2006
  9. ncbi request reprint Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    J Biol Chem 279:48941-9. 2004
  10. ncbi request reprint Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Anal Biochem 327:149-55. 2004

Collaborators

  • A Dean Sherry
  • Craig R Malloy
  • Shawn Burgess
  • Timothy D Spitzer
  • John G Jones
  • Eunsook S Jin
  • Jeffrey D Browning
  • R P Mason
  • Vikram D Kodibagkar
  • Hindrik Mulder
  • Steven Kliewer
  • Claudia Silva
  • Krista L Moulder
  • Lloyd Lumata
  • David H Rosenbaum
  • Zoltan Kovacs
  • Crystal Harrison
  • Ashish K Jindal
  • Karlos X Moreno
  • Santhosh Satapati
  • Michael E Jessen
  • Matthias Peltz
  • Ana C Mendes
  • Joseph E Ippolito
  • Kimberly A Stowe
  • Natasha Hausler
  • Donald E Woessner
  • Quan Zheng
  • Shanrong Zhang
  • Brian C Weis
  • F Caseiro Alves
  • Likai Song
  • Lu Yu
  • Stephen Hill
  • Johan van Tol
  • M A Hooshyar
  • Ralph J DeBerardinis
  • Chendong Yang
  • Ashish Jindal
  • A Dean Sherry
  • Scott M Sabelhaus
  • Eul Hyun Suh
  • Matthew Potthoff
  • TianTeng He
  • W Steves Ring
  • Michael A Wait
  • David J Mangelsdorf
  • Takeshi Inagaki
  • Victoria Esser
  • J Michael Dimaio
  • Dan M Meyer
  • Jeffrey E Thatcher
  • Hideki Sasaki
  • Seth T Gammon
  • David Piwnica-Worms
  • M Madalena Caldeira
  • Pedro Monteiro
  • Angela Milde
  • Charles Storey
  • Fatima Franco
  • Filipe Gomes
  • Jeffrey I Gordon
  • F Mark H Jeffrey
  • Teresa C Delgado
  • Cristina Barosa
  • Steven Mennerick
  • Fredrik Backhed
  • Jill K Manchester
  • Luis Providencia
  • Cai Yuan Pan
  • Houquan Dai
  • Wen Hong Li
  • Holly Wise
  • David Margolis
  • Robert E Lenkinski
  • John V Frangioni
  • Angelo Josue M Lubag
  • Paulo Donato
  • A C Santos
  • Atif Zaheer
  • Maria Neves
  • Carlos F G C Geraldes
  • João J P de Lima
  • M Isabel M Prata

Detail Information

Publications31

  1. pmc Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP
    Lloyd Lumata
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Phys Chem Chem Phys 15:9800-7. 2013
    ..5 GHz to 95 GHz, but becomes faster at 240 GHz and 336 GHz. The ESR properties of trityl OX063 reported here may provide insights into the efficiency of DNP of low-γ nuclei performed at various magnetic fields, from 0.35 T to 12 T...
  2. pmc Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR
    Matthew E Merritt
    Advanced Imaging Research Center, Department of Radiology, and Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:19773-7. 2007
    ..Thus, the rate of appearance of (13)CO(2) and H(13)CO(3)(-) from [1-(13)C(1)]pyruvate does not reflect production of CO(2) in the TCA cycle but rather reflects flux through pyruvate dehydrogenase exclusively...
  3. ncbi request reprint Adiabatic JHSQC for 13C isotopomer analysis
    Matthew E Merritt
    University of Texas Southwestern Medical Center, Advanced Imaging Research Center, 2201 Inwood Road, NE 4 204, Dallas, TX 775390 8568, USA
    Magn Reson Chem 44:463-6. 2006
    ..This new experiment allows the sensitivity gains from inverse detection to be realized in a time-efficient manner for the experimentalist...
  4. pmc Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-
    Matthew E Merritt
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 60:1029-36. 2008
    ..Using this multinuclear NMR approach, we established that during the first 90 s of reperfusion PDH flux is essentially zero and recovers within 20 min in reversibly-injured myocardium...
  5. pmc Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance
    Matthew E Merritt
    Advanced Imaging Research Center, Department of Molecular Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
    Proc Natl Acad Sci U S A 108:19084-9. 2011
    ..We conclude that MR detection of hyperpolarized TCA intermediates and bicarbonate is diagnostic of pyruvate carboxylase and PEPCK flux in the liver...
  6. pmc Dipolar cross-relaxation modulates signal amplitudes in the (1)H NMR spectrum of hyperpolarized [(13)C]formate
    Matthew E Merritt
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
    J Magn Reson 189:280-5. 2007
    ..The Solomon equations were used to model the proton signal as a function of time after polarization and to estimate (13)C polarization from the (1)H NMR spectra...
  7. ncbi request reprint Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra
    Matthew Merritt
    Department of Radiology, The Mary Nell and Ralph B Rogers Magnetic Resonance Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 50:659-63. 2003
    ..The combined MCMC Bayesian methodology is operationally simple and requires little intervention from the operator...
  8. pmc Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR
    Natasha Hausler
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Biochem J 394:465-73. 2006
    ..The tight correlation of these two pathways under multiple conditions suggest that interventions which increase or decrease hepatic tricarboxylic-acid-cycle flux will have a concomitant effect on gluconeogenesis and vice versa...
  9. ncbi request reprint Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    J Biol Chem 279:48941-9. 2004
    ..Inhibition of the TCA cycle and fatty acid oxidation due to increased TCA cycle intermediate concentrations and reduced mitochondrial red-ox state lead to the development of steatosis...
  10. ncbi request reprint Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Anal Biochem 327:149-55. 2004
    ..6), and TCA cycle flux (49.1+/-16.8). In a separate group of rats, glucose production was not different in the absence of (2)H(2)O and [U-(13)C]propionate, demonstrating that these tracers do not alter the measurement of glucose turnover...
  11. ncbi request reprint Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy
    Brian C Weis
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 51:649-54. 2004
    ..42 +/- 0.12 (P < 0.05) among subjects with lipoatrophy, and the TCA cycle contribution was reduced. Lipoatrophy was associated with an abnormal profile of glucose production as assessed by (13)C and (2)H NMR of plasma and urine...
  12. pmc The effect of 13C enrichment in the glassing matrix on dynamic nuclear polarization of [1-13C]pyruvate
    Lloyd Lumata
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Phys Med Biol 56:N85-92. 2011
    ..This indicates that (13)C-(13)C spin diffusion is a limiting factor in the kinetics of DNP in this system, but it has a minimal effect on the absolute value of polarization achievable for the target...
  13. pmc Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13 C NMR
    Crystal Harrison
    Department of Physics, University of Texas at Dallas, Richardson, TX 75390, USA
    NMR Biomed 25:1286-94. 2012
    ..The three-pool model was necessary to fit the combined data from both MS and HP, but the simpler two-pool exchange model was sufficient to determine the (13) C lactate concentration when the lactate appearance was measured only by HP...
  14. ncbi request reprint Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy
    Kimberly A Stowe
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    FEBS Lett 580:4282-7. 2006
    ..24 micromol/g dry wt/min, similar to the rate of oxidation of long-chain fatty acids, 0.16 micromol/g dry wt/min. Isoproterenol decreased the rate of de novo triglyceride synthesis and increased the rate of fatty acid oxidation...
  15. pmc Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism
    Santhosh Satapati
    The Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diabetes 57:2012-21. 2008
    ..The purpose of this study is to determine whether abnormal mitochondrial metabolism plays a role in the dysregulation of both hepatic fat and glucose metabolism during diabetes...
  16. pmc Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction
    Jeffrey D Browning
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, TX, USA
    Hepatology 48:1487-96. 2008
    ..However, the relationship between these two pathways is modified by carbohydrate restriction, suggesting an increased reliance of the hepatocyte on energy generated outside of the TCA cycle when GNG(PEP) is maximal...
  17. ncbi request reprint Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance
    Eunsook S Jin
    Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 53:1479-83. 2005
    ....
  18. ncbi request reprint Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Am J Physiol Endocrinol Metab 288:E654-62. 2005
    ..The differing mechanisms of excess glucose production in these models were easily distinguished by integrated 2H and 13C NMR analysis of plasma glucose...
  19. ncbi request reprint Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting
    Shawn C Burgess
    Mary Nell and Ralph B Rogers Magnetic Resonance Center, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
    Am J Physiol Endocrinol Metab 289:E53-61. 2005
    ..The techniques used here are amenable to use as a secondary or tertiary tool for studying mouse models with disruptions of intermediary metabolism...
  20. ncbi request reprint Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas 75235 9085, USA
    Anal Biochem 312:228-34. 2003
    ..The method should find use in metabolic studies of infants and other populations where blood sampling is either limited or problematic...
  21. pmc Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate
    Karlos X Moreno
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Am J Physiol Heart Circ Physiol 298:H1556-64. 2010
    ..In conclusion, studies of cardiac metabolism using hyperpolarized [1-(13)C]pyruvate are sensitive to the effects of competing substrates on pyruvate oxidation...
  22. ncbi request reprint Novel 1H NMR approach to quantitative tissue oximetry using hexamethyldisiloxane
    Vikram D Kodibagkar
    Cancer Imaging Program, Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9058, USA
    Magn Reson Med 55:743-8. 2006
    ..In tumors, altering the inspired gas also produced significant (albeit generally smaller) changes. This new pO2 reporter molecule offers a potentially valuable new tool for investigating pO2 in vivo...
  23. doi request reprint Perfusion preservation versus static preservation for cardiac transplantation: effects on myocardial function and metabolism
    David H Rosenbaum
    Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8879, USA
    J Heart Lung Transplant 27:93-9. 2008
    ..Continuous perfusion of donor hearts for transplantation has received increasing interest, but the effects on cellular metabolism, myocyte necrosis, and myocardial edema are not well defined...
  24. pmc Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance
    Matthew E Merritt
    Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8568, USA
    J Am Chem Soc 129:12942-3. 2007
  25. ncbi request reprint Benefits of perfusion preservation in canine hearts stored for short intervals
    David H Rosenbaum
    Department of Cardiovascular and Thoracic Surgery and the Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8879, USA
    J Surg Res 140:243-9. 2007
    ..Continuous perfusion of donor hearts for transplantation has been proposed to improve graft function or extend preservation intervals, but the effects on cellular metabolism, myocyte loss, and myocardial edema are not well-defined...
  26. ncbi request reprint Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI
    Donald E Woessner
    Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 53:790-9. 2005
    ....
  27. pmc Hyperpolarized 89Y complexes as pH sensitive NMR probes
    Ashish K Jindal
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    J Am Chem Soc 132:1784-5. 2010
    ..Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH...
  28. ncbi request reprint A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications
    Quan Zheng
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Am Chem Soc 127:16178-88. 2005
    ..The combined advantages of this new class of macrocyclic contrast agents ensure future imaging applications to track cell movement and localization in different biological systems...
  29. ncbi request reprint Hepatic UDP-glucose 13C isotopomers from [U-13C]glucose: a simple analysis by 13C NMR of urinary menthol glucuronide
    Ana C Mendes
    Department of Chemistry, University of Coimbra, Coimbra, Portugal
    Magn Reson Med 56:1121-5. 2006
    ..9% +/- 0.2%. From these data, flux of plasma glucose to hepatic UDPG was estimated to be 15% +/- 4% that of endogenous glucose production (EGP), and the Cori cycle accounted for at least 32% +/- 10% of GP...
  30. ncbi request reprint Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite binding
    F Caseiro Alves
    Department of Radiology, Faculty of Medicine and Hospital Service of Imageology, University of Coimbra, Coimbra, Portugal
    Invest Radiol 38:750-60. 2003
    ..To date, its pharmacokinetics, effects on organ relaxivity, and interaction with hydroxyapatite (HA) has not been described...
  31. pmc Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers
    Joseph E Ippolito
    Center for Genome Sciences, Washington University, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 103:12505-10. 2006
    ....