Ethan Merritt

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. Merritt E. To B or not to B: a question of resolution?. Acta Crystallogr D Biol Crystallogr. 2012;68:468-77 pubmed publisher
    ....
  2. Merritt E, Kuhn P, Sarfaty S, Erbe J, Holmes R, Hol W. The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site. J Mol Biol. 1998;282:1043-59 pubmed publisher
    ....
  3. Merritt E, Arakaki T, Gillespie R, Napuli A, Kim J, Buckner F, et al. Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol Biochem Parasitol. 2011;177:20-8 pubmed publisher
    ..Together with a previously reported structure of an unusual TrpRS from Giardia, these protozoan structures broaden our perspective on the extent of structural variation found in eukaryotic TrpRS homologs...
  4. Merritt E, Arakaki T, Larson E, Kelley A, Mueller N, Napuli A, et al. Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Mol Biochem Parasitol. 2010;169:95-100 pubmed publisher
    ..The E. histolytica AspRS structure shows a well-ordered N-terminus that contributes to the AspRS dimer interface. ..
  5. Merritt E, Arakaki T, Gillespie J, Larson E, Kelley A, Mueller N, et al. Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J Mol Biol. 2010;397:481-94 pubmed publisher
    ..The essentiality of the single HisRS gene in T. brucei is shown by a severe depression of parasite growth rate that results from even partial suppression of expression by RNA interference...

Detail Information

Publications5

  1. Merritt E. To B or not to B: a question of resolution?. Acta Crystallogr D Biol Crystallogr. 2012;68:468-77 pubmed publisher
    ....
  2. Merritt E, Kuhn P, Sarfaty S, Erbe J, Holmes R, Hol W. The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site. J Mol Biol. 1998;282:1043-59 pubmed publisher
    ....
  3. Merritt E, Arakaki T, Gillespie R, Napuli A, Kim J, Buckner F, et al. Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol Biochem Parasitol. 2011;177:20-8 pubmed publisher
    ..Together with a previously reported structure of an unusual TrpRS from Giardia, these protozoan structures broaden our perspective on the extent of structural variation found in eukaryotic TrpRS homologs...
  4. Merritt E, Arakaki T, Larson E, Kelley A, Mueller N, Napuli A, et al. Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Mol Biochem Parasitol. 2010;169:95-100 pubmed publisher
    ..The E. histolytica AspRS structure shows a well-ordered N-terminus that contributes to the AspRS dimer interface. ..
  5. Merritt E, Arakaki T, Gillespie J, Larson E, Kelley A, Mueller N, et al. Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J Mol Biol. 2010;397:481-94 pubmed publisher
    ..The essentiality of the single HisRS gene in T. brucei is shown by a severe depression of parasite growth rate that results from even partial suppression of expression by RNA interference...