Matthew J Merrins
Affiliation: University of Michigan
- Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle traffickingMatthew D'Andrea-Merrins
Department of Molecular and Integrative Physiology, Life Sciences Institute, University of Michigan, Ann Arbor 48109 0622, USA
J Biol Chem 282:16553-66. 2007..Therefore, in contradiction to previous models, our data indicates that the conformational "opening" of syntaxin 4 rather than the dissociation of Munc18c is the critical event required for GLUT4 vesicle docking...
- Phosphofructo-2-kinase/fructose-2,6-bisphosphatase modulates oscillations of pancreatic islet metabolismMatthew J Merrins
Department of Pharmacology and Brehm Diabetes Center, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 7:e34036. 2012....
- Metabolic oscillations in pancreatic islets depend on the intracellular Ca2+ level but not Ca2+ oscillationsMatthew J Merrins
Department of Pharmacology and Brehm Diabetes Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
Biophys J 99:76-84. 2010....
- Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic beta-cellsMatthew J Merrins
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 0622, USA
J Physiol 586:5367-81. 2008..In summary, Rab27a exerts dual roles in glucose-mediated insulin granule exocytosis, facilitating refilling of releasable granule pools while also limiting the rate of release from these pools...