PAUL MERMELSTEIN

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Corticotropin releasing factor-induced CREB activation in striatal neurons occurs via a novel Gβγ signaling pathway
    Christopher M Stern
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 6:e18114. 2011
  2. pmc Estrogen receptors stimulate brain region specific metabotropic glutamate receptors to rapidly initiate signal transduction pathways
    John Meitzen
    Dept of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    J Chem Neuroanat 42:236-41. 2011
  3. pmc Nervous system physiology regulated by membrane estrogen receptors
    Paul G Mermelstein
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Rev Neurosci 19:413-24. 2008
  4. pmc Membrane-localised oestrogen receptor alpha and beta influence neuronal activity through activation of metabotropic glutamate receptors
    P G Mermelstein
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    J Neuroendocrinol 21:257-62. 2009
  5. ncbi request reprint Calcitonin gene-related peptide regulates expression of neurokinin1 receptors by rat spinal neurons
    Virginia S Seybold
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 23:1816-24. 2003
  6. ncbi request reprint Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element-binding protein
    Marissa I Boulware
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 25:5066-78. 2005
  7. ncbi request reprint Interactions with PDZ proteins are required for L-type calcium channels to activate cAMP response element-binding protein-dependent gene expression
    Jason P Weick
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 23:3446-56. 2003
  8. pmc Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology
    Marissa I Boulware
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, United States
    Steroids 74:608-13. 2009
  9. ncbi request reprint Caveolin proteins are essential for distinct effects of membrane estrogen receptors in neurons
    Marissa I Boulware
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:9941-50. 2007
  10. ncbi request reprint Neurotrophin activation of NFAT-dependent transcription contributes to the regulation of pro-nociceptive genes
    Rachel D Groth
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurochem 102:1162-74. 2007

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc Corticotropin releasing factor-induced CREB activation in striatal neurons occurs via a novel Gβγ signaling pathway
    Christopher M Stern
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 6:e18114. 2011
    ..Additionally, these data provide additional insight into the mechanisms by which CRF can regulate neuronal function...
  2. pmc Estrogen receptors stimulate brain region specific metabotropic glutamate receptors to rapidly initiate signal transduction pathways
    John Meitzen
    Dept of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    J Chem Neuroanat 42:236-41. 2011
    ..It is becoming clear that ER signaling through mGluRs is one important mechanism by which estrogens can modulate neuron and glial physiology, ultimately impacting various aspects of nervous system function...
  3. pmc Nervous system physiology regulated by membrane estrogen receptors
    Paul G Mermelstein
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Rev Neurosci 19:413-24. 2008
    ..This ER/mGluR hypothesis explains how estradiol can activate a wide-range of intracellular pathways and provides an underlying mechanism for the hitherto seemingly unrelated rapid membrane actions in the nervous system...
  4. pmc Membrane-localised oestrogen receptor alpha and beta influence neuronal activity through activation of metabotropic glutamate receptors
    P G Mermelstein
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    J Neuroendocrinol 21:257-62. 2009
    ..ER/mGluR signalling is a potential means by which oestrogens can both rapidly and for extended periods, influence a variety of intracellular signalling processes and behaviours...
  5. ncbi request reprint Calcitonin gene-related peptide regulates expression of neurokinin1 receptors by rat spinal neurons
    Virginia S Seybold
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 23:1816-24. 2003
    ..The data provide evidence that a neuropeptide receptor controls gene expression in the CNS and add another dimension to understanding the cotransmission of substance P and CGRP by primary afferent neurons...
  6. ncbi request reprint Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element-binding protein
    Marissa I Boulware
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 25:5066-78. 2005
    ....
  7. ncbi request reprint Interactions with PDZ proteins are required for L-type calcium channels to activate cAMP response element-binding protein-dependent gene expression
    Jason P Weick
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 23:3446-56. 2003
    ..Collectively, these data suggest that localized calcium responses, regulated by interactions with PDZ domain proteins, are necessary for L-type calcium channels to effectively activate CREB and CRE-mediated gene expression...
  8. pmc Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology
    Marissa I Boulware
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, United States
    Steroids 74:608-13. 2009
    ..The review will conclude with several examples of physiological processes under the apparent regulation of ER/mGluR signaling...
  9. ncbi request reprint Caveolin proteins are essential for distinct effects of membrane estrogen receptors in neurons
    Marissa I Boulware
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:9941-50. 2007
    ..In addition, the functional isolation of distinct estrogen-sensitive signaling pathways by different caveolin proteins suggests novel mechanisms through which the membrane-initiated effects of estradiol are orchestrated...
  10. ncbi request reprint Neurotrophin activation of NFAT-dependent transcription contributes to the regulation of pro-nociceptive genes
    Rachel D Groth
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurochem 102:1162-74. 2007
    ..Our results suggest that regulation of pro-nociceptive genes through activation of NFAT-dependent transcription is one mechanism by which NGF and BDNF signaling contributes to the development of persistent pain states...
  11. ncbi request reprint Calcineurin regulation of neuronal plasticity
    Rachel D Groth
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 311:1159-71. 2003
    ..Intriguingly, due to the bi-directional influences of Ca(2+) and calmodulin on calcineurin activity, the strength and duration of particular stimulations may cause apparently antagonistic functions of calcineurin to work in concert...
  12. pmc Caveolin regulation of neuronal intracellular signaling
    Christopher M Stern
    Department of Neuroscience, University of Minnesota, Minneapolis, 5455, USA
    Cell Mol Life Sci 67:3785-95. 2010
    ..Through both protein aggregation and segregation, caveolin proteins can exert positive and negative influences on intracellular signaling. This review will detail recent findings regarding caveolin function in the brain...
  13. pmc Caveolin proteins and estrogen signaling in the brain
    Jessie I Luoma
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church Street S E, Minneapolis, MN 55455, USA
    Mol Cell Endocrinol 290:8-13. 2008
    ....

Research Grants14

  1. L-type calcium channel regulation of gene expression
    PAUL MERMELSTEIN; Fiscal Year: 2001
    ....
  2. Novel Actions of Estradiol that Influence Brain Function
    Paul G Mermelstein; Fiscal Year: 2010
    ..abstract_text> ..
  3. Novel Actions of Estradiol that Influence Brain Function
    PAUL MERMELSTEIN; Fiscal Year: 2009
    ..abstract_text> ..
  4. NFAT-mediated gene expression and striatal plasticity
    PAUL MERMELSTEIN; Fiscal Year: 2007
    ..Ultimately, this project will lead to a better understanding of the role NFAT-dependent transcription plays in shaping long-term changes in brain function. ..
  5. Novel Actions of Estradiol that Influence Brain Function
    PAUL MERMELSTEIN; Fiscal Year: 2007
    ..It will potentially provide a unifying theory detailing a principal mechanism by which estradiol can rapidly trigger changes in cell excitability and ultimately lead to a better understanding of how estradiol modulates brain function. ..
  6. NFAT-mediated gene expression and striatal plasticity
    PAUL MERMELSTEIN; Fiscal Year: 2006
    ..Ultimately, this project will lead to a better understanding of the role NFAT-dependent transcription plays in shaping long-term changes in brain function. ..
  7. Novel Actions of Estradiol that Influence Brain Function
    PAUL MERMELSTEIN; Fiscal Year: 2006
    ..It will potentially provide a unifying theory detailing a principal mechanism by which estradiol can rapidly trigger changes in cell excitability and ultimately lead to a better understanding of how estradiol modulates brain function. ..
  8. NFAT-mediated gene expression and striatal plasticity
    PAUL MERMELSTEIN; Fiscal Year: 2005
    ..Ultimately, this project will lead to a better understanding of the role NFAT-dependent transcription plays in shaping long-term changes in brain function. ..
  9. L-type calcium channel regulation of gene expression
    PAUL MERMELSTEIN; Fiscal Year: 2004
    ....
  10. L-type calcium channel regulation of gene expression
    PAUL MERMELSTEIN; Fiscal Year: 2003
    ....
  11. L-type calcium channel regulation of gene expression
    PAUL MERMELSTEIN; Fiscal Year: 2002
    ....
  12. Novel Actions of Estradiol that Influence Brain Function
    PAUL MERMELSTEIN; Fiscal Year: 2009
    ..abstract_text> ..