Stephen Meredith

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins
    Stephen C Meredith
    Department of Pathology, University of Chicago, 5841 S Maryland Avenue, MC 6079, Chicago IL 60637, USA
    Ann N Y Acad Sci 1066:181-221. 2005
  2. ncbi request reprint A mutant chaperone converts a wild-type protein into a tumor-specific antigen
    Andrea Schietinger
    Department of Pathology, Committee on Immunology, Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA
    Science 314:304-8. 2006
  3. ncbi request reprint Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells
    Michael T Spiotto
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 17:737-47. 2002
  4. ncbi request reprint Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions
    David J Gordon
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Biochemistry 42:475-85. 2003
  5. ncbi request reprint Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors
    Karin Schreiber
    Department of Pathology, The University of Chicago, 5841 S Maryland Ave, MC 3008, Chicago, IL 60637, USA
    Oncogene 23:3972-9. 2004
  6. ncbi request reprint Site-specific effects of peptide lipidation on beta-amyloid aggregation and cytotoxicity
    Isam M Qahwash
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:36987-97. 2007
  7. ncbi request reprint Peptide-based inhibitors of amyloid assembly
    Kimberly L Sciarretta
    The University of Chicago, Department of Pathology, Chicago, IL, USA
    Methods Enzymol 413:273-312. 2006
  8. ncbi request reprint Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution
    Erica J Reschly
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 277:9645-54. 2002
  9. pmc Mechanism of cis-inhibition of polyQ fibrillation by polyP: PPII oligomers and the hydrophobic effect
    Gregory D Darnell
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA
    Biophys J 97:2295-305. 2009
  10. doi request reprint Versatile cyclic templates for assembly of axially oriented ligands
    Neeraj Chopra
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    Bioconjug Chem 20:231-40. 2009

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins
    Stephen C Meredith
    Department of Pathology, University of Chicago, 5841 S Maryland Avenue, MC 6079, Chicago IL 60637, USA
    Ann N Y Acad Sci 1066:181-221. 2005
    ....
  2. ncbi request reprint A mutant chaperone converts a wild-type protein into a tumor-specific antigen
    Andrea Schietinger
    Department of Pathology, Committee on Immunology, Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA
    Science 314:304-8. 2006
    ..This epitope induced a high-affinity, highly specific, syngeneic monoclonal antibody with antitumor activity. Such tumor-specific glycopeptidic neo-epitopes represent potential targets for monoclonal antibody therapy...
  3. ncbi request reprint Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells
    Michael T Spiotto
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 17:737-47. 2002
    ..Thus, tumor antigens expressed at levels sufficient for crosspresentation by bone marrow-derived stromal cells may overcome immunological "ignorance" to solid tumors...
  4. ncbi request reprint Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions
    David J Gordon
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Biochemistry 42:475-85. 2003
    ..Abeta16-20e also inhibits the aggregation of the Abeta1-40 peptide and disassembles preformed Abeta1-40 fibrils. These results suggest that backbone hydrogen bonding is critical for the assembly of amyloid fibrils...
  5. ncbi request reprint Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors
    Karin Schreiber
    Department of Pathology, The University of Chicago, 5841 S Maryland Ave, MC 3008, Chicago, IL 60637, USA
    Oncogene 23:3972-9. 2004
    ..Thus, a remarkable synergy occurred between the v-Ha-ras and HPV16 E6/E7 oncogenes in the development of primary tumors in mice...
  6. ncbi request reprint Site-specific effects of peptide lipidation on beta-amyloid aggregation and cytotoxicity
    Isam M Qahwash
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:36987-97. 2007
    ..The greater cytotoxicity of K16-OA-Abeta and K28-OA-Abeta may reflect their greater amphiphilicity. We conclude that lipidation can make Abeta more prone to aggregation and more cytotoxic, but these effects are highly site-specific...
  7. ncbi request reprint Peptide-based inhibitors of amyloid assembly
    Kimberly L Sciarretta
    The University of Chicago, Department of Pathology, Chicago, IL, USA
    Methods Enzymol 413:273-312. 2006
    ..Finally, we consider potential applications of inhibitor peptides to therapeutic strategies...
  8. ncbi request reprint Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution
    Erica J Reschly
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 277:9645-54. 2002
    ..Human apoA-I self-associates more and activates human lecithin-cholesterol acyltransferase better than mouse apoA-I. These differential characteristics of human and mouse apoA-I are not dependent on helices 7/8...
  9. pmc Mechanism of cis-inhibition of polyQ fibrillation by polyP: PPII oligomers and the hydrophobic effect
    Gregory D Darnell
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA
    Biophys J 97:2295-305. 2009
    ..The conformational adaptability of the polyQ segment permits the cis-inhibitory effect of polyP segments on fibrillation by the polyQ segments in proteins such as huntingtin...
  10. doi request reprint Versatile cyclic templates for assembly of axially oriented ligands
    Neeraj Chopra
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    Bioconjug Chem 20:231-40. 2009
    ....
  11. pmc The specific amino acid sequence between helices 7 and 8 influences the binding specificity of human apolipoprotein A-I for high density lipoprotein (HDL) subclasses: a potential for HDL preferential generation
    Ronald Carnemolla
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:15779-88. 2008
    ..The expression of these mutants in mice may result in the preferential generation of HDL(2) or HDL(3) and allow us to examine experimentally the anti-atherogenicity of the HDL subclasses...
  12. ncbi request reprint Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure
    Gregory Darnell
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA
    J Mol Biol 374:688-704. 2007
    ..These structural observations may shed light on the threshold phenomenon of poly(Q) aggregation, and support the hypothesized evolution of "protective" poly(P) tracts adjacent to poly(Q) aggregation domains...
  13. ncbi request reprint Helix-turn-helix peptides that form alpha-helical fibrils: turn sequences drive fibril structure
    Kristi L Lazar
    Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA
    Biochemistry 44:12681-9. 2005
    ..These studies indicate that varying turn sequences between longer amphiphilic alpha-helical segments can drive the structure of fibrils...
  14. ncbi request reprint Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid
    Kimberly L Sciarretta
    Departments of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Biochemistry 44:6003-14. 2005
    ..Consistent with this view Abeta(1)(-)(40) growth is efficiently nucleated by Abeta(1)(-)(40)-Lactam(D23/K28) fibril seeds...
  15. ncbi request reprint Spatial separation of beta-sheet domains of beta-amyloid: disruption of each beta-sheet by N-methyl amino acids
    Kimberly L Sciarretta
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Biochemistry 45:9485-95. 2006
    ....
  16. ncbi request reprint Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE
    Hookang Im
    Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:25453-63. 2007
    ..Together, our results highlight the importance of the closed conformation for regulating the activity of IDE and provide new molecular details that will facilitate the development of activators and inhibitors of IDE...
  17. ncbi request reprint Encapsulation and NMR on an aggregating peptide before fibrillogenesis
    Kristi L Lazar
    Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA
    J Am Chem Soc 128:16460-1. 2006
    ....
  18. pmc Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallel
    David J Gordon
    Department of Biochemistry, The University of Chicago, Chicago, Illinois 60637, USA
    Biophys J 86:428-34. 2004
    ..This work also shows that all amyloid fibrils do not share a common supramolecular structure, and suggests a method for controlling the structure of amyloid fibrils...
  19. pmc High-resolution structure of a self-assembly-competent form of a hydrophobic peptide captured in a soluble beta-sheet scaffold
    Koki Makabe
    Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E 57th Street, Chicago, IL 60637, USA
    J Mol Biol 378:459-67. 2008
    ..The ability of the PSAM to "solubilize" an otherwise insoluble peptide stretch suggests the potential of the PSAM approach to the characterization of self-assembling peptides...
  20. pmc Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance
    John J Balbach
    Laboratory of Chemical Physics, The National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, Maryland 20892 0520 USA
    Biophys J 83:1205-16. 2002
    ..These results place strong constraints on any molecular-level structural model for full-length beta-amyloid fibrils...

Research Grants7

  1. N-Methyl and Other Peptide Inhibitors of Fibrillogenesis
    Stephen Meredith; Fiscal Year: 2003
    ..These inhibitor designs may be useful for understanding the forces that promote fibrillogenesis in neuro-degenerative diseases, and in designing novel diagnostic or therapeutic agents for these diseases. ..
  2. N-Methyl and Other Peptide Inhibitors of Fibrillogenesis
    Stephen Meredith; Fiscal Year: 2006
    ..These inhibitor designs may be useful for understanding the forces that promote fibrillogenesis in neuro-degenerative diseases, and in designing novel diagnostic or therapeutic agents for these diseases. ..
  3. N-Methyl and Other Peptide Inhibitors of Fibrillogenesis
    Stephen Meredith; Fiscal Year: 2007
    ..These inhibitor designs may be useful for understanding the forces that promote fibrillogenesis in neuro-degenerative diseases, and in designing novel diagnostic or therapeutic agents for these diseases. ..
  4. Structural Heterogeneity and Covalent Changes in Beta Amyloid Fibrils
    Stephen Meredith; Fiscal Year: 2009
    ..g., brains from individuals dying with AD and controls), and new, streamlined methods of solid-state NMR make this project entirely feasible in the two year time frame. ..
  5. Structural Heterogeneity and Covalent Changes in Beta Amyloid Fibrils
    Stephen C Meredith; Fiscal Year: 2010
    ..g., brains from individuals dying with AD and controls), and new, streamlined methods of solid-state NMR make this project entirely feasible in the two year time frame. ..