Research Topics
Species | Stephen MeredithSummaryAffiliation: University of Chicago Country: USA Publications
Research Grants
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Detail Information
Publications
Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteinsStephen C Meredith
Department of Pathology, University of Chicago, 5841 S Maryland Avenue, MC 6079, Chicago IL 60637, USA
Ann N Y Acad Sci 1066:181-221. 2005....- A mutant chaperone converts a wild-type protein into a tumor-specific antigenAndrea Schietinger
Department of Pathology, Committee on Immunology, Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA
Science 314:304-8. 2006..This epitope induced a high-affinity, highly specific, syngeneic monoclonal antibody with antitumor activity. Such tumor-specific glycopeptidic neo-epitopes represent potential targets for monoclonal antibody therapy... - Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cellsMichael T Spiotto
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
Immunity 17:737-47. 2002..Thus, tumor antigens expressed at levels sufficient for crosspresentation by bone marrow-derived stromal cells may overcome immunological "ignorance" to solid tumors... - Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positionsDavid J Gordon
Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA
Biochemistry 42:475-85. 2003..Abeta16-20e also inhibits the aggregation of the Abeta1-40 peptide and disassembles preformed Abeta1-40 fibrils. These results suggest that backbone hydrogen bonding is critical for the assembly of amyloid fibrils... - Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumorsKarin Schreiber
Department of Pathology, The University of Chicago, 5841 S Maryland Ave, MC 3008, Chicago, IL 60637, USA
Oncogene 23:3972-9. 2004..Thus, a remarkable synergy occurred between the v-Ha-ras and HPV16 E6/E7 oncogenes in the development of primary tumors in mice... - Site-specific effects of peptide lipidation on beta-amyloid aggregation and cytotoxicityIsam M Qahwash
Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 282:36987-97. 2007..The greater cytotoxicity of K16-OA-Abeta and K28-OA-Abeta may reflect their greater amphiphilicity. We conclude that lipidation can make Abeta more prone to aggregation and more cytotoxic, but these effects are highly site-specific... - Peptide-based inhibitors of amyloid assemblyKimberly L Sciarretta
The University of Chicago, Department of Pathology, Chicago, IL, USA
Methods Enzymol 413:273-312. 2006..Finally, we consider potential applications of inhibitor peptides to therapeutic strategies... - Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distributionErica J Reschly
Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 277:9645-54. 2002..Human apoA-I self-associates more and activates human lecithin-cholesterol acyltransferase better than mouse apoA-I. These differential characteristics of human and mouse apoA-I are not dependent on helices 7/8... 
Mechanism of cis-inhibition of polyQ fibrillation by polyP: PPII oligomers and the hydrophobic effectGregory D Darnell
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA
Biophys J 97:2295-305. 2009..The conformational adaptability of the polyQ segment permits the cis-inhibitory effect of polyP segments on fibrillation by the polyQ segments in proteins such as huntingtin...
Versatile cyclic templates for assembly of axially oriented ligandsNeeraj Chopra
Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
Bioconjug Chem 20:231-40. 2009....- The specific amino acid sequence between helices 7 and 8 influences the binding specificity of human apolipoprotein A-I for high density lipoprotein (HDL) subclasses: a potential for HDL preferential generationRonald Carnemolla
Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 283:15779-88. 2008..The expression of these mutants in mice may result in the preferential generation of HDL(2) or HDL(3) and allow us to examine experimentally the anti-atherogenicity of the HDL subclasses... - Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structureGregory Darnell
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA
J Mol Biol 374:688-704. 2007..These structural observations may shed light on the threshold phenomenon of poly(Q) aggregation, and support the hypothesized evolution of "protective" poly(P) tracts adjacent to poly(Q) aggregation domains... - Helix-turn-helix peptides that form alpha-helical fibrils: turn sequences drive fibril structureKristi L Lazar
Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA
Biochemistry 44:12681-9. 2005..These studies indicate that varying turn sequences between longer amphiphilic alpha-helical segments can drive the structure of fibrils... - Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloidKimberly L Sciarretta
Departments of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
Biochemistry 44:6003-14. 2005..Consistent with this view Abeta(1)(-)(40) growth is efficiently nucleated by Abeta(1)(-)(40)-Lactam(D23/K28) fibril seeds... - Spatial separation of beta-sheet domains of beta-amyloid: disruption of each beta-sheet by N-methyl amino acidsKimberly L Sciarretta
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
Biochemistry 45:9485-95. 2006.... - Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDEHookang Im
Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 282:25453-63. 2007..Together, our results highlight the importance of the closed conformation for regulating the activity of IDE and provide new molecular details that will facilitate the development of activators and inhibitors of IDE... - Encapsulation and NMR on an aggregating peptide before fibrillogenesisKristi L Lazar
Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA
J Am Chem Soc 128:16460-1. 2006.... - Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallelDavid J Gordon
Department of Biochemistry, The University of Chicago, Chicago, Illinois 60637, USA
Biophys J 86:428-34. 2004..This work also shows that all amyloid fibrils do not share a common supramolecular structure, and suggests a method for controlling the structure of amyloid fibrils... - High-resolution structure of a self-assembly-competent form of a hydrophobic peptide captured in a soluble beta-sheet scaffoldKoki Makabe
Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E 57th Street, Chicago, IL 60637, USA
J Mol Biol 378:459-67. 2008..The ability of the PSAM to "solubilize" an otherwise insoluble peptide stretch suggests the potential of the PSAM approach to the characterization of self-assembling peptides... - Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonanceJohn J Balbach
Laboratory of Chemical Physics, The National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, Maryland 20892-0520 USA
Biophys J 83:1205-16. 2002..These results place strong constraints on any molecular-level structural model for full-length beta-amyloid fibrils...
Research Grants
- N-Methyl and Other Peptide Inhibitors of FibrillogenesisStephen Meredith; Fiscal Year: 2003..These inhibitor designs may be useful for understanding the forces that promote fibrillogenesis in neuro-degenerative diseases, and in designing novel diagnostic or therapeutic agents for these diseases. ..
- N-Methyl and Other Peptide Inhibitors of FibrillogenesisStephen Meredith; Fiscal Year: 2006..These inhibitor designs may be useful for understanding the forces that promote fibrillogenesis in neuro-degenerative diseases, and in designing novel diagnostic or therapeutic agents for these diseases. ..
- N-Methyl and Other Peptide Inhibitors of FibrillogenesisStephen Meredith; Fiscal Year: 2007..These inhibitor designs may be useful for understanding the forces that promote fibrillogenesis in neuro-degenerative diseases, and in designing novel diagnostic or therapeutic agents for these diseases. ..
- Structural Heterogeneity and Covalent Changes in Beta Amyloid FibrilsStephen Meredith; Fiscal Year: 2009..g., brains from individuals dying with AD and controls), and new, streamlined methods of solid-state NMR make this project entirely feasible in the two year time frame. ..
- Structural Heterogeneity and Covalent Changes in Beta Amyloid FibrilsStephen C Meredith; Fiscal Year: 2010..g., brains from individuals dying with AD and controls), and new, streamlined methods of solid-state NMR make this project entirely feasible in the two year time frame. ..