Andrea L Meredith
Affiliation: University of Maryland
Lai M, Wu Y, Gao Z, Anderson M, Dalziel J, Meredith A. BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo. Am J Physiol Heart Circ Physiol. 2014;307:H1327-38 pubmed publisher
..Furthermore, these findings suggest BK channels are potential therapeutic targets for disorders of heart rate. ..
Zemen B, Lai M, Whitt J, Khan Z, Zhao G, Meredith A. Generation of Kcnma1fl-tdTomato, a conditional deletion of the BK channel Î± subunit in mouse. Physiol Rep. 2015;3: pubmed publisher
..These data demonstrate the utility of Kcnma1(fl)-tdTomato for conditional deletion of the BK channel, facilitating the understanding of tissue-specific contributions to physiological function inÂ vivo. ..
Singh H, Li M, Hall L, Chen S, Sukur S, Lu R, et al
. MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain. Neuroscience. 2016;317:76-107 pubmed publisher
..The interaction of MaxiK channel with GAT3 opens the possibility of a role of MaxiK channel in GABA homeostasis and signaling. ..
Meredith A, Wiler S, Miller B, Takahashi J, Fodor A, Ruby N, et al
. BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nat Neurosci. 2006;9:1041-9 pubmed
..Our findings implicate BK channels as important regulators of the SFR and suggest that the SCN pacemaker governs the expression of circadian behavioral rhythms through SFR modulation. ..
Whitt J, McNally B, Meredith A. Differential contribution of Ca2+ sources to day and night BK current activation in the circadian clock. J Gen Physiol. 2018;150:259-275 pubmed publisher
..These data reveal a dynamic coupling strategy between BK channels and their Ca2+ sources in the SCN, contributing to diurnal regulation of SCN excitability. ..