Juanita Merchant

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets
    Mohamad El-Zaatari
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e58935. 2013
  2. pmc Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia
    Milena Saqui-Salces
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e48039. 2012
  3. pmc Inhibition of Hedgehog signaling in the gastrointestinal tract: targeting the cancer microenvironment
    Juanita L Merchant
    Departments of Internal Medicine and Molecular and Integrative Physiology, Division of Gastroenterology, University of Michigan, United States Electronic address
    Cancer Treat Rev 40:12-21. 2014
  4. pmc Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia
    Natalia A Veniaminova
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, 48109 2200, USA
    Am J Physiol Gastrointest Liver Physiol 303:G752-64. 2012
  5. pmc A high-fat diet regulates gastrin and acid secretion through primary cilia
    Milena Saqui-Salces
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 26:3127-39. 2012
  6. pmc Hedgehog signalling in gut development, physiology and cancer
    Juanita L Merchant
    Internal Medicine, 109 Zina Pitcher Pl, BSRB, 2051, University of Michigan, Ann Arbor, MI 48105 2200, USA
    J Physiol 590:421-32. 2012
  7. pmc What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis
    Juanita L Merchant
    Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB Room 2051, Ann Arbor, Michigan 48198 2200, USA
    J Clin Invest 118:1628-31. 2008
  8. ncbi request reprint Inflammation, atrophy, gastric cancer: connecting the molecular dots
    Juanita L Merchant
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 129:1079-82. 2005
  9. ncbi request reprint ZBP-89 mediates butyrate regulation of gene expression
    Juanita L Merchant
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Nutr 133:2456S-2460S. 2003
  10. pmc Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease
    Juanita L Merchant
    Division of Gastroenterology, Department of Internal, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 117:6-12. 2007

Research Grants

  1. Mechanisms of Gastrointestional Growth & Transformation
    Juanita Merchant; Fiscal Year: 2009
  2. MECHANISMS OF GASTROINTESTINAL GROWTH AND TRANSFORMATION
    Juanita Merchant; Fiscal Year: 2002
  3. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2001
  4. Mechanisms of Gastrointestional Growth & Transformation
    Juanita Merchant; Fiscal Year: 2005
  5. Mechanisms of Gastrointestional Growth & Transformation
    Juanita Merchant; Fiscal Year: 2006
  6. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2003
  7. Altering Gastric Epithelial Cell Differentiation
    Juanita Merchant; Fiscal Year: 2003
  8. Mechanisms of Gastrointestional Growth & Transformation
    Juanita Merchant; Fiscal Year: 2007
  9. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2007
  10. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2000

Collaborators

  • Yana Zavros
  • LINDA SAMUELSON
  • KATHRYN EATON
  • Deborah Gumucio
  • Gabriele Rieder
  • John Y Kao
  • Z Wang
  • Joel V Weinstock
  • Akiko Shiotani
  • R Ishihara
  • D Kirschner
  • Noriya Uedo
  • CATHERINE CHEW
  • Malcolm J Low
  • T Kamada
  • Rainer Haas
  • James L Smith
  • Honglin Jiang
  • George G Chen
  • Longchuan Bai
  • Milena Saqui-Salces
  • Mohamad El-Zaatari
  • David J Law
  • Natalia A Veniaminova
  • Meghna Waghray
  • Edith Mensah-Osman
  • Andrea Todisco
  • Sivaprakash Rathinavelu
  • Weiqun Kang
  • Renu N Jain
  • Michael M Hayes
  • Edith J Mensah-Osman
  • Andrzej A Dlugosz
  • Asa Kolterud
  • Blair B Madison
  • Sergey Chupreta
  • Xiaotan T Qiao
  • Jamuna Thimmarayappa
  • Qingfu Xu
  • Lymari Lopez-Diaz
  • Morihiro Okada
  • Madhu S Malo
  • Edwin M Labut
  • Elizabeth A Holley-Guthrie
  • Vinzenz Stepan
  • Ian M P Joseph
  • Art Tessier
  • Clinton Fontaine
  • William E Dowdle
  • Li Jyun Syu
  • Jessica M Varney
  • Jeremy F Reiter
  • Evelyn Covés-Datson
  • C Bharath Alamelumangapuram
  • Chunbo Hu
  • Megna Waghray
  • Ann S Grosse
  • Katherine E Kretovich
  • Andreas H Kottmann
  • William J Zacharias
  • Katherine D Walton
  • Jennifer E Ferris
  • Theodora S Ross
  • Jianhua Ren
  • Asma A Al-Menhali
  • Mohammed El-Zaatari
  • Theresa M Keeley
  • Ed Labut
  • Xunsheng Chen
  • Holly Brevig
  • Wendy McKimpson
  • Joshua W Ziel
  • Jorge A Iniguez-Lluhi
  • Agata Giallongo
  • Cynthia S Brunkan
  • Jinhong Sun
  • Alexander Chen
  • Long Chuan Bai
  • Xiao Bo Zhang
  • Shaluk Biswas
  • Prapai Dejkhamron
  • Arthur Tessier
  • Lynn Springer
  • Theresa Keeley
  • Rachael D Adams
  • Karen L Hinkle
  • Chunxia Lu
  • Ram K Menon
  • Moushumi Mozumder
  • Richard A Hodin

Detail Information

Publications58

  1. pmc Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets
    Mohamad El-Zaatari
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e58935. 2013
    ....
  2. pmc Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia
    Milena Saqui-Salces
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e48039. 2012
    ..In summary, epithelial Gli2 expression was sufficient to stimulate Il-1β expression, repress Gast gene expression and increase proliferation, leading to antral hyperplasia...
  3. pmc Inhibition of Hedgehog signaling in the gastrointestinal tract: targeting the cancer microenvironment
    Juanita L Merchant
    Departments of Internal Medicine and Molecular and Integrative Physiology, Division of Gastroenterology, University of Michigan, United States Electronic address
    Cancer Treat Rev 40:12-21. 2014
    ....
  4. pmc Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia
    Natalia A Veniaminova
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, 48109 2200, USA
    Am J Physiol Gastrointest Liver Physiol 303:G752-64. 2012
    ..This result suggests that additional mutations in gene targets other than the Men1 locus are required to produce gastrin-secreting tumors...
  5. pmc A high-fat diet regulates gastrin and acid secretion through primary cilia
    Milena Saqui-Salces
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 26:3127-39. 2012
    ..Our results show that components of food (fat) are sensed by antral cilia on endocrine cells, which modulates gastrin secretion and gastric acidity...
  6. pmc Hedgehog signalling in gut development, physiology and cancer
    Juanita L Merchant
    Internal Medicine, 109 Zina Pitcher Pl, BSRB, 2051, University of Michigan, Ann Arbor, MI 48105 2200, USA
    J Physiol 590:421-32. 2012
    ..Therefore the goal of this review is to apply current knowledge of this pathway to further our understanding of gastrointestinal physiology and neoplasia, using the stomach as a prototype...
  7. pmc What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis
    Juanita L Merchant
    Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB Room 2051, Ann Arbor, Michigan 48198 2200, USA
    J Clin Invest 118:1628-31. 2008
    ..Collectively, the studies suggest that an important pathway of oncogenic transformation in the stomach is through suppression of growth inhibitory signals, such as members of the TGF-beta family, that originate from the stroma...
  8. ncbi request reprint Inflammation, atrophy, gastric cancer: connecting the molecular dots
    Juanita L Merchant
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 129:1079-82. 2005
  9. ncbi request reprint ZBP-89 mediates butyrate regulation of gene expression
    Juanita L Merchant
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Nutr 133:2456S-2460S. 2003
    ..Overall, ZBP-89 is a butyrate-regulated coactivator of p53 and is able to induce p21(Waf1) gene expression through both p53-dependent and -independent mechanisms to inhibit cell growth...
  10. pmc Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease
    Juanita L Merchant
    Division of Gastroenterology, Department of Internal, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 117:6-12. 2007
    ..A breach of the epithelial barrier of the GI tract can result in local and eventually systemic disease if the gut does not mount an aggressive immune response...
  11. ncbi request reprint EGF receptor activation of the human gastrin gene: a tale of two zinc finger transcription factor families
    J L Merchant
    Howard Hughes Medical Institute, University of Michigan, Ann Arbor 48109 0650, USA
    Keio J Med 49:106-10. 2000
    ..These findings contribute to our understanding of gastrin gene expression in the presence of the activated ras oncogene, e.g., during colonic transformation...
  12. pmc ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter
    J L Merchant
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    Mol Cell Biol 16:6644-53. 1996
    ..Collectively, these results demonstrate that ZBP-89 functions as a repressor of basal and inducible expression of the gastrin gene...
  13. pmc Treatment of Helicobacter gastritis with IL-4 requires somatostatin
    Yana Zavros
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:12944-9. 2003
    ..Thus, a mechanism by which IL-4 resolves inflammation in the stomach is by stimulating the release of SOM from gastric D cells...
  14. ncbi request reprint Somatostatin inhibits dendritic cell responsiveness to Helicobacter pylori
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, 6520A MSRB 1, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0650, USA
    Regul Pept 134:23-9. 2006
    ..pylori; a possible mechanism by which IL-4 mediates resolution of gastritis. We suggest that octreotide may be effective in treating immune-mediated diseases of the stomach...
  15. ncbi request reprint Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0682, USA
    Am J Physiol Gastrointest Liver Physiol 291:G73-81. 2006
    ..lwoffi. Our findings suggest that dendritic cells participate in the host immune response against H. pylori and that their suppression by H. pylori may explain why infected hosts fail to prevent bacterial colonization...
  16. ncbi request reprint Hypergastrinemia in response to gastric inflammation suppresses somatostatin
    Yana Zavros
    Howard Hughes Medical Institute, Ann Arbor, Michigan 48109 0650, USA
    Am J Physiol Gastrointest Liver Physiol 282:G175-83. 2002
    ..Thus the stomach responds to the presence of inflammation by reducing somatostatin levels, thereby releasing the inhibition on the G and parietal cells to maximize gastric acid output...
  17. pmc Sonic hedgehog in gastric physiology and neoplastic transformation: friend or foe?
    Mohamad El-Zaatari
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48198 2200, USA
    Curr Opin Endocrinol Diabetes Obes 16:60-5. 2009
    ..To understand the role of sonic hedgehog (Shh) in normal gastric physiology and neoplastic transformation...
  18. ncbi request reprint Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin
    Gabriele Rieder
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0682, USA
    J Biol Chem 280:4906-12. 2005
    ..Thus, H. pylori induction of villin in the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal promoter of villin...
  19. pmc Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog
    Meghna Waghray
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 138:562-72, 572.e1-2. 2010
    ..Sonic Hedgehog (Shh) is highly expressed in the gastric corpus and its loss correlates with gastric atrophy. Therefore, we tested the hypothesis that proinflammatory cytokines induce gastric atrophy by inhibiting Shh expression...
  20. pmc Induction of follistatin precedes gastric transformation in gastrin deficient mice
    Weiqun Kang
    Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB 2051, Ann Arbor, MI 48109 2200, USA
    Biochem Biophys Res Commun 376:573-7. 2008
    ..We concluded that antral hyperplasia in Gas(-/-) mice involves amplification of mucous cell lineages due to follistatin, suggesting its role in the development of antral gastric tumors...
  21. ncbi request reprint Intestinal overexpression of ZNF148 suppresses ApcMin/+ neoplasia
    David J Law
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, 48109 2200, USA
    Mamm Genome 17:999-1004. 2006
    ..These data suggest that enhanced ZNF148 expression activates intestinal apoptosis and thereby mitigates disease burden in ApcMin/+ mice. They also suggest that ZNF148 is a therapeutic target to inhibit colon cancer development...
  22. ncbi request reprint Acinetobacter lwoffii infection and gastritis
    Sivaprakash Rathinavelu
    Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, 3510 MSRB I, Ann Arbor, MI 48109 0650, USA
    Microbes Infect 5:651-7. 2003
    ..In this review, we will explore what is generally known about non-H. pylori organisms and their ability to induce gastritis, with particular focus on Acinetobacter lwoffi...
  23. ncbi request reprint Re-expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete intestinal metaplasia
    Akiko Shiotani
    Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan
    Int J Cancer 121:1182-9. 2007
    ..Pepsinogen I may be a useful marker in patients with a residual higher risk of gastric cancer after H. pylori eradication...
  24. pmc Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning
    Asa Kolterud
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Gastroenterology 137:618-28. 2009
    ..We profiled cellular Hedgehog response patterns from embryonic day 10.5 (E10.5) to adult in murine antrum, pyloric region, small intestine, and colon...
  25. ncbi request reprint Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89
    Sergey Chupreta
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0632, USA
    J Biol Chem 282:36155-66. 2007
    ..By regulating higher order functional interactions, sumoylation provides a reversible post-translational mechanism to control the activity of ZBP-89...
  26. pmc A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion
    Longchuan Bai
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    FEBS Lett 581:5904-10. 2007
    ..Additionally, ectopic expression of CITED2 arrested RKO cell growth. Thus, CITED2 regulates colon cancer invasion and might be a target for HDAC inhibitor-based intervention of colon cancer...
  27. pmc Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice
    Renu N Jain
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    J Clin Invest 118:2459-70. 2008
    ..Taken together, these studies demonstrate that Hip1r plays a significant role in gastric physiology, mucosal architecture, and secretory membrane dynamics in parietal cells...
  28. pmc Somatostatin stimulates menin gene expression by inhibiting protein kinase A
    Edith Mensah-Osman
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA
    Am J Physiol Gastrointest Liver Physiol 295:G843-54. 2008
    ..Using AGS cells, we also showed for the first time that menin directly inhibits endogenous gastrin gene expression. In conclusion, somatostatin receptor activation induces menin expression by suppressing PKA activation...
  29. pmc ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate
    Longchuan Bai
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Biochem Biophys Res Commun 359:817-21. 2007
    ..These results demonstrate that ATM phosphorylation of ZBP-89 contributes to HDACi induction of p21(waf1) gene expression...
  30. ncbi request reprint Modulating the cytokine response to treat Helicobacter gastritis
    Yana Zavros
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Biochem Pharmacol 69:365-71. 2005
    ..In humans, octreotide might accelerate recovery from H. pylori infection, reducing the duration of antibiotic therapy...
  31. ncbi request reprint Inflammation and cancer III. Somatostatin and the innate immune system
    Yana Zavros
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Physiol Gastrointest Liver Physiol 286:G698-701. 2004
    ..However, it was not until recently that the immunoregulation of gastric somatostatin was studied in vivo. This theme article discusses the role of somatostatin as an immunoregulatory peptide during gastritis...
  32. ncbi request reprint Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and function
    Sivaprakash Rathinavelu
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Helicobacter 10:424-32. 2005
    ..pylori proteins by sera from infected patients. In contrast to the high molecular weight proteins, serologic responses to small molecular weight proteins provide assessment of current infection with H. pylori and also of its eradication...
  33. ncbi request reprint Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma
    Yana Zavros
    Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Oncogene 24:2354-66. 2005
    ..Moreover, neoplastic transformation of the antral gastric mucosa does not require gastrin...
  34. ncbi request reprint Interferon gamma induction of gastric mucous neck cell hypertrophy
    Weiqun Kang
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Lab Invest 85:702-15. 2005
    ....
  35. pmc Prospective identification of a multilineage progenitor in murine stomach epithelium
    Xiaotan T Qiao
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 133:1989-98. 2007
    ..We identified an intestinal promoter that is active in a rare subpopulation of gastric epithelial cells and investigated whether these cells possess multilineage potential...
  36. pmc Regulated expression of the human gastrin gene in mice
    Edith Mensah-Osman
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA
    Regul Pept 151:115-22. 2008
    ....
  37. pmc Transcription factor ZBP-89 is required for STAT1 constitutive expression
    Longchuan Bai
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Nucleic Acids Res 31:7264-70. 2003
    ..g. caspase-3 and PARP. Taken together, we conclude that ZBP-89 is required for constitutive STAT1 expression and in this way contributes to the ability of cells to be activated by IFNgamma...
  38. ncbi request reprint Regulation of epithelial cell growth by ZBP-89: potential relevance in pancreatic cancer
    Longchuan Bai
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Gastrointest Cancer 31:79-88. 2002
    ..ZBP-89 protein is elevated in a variety of gastrointestinal cancers as well as the pancreas. In particular, ZBP-89 is normally expressed in pancreatic islets and ducts and in about 30% of pancreatic adenocarcinomas...
  39. ncbi request reprint A model for integrative study of human gastric acid secretion
    Ian M P Joseph
    Departments of Microbiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Appl Physiol 94:1602-18. 2003
    ..Our results may be useful in the design of therapeutic strategies for acid secretory dysfunctions such as hyper- and hypochlorhydria...
  40. ncbi request reprint Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice
    Yana Zavros
    Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 122:119-33. 2002
    ..Therefore, we investigated how the chronic gastritis in mice made hypochlorhydric by either gastrin deficiency or omeprazole treatment modulates epithelial cell function...
  41. ncbi request reprint Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice
    Lymari Lopez-Diaz
    Department of Molecular and Integrative Physiology, University of Michigan, 7761 Medical Science II Building, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 290:G970-9. 2006
    ..High Ctox in parietal cells can also induce progressive changes in the cellular architecture of the gastric glands, corresponding to the development of anti-parietal cell antibodies and autoimmune gastritis...
  42. ncbi request reprint Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection
    Longchuan Bai
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 131:841-52. 2006
    ..HDACi induction of the cyclin-dependent kinase inhibitor p21(waf1) has been shown to require ataxia-telangiectasia mutated (ATM). Nevertheless, how ATM participates in p21(waf1) gene expression has not been defined...
  43. ncbi request reprint P53 mutants suppress ZBP-89 function
    Morihiro Okada
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Anticancer Res 26:2023-8. 2006
    ..ZBP-89 stabilizes wild-type p53 and can induce apoptosis independently of p53. Tissues with p53 mutations are predisposed to transformation and are more resistant to chemotherapy...
  44. ncbi request reprint Inhibition of growth hormone receptor gene expression by saturated fatty acids: role of Kruppel-like zinc finger factor, ZBP-89
    Jamuna Thimmarayappa
    University of Michigan Medical School, 1205 Medical Professional Building, Box 0718, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 0718, USA
    Mol Endocrinol 20:2747-60. 2006
    ....
  45. pmc An isoform of ZBP-89 predisposes the colon to colitis
    David J Law
    Department of Internal Medicine, University of Michigan, 1150 W Medical Center Dr, MSRB I, rm 3510, Ann Arbor, MI 48109 0650, USA
    Nucleic Acids Res 34:1342-50. 2006
    ..We conclude that ZBP-89(DeltaN) antagonizes ZBP-89(FL) function and that over-expression of the truncated isoform disrupts gastrointestinal homeostasis...
  46. pmc Menin and JunD regulate gastrin gene expression through proximal DNA elements
    Edith J Mensah-Osman
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, 48109 2200, USA
    Am J Physiol Gastrointest Liver Physiol 301:G783-90. 2011
    ..In conclusion, proximal DNA elements within the human gastrin gene promoter mediate interactions between JunD, which induces gastrin gene expression and menin, which suppresses JunD-mediated activation...
  47. ncbi request reprint Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells
    Vinzenz Stepan
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:15700-8. 2005
    ..These effects might represent novel mechanisms mediating the actions of growth factors on gastric epithelial cell differentiation...
  48. ncbi request reprint Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation
    Yana Zavros
    Department of Internal Medicine Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:33265-74. 2007
    ..Moreover parietal cell atrophy, a known pre-neoplastic lesion, correlates with loss of Shh processing...
  49. ncbi request reprint Hedgehog signaling and gastrointestinal cancer
    Milena Saqui-Salces
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Biochim Biophys Acta 1803:786-95. 2010
    ....
  50. ncbi request reprint Epithelial cell turnover in relation to ongoing damage of the gastric mucosa in patients with early gastric cancer: increase of cell proliferation in paramalignant lesions
    Akiko Shiotani
    Health Administration Center, Wakayama University, 930 Sakaedani, Wakayama 640 8510, Japan
    J Gastroenterol 40:337-44. 2005
    ..In this study, we aimed to compare apoptosis and proliferation in the noncancer-containing mucosa of H. pylori-positive patients with early gastric cancer with these phenomena in H. pylori-positive controls...
  51. ncbi request reprint Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils
    Gabriele Rieder
    Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig Maximilians University, Munich, Germany
    Gastroenterology 128:1229-42. 2005
    ..The role of the Helicobacter pylori type IV secretion system (T4SS) for pathogenesis in the Mongolian gerbil model was explored...
  52. pmc The Epstein-Barr virus protein BMRF1 activates gastrin transcription
    Elizabeth A Holley-Guthrie
    Lineberger Comprehensive Cancer Center, CB 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 79:745-55. 2005
    ....
  53. pmc Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89
    George G Chen
    Department of Surgery and the Sir Y K Pao Center for Cancer, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Am J Pathol 162:1823-9. 2003
    ..Therefore, co-localization of p53 protein with ZBP-89 may define a subgroup of recurrent HCC that is more sensitive to treatment...
  54. ncbi request reprint H pylori infection causes chronic pancreatitis in Mongolian gerbils
    Gabriele Rieder
    Max von Pettenkofer Institute, Pettenkoferstr 9a, D 80336 Munich, Germany
    World J Gastroenterol 13:3939-47. 2007
    ..To investigate whether chronic H pylori infection has the potential to induce pancreatitis in the Mongolian gerbil model, and whether it is dependent on an intact type IV secretion system...
  55. ncbi request reprint Identification of zinc finger binding protein 89 (ZBP-89) as a transcriptional activator for a major bovine growth hormone receptor promoter
    Qingfu Xu
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, 24061 0306, USA
    Mol Cell Endocrinol 251:88-95. 2006
    ..These results together indicate that ZBP-89 is a transcription factor that regulates the expression of GHR1A mRNA...
  56. ncbi request reprint Intestinal alkaline phosphatase gene expression is activated by ZBP-89
    Madhu S Malo
    Gastrointestinal Unit and Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Physiol Gastrointest Liver Physiol 290:G737-46. 2006
    ..These findings are consistent with the role that this transcription factor is thought to play as a tumor suppressor and suggests its possible function in the physiology of fat absorption...
  57. ncbi request reprint Evidence that loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer
    Akiko Shiotani
    Health Administration Center, Wakayama University, Japan
    Am J Gastroenterol 100:581-7. 2005
    ..The absence of sonic hedgehog (Shh) correlates with the development of intestinal metaplasia (IM) suggesting the possibility of an association between Shh expression and neoplastic transformation...
  58. pmc Kinetic profiles of p300 occupancy in vivo predict common features of promoter structure and coactivator recruitment
    James L Smith
    Laboratory of Receptor Biology and Gene Expression and Microarray Facility, Advanced Technology Center, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:11554-9. 2004
    ..This "reverse genomic" approach will have broad application for the genome-wide classification of promoter structure and function...

Research Grants38

  1. Mechanisms of Gastrointestional Growth & Transformation
    Juanita Merchant; Fiscal Year: 2009
    ..In this way, we will further the understanding of how butyrate inhibition of HDACs ultimately suppresses cell growth and prevents neoplastic transformation. ..
  2. MECHANISMS OF GASTROINTESTINAL GROWTH AND TRANSFORMATION
    Juanita Merchant; Fiscal Year: 2002
    ..Insertion of the beta-galactosidase gene will permit the study of ZBP-89 expression during mouse development and to assess in which tissues ZBP-89 is critical for function. ..
  3. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2001
    ..Collectively, these studies will dissect the signaling pathways and factors capable of regulating gastrin and further validate these pathways through in vivo studies in transgenic mice. ..
  4. Mechanisms of Gastrointestional Growth & Transformation
    Juanita Merchant; Fiscal Year: 2005
    ..In this way, we will further the understanding of how butyrate inhibition of HDACs ultimately suppresses cell growth and prevents neoplastic transformation. ..
  5. Mechanisms of Gastrointestional Growth & Transformation
    Juanita Merchant; Fiscal Year: 2006
    ..In this way, we will further the understanding of how butyrate inhibition of HDACs ultimately suppresses cell growth and prevents neoplastic transformation. ..
  6. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2003
    ..Collectively, these studies will dissect the signaling pathways and factors capable of regulating gastrin and further validate these pathways through in vivo studies in transgenic mice. ..
  7. Altering Gastric Epithelial Cell Differentiation
    Juanita Merchant; Fiscal Year: 2003
    ..These studies will further our understanding of how corpus atrophy predisposes the gastric mucosa to neoplastic transformation. ..
  8. Mechanisms of Gastrointestional Growth & Transformation
    Juanita Merchant; Fiscal Year: 2007
    ..In this way, we will further the understanding of how butyrate inhibition of HDACs ultimately suppresses cell growth and prevents neoplastic transformation. ..
  9. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2007
    ..Name Organization Role on Project Juanita Merchant UniversityOf Michigan PI Sergey Chupreta University Of Michigan Postdoc Gabriele Rieder University Of ..
  10. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2000
    ..g. neoplastic transformation. ..
  11. Cellular Decisions of Differentiation in the GI Tract
    Juanita Merchant; Fiscal Year: 2007
    ..abstract_text> ..
  12. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2004
    ..Collectively, these studies will dissect the signaling pathways and factors capable of regulating gastrin and further validate these pathways through in vivo studies in transgenic mice. ..
  13. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2005
    ..Collectively, these studies will dissect the signaling pathways and factors capable of regulating gastrin and further validate these pathways through in vivo studies in transgenic mice. ..
  14. Altering Gastric Epithelial Cell Differentiation
    Juanita Merchant; Fiscal Year: 2006
    ..These studies will further our understanding of how corpus atrophy predisposes the gastric mucosa to neoplastic transformation. ..
  15. Cellular Decisions of Differentiation in the GI Tract
    Juanita Merchant; Fiscal Year: 2006
    ....
  16. Altering Gastric Epithelial Cell Differentiation
    Juanita Merchant; Fiscal Year: 2007
    ..These studies will further our understanding of how corpus atrophy predisposes the gastric mucosa to neoplastic transformation. ..
  17. Mechanisms of Gastrointestional Growth & Transformation
    Juanita Merchant; Fiscal Year: 2009
    ..In this way, we will further the understanding of how butyrate inhibition of HDACs ultimately suppresses cell growth and prevents neoplastic transformation. ..
  18. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2004
    ..Collectively, these studies will dissect the signaling pathways and factors capable of regulating gastrin and further validate these pathways through in vivo studies in transgenic mice. ..
  19. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 1999
    ..g. neoplastic transformation. ..
  20. TRANSCRIPTIONAL CONTROL OF GASTRIN BY GROWTH FACTORS
    Juanita Merchant; Fiscal Year: 1993
    ..Therefore these studies hope to explore the molecular mechanisms by which the gastrin is regulated, in particular by growth factors...
  21. MECHANISMS OF GASTROINTESTINAL GROWTH AND TRANSFORMATION
    Juanita Merchant; Fiscal Year: 2001
    ..Insertion of the beta-galactosidase gene will permit the study of ZBP-89 expression during mouse development and to assess in which tissues ZBP-89 is critical for function. ..
  22. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2002
    ..Collectively, these studies will dissect the signaling pathways and factors capable of regulating gastrin and further validate these pathways through in vivo studies in transgenic mice. ..
  23. MECHANISMS OF GASTROINTESTINAL GROWTH AND TRANSFORMATION
    Juanita Merchant; Fiscal Year: 2003
    ..Insertion of the beta-galactosidase gene will permit the study of ZBP-89 expression during mouse development and to assess in which tissues ZBP-89 is critical for function. ..
  24. Altering Gastric Epithelial Cell Differentiation
    Juanita Merchant; Fiscal Year: 2004
    ..These studies will further our understanding of how corpus atrophy predisposes the gastric mucosa to neoplastic transformation. ..
  25. MECHANISMS OF GASTROINTESTINAL GROWTH AND TRANSFORMATION
    Juanita Merchant; Fiscal Year: 2004
    ..Insertion of the beta-galactosidase gene will permit the study of ZBP-89 expression during mouse development and to assess in which tissues ZBP-89 is critical for function. ..
  26. MECHANISMS OF GASTROINTESTINAL GROWTH AND TRANSFORMATION
    Juanita Merchant; Fiscal Year: 2003
    ..Insertion of the beta-galactosidase gene will permit the study of ZBP-89 expression during mouse development and to assess in which tissues ZBP-89 is critical for function. ..
  27. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita Merchant; Fiscal Year: 2004
    ..Collectively, these studies will dissect the signaling pathways and factors capable of regulating gastrin and further validate these pathways through in vivo studies in transgenic mice. ..
  28. Altering Gastric Epithelial Cell Differentiation
    Juanita Merchant; Fiscal Year: 2005
    ..These studies will further our understanding of how corpus atrophy predisposes the gastric mucosa to neoplastic transformation. ..