Research Topics
| J J MenegazziSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Ventricular fibrillation scaling exponent can guide timing of defibrillation and other therapiesJames J Menegazzi
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Circulation 109:926-31. 2004..The scaling exponent (ScE) of the ventricular fibrillation (VF) waveform correlates with duration of VF and predicts defibrillation outcome. We compared 4 therapeutic approaches to the treatment of VF of various durations...- Effects of an impedance threshold device on hemodynamics and restoration of spontaneous circulation in prolonged porcine ventricular fibrillationJames J Menegazzi
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Prehosp Emerg Care 11:179-85. 2007..An impedance threshold device (ITD) has been designed to enhance circulation during CPR by creating a negative intrathoracic pressure during the relaxation phase of chest compression... - Combination pharmacotherapy with delayed countershock vs standard advanced cardiac life support after prolonged ventricular fibrillationJ J Menegazzi
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
Prehosp Emerg Care 4:31-7. 2000.... - Immediate defibrillation versus interventions first in a swine model of prolonged ventricular fibrillationJames J Menegazzi
Department of Emergency Medicine, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
Resuscitation 59:261-70. 2003..We also sought to determine the predictive value of the ScE in determining post-shock outcomes... - Evaluation of biphasic transthoracic defibrillation in an animal model of prolonged ventricular fibrillationM D Scheatzle
Department of Emergency Medicine, Allegheny General Hospital, MCP Hahnemann University, School of Medicine, Pittsburgh, PA 15212, USA
Acad Emerg Med 6:880-6. 1999.... - Use of a cardiocerebral-protective drug cocktail prior to countershock in a porcine model of prolonged ventricular fibrillationD C Seaberg
Department of Emergency Medicine, University of Florida Health Sciences Center, PO Box 100186, Gainesville, FL 32610 0186, USA
Resuscitation 51:301-8. 2001.... - Effects of biphasic vs monophasic defibrillation on the scaling exponent in a swine model of prolonged ventricular fibrillationH E Wang
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Acad Emerg Med 8:771-80. 2001..The purpose of this study was to compare the effects of biphasic defibrillation waveform (BDW) and monophasic defibrillation waveform (MDW) rescue shocks on ScE in a swine model of prolonged VF... - A randomized, crossover comparison of various ventilation devices in a swine pneumothorax modelT E Platt
Emergency Medicine Program, School of Health and Rehabilitation Sciences, University of Pittsburgh, PA, USA
Prehosp Emerg Care 2:167-9. 1998..Use of the MTV and the ATVs has been limited by concern for causing or worsening a pneumothorax (PTX). The purpose of this study was to compare the effects of ventilation with a BVM, ATV, and MTV in a swine PTX model... - Scaling structure of electrocardiographic waveform during prolonged ventricular fibrillation in swineC W Callaway
Department of Emergency Medicine, University of Pittsburgh, PA 15213, USA
Pacing Clin Electrophysiol 23:180-91. 2000..As a quantitative descriptor of waveform structure, the scaling exponent characterizes the time dependent organization of VF... - Ventricular fibrillation exhibits dynamical properties and self-similarityL D Sherman
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Suite 400, 230 McKee Place, Pittsburgh, PA 15213, USA
Resuscitation 47:163-73. 2000..Analyses of the Hurst exponents and self-similarity dimensions are correlated with the duration of VF, which may have clinical applications... - Physician interpretation and quantitative measures of electrocardiographic ventricular fibrillation waveformC B Lightfoot
Department of Emergency Medicine, University of Pittsburgh, Pennsylvania, USA
Prehosp Emerg Care 5:147-54. 2001..These data suggest that quantitative measures of the VF waveform could augment the current standard of subjective classification of VF by emergency care providers... - Comparison of automated and manual ventilation in a prehospital pediatric modelT E Auble
Department of Emergency Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
Prehosp Emerg Care 2:108-11. 1998..The purpose of the study was to determine whether such devices maintain arterial blood gases and airway pressures similar to those for BV in a pediatric swine model... - Statistical methodology: IX. survival analysisK D Young
Department of Emergency Medicine, Harbor UCLA Medical Center, UCLA School of Medicine, Torrance, CA 90509, USA
Acad Emerg Med 6:244-9. 1999..Specific methods discussed include life tables, the Kaplan-Meier product limit estimate, the log-rank test, and the multivariate Cox proportional hazards model... - Bench to bedside: resuscitation from prolonged ventricular fibrillationM G Angelos
Department of Emergency Medicine, Ohio State University, Columbus, OH 43210 1270, USA
Acad Emerg Med 8:909-24. 2001..This review focuses first on the initial resuscitation (achieving ROSC) and then on the reperfusion issues affecting the heart and brain... - The locations of nonresidential out-of-hospital cardiac arrests in the City of Pittsburgh over a three-year period: implications for automated external defibrillator placementR L Frank
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
Prehosp Emerg Care 5:247-51. 2001..CONCLUSION: The majority of nonresidential OHCAs occur as singular, isolated events. Other than nursing homes and dialysis centers, there were no identifiable high-risk locations for nonresidential OHCA within the City of Pittsburgh... 
The effect of ischemia on ventricular fibrillation as measured by fractal dimension and frequency measuresLawrence D Sherman
St Francis Hospital, Federal Way, WA, USA
Resuscitation 75:499-505. 2007..The scaling exponent (ScE), the logarithm of the absolute correlations (LAC) and the Hurst exponent (HE) are three measures of the fractal dimension of VF...
Derivation of clinical predictors of failed rescue shock during out-of-hospital ventricular fibrillationJames J Menegazzi
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Prehosp Emerg Care 12:347-51. 2008..Failed rescue shocks have been shown to decrease the likelihood of survival in the treatment of out-of-hospital ventricular fibrillation (VF). Avoidance of failed shocks may improve survival...- Drug administration in animal studies of cardiac arrest does not reflect human clinical experienceJoshua C Reynolds
School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, United States
Resuscitation 74:13-26. 2007..Our previous work has shown the mean time to first drug administration in clinical trials is 19.4min. We hypothesized that the average time to drug administration in large animal experiments occurs earlier than in OOHCA clinical trials... - Association of delay to first intervention with return of spontaneous circulation in a swine model of cardiac arrestJon C Rittenberger
University of Pittsburgh, Department of Emergency Medicine, Pittsburgh, PA 15213, USA
Resuscitation 73:154-60. 2007..We sought to determine the duration of circulatory arrest after which maximal drug treatment and a rescue shock would fail to achieve return of spontaneous circulation (ROSC)... - Adenosine A1 receptor antagonism hastens the decay in ventricular fibrillation waveform morphology during porcine cardiac arrestTimothy J Mader
The Department of Emergency Medicine, Baystate Medical Center Tufts University School of Medicine, 759 Chestnut Street, Springfield, MA 01199, United States
Resuscitation 71:254-9. 2006..The objective of this study was to determine the effect of ADO receptor antagonism, as measured by the scaling exponent (ScE), on the degeneration of VF over time during the circulatory phase of cardiac arrest... - A randomized comparison of manual, mechanical and high-impulse chest compression in a porcine model of prolonged ventricular fibrillationAmy E Betz
Department of Emergency Medicine, University of Pittsburgh School of Medicine, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
Resuscitation 69:495-501. 2006..We hypothesized that HI (very rapid acceleration of the down-stroke) would produce greater CPPs than MAN or MECH, and that HI would also produce a higher rate of ROSC... - The effect of adenosine A1 receptor antagonism on return of spontaneous circulation and short-term survival in prolonged ventricular fibrillationTimothy J Mader
Department of Emergency Medicine, Baystate Medical Center Tufts University School of Medicine, Boston, Massachusetts, USA
Prehosp Emerg Care 12:352-8. 2008..We have previously shown that ADO A1 receptor (ADOA1R) antagonism hastens the time-dependent decay in VF waveform morphology during the circulatory phase of cardiac arrest... - Waveform analysis of ventricular fibrillation to predict defibrillationClifton W Callaway
University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Curr Opin Crit Care 11:192-9. 2005..Quantitative analysis of the ventricular fibrillation waveform may distinguish coarse ventricular fibrillation from fine ventricular fibrillation, allowing more appropriate delivery of rescue shocks... - Angular velocity: a new method to improve prediction of ventricular fibrillation durationLawrence D Sherman
Department of Emergency Medicine, University of Pittsburg School of Medicine, Pittsburgh, PA 15213, USA
Resuscitation 60:79-90. 2004..The combination of ScE and AV can be used in developing strategies for the treatment of VF during the different clinical phases of VF... - Dynamic nature of electrocardiographic waveform predicts rescue shock outcome in porcine ventricular fibrillationChristopher B Lightfoot
Department of Emergency Medicine, Center for Emergency Medicine of Western Pennsylvania, University of Pittsburgh, Pittsburgh, PA 15213, USA
Ann Emerg Med 42:230-41. 2003..In addition, unsuccessful rescue shocks might decrease post-rescue shock ventricular fibrillation waveform organization... - Overcoming ACLS dogma: how quickly should we change?James J Menegazzi
Prehosp Emerg Care 7:410-3. 2003..At the end of the year 2000 there was insufficient evidence to recommend any other approach than shock as soon as possible and perform CPR at all other times... - Time to give the first medication during resuscitation in out-of-hospital cardiac arrestJon C Rittenberger
Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Resuscitation 70:201-6. 2006..Then, the mean time and ranges of reported study medication delivery in clinical trials where medication was the experimental intervention was determined... - Why isn't hypothermia after cardiac arrest the standard of care?James J Menegazzi
Prehosp Emerg Care 9:475-6. 2005 - Use of prehospital-induced hypothermia after out-of-hospital cardiac arrest: a survey of the National Association of Emergency Medical Services PhysiciansBrian P Suffoletto
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Prehosp Emerg Care 12:52-6. 2008..We sought to determine the prevalence of EMS agencies that use prehospital IH. We also sought to determine what perceived barriers to initiating IH might exist and the understanding EMS physicians have of guidelines for IH... - A randomized, controlled comparison of cardiopulmonary resuscitation performed on the floor and on a moving ambulance stretcherJohn A Kim
Affiliated Residency in Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Prehosp Emerg Care 10:68-70. 2006..04). CONCLUSIONS: Chest compression and ventilation quality of CPR performed on the floor was superior to that of CPR performed on a moving stretcher in this manikin model. The quality of CPR while moving was significantly compromised...