Christopher L Mendias

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi Reduced muscle fiber force production and disrupted myofibril architecture in patients with chronic rotator cuff tears
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA Electronic address
    J Shoulder Elbow Surg 24:111-9. 2015
  2. pmc Changes in circulating biomarkers of muscle atrophy, inflammation, and cartilage turnover in patients undergoing anterior cruciate ligament reconstruction and rehabilitation
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI 48109 2200, USA
    Am J Sports Med 41:1819-26. 2013
  3. pmc Mechanical loading and TGF-β change the expression of multiple miRNAs in tendon fibroblasts
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Appl Physiol (1985) 113:56-62. 2012
  4. pmc Physiological loading of tendons induces scleraxis expression in epitenon fibroblasts
    Christopher L Mendias
    Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, 48109, USA
    J Orthop Res 30:606-12. 2012
  5. pmc Decreased specific force and power production of muscle fibers from myostatin-deficient mice are associated with a suppression of protein degradation
    Christopher L Mendias
    School of Kinesiology, Department of Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Pl, BSRB 2017, Ann Arbor, MI 48109 2200, USA
    J Appl Physiol (1985) 111:185-91. 2011
  6. pmc Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, Michigan 48109, USA
    Muscle Nerve 45:55-9. 2012
  7. pmc Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear
    Jonathan P Gumucio
    Department Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA
    J Shoulder Elbow Surg 23:99-108. 2014
  8. pmc Changes in macrophage phenotype and induction of epithelial-to-mesenchymal transition genes following acute Achilles tenotomy and repair
    Kristoffer B Sugg
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, Biomedical Science Research Building, Room 2017, Ann Arbor, Michigan Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, Michigan
    J Orthop Res 32:944-51. 2014
  9. pmc Inhibition of 5-LOX, COX-1, and COX-2 increases tendon healing and reduces muscle fibrosis and lipid accumulation after rotator cuff repair
    Nikhil R Oak
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Sports Med 42:2860-8. 2014
  10. pmc Targeted inhibition of TGF-β results in an initial improvement but long-term deficit in force production after contraction-induced skeletal muscle injury
    Jonathan P Gumucio
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Appl Physiol (1985) 115:539-45. 2013

Collaborators

Detail Information

Publications27

  1. doi Reduced muscle fiber force production and disrupted myofibril architecture in patients with chronic rotator cuff tears
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA Electronic address
    J Shoulder Elbow Surg 24:111-9. 2015
    ..We hypothesized that muscles from patients with chronic rotator cuff tears have reduced muscle fiber force production, disordered myofibrils, and an accumulation of fat vacuoles...
  2. pmc Changes in circulating biomarkers of muscle atrophy, inflammation, and cartilage turnover in patients undergoing anterior cruciate ligament reconstruction and rehabilitation
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI 48109 2200, USA
    Am J Sports Med 41:1819-26. 2013
    ..The cause of this muscle atrophy is not fully understood...
  3. pmc Mechanical loading and TGF-β change the expression of multiple miRNAs in tendon fibroblasts
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Appl Physiol (1985) 113:56-62. 2012
    ..The results from this study provide novel insight into the mechanobiology of tendons and indicate that miRNA could play an important role in the adaptation of tendons to growth stimuli...
  4. pmc Physiological loading of tendons induces scleraxis expression in epitenon fibroblasts
    Christopher L Mendias
    Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, 48109, USA
    J Orthop Res 30:606-12. 2012
    ..These results suggest that in addition to regulating the embryonic formation of limb tendons, scleraxis also appears to play an important role in the adaptation of adult tendons to physiological loading...
  5. pmc Decreased specific force and power production of muscle fibers from myostatin-deficient mice are associated with a suppression of protein degradation
    Christopher L Mendias
    School of Kinesiology, Department of Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Pl, BSRB 2017, Ann Arbor, MI 48109 2200, USA
    J Appl Physiol (1985) 111:185-91. 2011
    ..These findings suggest that myostatin inhibition in otherwise healthy muscle increases the size of muscle fibers and decreases atrogin-1 levels, but does not increase the force production of individual muscle fibers...
  6. pmc Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, Michigan 48109, USA
    Muscle Nerve 45:55-9. 2012
    ..In skeletal muscle, TGF-β has been shown to induce atrophy and fibrosis, but the effect of TGF-β on muscle contractility and the expression of scleraxis and atrogin-1, an important regulator of muscle atrophy, were not known...
  7. pmc Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear
    Jonathan P Gumucio
    Department Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA
    J Shoulder Elbow Surg 23:99-108. 2014
    ..To improve the treatment of cuff tears in elderly patients, a greater understanding of the changes in the contractile properties of muscle fibers and the molecular regulation of fatty degeneration is essential...
  8. pmc Changes in macrophage phenotype and induction of epithelial-to-mesenchymal transition genes following acute Achilles tenotomy and repair
    Kristoffer B Sugg
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, Biomedical Science Research Building, Room 2017, Ann Arbor, Michigan Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, Michigan
    J Orthop Res 32:944-51. 2014
    ..The results from this study suggest that changes in macrophage phenotype and activation of EMT-related programs likely contribute to the degradation and subsequent repair of injured tendon tissue...
  9. pmc Inhibition of 5-LOX, COX-1, and COX-2 increases tendon healing and reduces muscle fibrosis and lipid accumulation after rotator cuff repair
    Nikhil R Oak
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Sports Med 42:2860-8. 2014
    ....
  10. pmc Targeted inhibition of TGF-β results in an initial improvement but long-term deficit in force production after contraction-induced skeletal muscle injury
    Jonathan P Gumucio
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Appl Physiol (1985) 115:539-45. 2013
    ..These results indicate that the inhibition of TGF-β promotes the early recovery of muscle function but is detrimental overall to full muscle recovery following moderate to severe muscle injuries...
  11. pmc Rotator cuff tear reduces muscle fiber specific force production and induces macrophage accumulation and autophagy
    Jonathan P Gumucio
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, Michigan 48109 2200, USA
    J Orthop Res 30:1963-70. 2012
    ....
  12. pmc Tendons of myostatin-deficient mice are small, brittle, and hypocellular
    Christopher L Mendias
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:388-93. 2008
    ..We conclude that, in addition to the regulation of muscle mass and force, myostatin regulates the structure and function of tendon tissues...
  13. pmc Elevation in circulating biomarkers of cartilage damage and inflammation in athletes with femoroacetabular impingement
    Asheesh Bedi
    Asheesh Bedi, Department of Orthopaedic Surgery, University of Michigan Medical School, 24 Frank Lloyd Wright Drive, Lobby A, Ann Arbor, MI 48106
    Am J Sports Med 41:2585-90. 2013
    ..Biomarkers of cartilage degradation and inflammation are associated with osteoarthritis. It was not known whether patients with FAI have elevated levels of biomarkers of cartilage degradation and inflammation...
  14. pmc Simvastatin reduces fibrosis and protects against muscle weakness after massive rotator cuff tear
    Max E Davis
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA
    J Shoulder Elbow Surg 24:280-7. 2015
    ..We hypothesized that after the induction of a massive supraspinatus tear, simvastatin would protect muscles from a loss of force production and fibrosis...
  15. pmc MMP inhibition as a potential method to augment the healing of skeletal muscle and tendon extracellular matrix
    Max E Davis
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan
    J Appl Physiol (1985) 115:884-91. 2013
    ..This review will discuss the mechanobiology of MMPs, and the potential use of MMP inhibitors to improve the treatment of injured and diseased skeletal muscle and tendon tissue. ..
  16. pmc The aging of elite male athletes: age-related changes in performance and skeletal muscle structure and function
    John A Faulkner
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Clin J Sport Med 18:501-7. 2008
    ..The paper addresses the degree to which the attainment of the status as an elite athlete in different sports ameliorates the known age-related losses in skeletal muscle structure and function...
  17. doi Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA
    J Physiol 593:2037-52. 2015
    ..Furthermore, the greatest impact of myostatin in the regulation of muscle mass may not be to induce atrophy directly, but rather to block hypertrophy signalling...
  18. pmc Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy
    Sarah Calve
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Am J Physiol Cell Physiol 303:C577-88. 2012
    ..These results indicate that HA levels dynamically change in response to a hypertrophic stimulus and various cells may participate in this mechanism of skeletal muscle adaptation...
  19. pmc Intrinsic stiffness of extracellular matrix increases with age in skeletal muscles of mice
    Lauren K Wood
    Biomedical Engineering, University of Michigan, Ann Arbor, Michigan
    J Appl Physiol (1985) 117:363-9. 2014
    ..Taken together, these findings indicate that the ECM of tibialis anterior muscles from old mice has a higher modulus than the ECM of adult muscles, likely driven by an accumulation of densely packed extensively crosslinked collagen. ..
  20. doi Muscle fibers are injured at the time of acute and chronic rotator cuff repair
    Max E Davis
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI, 48109 2200, USA
    Clin Orthop Relat Res 473:226-32. 2015
    ....
  21. pmc TGF-β1 enhances contractility in engineered skeletal muscle
    Michael R Weist
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Tissue Eng Regen Med 7:562-71. 2013
    ..0 ng/ml TGF-β1 versus 0, 0.5 and 1.0 ng/ml. The addition of 2.0 ng/ml TGF-β1 to the culture medium of engineered 3D skeletal muscle constructs enhanced contractility and extracellular matrix organization...
  22. pmc Contractile properties of EDL and soleus muscles of myostatin-deficient mice
    Christopher L Mendias
    Dept of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 2007, USA
    J Appl Physiol (1985) 101:898-905. 2006
    ..The results support a significant role for myostatin not only in the mass of muscles but also in the contractility and the composition of the extracellular matrix of muscles...
  23. doi Mouse forepaw lumbrical muscles are resistant to age-related declines in force production
    Katelyn A Russell
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States
    Exp Gerontol 65:42-5. 2015
    ..Combined, these results indicate that forepaw lumbrical muscles from 30month old mice are largely protected from the aging-associated declines in size and force production that are typically observed in larger limb muscles. ..
  24. pmc Synergist ablation induces rapid tendon growth through the synthesis of a neotendon matrix
    Jonathan P Gumucio
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan and Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan
    J Appl Physiol (1985) 117:1287-91. 2014
    ..The results from this study provide new insight into the mechanisms of tendon growth, indicate tendon consists mostly of postmitotic cells, and that growth of tendon primarily occurs from the most superficial layers outward. ..
  25. doi TGF-β Superfamily Signaling in Muscle and Tendon Adaptation to Resistance Exercise
    Jonathan P Gumucio
    Departments of 1Orthopaedic Surgery, 2Molecular and Integrative Physiology, and 3Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, MI
    Exerc Sport Sci Rev 43:93-9. 2015
    ..We provide a novel framework for TGF-β and myostatin signaling in controlling the coordinated adaptation of both skeletal muscle and tendon tissue to resistance training. ..
  26. doi p38 MAPK Signaling in Postnatal Tendon Growth and Remodeling
    Andrew J Schwartz
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States of America Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 10:e0120044. 2015
    ..The combined results from this study provided novel insights into tendon mechanobiology, and suggest that p38 MAPK signaling does not appear to be necessary for tendon growth in vivo. ..
  27. pmc Atrogin-1, MuRF-1, and sarcopenia
    Jonathan P Gumucio
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI, 48109 2200, USA
    Endocrine 43:12-21. 2013
    ....