Christopher L Mendias

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Changes in circulating biomarkers of muscle atrophy, inflammation, and cartilage turnover in patients undergoing anterior cruciate ligament reconstruction and rehabilitation
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI 48109 2200, USA
    Am J Sports Med 41:1819-26. 2013
  2. pmc Mechanical loading and TGF-β change the expression of multiple miRNAs in tendon fibroblasts
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Appl Physiol (1985) 113:56-62. 2012
  3. pmc Physiological loading of tendons induces scleraxis expression in epitenon fibroblasts
    Christopher L Mendias
    Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, 48109, USA
    J Orthop Res 30:606-12. 2012
  4. pmc Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, Michigan 48109, USA
    Muscle Nerve 45:55-9. 2012
  5. pmc Decreased specific force and power production of muscle fibers from myostatin-deficient mice are associated with a suppression of protein degradation
    Christopher L Mendias
    School of Kinesiology, Department of Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Pl, BSRB 2017, Ann Arbor, MI 48109 2200, USA
    J Appl Physiol (1985) 111:185-91. 2011
  6. pmc Changes in macrophage phenotype and induction of epithelial-to-mesenchymal transition genes following acute Achilles tenotomy and repair
    Kristoffer B Sugg
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, Biomedical Science Research Building, Room 2017, Ann Arbor, Michigan Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, Michigan
    J Orthop Res 32:944-51. 2014
  7. pmc Targeted inhibition of TGF-β results in an initial improvement but long-term deficit in force production after contraction-induced skeletal muscle injury
    Jonathan P Gumucio
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Appl Physiol (1985) 115:539-45. 2013
  8. pmc Rotator cuff tear reduces muscle fiber specific force production and induces macrophage accumulation and autophagy
    Jonathan P Gumucio
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, Michigan 48109 2200, USA
    J Orthop Res 30:1963-70. 2012
  9. pmc Tendons of myostatin-deficient mice are small, brittle, and hypocellular
    Christopher L Mendias
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:388-93. 2008
  10. pmc Elevation in circulating biomarkers of cartilage damage and inflammation in athletes with femoroacetabular impingement
    Asheesh Bedi
    Asheesh Bedi, Department of Orthopaedic Surgery, University of Michigan Medical School, 24 Frank Lloyd Wright Drive, Lobby A, Ann Arbor, MI 48106
    Am J Sports Med 41:2585-90. 2013

Collaborators

Detail Information

Publications18

  1. pmc Changes in circulating biomarkers of muscle atrophy, inflammation, and cartilage turnover in patients undergoing anterior cruciate ligament reconstruction and rehabilitation
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI 48109 2200, USA
    Am J Sports Med 41:1819-26. 2013
    ..The cause of this muscle atrophy is not fully understood...
  2. pmc Mechanical loading and TGF-β change the expression of multiple miRNAs in tendon fibroblasts
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Appl Physiol (1985) 113:56-62. 2012
    ..The results from this study provide novel insight into the mechanobiology of tendons and indicate that miRNA could play an important role in the adaptation of tendons to growth stimuli...
  3. pmc Physiological loading of tendons induces scleraxis expression in epitenon fibroblasts
    Christopher L Mendias
    Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, 48109, USA
    J Orthop Res 30:606-12. 2012
    ..These results suggest that in addition to regulating the embryonic formation of limb tendons, scleraxis also appears to play an important role in the adaptation of adult tendons to physiological loading...
  4. pmc Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis
    Christopher L Mendias
    Department of Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, Michigan 48109, USA
    Muscle Nerve 45:55-9. 2012
    ..In skeletal muscle, TGF-β has been shown to induce atrophy and fibrosis, but the effect of TGF-β on muscle contractility and the expression of scleraxis and atrogin-1, an important regulator of muscle atrophy, were not known...
  5. pmc Decreased specific force and power production of muscle fibers from myostatin-deficient mice are associated with a suppression of protein degradation
    Christopher L Mendias
    School of Kinesiology, Department of Orthopaedic Surgery, University of Michigan, 109 Zina Pitcher Pl, BSRB 2017, Ann Arbor, MI 48109 2200, USA
    J Appl Physiol (1985) 111:185-91. 2011
    ..These findings suggest that myostatin inhibition in otherwise healthy muscle increases the size of muscle fibers and decreases atrogin-1 levels, but does not increase the force production of individual muscle fibers...
  6. pmc Changes in macrophage phenotype and induction of epithelial-to-mesenchymal transition genes following acute Achilles tenotomy and repair
    Kristoffer B Sugg
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, Biomedical Science Research Building, Room 2017, Ann Arbor, Michigan Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, Michigan
    J Orthop Res 32:944-51. 2014
    ..The results from this study suggest that changes in macrophage phenotype and activation of EMT-related programs likely contribute to the degradation and subsequent repair of injured tendon tissue...
  7. pmc Targeted inhibition of TGF-β results in an initial improvement but long-term deficit in force production after contraction-induced skeletal muscle injury
    Jonathan P Gumucio
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Appl Physiol (1985) 115:539-45. 2013
    ..These results indicate that the inhibition of TGF-β promotes the early recovery of muscle function but is detrimental overall to full muscle recovery following moderate to severe muscle injuries...
  8. pmc Rotator cuff tear reduces muscle fiber specific force production and induces macrophage accumulation and autophagy
    Jonathan P Gumucio
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, Michigan 48109 2200, USA
    J Orthop Res 30:1963-70. 2012
    ....
  9. pmc Tendons of myostatin-deficient mice are small, brittle, and hypocellular
    Christopher L Mendias
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:388-93. 2008
    ..We conclude that, in addition to the regulation of muscle mass and force, myostatin regulates the structure and function of tendon tissues...
  10. pmc Elevation in circulating biomarkers of cartilage damage and inflammation in athletes with femoroacetabular impingement
    Asheesh Bedi
    Asheesh Bedi, Department of Orthopaedic Surgery, University of Michigan Medical School, 24 Frank Lloyd Wright Drive, Lobby A, Ann Arbor, MI 48106
    Am J Sports Med 41:2585-90. 2013
    ..Biomarkers of cartilage degradation and inflammation are associated with osteoarthritis. It was not known whether patients with FAI have elevated levels of biomarkers of cartilage degradation and inflammation...
  11. pmc MMP inhibition as a potential method to augment the healing of skeletal muscle and tendon extracellular matrix
    Max E Davis
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan
    J Appl Physiol (1985) 115:884-91. 2013
    ..This review will discuss the mechanobiology of MMPs, and the potential use of MMP inhibitors to improve the treatment of injured and diseased skeletal muscle and tendon tissue. ..
  12. pmc Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear
    Jonathan P Gumucio
    Department Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA
    J Shoulder Elbow Surg 23:99-108. 2014
    ..To improve the treatment of cuff tears in elderly patients, a greater understanding of the changes in the contractile properties of muscle fibers and the molecular regulation of fatty degeneration is essential...
  13. pmc The aging of elite male athletes: age-related changes in performance and skeletal muscle structure and function
    John A Faulkner
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Clin J Sport Med 18:501-7. 2008
    ..The paper addresses the degree to which the attainment of the status as an elite athlete in different sports ameliorates the known age-related losses in skeletal muscle structure and function...
  14. ncbi Intrinsic stiffness of extracellular matrix increases with age in skeletal muscles of mice
    Lauren K Wood
    Biomedical Engineering, University of Michigan, Ann Arbor, Michigan
    J Appl Physiol (1985) 117:363-9. 2014
    ..Taken together, these findings indicate that the ECM of tibialis anterior muscles from old mice has a higher modulus than the ECM of adult muscles, likely driven by an accumulation of densely packed extensively crosslinked collagen. ..
  15. pmc TGF-β1 enhances contractility in engineered skeletal muscle
    Michael R Weist
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Tissue Eng Regen Med 7:562-71. 2013
    ..0 ng/ml TGF-β1 versus 0, 0.5 and 1.0 ng/ml. The addition of 2.0 ng/ml TGF-β1 to the culture medium of engineered 3D skeletal muscle constructs enhanced contractility and extracellular matrix organization...
  16. pmc Contractile properties of EDL and soleus muscles of myostatin-deficient mice
    Christopher L Mendias
    Dept of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 2007, USA
    J Appl Physiol (1985) 101:898-905. 2006
    ..The results support a significant role for myostatin not only in the mass of muscles but also in the contractility and the composition of the extracellular matrix of muscles...
  17. pmc Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy
    Sarah Calve
    Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Am J Physiol Cell Physiol 303:C577-88. 2012
    ..These results indicate that HA levels dynamically change in response to a hypertrophic stimulus and various cells may participate in this mechanism of skeletal muscle adaptation...
  18. pmc Atrogin-1, MuRF-1, and sarcopenia
    Jonathan P Gumucio
    Department of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI, 48109 2200, USA
    Endocrine 43:12-21. 2013
    ....