MARIO FERNANDO MENDEZ

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The accurate diagnosis of early-onset dementia
    Mario F Mendez
    University of California at Los Angeles, USA
    Int J Psychiatry Med 36:401-12. 2006
  2. ncbi request reprint Clinicopathologic case report: progressive aphasia in a 77-year-old man
    David G Clark
    Department of Neurology, University of California, Los Angeles, Medical Center, USA
    J Neuropsychiatry Clin Neurosci 15:231-8. 2003
  3. ncbi request reprint Surveying a blank field with the attentional spotlight
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, School of Medicine, VA Greater Los Angeles Healthcare System, 90073, USA
    Percept Mot Skills 97:560-8. 2003
  4. doi request reprint Mild traumatic brain injury from primary blast vs. blunt forces: post-concussion consequences and functional neuroimaging
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA
    NeuroRehabilitation 32:397-407. 2013
  5. pmc Hypersexual behavior in frontotemporal dementia: a comparison with early-onset Alzheimer's disease
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, 300 Medical Plaza, suite B 200, Box 956975, Los Angeles, CA 90095 6975, USA
    Arch Sex Behav 42:501-9. 2013
  6. doi request reprint Changes in personality after mild traumatic brain injury from primary blast vs. blunt forces
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, USA
    Brain Inj 27:10-8. 2013
  7. pmc Early-onset Alzheimer's disease: nonamnestic subtypes and type 2 AD
    Mario F Mendez
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Arch Med Res 43:677-85. 2012
  8. pmc Nonamnestic presentations of early-onset Alzheimer's disease
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    Am J Alzheimers Dis Other Demen 27:413-20. 2012
  9. ncbi request reprint Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 15:84-7. 2007
  10. ncbi request reprint "Apperceptive" alexia in posterior cortical atrophy
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA, USA
    Cortex 43:264-70. 2007

Detail Information

Publications94

  1. ncbi request reprint The accurate diagnosis of early-onset dementia
    Mario F Mendez
    University of California at Los Angeles, USA
    Int J Psychiatry Med 36:401-12. 2006
    ..Clinicians can successfully diagnose most EODs with careful cognitive and family histories, mental status and neurological examinations, and neuroimaging...
  2. ncbi request reprint Clinicopathologic case report: progressive aphasia in a 77-year-old man
    David G Clark
    Department of Neurology, University of California, Los Angeles, Medical Center, USA
    J Neuropsychiatry Clin Neurosci 15:231-8. 2003
  3. ncbi request reprint Surveying a blank field with the attentional spotlight
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, School of Medicine, VA Greater Los Angeles Healthcare System, 90073, USA
    Percept Mot Skills 97:560-8. 2003
    ..Together these findings suggest that a small attentional spotlight serially monitors different regions of the visual field when there are anticipated locations to be attended...
  4. doi request reprint Mild traumatic brain injury from primary blast vs. blunt forces: post-concussion consequences and functional neuroimaging
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA
    NeuroRehabilitation 32:397-407. 2013
    ..Primary blast forces may cause dysfunction from mild traumatic brain injury (mTBI)...
  5. pmc Hypersexual behavior in frontotemporal dementia: a comparison with early-onset Alzheimer's disease
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, 300 Medical Plaza, suite B 200, Box 956975, Los Angeles, CA 90095 6975, USA
    Arch Sex Behav 42:501-9. 2013
    ....
  6. doi request reprint Changes in personality after mild traumatic brain injury from primary blast vs. blunt forces
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, USA
    Brain Inj 27:10-8. 2013
    ..Injuries from explosive devices can cause blast-force injuries, including mild traumatic brain injury (mTBI)...
  7. pmc Early-onset Alzheimer's disease: nonamnestic subtypes and type 2 AD
    Mario F Mendez
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Arch Med Res 43:677-85. 2012
    ..In sum, the study of EOAD can reveal much about the clinical heterogeneity, predisposing factors, and neurobiology of this disease...
  8. pmc Nonamnestic presentations of early-onset Alzheimer's disease
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    Am J Alzheimers Dis Other Demen 27:413-20. 2012
    ..These findings indicate that EOAD differs from LOAD in a more aggressive course and in having predominantly nonamnestic presentations that vary in neuropathological location...
  9. ncbi request reprint Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 15:84-7. 2007
    ..The objective of this study was to evaluate donepezil, an acetylcholinesterase inhibitor, in the treatment of frontotemporal dementia (FTD)...
  10. ncbi request reprint "Apperceptive" alexia in posterior cortical atrophy
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA, USA
    Cortex 43:264-70. 2007
    ..Disproportionate difficulty reading pseudowords suggests an additional impairment in phonological processing. PCA patients have variable neuropathology and individual patients may have other contributions to their reading impairment...
  11. ncbi request reprint Accuracy of the clinical evaluation for frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    Arch Neurol 64:830-5. 2007
    ..Without a definitive clinical test, the early diagnosis of frontotemporal dementia (FTD) can be difficult...
  12. ncbi request reprint The scale for emotional blunting in patients with frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    Neurocase 12:242-6. 2006
    ..5% for FTD. These findings suggest that the SEB may be a good instrument for the early detection and quantification of emotional blunting in patient with FTD...
  13. ncbi request reprint Frontotemporal dementia-like phenotypes associated with presenilin-1 mutations
    Mario F Mendez
    Neurobehavior Unit, VA Greater Los Angeles Healthcare, CA 90073, USA
    Am J Alzheimers Dis Other Demen 21:281-6. 2006
    ..In PS-1 mutations, the expression of AD or FTD may depend on the degree of loss of function of the PS-1 gene and the resultant tau pathophysiology...
  14. pmc Interhemispheric differences in knowledge of animals among patients with semantic dementia
    Mario F Mendez
    Departments of Neurology and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, The University of California at Los Angeles, Los Angeles, CA, USA
    Cogn Behav Neurol 23:240-6. 2010
    ..To investigate interhemispheric differences on naming and fluency tasks for living versus nonliving things among patients with semantic dementia (SD)...
  15. ncbi request reprint What frontotemporal dementia reveals about the neurobiological basis of morality
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, Neurobehavior Unit 691 116AF, V A Greater Los Angeles Healthcare Center, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Med Hypotheses 67:411-8. 2006
    ..More investigations are needed to fully understand how the brain mediates moral or ethical behavior...
  16. ncbi request reprint Acquired extroversion associated with bitemporal variant of frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California Los Angeles, Los Angeles, CA 90073, USA
    J Neuropsychiatry Clin Neurosci 18:100-7. 2006
    ..FTD can be a vehicle for unraveling the basis of personality characteristics such as the introversion/extroversion dimension...
  17. ncbi request reprint An investigation of moral judgement in frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90073, USA
    Cogn Behav Neurol 18:193-7. 2005
    ..To investigate the basis of disturbed moral judgment in patients with frontotemporal dementia (FTD)...
  18. ncbi request reprint Disrupted facial empathy in drawings from artists with frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles 90073, USA
    Neurocase 9:44-50. 2003
    ..These FTD patients and the literature suggest that FTD, possibly with greater right temporal involvement, disrupts the sense of empathy from human faces...
  19. ncbi request reprint Loss of insight and functional neuroimaging in frontotemporal dementia
    Mario F Mendez
    Neurobehavior Unit 116AF, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    J Neuropsychiatry Clin Neurosci 17:413-6. 2005
    ..It is associated with hypoperfusion/hypometabolism in the right hemisphere, particularly the frontal lobe. Loss of insight is often an anosodiaphoria (i.e., lack of concern) rather than an anosognosia (i.e., decreased awareness)...
  20. pmc Functional neuroimaging and presenting psychiatric features in frontotemporal dementia
    M F Mendez
    Department of Neurology, UCLA, Los Angeles, California, USA
    J Neurol Neurosurg Psychiatry 77:4-7. 2006
    ..Behavioural disturbances include psychiatric features. Whether patients with FTD present with psychiatric features varies with the initial neuroanatomical variability of FTD...
  21. doi request reprint Changes in dietary or eating behavior in frontotemporal dementia versus Alzheimer's disease
    Mario F Mendez
    Department of Neurology, University of California, Los Angeles, CA, USA
    Am J Alzheimers Dis Other Demen 23:280-5. 2008
    ..Objective: To evaluate and characterize differences in dietary and eating behavior among patients with early frontotemporal dementia (FTD) versus Alzheimer's disease (AD)...
  22. doi request reprint Psychotic symptoms in frontotemporal dementia: prevalence and review
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, Calif, USA
    Dement Geriatr Cogn Disord 25:206-11. 2008
    ....
  23. pmc Loss of emotional insight in behavioral variant frontotemporal dementia or "frontal anosodiaphoria"
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, The University of California at Los Angeles, USA
    Conscious Cogn 20:1690-6. 2011
    ....
  24. doi request reprint False reports from patients with frontotemporal dementia: delusions or confabulations?
    Mario F Mendez
    Departments of Neurology and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, The University of California at Los Angeles, V A Greater Los Angeles Healthcare Center, USA
    Behav Neurol 24:237-44. 2011
    ..We propose that both phenomena result from known disturbances of ventromedial prefrontal cortex in bvFTD, including deficits in source monitoring and in activating an automatic "doubt tag" for false reports...
  25. pmc The spectrum of sociopathy in dementia
    Mario F Mendez
    Departments of Neurology and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, The University of California at Los Angeles VA Greater Los Angeles Healthcare Center
    J Neuropsychiatry Clin Neurosci 23:132-40. 2011
    ..Two common mechanisms are disinhibition, with frontally predominant disease, and agitation-paranoia, with greater cognitive impairment. These forms of sociopathy differ significantly from the antisocial/psychopathic personality...
  26. doi request reprint Pedophilic behavior from brain disease
    Mario Mendez
    VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    J Sex Med 8:1092-100. 2011
    ..Child molestation or other pedophilic behavior may result as a consequence of a brain disorder...
  27. pmc The false memory syndrome: experimental studies and comparison to confabulations
    M F Mendez
    Neurobehavior Unit, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Med Hypotheses 76:492-6. 2011
    ..Furthermore, like confabulations, in order for false memories to occur there must be an attenuation of the normal, nonconscious, right frontal "doubt tag" regarding their certainty...
  28. pmc The unique predisposition to criminal violations in frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    J Am Acad Psychiatry Law 38:318-23. 2010
    ..Patients with early FTD present a challenge to the criminal justice system to consider alterations in moral cognition before ascribing criminal responsibility...
  29. pmc The neurobiology of moral behavior: review and neuropsychiatric implications
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    CNS Spectr 14:608-20. 2009
    ..The existence of this neuromoral system has major clinical implications for the management of patients with dysmoral behavior from brain disorders and for forensic neuropsychiatry...
  30. doi request reprint Altered emotional morality in frontotemporal dementia
    Mario F Mendez
    Departments of Neurology and Psychiatry and Biobehavioral Sciences, University of California at Los Angeles V A Greater Los Angeles Healthcare Center, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Cogn Neuropsychiatry 14:165-79. 2009
    ..This study investigated the basis of altered moral judgements in patients with FTD...
  31. doi request reprint Frontal-executive versus posterior-perceptual mental status deficits in early-onset dementias
    Mario F Mendez
    Department of Neurology, Neurobehavior Unit, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Alzheimers Dis Other Demen 24:220-7. 2009
    ..Compared to late-onset dementias, early-onset dementias (EODs) may have greater focal cognitive involvement with differences in frontal-executive compared to posterior-perceptual deficits...
  32. doi request reprint Frontotemporal dementia: therapeutic interventions
    Mario F Mendez
    David Geffen School of Medicine at UCLA, and Neurobehavior V A Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Front Neurol Neurosci 24:168-78. 2009
    ..This approach holds great promise for an eventual treatment for this devastating early-onset dementia...
  33. doi request reprint "Denkfaulheit" in frontotemporal dementia: a preliminary analysis
    Mario F Mendez
    Department of Neurology, University of California, Los Angeles, CA, USA
    J Neuropsychiatry Clin Neurosci 20:219-22. 2008
    ..The authors report an analysis of cognitive shallowness, or "Denkfaulheit," in patients with frontotemporal dementia early in its course...
  34. doi request reprint An evidence-based review of the psychopathology of frontotemporal dementia: a report of the ANPA Committee on Research
    Mario F Mendez
    Department of Neurology and Psychiatry, UCLA, USA
    J Neuropsychiatry Clin Neurosci 20:130-49. 2008
    ..The results of this review highlight the distinct neuropsychiatric manifestations of frontotemporal dementia and the need to reconsider the current diagnostic criteria for this disorder...
  35. ncbi request reprint The spectrum of recurrent thoughts and behaviors in frontotemporal dementia
    Mario F Mendez
    Department of Neurology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    CNS Spectr 13:202-8. 2008
    ..The amelioration of these recurrent events with the administration of serotonin selective reuptake inhibitors further suggests a serotonergic deficit...
  36. ncbi request reprint Acquired sociopathy and frontotemporal dementia
    Mario F Mendez
    Department of Neurology and Psychiatry, University of California at Los Angeles, USA
    Dement Geriatr Cogn Disord 20:99-104. 2005
    ..It is not understood why some patients with frontotemporal dementia (FTD) manifest sociopathic behavior...
  37. ncbi request reprint Alterations of the sense of "humanness" in right hemisphere predominant frontotemporal dementia patients
    Mario F Mendez
    David Geffen School of Medicine at UCLA, The University of California at Los Angeles, Los Angeles, California, USA
    Cogn Behav Neurol 17:133-8. 2004
    ..To evaluate the sense of "humanness" in frontotemporal dementia (FTD) patients with right hemispheric involvement...
  38. ncbi request reprint Dementia as a window to the neurology of art
    Mario F Mendez
    Focal type Dementias Clinic, University of California Los Angeles, Los Angeles, CA 90073, USA
    Med Hypotheses 63:1-7. 2004
    ..Further study of art in dementia can profitably evaluate this proposed schema for the mechanisms of art in the brain...
  39. ncbi request reprint Pedophilia and temporal lobe disturbances
    M F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    J Neuropsychiatry Clin Neurosci 12:71-6. 2000
    ..A predisposition to pedophilia may be unmasked by hypersexuality from brain disease. These observations have potential implications for all neurologically based paraphilias...
  40. ncbi request reprint Corticobasal ganglionic degeneration with Balint's syndrome
    M F Mendez
    Department of Neurology, UCLA School of Medicine, USA
    J Neuropsychiatry Clin Neurosci 12:273-5. 2000
    ..This report describes a patient with CBGD who developed Balint's syndrome with simultanagnosia, oculomotor apraxia, and optic ataxia...
  41. ncbi request reprint Hypersexuality after right pallidotomy for Parkinson's disease
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    J Neuropsychiatry Clin Neurosci 16:37-40. 2004
    ..This patient and literature review suggest important roles for the pallidum in sexual behavior and dopamine in sexual arousal...
  42. ncbi request reprint Mania in neurologic disorders
    M F Mendez
    Neurobehavior Unit 116AF, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Psychiatry Rep 2:440-5. 2000
    ..The management of patients with neurologic mania involving correcting the underlying disorder when possible and the judicious use of drugs such as the anticonvulsant medications...
  43. ncbi request reprint Generalized auditory agnosia with spared music recognition in a left-hander. Analysis of a case with a right temporal stroke
    M F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    Cortex 37:139-50. 2001
    ..The findings further suggest a separate and possibly rhythm-based mechanism for music recognition...
  44. ncbi request reprint Agnosia for scenes in topographagnosia
    Mario F Mendez
    Departments of Neurology and Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA 90073, USA
    Neuropsychologia 41:1387-95. 2003
    ....
  45. ncbi request reprint Agnosia for familiar faces and odors in a patient with right temporal lobe dysfunction
    M F Mendez
    Department of Neurology, University of California at Los Angeles, VA Greater Los Angeles Healthcare Center, 90073, USA
    Neurology 57:519-21. 2001
    ..Neuroimaging revealed temporal lobe changes, especially on the right. Right temporal lesions may produce face and odor agnosia by preventing perceptual familiarity units from accessing semantic associations...
  46. ncbi request reprint Aphemia-like syndrome from a right supplementary motor area lesion
    Mario F Mendez
    Department of Neurology, Reed Neurological Research Center, University of California at Los Angeles, Neurobehavior Unit 116AF, VA Greater Los Angeles Healthcare, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Clin Neurol Neurosurg 106:337-9. 2004
    ....
  47. ncbi request reprint Visuospatial deficits with preserved reading ability in a patient with posterior cortical atrophy
    M F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    Cortex 37:535-43. 2001
    ..These findings suggested a dissociation between reading routes. Although the patient had a phonological dyslexia, her visuospatial processing was sufficient for access to preserved visual word forms for efficient lexical reading...
  48. ncbi request reprint Dementia with leukoaraiosis: clinical differentiation by temporoparietal hypometabolism on (18)FDG-PET imaging
    M F Mendez
    Psychiatry, VA Greater Los Angeles Healthcare System, UCLA School of Medicine, Los Angeles, CA 90073, USA
    Dement Geriatr Cogn Disord 10:518-25. 1999
    ..Copyrightz1999S.KargerAG,Basel..
  49. ncbi request reprint Neuropsychiatric features of frontotemporal dementia: evaluation of consensus criteria and review
    Mario F Mendez
    Department of Neurology, UCLA School of Medicine, Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    J Neuropsychiatry Clin Neurosci 14:424-9. 2002
    ..Consensus Criteria for FTD offer guidelines for diagnosis, but further refinement is needed, particularly for patients who lack early changes in social interpersonal conduct...
  50. ncbi request reprint Stereotypical movements and frontotemporal dementia
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Mov Disord 20:742-5. 2005
    ....
  51. ncbi request reprint Posterior cortical atrophy: clinical characteristics and differences compared to Alzheimer's disease
    Mario F Mendez
    Department of Neurology, University of California at Los Angeles, CA, USA
    Dement Geriatr Cogn Disord 14:33-40. 2002
    ..In clinicopathological studies, PCA is most commonly considered a form of Alzheimer's disease (AD); no prior study has evaluated clinical differences between PCA and AD...
  52. ncbi request reprint The vascular dementia of Fabry's disease
    M F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    Dement Geriatr Cogn Disord 8:252-7. 1997
    ..Fabry's disease is a consideration in the workup of an otherwise unexplained vascular dementia, particularly in males less than 65 years of age...
  53. ncbi request reprint Behavioral differences between frontotemporal dementia and Alzheimer's disease: a comparison on the BEHAVE-AD rating scale
    M F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    Int Psychogeriatr 10:155-62. 1998
    ..The assessment of neuropsychiatric symptoms with a standardized scale or inventory can help distinguish dementia patients with FTD and AD...
  54. ncbi request reprint Speech and language in progressive nonfluent aphasia compared with early Alzheimer's disease
    Mario F Mendez
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, USA
    Neurology 61:1108-13. 2003
    ..The differentiation of PA from early Alzheimer's disease (AD) is important, given the presence of early language changes in AD...
  55. ncbi request reprint Involuntary laughter and inappropriate hilarity
    M F Mendez
    Department of Neurology, University of California at Los Angeles, USA
    J Neuropsychiatry Clin Neurosci 11:253-8. 1999
    ..Treatment includes the use of antidepressant and antimanic agents for disorders of laughter...
  56. ncbi request reprint The accuracy of clinical criteria for the diagnosis of frontotemporal dementia
    Mario F Mendez
    UCLA School of Medicine, USA
    Int J Psychiatry Med 34:125-30. 2004
    ..Future research should refine the clinical criteria for FTD using clinicopathological correlation in addition to working on the development of neurobiological markers...
  57. ncbi request reprint Emergent neuroleptic hypersensitivity as a herald of presenile dementia
    M F Mendez
    Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles 90073, USA
    J Neuropsychiatry Clin Neurosci 13:347-56. 2001
    ..The predisposition to neuroleptic hypersensitivity could result from depleted nigral dopaminergic neurons suggested by "smudging" of the substantia nigra pars compacta on magnetic resonance imaging...
  58. doi request reprint Content-specific delusions from right caudate lacunar stroke: association with prefrontal hypometabolism
    Aaron M McMurtray
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Neuropsychiatry Clin Neurosci 20:62-7. 2008
    ..These patients suggest an etiological relationship between alterations in inferior prefrontal functions and the development of content-specific delusions...
  59. ncbi request reprint Positron emission tomography facilitates diagnosis of early-onset Alzheimer's disease
    Aaron M McMurtray
    Department of Neurology, University of California at Los Angeles UCLA, Calif, USA
    Eur Neurol 59:31-7. 2008
    ..Clinical positron emission tomography (PET) may help in the evaluation of presenile patients with memory complaints for the presence of Alzheimer's disease (AD)...
  60. pmc Development of methodology for conducting clinical trials in frontotemporal lobar degeneration
    David S Knopman
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Brain 131:2957-68. 2008
    ..There are several candidate outcome measures -- including the FTLD-CDR and the cognitive composites -- that could be used in clinical trials across the spectrum of FTLD...
  61. ncbi request reprint Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia
    George Bartzokis
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biol Psychiatry 62:1380-7. 2007
    ..Apolipoprotein E (ApoE) 4 allele is the second most important AD risk factor. We tested the hypothesis that ApoE4 accelerates age-related slowing in CPS through the process of myelin breakdown...
  62. ncbi request reprint Fluent versus nonfluent primary progressive aphasia: a comparison of clinical and functional neuroimaging features
    David Glenn Clark
    David Geffen School of Medicine, Department of Neurology, University of California Los Angeles, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, 3 South Neurobehavior Unit 116AF, Los Angeles, CA 90073, USA
    Brain Lang 94:54-60. 2005
    ..Nevertheless, there is a large amount of overlap between dysfunctional anatomic regions associated with these syndromes...
  63. pmc Lifespan trajectory of myelin integrity and maximum motor speed
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA
    Neurobiol Aging 31:1554-62. 2010
    ..We tested the hypothesis that the age-related trajectory of FTS is related to brain myelin integrity...
  64. ncbi request reprint Early-onset dementia: frequency and causes compared to late-onset dementia
    Aaron McMurtray
    Department of Neurology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA, USA
    Dement Geriatr Cogn Disord 21:59-64. 2006
    ..Few investigations have studied differences in etiologic frequencies between early-onset dementia (EOD), with onset at an age of less than 65 years old, and the more common late-onset disorder...
  65. ncbi request reprint Delusional thoughts and regional frontal/temporal cortex metabolism in Alzheimer's disease
    David L Sultzer
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, USA
    Am J Psychiatry 160:341-9. 2003
    ..In this study the authors examined the relationship between delusional thoughts and regional cortical metabolism in patients with Alzheimer's disease...
  66. pmc "Fantastic thinking" in pathologically proven Pick disease
    Sarah A Kremen
    Neurobehavior Unit, Department of Neurology, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Cogn Behav Neurol 23:130-4. 2010
    ..Reports of false beliefs may be a unique feature of behavioral variant frontotemporal dementia (bvFTD) but the nature of these experiences is unclear...
  67. ncbi request reprint Family history of dementia in early-onset versus very late-onset Alzheimer's disease
    Aaron M McMurtray
    Department of Neurology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90073, USA
    Int J Geriatr Psychiatry 21:597-8. 2006
  68. pmc The use of profanity during letter fluency tasks in frontotemporal dementia and Alzheimer disease
    John M Ringman
    UCLA Department of Neurology, Easton Center for Alzheimer s Disease Research at UCLA, Los Angeles, CA 90095 7226, USA
    Cogn Behav Neurol 23:159-64. 2010
    ..To assess whether the production of profanity during letter fluency testing distinguishes frontotemporal dementia (FTD) and Alzheimer disease (AD) patients...
  69. pmc Extrapyramidal signs in the primary progressive aphasias
    Sarah A Kremen
    VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Am J Alzheimers Dis Other Demen 26:72-7. 2011
    ..Extrapyramidal signs (EPS) may vary across 3 major subtypes of primary progressive aphasia (PPA): progressive nonfluent aphasia (PNFA), semantic dementia (SD), and progressive logopenic aphasia (PLA)...
  70. pmc Off-label medication use in frontotemporal dementia
    - Bei Hu
    Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Alzheimers Dis Other Demen 25:128-33. 2010
    ..We sought to determine the most commonly used drugs used to treat behavioral variant FTD (bvFTD) in specialized dementia clinics...
  71. ncbi request reprint Cognitive performance after lacunar stroke correlates with leukoaraiosis severity
    Aaron M McMurtray
    Department of Neurology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90073, USA
    Cerebrovasc Dis 24:271-6. 2007
    ..This study investigates the effect of leukoaraiosis on patients presenting with cognitive impairment after lacunar stroke...
  72. ncbi request reprint Cognitive differences between early- and late-onset Alzheimer's disease
    Eliot A Licht
    Neurobehavior Unit, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Am J Alzheimers Dis Other Demen 22:218-22. 2007
    ..We conclude that Alzheimer's disease is a clinically heterogeneous disorder whose manifestations can vary with age of onset. These differences indicate age-related vulnerabilities in this disease...
  73. ncbi request reprint Functional imaging as a window to dementia: corticobasal degeneration
    Andreea L Seritan
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, California, USA
    J Neuropsychiatry Clin Neurosci 16:393-9. 2004
  74. ncbi request reprint Clinicopathologic case report: akinetic mutism with findings of white matter hyperintensity
    Gerald T Lim
    Department of Neurology, University of California at Los Angeles Medical Center, USA
    J Neuropsychiatry Clin Neurosci 14:214-21. 2002
  75. doi request reprint Neuroanatomy of pathological laughing and crying: a report of the American Neuropsychiatric Association Committee on Research
    Josef Parvizi
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Neuropsychiatry Clin Neurosci 21:75-87. 2009
    ..It concludes with a presentation of the remaining questions and directions for future research...
  76. ncbi request reprint Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions
    Katya Rascovsky
    Memory and Aging Center, University of California, San Francisco, CA 94117, USA
    Alzheimer Dis Assoc Disord 21:S14-8. 2007
    ..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia...
  77. ncbi request reprint Developmental stuttering: manifestations, treatment and dental implications
    Arthur H Friedlander
    Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Spec Care Dentist 24:7-12. 2004
    ..Some people who stutter have sensory-motor and tactile-proprioceptive deficits that impede accurate and timely movements of the mandible, lips, and tongue, necessitating protection of the airway by staff during dental care...
  78. ncbi request reprint Depressive and memory symptoms as presenting features of spinocerebellar ataxia
    Aaron M McMurtray
    Department of Neurology, University of California at Los Angeles UCLA, USA
    J Neuropsychiatry Clin Neurosci 18:420-2. 2006
    ..Memory symptoms occurred across all SCA groups with relative sparing of SCA6. These differences in neuropsychiatric symptoms suggest the subtype of SCA and the corresponding neuropathological involvement...
  79. ncbi request reprint Frontotemporal lobar degeneration: demographic characteristics of 353 patients
    Julene K Johnson
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, 94117, USA
    Arch Neurol 62:925-30. 2005
    ..The publication of consensus criteria for FTLD, however, prompted systematic studies. The criteria categorize FTLD into 3 subgroups: frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia...
  80. ncbi request reprint Longitudinal tracking of FTLD: toward developing clinical trial methodology
    David S Knopman
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Alzheimer Dis Assoc Disord 21:S58-63. 2007
    ..In addition, a multicenter trial is described in which some aspects of diagnosis and longitudinal measurement in the frontotemporal lobar degenerations are being specifically explored...
  81. ncbi request reprint Semantic dementia in multilingual patients
    Mario F Mendez
    J Neuropsychiatry Clin Neurosci 16:381. 2004
  82. ncbi request reprint Intermetamorphosis in a patient with Alzheimer's disease
    Frederic Assal
    J Neuropsychiatry Clin Neurosci 15:246-7. 2003
  83. ncbi request reprint Neuropsychiatric complications of traumatic brain injury: a critical review of the literature (a report by the ANPA Committee on Research)
    Edward Kim
    Bristol Myers Squibb Company, Neuroscience Medical Strategy, 777 Scudders Mill Road, Plainsboro, NJ 08536, USA
    J Neuropsychiatry Clin Neurosci 19:106-27. 2007
    ..Larger multicenter prospective studies using standardized diagnostic instruments are needed to further clarify the nosology, risk factors, and clinical course of these disorders. Specific directions for research are provided...
  84. ncbi request reprint Slowly progressive alexia
    Mario F Mendez
    J Neuropsychiatry Clin Neurosci 14:84. 2002
  85. doi request reprint Distraction during relational reasoning: the role of prefrontal cortex in interference control
    Daniel C Krawczyk
    Center for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA
    Neuropsychologia 46:2020-32. 2008
    ..These results demonstrate that intact prefrontal cortex (PFC) is necessary for controlling interference from perceptual and semantic distractors in order to reason from relational structure...
  86. ncbi request reprint Moria and Witzelsucht from frontotemporal dementia
    Mario F Mendez
    J Neuropsychiatry Clin Neurosci 17:429-30. 2005
  87. pmc Referral patterns for syndromes associated with frontotemporal lobar degeneration
    Tiffany W Chow
    The Rotman Research Institute, University of Toronto, Toronto, Ontario
    Alzheimer Dis Assoc Disord 19:17-9. 2005
    ..Clinics specializing in FTD recruit more language presentation cases. There were statistical but not clinically significant differences in ages at onset...
  88. ncbi request reprint Hypergraphia for poetry in an epileptic patient
    Mario F Mendez
    J Neuropsychiatry Clin Neurosci 17:560-1. 2005
  89. pmc The A431E mutation in PSEN1 causing familial Alzheimer's disease originating in Jalisco State, Mexico: an additional fifteen families
    Jill Murrell
    Department of Pathology and Laboratory Medicine, University of Indiana Medical School, 635 Barnhill Drive, MS A128, Indianapolis, IN 46202 5126, USA
    Neurogenetics 7:277-9. 2006
    ....
  90. ncbi request reprint Impaired knowledge for fruits and vegetables in semantic dementia
    Mario F Mendez
    J Neuropsychiatry Clin Neurosci 19:349-50. 2007
  91. ncbi request reprint Thalamic acalculia
    Mario F Mendez
    J Neuropsychiatry Clin Neurosci 15:115-6. 2003
  92. ncbi request reprint Prominent echolalia from isolation of the speech area
    Mario F Mendez
    J Neuropsychiatry Clin Neurosci 14:356-7. 2002
  93. ncbi request reprint Goals in symptomatic pharmacologic management of frontotemporal lobar degeneration
    Tiffany W Chow
    University of Southern California at Los Angeles, USA
    Am J Alzheimers Dis Other Demen 17:267-72. 2002
    ..Behavioral disturbances can be alleviatedpharmacologically, but further research might determine guidelines for management of this non-Alzheimer's dementia syndrome that could decrease the frequency of adverse drug events...

Research Grants2

  1. Multidisciplinary Study of Social Behavior and Emotion in Frontotemporal Dementia
    Mario Mendez; Fiscal Year: 2009
    ..This application combines many specialists to study disturbed social behavior in frontotemporal dementia. The results of the project can clarify how social behavior is altered by mental disorders or brain diseases. ..
  2. Multidisciplinary Study of Social Behavior and Emotion in Frontotemporal Dementia
    MARIO FERNANDO MENDEZ; Fiscal Year: 2010
    ..This application combines many specialists to study disturbed social behavior in frontotemporal dementia. The results of the project can clarify how social behavior is altered by mental disorders or brain diseases. ..