C R Mendelson

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Transcriptional regulation of aromatase in placenta and ovary
    Carole R Mendelson
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    J Steroid Biochem Mol Biol 95:25-33. 2005
  2. ncbi Transcription factor USF2 is developmentally regulated in fetal lung and acts together with USF1 to induce SP-A gene expression
    Erwei Gao
    Departments of Biochemistry and Obstetrics and Gynecology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9038, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1027-36. 2003
  3. ncbi New insights into the molecular endocrinology of parturition
    Carole R Mendelson
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    J Steroid Biochem Mol Biol 93:113-9. 2005
  4. ncbi Role of transcription factors in fetal lung development and surfactant protein gene expression
    C R Mendelson
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas 75235 9038, USA
    Annu Rev Physiol 62:875-915. 2000
  5. ncbi The basic helix-loop-helix-zipper transcription factor USF1 regulates expression of the surfactant protein-A gene
    E Gao
    Department of Obstetrics Gynecology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9038, USA
    J Biol Chem 272:23398-406. 1997
  6. ncbi Identification of enhancers in the 5'-flanking region of the rabbit surfactant protein A (SP-A) gene and characterization of their binding proteins
    E Gao
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038
    J Biol Chem 268:19697-709. 1993
  7. ncbi Characterization of mRNA transcripts and organization of human SP-A1 and SP-A2 genes
    S M McCormick
    Department of Biochemistry, Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas 75235 9038
    Am J Physiol 266:L354-66. 1994
  8. ncbi Tissue-specific expression of the human CYP19 (aromatase) gene in ovary and adipose tissue of transgenic mice
    M M Hinshelwood
    Department of Obstetrics and Gynecology, University of Texas, Southwestern Medical Center, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    J Steroid Biochem Mol Biol 79:193-201. 2001
  9. ncbi Glucocorticoid inhibition of SP-A gene expression in lung type II cells is mediated via the TTF-1-binding element
    Joseph L Alcorn
    Dept of Biochemistry, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9038, USA
    Am J Physiol Lung Cell Mol Physiol 286:L767-76. 2004
  10. ncbi Potential role of nuclear factor kappaB and reactive oxygen species in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells
    Kazi Nazrul Islam
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 16:1428-40. 2002

Collaborators

Detail Information

Publications39

  1. ncbi Transcriptional regulation of aromatase in placenta and ovary
    Carole R Mendelson
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    J Steroid Biochem Mol Biol 95:25-33. 2005
    ....
  2. ncbi Transcription factor USF2 is developmentally regulated in fetal lung and acts together with USF1 to induce SP-A gene expression
    Erwei Gao
    Departments of Biochemistry and Obstetrics and Gynecology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9038, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1027-36. 2003
    ..We suggest that heterodimers of USF2 and USF1 bound to two E-box elements in the SP-A gene 5'-flanking region serve a key role in developmental and hormonal regulation of SP-A gene expression in pulmonary type II cells...
  3. ncbi New insights into the molecular endocrinology of parturition
    Carole R Mendelson
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    J Steroid Biochem Mol Biol 93:113-9. 2005
    ..Our findings, therefore, indicate that SP-A secreted into amniotic fluid by the maturing fetal lung serves as a hormone of parturition...
  4. ncbi Role of transcription factors in fetal lung development and surfactant protein gene expression
    C R Mendelson
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas 75235 9038, USA
    Annu Rev Physiol 62:875-915. 2000
    ..In this chapter, the cellular and molecular mechanisms that control lung development are considered, as well as those that regulate expression of the genes encoding the surfactant proteins...
  5. ncbi The basic helix-loop-helix-zipper transcription factor USF1 regulates expression of the surfactant protein-A gene
    E Gao
    Department of Obstetrics Gynecology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9038, USA
    J Biol Chem 272:23398-406. 1997
    ..It is suggested that rUSF1s, which bind to two E-box elements in the SP-A gene 5'-flanking region, may serve a key role in the regulation of SP-A gene expression in pulmonary type II cells...
  6. ncbi Identification of enhancers in the 5'-flanking region of the rabbit surfactant protein A (SP-A) gene and characterization of their binding proteins
    E Gao
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038
    J Biol Chem 268:19697-709. 1993
    ..These findings suggest that the DBE and PBE act as enhancers that interact with the same or related trans-acting proteins and serve an important role in type II cell-specific, cyclic AMP-mediated regulation of SP-A gene expression...
  7. ncbi Characterization of mRNA transcripts and organization of human SP-A1 and SP-A2 genes
    S M McCormick
    Department of Biochemistry, Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas 75235 9038
    Am J Physiol 266:L354-66. 1994
    ..266 (Lung Cell. Mol. Physiol. 10): L367-L374, 1994], we report that the SP-A1 and SP-A2 genes are differentially regulated during development and by adenosine 3',5'-cyclic monophosphate and glucocorticoids in human fetal lung in culture...
  8. ncbi Tissue-specific expression of the human CYP19 (aromatase) gene in ovary and adipose tissue of transgenic mice
    M M Hinshelwood
    Department of Obstetrics and Gynecology, University of Texas, Southwestern Medical Center, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    J Steroid Biochem Mol Biol 79:193-201. 2001
    ..4 mediate adipose- and skin-specific CYP19 gene expression. Studies are in progress using transgenic mice to further define the response elements that mediate ovary and adipose-specific hCYP19 gene expression...
  9. ncbi Glucocorticoid inhibition of SP-A gene expression in lung type II cells is mediated via the TTF-1-binding element
    Joseph L Alcorn
    Dept of Biochemistry, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9038, USA
    Am J Physiol Lung Cell Mol Physiol 286:L767-76. 2004
    ..Our finding that Dex increased expression of the NF-kappaB inhibitory partner IkappaB-alpha suggests that the decrease in TBE-binding activity may be caused, in part, by GR inhibition of NF-kappaB interaction with this site...
  10. ncbi Potential role of nuclear factor kappaB and reactive oxygen species in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells
    Kazi Nazrul Islam
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 16:1428-40. 2002
    ..This provides intriguing evidence that permissive effects of O2/reactive oxygen species on cAMP regulation of SP-A expression may be mediated by cooperative interactions of TTF-1 and NF-kappaB at the TBE...
  11. pmc TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity
    Dongyuan Liu
    Department of Biochemistry, North Texas March of Dimes Birth Defects Center, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235 9038, USA
    Am J Physiol Lung Cell Mol Physiol 295:L264-71. 2008
    ....
  12. ncbi Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactant protein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1)
    Ming Yi
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9038, USA
    J Biol Chem 277:2997-3005. 2002
    ..This suggests that cAMP-mediated TTF-1 phosphorylation facilitates interaction with CBP and SRC-1, resulting in its hyperacetylation, further enhancing TTF-1 DNA-binding and transcriptional activity...
  13. pmc Permissive effects of oxygen on cyclic AMP and interleukin-1 stimulation of surfactant protein A gene expression are mediated by epigenetic mechanisms
    Kazi Nazrul Islam
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Mol Cell Biol 26:2901-12. 2006
    ..The binding of these transcription factors facilitates the recruitment of coactivators, resulting in the further opening of the chromatin structure and activation of SP-A transcription...
  14. ncbi Temporal and spatial expression of liver receptor homologue-1 (LRH-1) during embryogenesis suggests a potential role in gonadal development
    Margaret M Hinshelwood
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Dev Dyn 234:159-68. 2005
    ....
  15. pmc Glucocorticoid/glucocorticoid receptor inhibition of surfactant protein-A (SP-A) gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A promoter
    Kazi Nazrul Islam
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 22:585-96. 2008
    ..Collectively, these events may culminate in the closing of chromatin structure surrounding the SP-A gene and inhibition of its transcription...
  16. pmc cAMP enhances estrogen-related receptor alpha (ERRalpha) transcriptional activity at the SP-A promoter by increasing its interaction with protein kinase A and steroid receptor coactivator 2 (SRC-2)
    Dongyuan Liu
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 75390 9038, USA
    Mol Endocrinol 23:772-83. 2009
    ....
  17. doi Regulation of human aromatase cytochrome P450 gene expression
    E R Simpson
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics Gynecology, The University of Texas Southwestern Medical Center, Dallas, TX 75235 9051, USA
    J Steroid Biochem Mol Biol 43:923-30. 1992
    ..This means that the protein expressed in each of the various tissue-specific sites of estrogen biosynthesis is identical...
  18. ncbi Identification of the regulatory regions of the human aromatase P450 (CYP19) gene involved in placenta-specific expression
    A Kamat
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Steroid Biochem Mol Biol 79:173-80. 2001
    ..Our findings from transgenic studies further indicate that mouse placenta contains the necessary transcription factors required to activate the human CYP19 promoter although mouse placenta does not express endogenous aromatase...
  19. ncbi Peroxisome proliferator-activated receptor gamma1 expression is induced during cyclic adenosine monophosphate-stimulated differentiation of alveolar type II pneumonocytes
    L F Michael
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 75235 9038, USA
    Endocrinology 138:3695-703. 1997
    ..In view of the role of PPARgamma in adipocyte differentiation and lipid homeostasis, we postulate that PPARgamma1 induction by cAMP plays a role in the differentiation and expression of lipogenic enzymes in lung type II cells...
  20. pmc Mechanisms in the regulation of aromatase in developing ovary and placenta
    Carole R Mendelson
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, TX 75390 9038, USA
    J Steroid Biochem Mol Biol 106:62-70. 2007
    ..The temporal and spatial expression of LRH-1 versus SF-1 in the developing gonad during mouse embryogenesis and in the postnatal ovary also will be considered...
  21. pmc Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms
    Daniel B Hardy
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 22:1812-24. 2008
    ..Collectively, these findings suggest that PR plays an important antiinflammatory role in breast cancer cells via ligand-dependent and ligand-independent mechanisms...
  22. ncbi Genomic regions that mediate placental cell-specific and developmental regulation of human Cyp19 (aromatase) gene expression in transgenic mice
    Amrita Kamat
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Endocrinology 146:2481-8. 2005
    ....
  23. pmc USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia
    Bing Jiang
    Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Mol Cell Biol 23:6117-28. 2003
    ..These findings suggest that increased protein levels and DNA binding of USF1 and USF2 mediate the inhibitory effects of hypoxia and of Mash-2 on CYP19 gene expression in human placenta...
  24. ncbi Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function
    Margaret M Hinshelwood
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390 9038, USA
    Mol Cell Endocrinol 207:39-45. 2003
    ..Based on these findings, we propose that LRH-1 plays an important role as a competence factor in regulating aromatase, and thus estrogen biosynthesis, in ovary...
  25. pmc Estrogen receptor alpha (ERalpha) mediates stimulatory effects of estrogen on aromatase (CYP19) gene expression in human placenta
    Premlata Kumar
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 75390 9038, USA
    Mol Endocrinol 23:784-93. 2009
    ..Thus, during trophoblast differentiation, estrogen/ERalpha exerts a positive feedback role, which promotes permissive histone modifications that are associated with induction of hCYP19 gene transcription...
  26. ncbi Estrogen related receptor-alpha enhances surfactant protein-A gene expression in fetal lung type II cells
    Dongyuan Liu
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    Endocrinology 147:5187-95. 2006
    ..These findings suggest that ERRalpha acting through NRE(SP-A) is an important mediator of hSP-A gene expression and its induction by cAMP...
  27. ncbi Rabbit lung surfactant protein A gene: identification of a lung-specific DNase I hypersensitive site
    Q Chen
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038
    Am J Physiol 262:L662-71. 1992
    ..The presence of this tissue-specific DNase I hypersensitive site in lung nuclei from 21-day gestational age fetal rabbits suggests that the SP-A gene may exist in an accessible conformation prior to the time of transcription initiation...
  28. ncbi Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression
    Daniel B Hardy
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 20:2724-33. 2006
    ..Based on these findings, we propose that PR may inhibit NF-kappaB activation of COX-2 gene expression and uterine contractility via ligand-dependent and ligand-independent mechanisms...
  29. pmc Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition
    Jennifer C Condon
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:4978-83. 2004
    ..We have revealed a response pathway that ties augmented surfactant production by the maturing fetal lung to the initiation of labor. We suggest that SP-A secreted by the fetal lung serves as a hormone of parturition...
  30. ncbi Adenoviral-mediated gene delivery to trophoblast cells
    Bing Jiang
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, USA
    Methods Mol Med 121:451-61. 2006
    ....
  31. pmc Inflammatory status influences aromatase and steroid receptor expression in endometriosis
    Orhan Bukulmez
    Department of Obstetrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9032, USA
    Endocrinology 149:1190-204. 2008
    ..PR-A protein was barely detectable in endometriomas. Thus, whereas PR-C may enhance disease progression, up-regulation of ERbeta may play an antiinflammatory and opposing role...
  32. pmc Role of the progesterone receptor (PR) in the regulation of inflammatory response pathways and aromatase in the breast
    Carole R Mendelson
    Department of Biochemistry, The North Texas March of Dimes Birth Defects Center, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    J Steroid Biochem Mol Biol 102:241-9. 2006
    ....
  33. ncbi Mechanisms in tissue-specific regulation of estrogen biosynthesis in humans
    Amrita Kamat
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9038, USA
    Trends Endocrinol Metab 13:122-8. 2002
    ....
  34. ncbi Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function
    Jennifer C Condon
    Department of Biochemistry, North Texas March of Dimes Birth Defects Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 20:764-75. 2006
    ....
  35. pmc O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated by proteasomal degradation of USF1 and USF2
    Bing Jiang
    Departments of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Mol Cell Biol 25:8824-33. 2005
    ..In the second trimester, increased O(2) tension promotes proteasomal degradation of USF1/2, resulting in syncytiotrophoblast differentiation and induction of hCYP19 expression...
  36. pmc A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition
    Jennifer C Condon
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 100:9518-23. 2003
    ..The resulting decrease in expression of PR-responsive genes should increase sensitivity of the uterus to contractile stimuli...
  37. ncbi Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Chem Biol 1:210-5. 2005
    ..agPNAs provide a general approach for controlling transcription initiation and a distinct option for target validation and therapeutic development...
  38. pmc Minireview: fetal-maternal hormonal signaling in pregnancy and labor
    Carole R Mendelson
    Departments of Biochemistry and Obstetrics and Gynecology, North Texas March of Dimes Birth Defects Center, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 23:947-54. 2009
    ..Alternatively, we propose that uterine quiescence during pregnancy is regulated, in part, by PR antagonism of the inflammatory response...
  39. pmc Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress
    Meenakshi Maitra
    Eugene McDermott Center for Human Growth and Development, Dallas, Texas 75390, USA
    J Biol Chem 285:22103-13. 2010
    ....