Michael Menaker

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Neurobiology: The Eye within the Brain
    Michael Menaker
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA Electronic address
    Curr Biol 24:R613-5. 2014
  2. pmc Methamphetamine and dopamine receptor D1 regulate entrainment of murine circadian oscillators
    Jennifer A Mohawk
    Department of Biology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 8:e62463. 2013
  3. doi request reprint Central control of peripheral circadian oscillators
    Michael Menaker
    Department of Biology, University of Virginia, Charlottesville, VA, United States Electronic address
    Curr Opin Neurobiol 23:741-6. 2013
  4. ncbi request reprint Circadian rhythms. Circadian photoreception
    Michael Menaker
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Science 299:213-4. 2003
  5. ncbi request reprint Circadian rhythm of iguana electroretinogram: the role of dopamine and melatonin
    Manuel Miranda-Anaya
    Department of Biology and National Science Foundation Centerfor Biological Timing, University of Virginia, Charlottesville, VA 22904 4328, USA
    J Biol Rhythms 17:526-38. 2002
  6. pmc Circadian organization in the real world
    Michael Menaker
    Department of Biology, University of Virginia, Charlottesville, 22904 4328, USA
    Proc Natl Acad Sci U S A 103:3015-6. 2006
  7. ncbi request reprint Entrainment of the circadian clock in the liver by feeding
    K A Stokkan
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
    Science 291:490-3. 2001
  8. ncbi request reprint Evolution of circadian organization in vertebrates
    M Menaker
    NSF Center for Biological Timing, University of Virginia, Charlottesville 22903, USA
    Braz J Med Biol Res 30:305-13. 1997
  9. pmc Effects of aging on central and peripheral mammalian clocks
    Shin Yamazaki
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    Proc Natl Acad Sci U S A 99:10801-6. 2002
  10. pmc Retinal pathways influence temporal niche
    Susan E Doyle
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Proc Natl Acad Sci U S A 105:13133-8. 2008

Research Grants

  1. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2005
  2. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2004
  3. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2003
  4. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2002
  5. CIRCADIAN OSCILLATORS IN CULTURED MAMMALIAN RETINA
    Michael Menaker; Fiscal Year: 2001
  6. CIRCADIAN OSCILLATORS IN CULTURED MAMMALIAN RETINA
    Michael Menaker; Fiscal Year: 2000
  7. CIRCADIAN OSCILLATORS IN CULTURED MAMMALIAN RETINA
    Michael Menaker; Fiscal Year: 1999
  8. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2006

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Neurobiology: The Eye within the Brain
    Michael Menaker
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA Electronic address
    Curr Biol 24:R613-5. 2014
    ..A new paper provides direct evidence of photosensitivity in cerebrospinal fluid (CSF)-contacting neurons in quail brain that mediate the seasonal reproductive response. ..
  2. pmc Methamphetamine and dopamine receptor D1 regulate entrainment of murine circadian oscillators
    Jennifer A Mohawk
    Department of Biology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 8:e62463. 2013
    ..This study also identifies a role for dopamine signaling in normal entrainment of circadian oscillators...
  3. doi request reprint Central control of peripheral circadian oscillators
    Michael Menaker
    Department of Biology, University of Virginia, Charlottesville, VA, United States Electronic address
    Curr Opin Neurobiol 23:741-6. 2013
    ..It is likely that there are many unknown signals as well. Disrupting the network can produce severe pathology. ..
  4. ncbi request reprint Circadian rhythms. Circadian photoreception
    Michael Menaker
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Science 299:213-4. 2003
  5. ncbi request reprint Circadian rhythm of iguana electroretinogram: the role of dopamine and melatonin
    Manuel Miranda-Anaya
    Department of Biology and National Science Foundation Centerfor Biological Timing, University of Virginia, Charlottesville, VA 22904 4328, USA
    J Biol Rhythms 17:526-38. 2002
    ..The results of this study suggest that in iguana, a negative feedback loop involving dopamine and melatonin regulates the circadian rhythm of the ERG b-wave amplitude that is at least in part generated in the brain...
  6. pmc Circadian organization in the real world
    Michael Menaker
    Department of Biology, University of Virginia, Charlottesville, 22904 4328, USA
    Proc Natl Acad Sci U S A 103:3015-6. 2006
  7. ncbi request reprint Entrainment of the circadian clock in the liver by feeding
    K A Stokkan
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
    Science 291:490-3. 2001
    ..They also raise the possibility that peripheral circadian oscillators like those in the liver may be coupled to the SCN primarily through rhythmic behavior, such as feeding...
  8. ncbi request reprint Evolution of circadian organization in vertebrates
    M Menaker
    NSF Center for Biological Timing, University of Virginia, Charlottesville 22903, USA
    Braz J Med Biol Res 30:305-13. 1997
    ....
  9. pmc Effects of aging on central and peripheral mammalian clocks
    Shin Yamazaki
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    Proc Natl Acad Sci U S A 99:10801-6. 2002
    ..Aging seems to affect rhythms in some but not in all tissues and may act primarily on interactions among circadian oscillators, perhaps attenuating the ability of the SCN to drive damped oscillators in the periphery...
  10. pmc Retinal pathways influence temporal niche
    Susan E Doyle
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Proc Natl Acad Sci U S A 105:13133-8. 2008
    ..These results reveal a novel mechanism by which changes in retinal input can mediate acute temporal-niche switching...
  11. doi request reprint Circadian organization is governed by extra-SCN pacemakers
    Pinar Pezuk
    Department of Biology, University of Virginia, Charlottesville, VA, USA
    J Biol Rhythms 25:432-41. 2010
    ..Taken together, these data show that FEO and MASCO are strong circadian pacemakers able to regulate the phases of peripheral oscillators...
  12. pmc Glucocorticoids as entraining signals for peripheral circadian oscillators
    Pinar Pezuk
    Department of Biology, University of Virginia, Charlottesville, Virginia 22904 4328, USA
    Endocrinology 153:4775-83. 2012
    ..Our data show that glucocorticoids act as strong entraining signals for peripheral circadian oscillators and may feed back on central oscillators as well...
  13. pmc Resetting of central and peripheral circadian oscillators in aged rats
    Alec J Davidson
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    Neurobiol Aging 29:471-7. 2008
    ..The consequences of these deficits are unknown, but may contribute to organ and brain diseases in the aged as well as the health problems that are common in older shift-workers...
  14. ncbi request reprint Resetting central and peripheral circadian oscillators in transgenic rats
    S Yamazaki
    NSF Center for Biological Timing and Department of Biology, University of Virginia, Charlottesville, VA 22903-2477, USA
    Science 288:682-5. 2000
    ....
  15. pmc Estrogen directly modulates circadian rhythms of PER2 expression in the uterus
    Takahiro J Nakamura
    Department of Biology, University of Virginia, Charlottesville, Virginia, USA
    Am J Physiol Endocrinol Metab 295:E1025-31. 2008
    ..These data indicate that estrogen directly affects the timing of the molecular clock in the uterus via an estrogen receptor-mediated response...
  16. ncbi request reprint Interactions between dopamine and melatonin organize circadian rhythmicity in the retina of the green iguana
    Paul A Bartell
    Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
    J Biol Rhythms 22:515-23. 2007
    ..The data suggest that in iguanas, the amplitude of the circadian rhythm of melatonin synthesis in the eye is suppressed by dopamine while the rhythm of dopamine depends, at least in part, on the presence of melatonin...
  17. ncbi request reprint The methamphetamine-sensitive circadian oscillator (MASCO) in mice
    Ozgur Tataroglu
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    J Biol Rhythms 21:185-94. 2006
    ....
  18. ncbi request reprint Circadian rhythms in isolated brain regions
    Michikazu Abe
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, Charlottesville, Virginia 22904, USA
    J Neurosci 22:350-6. 2002
    ..The phasing of these oscillators to one another may play a critical role in coordinating brain activity and its adjustment to changes in the light cycle...
  19. ncbi request reprint Food-anticipatory activity and liver per1-luc activity in diabetic transgenic rats
    Alec J Davidson
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Physiol Behav 76:21-6. 2002
    ..In two separate experiments, FAA emerged and liver Per1 phase-shifted in response to daytime 8-h food restriction. The results rule out insulin as a necessary component of this system...
  20. pmc Lithium and genetic inhibition of GSK3beta enhance the effect of methamphetamine on circadian rhythms in the mouse
    Jennifer A Mohawk
    Department of Biology, University of Virginia, Charlottesville, Virginia 22904 4328, USA
    Behav Pharmacol 20:174-83. 2009
    ..These data, together with many others in the literature, point to a complicated interaction between the circadian system and the development and possible treatment of psychopathologies such as bipolar disorder and drug addiction...
  21. doi request reprint Interferon-gamma alters electrical activity and clock gene expression in suprachiasmatic nucleus neurons
    Yongho Kwak
    Department of Biology, University of Virginia, Charlottesville, VA, USA
    J Biol Rhythms 23:150-9. 2008
    ..The authors hypothesize that IFN-gamma can modulate circadian output, which may be associated with sleep and rhythm disturbances observed in certain infections and in aging...
  22. pmc Ontogeny of circadian organization in the rat
    Shin Yamazaki
    Department of Biology, University of Virginia, Charlottesville, VA, USA
    J Biol Rhythms 24:55-63. 2009
    ....
  23. pmc The methamphetamine-sensitive circadian oscillator does not employ canonical clock genes
    Jennifer A Mohawk
    Department of Biology, University of Virginia, Charlottesville VA 22904, USA
    Proc Natl Acad Sci U S A 106:3519-24. 2009
    ..The properties of MASCO may provide insight into the evolution of circadian mechanisms. Importantly, MASCO may play a role in addiction to psychostimulants...
  24. pmc Effects of preparation time on phase of cultured tissues reveal complexity of circadian organization
    Tomoko Yoshikawa
    Department of Biology, University of Virginia, Charlottesville, 22903, USA
    J Biol Rhythms 20:500-12. 2005
    ....
  25. ncbi request reprint Circadian rhythms. Clocks on the brain
    Carla B Green
    Department of Biology and Center for Biological Timing, University of Virginia, Charlottesville, VA 22904, USA
    Science 301:319-20. 2003
  26. pmc Sympathetic input modulates, but does not determine, phase of peripheral circadian oscillators
    Nina Vujovic
    Department of Biology, University of Virginia, Charlottesville, Virginia, USA
    Am J Physiol Regul Integr Comp Physiol 295:R355-60. 2008
    ..Arrhythmicity may result if one signal is not clearly dominant. Elimination of the dominant signal (e.g., surgical sympathectomy) may allow a secondary signal to control phase...
  27. pmc Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liver
    Alec J Davidson
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Int J Cancer 118:1623-7. 2006
    ..Specifically, meal and treatment schedules could be designed that take advantage of coincident times of greatest tumor sensitivity and lowest sensitivity of host tissue to damage...
  28. ncbi request reprint Circadian rhythms of dopamine in mouse retina: the role of melatonin
    Susan E Doyle
    Department of Biology and NSF Center for Biological Timing, University of Virginia, Charlottesville 22903, USA
    Vis Neurosci 19:593-601. 2002
    ..Our results also indicate that circadian rhythms of retinal dopamine depend upon the rhythmic presence of melatonin, but that cyclic light can drive dopamine rhythms in the absence of melatonin...
  29. ncbi request reprint SCN: ringmaster of the circadian circus or conductor of the circadian orchestra?
    Alec J Davidson
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Novartis Found Symp 253:110-21; discussion 121-5, 281-4. 2003
    ..We have tried to make some of the issues concerning the role of the SCN within the entire system more explicit using the somewhat fanciful metaphor referred to in the title...
  30. doi request reprint Photic resetting of the circadian clock is correlated with photic habitat in Anolis lizards
    Ashli F Moore
    Department of Biology, University of Virginia, PO Box 400328, Charlottesville, VA 22904 4328, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198:375-87. 2012
    ..Surprisingly, thermal resetting was not statistically significant. Overall, the results suggest that the Anolis circadian system is adapted to photic habitat...
  31. pmc Nonvisual light responses in the Rpe65 knockout mouse: rod loss restores sensitivity to the melanopsin system
    Susan E Doyle
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Proc Natl Acad Sci U S A 103:10432-7. 2006
    ..Our findings demonstrate that RPE65 is not required for ipRGC function but reveal the existence of a mechanism whereby rods may influence the function of ipRGCs...
  32. doi request reprint Photic induction of locomotor activity is correlated with photic habitat in Anolis lizards
    Ashli F Moore
    Department of Biology, University of Virginia, PO Box 400328, Charlottesville, VA 22904 4328, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198:193-201. 2012
    ..The responses at the highest irradiances were significantly greater in species occupying relatively more shaded habitats, suggesting that non-visual photoreception may be adapted to habitat light in Anolis lizards...
  33. ncbi request reprint Circadian photoreception in the retinally degenerate mouse (rd/rd)
    R G Foster
    Department of Biology, University of Virginia, Charlottesville 22901
    J Comp Physiol A 169:39-50. 1991
    ..We have yet to determine whether the opsin immunoreactive perikarya or some other unidentified cell type mediate circadian light detection in the rd/rd retina...
  34. ncbi request reprint Birds of a feather clock together--sometimes: social synchronization of circadian rhythms
    Alec J Davidson
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    Curr Opin Neurobiol 13:765-9. 2003
    ..Social influences on circadian timing might function to tightly organize the social group, thereby decreasing the chances of predation and increasing the likelihood of mating...
  35. doi request reprint The effect of light on melatonin secretion in the cultured pineal glands of Anolis lizards
    Ashli F Moore
    Department of Biology, University of Virginia, Charlotteville, VA, USA
    Comp Biochem Physiol A Mol Integr Physiol 160:301-8. 2011
    ..Given their extensive phylogenetic and ecological divergence, Anolis lizards provide a promising system for investigating the ecology and evolution of circadian organization...
  36. ncbi request reprint Circadian rhythmicity in dopamine content of mammalian retina: role of the photoreceptors
    Susan E Doyle
    Department of Biology and National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, VA 22903, USA
    J Neurochem 83:211-9. 2002
    ..Our results demonstrate for the first time clear circadian rhythms of dopamine content and turnover in a free-running mammal, and suggest that rods and cones are not required for dopamine rhythmicity...
  37. ncbi request reprint Interaction of the retina with suprachiasmatic pacemakers in the control of circadian behavior
    Shin Yamazaki
    Department of Biology and National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville 22904 4328, USA
    J Biol Rhythms 17:315-29. 2002
    ..The presence of an intact retina appears to contribute to system-level circadian organization in mammals perhaps as a consequence of interaction between its circadian oscillators and those in the SCN...
  38. ncbi request reprint The pineal complex and melatonin affect the expression of the daily rhythm of behavioral thermoregulation in the green iguana
    G Tosini
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    J Comp Physiol A 179:135-42. 1996
    ..Control injections of saline solution had no effect. The significance of these results is discussed in relation to the role of the pineal complex and melatonin in the mediation of thermoregulatory behavior...
  39. ncbi request reprint Circadian photoreception in vertebrates
    S Doyle
    Department of Biology, University of Virginia, Charlottesville, Virginia 22936, USA
    Cold Spring Harb Symp Quant Biol 72:499-508. 2007
    ..We review some of the early work on birds and describe new findings that indicate specific roles for retinal rods, cones, and photosensitive retinal ganglion cells in mammals...
  40. ncbi request reprint Effects of circadian regulation and rest-activity state on spontaneous seizures in a rat model of limbic epilepsy
    M Quigg
    Comprehensive Epilepsy Program, Department of Neurology, National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, Virginia 22908, USA
    Epilepsia 41:502-9. 2000
    ..Circadian regulation via the suprachiasmatic nuclei and rest-activity state may influence expression of limbic seizures...
  41. ncbi request reprint The tau mutation shortens the period of rhythmic photoreceptor outer segment disk shedding in the hamster
    M S Grace
    National Science Foundation Science and Technology Center for Biological Timing, Charlottesville, VA, USA
    Brain Res 735:93-100. 1996
    ..These results indicate that a rhythm of retinal photoreceptor outer segment disk shedding exists in the hamster eye, and that the period of this rhythm is shortened by the tau mutation...
  42. ncbi request reprint The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration
    G Tosini
    Department of Biology and NSF Center for Biological Timing, University of Virginia, Charlottesville, VA 22903, USA
    Brain Res 789:221-8. 1998
    ..The many genetic and molecular tools available in the mouse can now be applied to analysis of the retinal circadian oscillator...
  43. ncbi request reprint Cardiovascular tissues contain independent circadian clocks
    A J Davidson
    Department of Biology, University of Virginia, Charlottesville, Virginia 22904 4328, USA
    Clin Exp Hypertens 27:307-11. 2005
    ..However, phase relationships among tissues were consistent across culture times; this suggests diversity in circadian regulation among components of the cardiovascular system...
  44. ncbi request reprint Seizures induce phase shifts of rat circadian rhythms
    M Quigg
    Comprehensive Epilepsy Program, Department of Neurology, University of Virginia, Box 394, Health Sciences Center, Charlottesville, VA 22908, USA
    Brain Res 913:165-9. 2001
    ..Epileptic seizures may alter neuroendocrinological cycles. Light pulses induce phase shifts in circadian rhythms. Using hippocampal-kindled rats to ensure maximal clinical expression, we determined if seizures likewise induce phase shifts...
  45. ncbi request reprint Hypothalamic neuronal loss and altered circadian rhythm of temperature in a rat model of mesial temporal lobe epilepsy
    M Quigg
    Department of Neurology, University of Virginia, Charlottesville 22908, USA
    Epilepsia 40:1688-96. 1999
    ..We then wished to determine whether there was a structural basis for regulatory alterations...
  46. ncbi request reprint Effects of physiological cycles of infused melatonin on circadian rhythmicity in pigeons
    C C Chabot
    Biology Department, University of Virginia, Charlottesville 22903
    J Comp Physiol A 170:615-22. 1992
    ..These results strongly suggest that endogenous melatonin, released by the pineal gland and the retinae, regulates the timing of feeding rhythms by entraining other oscillators in the circadian system of the pigeon...
  47. pmc Timing of the ovarian circadian clock is regulated by gonadotropins
    Tomoko Yoshikawa
    Department of Biology, University of Virginia, Charlottesville, Virginia 22904 4328, USA
    Endocrinology 150:4338-47. 2009
    ..We hypothesize that the ovarian circadian clock is entrained by hormonal signals from the pituitary and that ovulation depends, in part, on the phase in the ovarian circadian cycle at which these signals occur...
  48. pmc Circadian clocks in the ovary
    Michael T Sellix
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Trends Endocrinol Metab 21:628-36. 2010
    ..In this paper, we review evidence for clock function in the ovary across a number of species and offer a novel perspective into the role of this clock in normal ovarian physiology and in diseases that negatively affect fertility...
  49. ncbi request reprint Circadian clocks in mammalian reproductive physiology: effects of the "other" biological clock on fertility
    Michael T Sellix
    Department of Biology, University of Virginia, Charlottesville, 22904, USA
    Discov Med 11:273-81. 2011
    ..Advances in this area will certainly yield novel insights into the etiology of these disorders and may provide new and exciting avenues for clinical research in reproduction and fertility...
  50. ncbi request reprint Social stimuli fail to act as entraining agents of circadian rhythms in the golden hamster
    R Refinetti
    Department of Biology, University of Virginia, Charlottesville 22901
    J Comp Physiol A 170:181-7. 1992
    ..These results suggest strongly that social stimuli are not effective entraining agents of circadian rhythms in the golden hamster...
  51. ncbi request reprint Regulation of melatonin production by light, darkness, and temperature in the trout pineal
    M Max
    Department of Biology, University of Virginia, Charlottesville 22901
    J Comp Physiol A 170:479-89. 1992
    ..The possible adaptive significance of control of melatonin synthesis by light and temperature is considered...
  52. pmc Fluorescence/Luminescence circadian imaging of complex tissues at single-cell resolution
    Michael T Sellix
    Department of Biology, University of Virginia, Charlottesville, Virginia
    J Biol Rhythms 25:228-32. 2010
    ....
  53. ncbi request reprint Circadian control of photoreceptor outer segment membrane turnover in mice genetically incapable of melatonin synthesis
    M S Grace
    National Science Foundation Science and Technology Center for Biological Timing, and Department of Biology, University of Virginia, Charlottesville, USA
    Vis Neurosci 16:909-18. 1999
    ..More importantly, melatonin is required neither for cyclic changes in the rate of disk shedding in cyclic light, nor for the circadian rhythm of disk shedding in constant darkness...
  54. ncbi request reprint Circadian clocks: 50 years on
    M Menaker
    Department of Biology and Center for Biological Timing, University of Virginia, Charlottesville, Virginia 22904 4328, USA
    Cold Spring Harb Symp Quant Biol 72:655-9. 2007
    ..Many of the seminal discoveries of the last 47 years were presented and discussed at this exciting meeting...
  55. pmc PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
    Seung Hee Yoo
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 101:5339-46. 2004
    ..These results demonstrate that peripheral tissues express self-sustained, rather than damped, circadian oscillations and suggest the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level...
  56. pmc Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms
    Rika Numano
    Human Genome Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 103:3716-21. 2006
    ....
  57. pmc Inner retinal photoreception independent of the visual retinoid cycle
    Daniel C Tu
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:10426-31. 2006
    ..These results demonstrate that the melanopsin-dependent ipRGC photocycle is independent of the visual retinoid cycle...
  58. pmc Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice invivo
    Lisa D Wilsbacher
    Howard Hughes Medical Institute, 2153 North Campus Drive, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 99:489-94. 2002
    ..75-kb mPer1 promoter fragment is sufficient to confer both circadian and photic regulation in vivo and reveals a potential posttranscriptional regulatory mechanism within the mammalian circadian oscillator...
  59. ncbi request reprint Period and phase control in a multioscillatory circadian system (Iguana iguana)
    Paul A Bartell
    Forschungsstelle für Ornithologie der Max Planck Gesellschaft, Von der Tann Strasse 7, D 82346 Erling Andechs, Germany
    J Biol Rhythms 19:47-57. 2004
    ..Their data suggest that rhythmicity, period, and phase of overt circadian behaviors are regulated through the combined output of multiple endogenous circadian oscillators...
  60. ncbi request reprint Are age-related deficits in balance performance mediated by time of day in a prosimian primate (Microcebus murinus)?
    Florence Nemoz-Bertholet
    Département d Ecologie et de Gestion de la Biodiversité, Museum national d histoire naturelle, CNRS UMR 5176, 4 avenue du petit chateau, 91800 Brunoy, France
    Exp Gerontol 39:841-8. 2004
    ..The time of day effect on balance performance and the loss of daily variations with age suggest the influence of age-related changes within the biological clock...

Research Grants10

  1. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2005
    ..Furthermore, it is basic to the design of treatments for many serious conditions (e.g., high blood pressure, cancer) in which responses to therapeutic agents are modulated both positively and negatively by the circadian system. ..
  2. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2004
    ..Furthermore, it is basic to the design of treatments for many serious conditions (e.g., high blood pressure, cancer) in which responses to therapeutic agents are modulated both positively and negatively by the circadian system. ..
  3. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2003
    ..Furthermore, it is basic to the design of treatments for many serious conditions (e.g., high blood pressure, cancer) in which responses to therapeutic agents are modulated both positively and negatively by the circadian system. ..
  4. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2002
    ..Furthermore, it is basic to the design of treatments for many serious conditions (e.g., high blood pressure, cancer) in which responses to therapeutic agents are modulated both positively and negatively by the circadian system. ..
  5. CIRCADIAN OSCILLATORS IN CULTURED MAMMALIAN RETINA
    Michael Menaker; Fiscal Year: 2001
    ..What we learn about rhythmicity in mammalian retinas in culture is likely to be applicable to pathologies of retinal function in humans, particularly since so many aspects of retinal physiology have been shown to be rhythmic. ..
  6. CIRCADIAN OSCILLATORS IN CULTURED MAMMALIAN RETINA
    Michael Menaker; Fiscal Year: 2000
    ..What we learn about rhythmicity in mammalian retinas in culture is likely to be applicable to pathologies of retinal function in humans, particularly since so many aspects of retinal physiology have been shown to be rhythmic. ..
  7. CIRCADIAN OSCILLATORS IN CULTURED MAMMALIAN RETINA
    Michael Menaker; Fiscal Year: 1999
    ..What we learn about rhythmicity in mammalian retinas in culture is likely to be applicable to pathologies of retinal function in humans, particularly since so many aspects of retinal physiology have been shown to be rhythmic. ..
  8. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2006
    ..Furthermore, it is basic to the design of treatments for many serious conditions (e.g., high blood pressure, cancer) in which responses to therapeutic agents are modulated both positively and negatively by the circadian system. ..