C C Meltzer

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi [Imaging of mild cognitive impairment]
    C C Meltzer
    Departamento de Radiologia, University of Pittsburgh, Pittsburgh, Pensilbania 15213 2582, USA
    Rev Neurol 37:145-9. 2003
  2. ncbi Positron emission tomography imaging of the aging brain
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh School of Medicine, CHP MT 3972, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Neuroimaging Clin N Am 13:759-67. 2003
  3. ncbi Serotonin 1A receptor binding and treatment response in late-life depression
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2258-65. 2004
  4. ncbi PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders
    C C Meltzer
    Department of Radiology, University of Pittsburgh, PA, USA
    Am J Psychiatry 156:1871-8. 1999
  5. ncbi Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression
    G S Smith
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:683-9. 1999
  6. ncbi Cerebral blood flow in hypertensive patients: an initial report of reduced and compensatory blood flow responses during performance of two cognitive tasks
    J R Jennings
    University of Pittsburgh, PA, USA
    Hypertension 31:1216-22. 1998
  7. ncbi Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction
    C C Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res 813:167-71. 1998
  8. ncbi Psychiatric symptoms associated with cortical-subcortical dysfunction in Alzheimer's disease
    O L Lopez
    Alzheimer's Disease Research Center and Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 13:56-60. 2001
  9. ncbi Towards a neurobiology of dysfunctional arousal in depression: the relationship between beta EEG power and regional cerebral glucose metabolism during NREM sleep
    E A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatry Res 98:71-91. 2000
  10. ncbi Changes in forebrain function from waking to REM sleep in depression: preliminary analyses of [18F]FDG PET studies
    E A Nofzinger
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Psychiatry Res 91:59-78. 1999

Collaborators

Detail Information

Publications47

  1. ncbi [Imaging of mild cognitive impairment]
    C C Meltzer
    Departamento de Radiologia, University of Pittsburgh, Pittsburgh, Pensilbania 15213 2582, USA
    Rev Neurol 37:145-9. 2003
    ..Further, emerging imaging strategies may be used to monitor the efficacy of therapeutic regimens...
  2. ncbi Positron emission tomography imaging of the aging brain
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh School of Medicine, CHP MT 3972, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Neuroimaging Clin N Am 13:759-67. 2003
    ..Recognition of inherent potential confounds in the use of PET in aging studies is essential to the proper interpretation of these data...
  3. ncbi Serotonin 1A receptor binding and treatment response in late-life depression
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2258-65. 2004
    ..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression...
  4. ncbi PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders
    C C Meltzer
    Department of Radiology, University of Pittsburgh, PA, USA
    Am J Psychiatry 156:1871-8. 1999
    ....
  5. ncbi Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression
    G S Smith
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:683-9. 1999
    ....
  6. ncbi Cerebral blood flow in hypertensive patients: an initial report of reduced and compensatory blood flow responses during performance of two cognitive tasks
    J R Jennings
    University of Pittsburgh, PA, USA
    Hypertension 31:1216-22. 1998
    ..Essential hypertension appears to selectively influence the circulatory reserve of portions of cerebral cortex and secondarily induce recruitment of other cortical areas to process certain tasks...
  7. ncbi Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction
    C C Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res 813:167-71. 1998
    ..This finding, which is consistent with prior postmortem and in vivo studies, has both etiological and potential therapeutic implications for behavioral changes commonly observed in the elderly, including geriatric depression...
  8. ncbi Psychiatric symptoms associated with cortical-subcortical dysfunction in Alzheimer's disease
    O L Lopez
    Alzheimer's Disease Research Center and Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 13:56-60. 2001
    ..Frontal-subcortical dysfunction may also be associated with emotional lability and apathy in AD, although these may be related to a greater involvement of frontal-basal ganglia circuits...
  9. ncbi Towards a neurobiology of dysfunctional arousal in depression: the relationship between beta EEG power and regional cerebral glucose metabolism during NREM sleep
    E A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatry Res 98:71-91. 2000
    ....
  10. ncbi Changes in forebrain function from waking to REM sleep in depression: preliminary analyses of [18F]FDG PET studies
    E A Nofzinger
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Psychiatry Res 91:59-78. 1999
    ..These observations indicate that changes in limbic and paralimbic function from waking to REM sleep differ significantly from normal in depressed patients...
  11. ncbi Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depression
    R D Nebes
    Western Psychiatric Institute and Clinic, Thomas Detre Hall, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:878-84. 2001
    ....
  12. ncbi Test-retest variability of serotonin 5-HT2A receptor binding measured with positron emission tomography and [18F]altanserin in the human brain
    G S Smith
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Synapse 30:380-92. 1998
    ..These findings support the usefulness of [18F]altanserin as a radioligand for PET studies of 5-HT2A receptors...
  13. ncbi Effects of bupropion SR on anterior paralimbic function during waking and REM sleep in depression: preliminary findings using
    E A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 106:95-111. 2001
    ..REM sleep are discussed...
  14. ncbi Analyses of [(18)F]altanserin bolus injection PET data. II: consideration of radiolabeled metabolites in humans
    J C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Synapse 41:11-21. 2001
    ..Further study is needed to better understand how the cerebellar kinetics of [(18)F]altanserin and its radiometabolites impact the reference tissue measures...
  15. ncbi Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity
    P M Fisher
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Nat Neurosci 9:1362-3. 2006
    ..Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity...
  16. ncbi The psychotic phenomenon in probable Alzheimer's disease: a positron emission tomography study
    O L Lopez
    Alzheimer's Disease Research Center and Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 13:50-5. 2001
    ..In these patients, a left prefrontal-temporal cortex dysfunction appears to be a common denominator for the development of the psychotic phenomenon in AD...
  17. ncbi Planned ictal FDG PET imaging for localization of extratemporal epileptic foci
    C C Meltzer
    Department of Radiology, University of Pittsburgh, Pennsylvania, USA
    Epilepsia 41:193-200. 2000
    ..This work demonstrates the feasibility of planned ictal positron emission tomography (PET) with [18F]fluoro-2-deoxy-glucose (FDG) for localization of epileptic activity in patients with frequent partial seizures of extratemporal origin...
  18. ncbi Reduced cerebral blood flow response and compensation among patients with untreated hypertension
    J R Jennings
    University of Pittsburgh, USA
    Neurology 64:1358-65. 2005
    ..To determine whether memory performance in hypertensive subjects induces diminished parietal and prefrontal blood flow activation relative to normotensive subjects but compensatory amygdala/hippocampal activation...
  19. ncbi Whole-body FDG positron emission tomographic imaging for staging esophageal cancer comparison with computed tomography
    C C Meltzer
    Department of Radiology, University of Pittsburgh, Pennsylvania, USA
    Clin Nucl Med 25:882-7. 2000
    ....
  20. ncbi Altered serotonin 2A receptor activity in women who have recovered from bulimia nervosa
    W H Kaye
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:1152-5. 2001
    ..Positron emission tomography imaging with [(18)F]altanserin was used to characterize binding of the 5-HT(2A) receptor, which might contribute to altered feeding, mood, or impulse control...
  21. ncbi [Neuropharmacology and receptor studies in the elderly]
    C C Meltzer
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582 USA
    Rev Neurol 35:767-77. 2002
    ....
  22. ncbi Role of positron emission tomography in staging esophageal cancer
    J D Luketich
    Section of Thoracic Surgery, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Ann Thorac Surg 64:765-9. 1997
    ..Conventional noninvasive staging of esophageal cancer is inaccurate. This study investigated the role of positron emission tomography (PET) in staging esophageal cancer...
  23. ncbi Evaluation of distant metastases in esophageal cancer: 100 consecutive positron emission tomography scans
    J D Luketich
    Section of Thoracic Surgery, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Ann Thorac Surg 68:1133-6; discussion 1136-7. 1999
    ..This report summarizes our experience with PET in staging esophageal cancer...
  24. ncbi Venous angioma adjacent to the root entry zone of the trigeminal nerve: implications for management of trigeminal neuralgia
    A M Peterson
    Division of Neuroradiology, Department of Radiology, D 132, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213 2546, USA
    Neuroradiology 44:342-6. 2002
    ....
  25. ncbi Serum anticholinergic activity, white matter hyperintensities, and cognitive performance
    R D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Neurology 65:1487-9. 2005
    ....
  26. ncbi Serial [18F] fluorodeoxyglucose positron emission tomography after human neuronal implantation for stroke
    C C Meltzer
    Department of Radiology, University of Pittsburgh Medical Center, Pennsylvania 15213 2582, USA
    Neurosurgery 49:586-91; discussion 591-2. 2001
    ..In this report, we used positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) to map the metabolic brain response to neuronal cell implantation in the first human neuroimplantation trial for stroke...
  27. ncbi Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease
    N I Bohnen
    University of Pittsburgh, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Neurol Neurosurg Psychiatry 76:315-9. 2005
    ..To determine in vivo cortical acetylcholinesterase (AChE) activity and cognitive effects in subjects with mild Alzheimer's disease (AD, n = 14) prior to and after 12 weeks of donepezil therapy...
  28. ncbi Alterations in cortical thickness and white matter integrity in mild cognitive impairment measured by whole-brain cortical thickness mapping and diffusion tensor imaging
    L Wang
    Department of Radiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    AJNR Am J Neuroradiol 30:893-9. 2009
    ....
  29. ncbi Cerebral responses to noxious thermal stimulation in chronic low back pain patients and normal controls
    S W G Derbyshire
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA
    Neuroimage 16:158-68. 2002
    ..Although some small differences were observed between the groups these were not considered sufficient to suggest abnormal nociceptive processing in patients with nonspecific low back pain...
  30. ncbi The relation of White Matter Hyperintensities to implicit learning in healthy older adults
    H J Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 17:664-9. 2002
    ....
  31. ncbi Atlas-based hippocampus segmentation in Alzheimer's disease and mild cognitive impairment
    Owen T Carmichael
    Radiology Department, University of Pittsburgh, B 938 PUH, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Neuroimage 27:979-90. 2005
    ..The use of fully deformable registration methods, cohort atlases, and user-defined manual tracings are recommended for highest performance in fully automated hippocampus segmentation...
  32. ncbi Differential cortical atrophy in subgroups of mild cognitive impairment
    Sandra Bell-McGinty
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Neurol 62:1393-7. 2005
    ..These data also suggest that these structural abnormalities precede the development of Alzheimer disease...
  33. ncbi Gender differences in a fenfluramine-activated FDG PET study of borderline personality disorder
    Paul H Soloff
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Psychiatry Res 138:183-95. 2005
    ..Gender differences in serotonergic function may mediate differences in behavioral expression of impulsive aggression in subjects with BPD...
  34. ncbi No interruption of lactation is needed after (11)C-WAY 100635 or (11)C-raclopride PET
    Eydie L Moses-Kolko
    J Nucl Med 46:1765. 2005
  35. ncbi Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment
    James T Becker
    Alzheimer s Disease Research Center, University of Pittsburgh, PA 15213, USA
    Arch Neurol 63:97-101. 2006
    ....
  36. ncbi Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635
    Eydie L Moses-Kolko
    Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Synapse 61:523-30. 2007
    ..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder...
  37. ncbi PET/CT imaging in recurrent head and neck cancer
    Melanie B Fukui
    Division of Neuroradiology, Department of Diagnostic Radiology, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Semin Ultrasound CT MR 24:157-63. 2003
    ..Development of specific tumor markers may allow for tumor-specific ligands that will increase sensitivity to head and neck neoplasia. Treatment targeting for radiation therapy is an application that is likely to become widely used...
  38. ncbi The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
    ..Further studies of neuropsychological functioning in remitted LLD patients are needed to parse episode-related and persistent factors and to relate them to underlying neural dysfunction...
  39. ncbi Physiologic uterine uptake of FDG during menstruation demonstrated with serial combined positron emission tomography and computed tomography
    Subhash Chander
    Department of Radiology, University of Pittsburgh, Pennsylvania, USA
    Clin Nucl Med 27:22-4. 2002
    ..This case shows that physiologic FDG accumulation in the uterus should be considered when focal FDG accumulation is observed in the pelvis in women of reproductive age...
  40. ncbi Impulsivity and prefrontal hypometabolism in borderline personality disorder
    Paul H Soloff
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Psychiatry Res 123:153-63. 2003
    ..Decreased glucose uptake in medial orbital frontal cortex may be associated with diminished regulation of impulsive behavior in BPD...
  41. ncbi The role of imaging in United States courtrooms
    Purvak Patel
    Department of Radiology, Emory University Hospital, D 112, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
    Neuroimaging Clin N Am 17:557-67, x. 2007
    ..This article reviews and discusses the current state of these issues...
  42. ncbi Heterogeneity of microvascular dysfunction in women with chest pain not attributable to coronary artery disease: implications for clinical practice
    Oscar C Marroquin
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Am Heart J 145:628-35. 2003
    ..Assessment of CFR in a single coronary artery during cardiac catheterization may not provide an accurate assessment of the coronary microcirculation in women with chest pain not attributable to CAD...
  43. ncbi Ventricular volume and dementia progression in the Cardiovascular Health Study
    Owen T Carmichael
    Neurology Department, University of California, Davis, CA 95616, USA
    Neurobiol Aging 28:389-97. 2007
    ..Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology...
  44. ncbi Estradiol effects on the postmenopausal brain
    Eydie L Moses-Kolko
    Am J Psychiatry 161:2136; author reply 2136. 2004
  45. ncbi MR atlas of the baboon brain for functional neuroimaging
    Phil J Greer
    University of Pittsburgh PET Facility, Pittsburgh, PA 15213-2582, USA
    Brain Res Bull 58:429-38. 2002
    ..Overall, the digital MR-based atlas allowed for automatic co-registration, proved useful across a range of PET Studies, and is accessible electronically via the Internet...
  46. ncbi PET/CT of Teflon granulomas
    Barton F Branstetter
    AJR Am J Roentgenol 183:1173; author reply 1173-4. 2004
  47. ncbi Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration
    Sandra Bell-McGinty
    Neuropsychology Research Program, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Psychiatry 159:1424-7. 2002
    ..CONCLUSIONS: These data provide further evidence of structural brain abnormalities in geriatric depression, particularly in patients with a longer course of illness...