Michael Melnick

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. doi request reprint Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-α, and IL-6 signal dysregulation and neoplasia
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Exp Mol Pathol 94:386-97. 2013
  2. doi request reprint An in vitro mouse model of congenital cytomegalovirus-induced pathogenesis of the inner ear cochlea
    Michael Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089, USA
    Birth Defects Res A Clin Mol Teratol 97:69-78. 2013
  3. doi request reprint Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Exp Mol Pathol 92:118-25. 2012
  4. pmc Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model
    Michael Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    BMC Dev Biol 6:42. 2006
  5. pmc Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice
    Michael Melnick
    Laboratory for Developmental Genetics, University of Southern California, 925 W 34th Street, DEN 4266, Los Angeles, CA 90089 0641, USA
    Arch Oral Biol 51:433-8. 2006
  6. ncbi request reprint Meckel's cartilage differentiation is dependent on hedgehog signaling
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 179:146-57. 2005
  7. pmc Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA, USA
    BMC Dev Biol 9:32. 2009
  8. pmc Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesis
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Exp Mol Pathol 91:400-10. 2011
  9. doi request reprint Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 192:221-39. 2010
  10. pmc Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development
    Tina Jaskoll
    Laboratory for Developmental Genetics, USC, Los Angeles, CA, USA
    BMC Dev Biol 8:33. 2008

Collaborators

Detail Information

Publications19

  1. doi request reprint Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-α, and IL-6 signal dysregulation and neoplasia
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Exp Mol Pathol 94:386-97. 2013
    ..These findings provide a mechanistic foundation for potential clinical trials that utilize similar concurrent treatment with extant FDA-approved drugs...
  2. doi request reprint An in vitro mouse model of congenital cytomegalovirus-induced pathogenesis of the inner ear cochlea
    Michael Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089, USA
    Birth Defects Res A Clin Mol Teratol 97:69-78. 2013
    ..Thus, this model provides a relevant and reliable platform within which the detailed cell and molecular biology of CMV-induced deafness may be studied...
  3. doi request reprint Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Exp Mol Pathol 92:118-25. 2012
    ..In the absence of any contrary evidence, hCMV can reasonably be designated an "oncovirus."..
  4. pmc Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model
    Michael Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    BMC Dev Biol 6:42. 2006
    ..In this study, we chose to model the vulnerability by investigating the cell and molecular pathogenesis of CMV infected mouse embryonic submandibular salivary glands (SMGs)...
  5. pmc Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice
    Michael Melnick
    Laboratory for Developmental Genetics, University of Southern California, 925 W 34th Street, DEN 4266, Los Angeles, CA 90089 0641, USA
    Arch Oral Biol 51:433-8. 2006
    ..We addressed the proposition that normal Twsg1 expression is critical to normal SMG ontogenesis...
  6. ncbi request reprint Meckel's cartilage differentiation is dependent on hedgehog signaling
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 179:146-57. 2005
    ..Taken together, our results indicate that the Hh signaling pathway is critical to Meckel's cartilage ontogenesis and the rate of chondrogenesis, but not to initial primordium formation. The reliance on Hh signaling is stage dependent...
  7. pmc Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA, USA
    BMC Dev Biol 9:32. 2009
    ....
  8. pmc Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesis
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Exp Mol Pathol 91:400-10. 2011
    ..Our results indicate that upregulation of ERK phosphorylation is necessary for initial mCMV-induced pathogenesis, and that ErbB receptor family phosphorylation and downstream signaling are highly relevant targets for drug discovery...
  9. doi request reprint Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 192:221-39. 2010
    ..Importantly, our data indicate that specific levels of Amelx and Dspp gene expression define whether mouse CMV induces enamel agenesis or hypoplasia...
  10. pmc Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development
    Tina Jaskoll
    Laboratory for Developmental Genetics, USC, Los Angeles, CA, USA
    BMC Dev Biol 8:33. 2008
    ....
  11. pmc Cytomegalovirus inhibition of embryonic mouse tooth development: a model of the human amelogenesis imperfecta phenocopy
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Arch Oral Biol 53:405-15. 2008
    ..S. with CMV-induced birth defects, more than 1/3 of these children exhibit hypoplasia and hypocalcification of tooth enamel. Our objective was to initiate the investigation of the pathogenesis of CMV-induced tooth defects...
  12. pmc FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis
    Tina Jaskoll
    Laboratory Developmental Genetics, University of Southern California, Los Angeles, CA, USA
    BMC Dev Biol 5:11. 2005
    ..We have designed in vivo and in vitro experiments to address this question...
  13. ncbi request reprint FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Dev Biol 268:457-69. 2004
    ..This is as expected, though there is no synergistic effect with FGF10 + Shh peptide supplementation. These in vitro experiments model the principle that mutations have different effects in the context of different epigenotypes...
  14. ncbi request reprint Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California Los Angeles, Los Angeles, California 90089 0641, USA
    Anat Rec A Discov Mol Cell Evol Biol 271:322-31. 2003
    ..Taken together, our results suggest that the Eda/Edar/NF-kappaB pathway exerts its effect on SMG epithelial cell proliferation, lumina formation, and histodifferentiation...
  15. ncbi request reprint Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 170:83-98. 2002
    ..Finally, our observations of abnormal SMGs in BMP7(-/-) and Pax6(-/-) indicate that both BMP7 and Pax6 play important roles during embryonic SMG branching morphogenesis...
  16. pmc CRTC1 expression during normal and abnormal salivary gland development supports a precursor cell origin for mucoepidermoid cancer
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Gene Expr Patterns 11:57-63. 2011
    ..Moreover, the coincident expression of CRTC1 protein and cell proliferation markers in tumor-like histopathology suggests that CRTC1-mediated cell proliferation may contribute, in part, to initial tumor formation...
  17. pmc Cytomegalovirus-induced salivary gland pathology: resistance to kinase inhibitors of the upregulated host cell EGFR/ERK pathway is associated with CMV-dependent stromal overexpression of IL-6 and fibronectin
    Michael Melnick
    Laboratory for Developmental Genetics, University of Southern California, 925 W 34th Street, MC 0641, Los Angeles, CA 90089 0641, USA
    Herpesviridae 4:1. 2013
    ..Our previously characterized, novel mouse organ culture model of mouse CMV (mCMV)-induced tumorigenesis displays a number of histologic and molecular characteristics similar to human MEC...
  18. ncbi request reprint Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals
    Jeonghee Cho
    Molecular Oncology Research Institute, Tufts New England Medical Center and Tufts Cancer Center, Boston, Massachusetts 02111, USA
    J Biol Chem 280:20442-8. 2005
    ..We conclude that Tpl2 phosphorylation at Thr(290) is induced by LPS, depends on IKKbeta, and is required for the physiological activation of Tpl2 by external signals...
  19. pmc CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila
    Hua Wei Chen
    The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Mol Cell Biol 22:1792-803. 2002
    ..These data suggest that CKA represents a novel molecule regulating AP-1 activity by organizing a molecular complex of kinases and transcription factors, thus coordinating the spatial-temporal expression of AP-1-regulated genes...