N M Mellen
Affiliation: University of California
- Vagal stimulation induces expiratory lengthening in the in vitro neonate ratN M Mellen
Department of Physiological Science, University of California, Los Angeles 90095 1527, USA
J Appl Physiol 83:1607-11. 1997..All stimulus modalities prolonged expiration (P < 0.05). These results indicate that the neural circuitry mediating pulmonary afferent modulation of expiratory duration is retained in vitro...
- Phasic vagal sensory feedback transforms respiratory neuron activity in vitroN M Mellen
Department of Neurobiology, University of California Los Angeles, Los Angeles, California 90095 1763, USA
J Neurosci 21:7363-71. 2001..On the basis of relative onset times and responses to phasic inflation, connectivity between these cell types is proposed...
- Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparationNicholas M Mellen
Department of Neurobiology, School of Medicine, University of California, Los Angeles, California 90095 1763, USA
Am J Physiol Regul Integr Comp Physiol 282:R484-91. 2002..On being rewarmed, the motor output recorded at both sites was usually fractionated, initially suggesting that changes occurred in network synchronization either during cooling or during reactivation following hypothermic arrest...
- Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generationNicholas M Mellen
Department of Neurobiology, University of California, Los Angeles, P O Box 951763, Los Angeles, CA 90095, USA
Neuron 37:821-6. 2003..Thus, both I (in the slice), and pre-I neurons are sufficient for respiratory rhythmogenesis...
- Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanismsNicholas M Mellen
Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1763, USA
J Physiol 556:859-74. 2004..These findings are qualitatively similar to studies of the BHE in vivo. Where there are differences, they can largely be accounted for by developmental changes and experimental conditions...
- Functional imaging reveals respiratory network activity during hypoxic and opioid challenge in the neonate rat tilted sagittal slab preparationBenjamin J Barnes
Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Baxter Bldg 1, Suite 304, Louisville, KY 40202, USA
J Neurophysiol 97:2283-92. 2007..Within these regions neurons active during hypoxia- and/or opioid-induced depression were ubiquitous and interdigitated. In particular, contrary to earlier reports, opiate-insensitive neurons were found at the level of the preBötC...
- A vibrating microtome attachment for cutting brain slice preparations at reproducible compound angles relative to the midlineNicholas M Mellen
Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
J Neurosci Methods 168:113-8. 2008..Its use in cutting a thick medullary slab preparation, isolated from the neonate rat, which exposes respiratory networks at the cut surface is described...
- Belt-and-suspenders as a biological design principleNicholas M Mellen
Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Baxter Building 1, Suite 304, Louisville, KY 40202, USA
Adv Exp Med Biol 605:99-103. 2008..We propose that degeneracy is ubiquitous because it reduces the phenotype's sensitivity to genetic mutation and environmental perturbation, and broadens the adaptiveness of motor patterns...