N M Mellen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Vagal stimulation induces expiratory lengthening in the in vitro neonate rat
    N M Mellen
    Department of Physiological Science, University of California, Los Angeles 90095 1527, USA
    J Appl Physiol 83:1607-11. 1997
  2. ncbi request reprint Phasic vagal sensory feedback transforms respiratory neuron activity in vitro
    N M Mellen
    Department of Neurobiology, University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 21:7363-71. 2001
  3. ncbi request reprint Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation
    Nicholas M Mellen
    Department of Neurobiology, School of Medicine, University of California, Los Angeles, California 90095 1763, USA
    Am J Physiol Regul Integr Comp Physiol 282:R484-91. 2002
  4. pmc Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation
    Nicholas M Mellen
    Department of Neurobiology, University of California, Los Angeles, P O Box 951763, Los Angeles, CA 90095, USA
    Neuron 37:821-6. 2003
  5. pmc Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanisms
    Nicholas M Mellen
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    J Physiol 556:859-74. 2004
  6. ncbi request reprint Functional imaging reveals respiratory network activity during hypoxic and opioid challenge in the neonate rat tilted sagittal slab preparation
    Benjamin J Barnes
    Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Baxter Bldg 1, Suite 304, Louisville, KY 40202, USA
    J Neurophysiol 97:2283-92. 2007
  7. pmc A vibrating microtome attachment for cutting brain slice preparations at reproducible compound angles relative to the midline
    Nicholas M Mellen
    Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    J Neurosci Methods 168:113-8. 2008
  8. ncbi request reprint Belt-and-suspenders as a biological design principle
    Nicholas M Mellen
    Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Baxter Building 1, Suite 304, Louisville, KY 40202, USA
    Adv Exp Med Biol 605:99-103. 2008

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Vagal stimulation induces expiratory lengthening in the in vitro neonate rat
    N M Mellen
    Department of Physiological Science, University of California, Los Angeles 90095 1527, USA
    J Appl Physiol 83:1607-11. 1997
    ..All stimulus modalities prolonged expiration (P < 0.05). These results indicate that the neural circuitry mediating pulmonary afferent modulation of expiratory duration is retained in vitro...
  2. ncbi request reprint Phasic vagal sensory feedback transforms respiratory neuron activity in vitro
    N M Mellen
    Department of Neurobiology, University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 21:7363-71. 2001
    ..On the basis of relative onset times and responses to phasic inflation, connectivity between these cell types is proposed...
  3. ncbi request reprint Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation
    Nicholas M Mellen
    Department of Neurobiology, School of Medicine, University of California, Los Angeles, California 90095 1763, USA
    Am J Physiol Regul Integr Comp Physiol 282:R484-91. 2002
    ..On being rewarmed, the motor output recorded at both sites was usually fractionated, initially suggesting that changes occurred in network synchronization either during cooling or during reactivation following hypothermic arrest...
  4. pmc Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation
    Nicholas M Mellen
    Department of Neurobiology, University of California, Los Angeles, P O Box 951763, Los Angeles, CA 90095, USA
    Neuron 37:821-6. 2003
    ..Thus, both I (in the slice), and pre-I neurons are sufficient for respiratory rhythmogenesis...
  5. pmc Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanisms
    Nicholas M Mellen
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    J Physiol 556:859-74. 2004
    ..These findings are qualitatively similar to studies of the BHE in vivo. Where there are differences, they can largely be accounted for by developmental changes and experimental conditions...
  6. ncbi request reprint Functional imaging reveals respiratory network activity during hypoxic and opioid challenge in the neonate rat tilted sagittal slab preparation
    Benjamin J Barnes
    Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Baxter Bldg 1, Suite 304, Louisville, KY 40202, USA
    J Neurophysiol 97:2283-92. 2007
    ..Within these regions neurons active during hypoxia- and/or opioid-induced depression were ubiquitous and interdigitated. In particular, contrary to earlier reports, opiate-insensitive neurons were found at the level of the preBötC...
  7. pmc A vibrating microtome attachment for cutting brain slice preparations at reproducible compound angles relative to the midline
    Nicholas M Mellen
    Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    J Neurosci Methods 168:113-8. 2008
    ..Its use in cutting a thick medullary slab preparation, isolated from the neonate rat, which exposes respiratory networks at the cut surface is described...
  8. ncbi request reprint Belt-and-suspenders as a biological design principle
    Nicholas M Mellen
    Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Baxter Building 1, Suite 304, Louisville, KY 40202, USA
    Adv Exp Med Biol 605:99-103. 2008
    ..We propose that degeneracy is ubiquitous because it reduces the phenotype's sensitivity to genetic mutation and environmental perturbation, and broadens the adaptiveness of motor patterns...