Loren K Mell

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Reporting of cause-specific treatment effects in cancer clinical trials with competing risks: a systematic review
    Loren K Mell
    Department of Radiation Oncology, University of California San Diego, La Jolla, CA, USA
    Contemp Clin Trials 33:920-4. 2012
  2. pmc A comparison of dose-response characteristics of four NTCP models using outcomes of radiation-induced optic neuropathy and retinopathy
    Vitali Moiseenko
    University of Florida Health Sciences Center, Gainesville, FL 32610 0385, USA
    Radiat Oncol 6:61. 2011
  3. doi request reprint Predictors of competing mortality in advanced head and neck cancer
    Loren K Mell
    University of California San Diego, Moores Cancer Center, Department of Radiation Oncology, 3855 Health Sciences Dr MC 0843, La Jolla, CA 92129, USA
    J Clin Oncol 28:15-20. 2010
  4. doi request reprint Predictors of competing mortality in early breast cancer
    Loren K Mell
    Department of Radiation Oncology, University of California San Diego Moores Cancer Center, La Jolla, California 92129, USA
    Cancer 116:5365-73. 2010
  5. pmc Normal tissue complication probability modeling of acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy
    Brent S Rose
    Department of Radiation Oncology and Center for Advanced Radiotherapy Technologies, University of California, San Diego, La Jolla, CA 92093 0843, USA
    Int J Radiat Oncol Biol Phys 79:800-7. 2011
  6. doi request reprint Correlation between radiation dose to ¹⁸F-FDG-PET defined active bone marrow subregions and acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy
    Brent S Rose
    Department of Radiation Oncology and Center for Advanced Radiotherapy Technologies, Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, CA, USA
    Int J Radiat Oncol Biol Phys 83:1185-91. 2012
  7. doi request reprint Prospective study of functional bone marrow-sparing intensity modulated radiation therapy with concurrent chemotherapy for pelvic malignancies
    Yun Liang
    Department of Radiation Oncology, and Center for Advanced Radiotherapy Technologies, University of California, San Diego, La Jolla, California 92093, USA
    Int J Radiat Oncol Biol Phys 85:406-14. 2013
  8. doi request reprint Normal tissue complication probability analysis of acute gastrointestinal toxicity in cervical cancer patients undergoing intensity modulated radiation therapy and concurrent cisplatin
    Daniel R Simpson
    Center for Advanced Radiotherapy Technologies, Department of Radiation Oncology, University of California San Diego, La Jolla, CA, USA
    Int J Radiat Oncol Biol Phys 83:e81-6. 2012
  9. pmc A survey of image-guided radiation therapy use in the United States
    Daniel R Simpson
    Department of Radiation Oncology, Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, California 92093 0843, USA
    Cancer 116:3953-60. 2010
  10. doi request reprint Optimized planning target volume for intact cervical cancer
    Alvin Khan
    Department of Radiation Oncology, Center for Advanced Radiotherapy Technologies, University of California, San Diego, La Jolla, CA, USA
    Int J Radiat Oncol Biol Phys 83:1500-5. 2012

Collaborators

Detail Information

Publications26

  1. doi request reprint Reporting of cause-specific treatment effects in cancer clinical trials with competing risks: a systematic review
    Loren K Mell
    Department of Radiation Oncology, University of California San Diego, La Jolla, CA, USA
    Contemp Clin Trials 33:920-4. 2012
    ..We sought to determine the extent to which cause-specific effects on primary events are reported in contemporary randomized controlled trials in oncology...
  2. pmc A comparison of dose-response characteristics of four NTCP models using outcomes of radiation-induced optic neuropathy and retinopathy
    Vitali Moiseenko
    University of Florida Health Sciences Center, Gainesville, FL 32610 0385, USA
    Radiat Oncol 6:61. 2011
    ..In particular, the question to what extent model predictions are data-driven or dependent on the choice of the model has to be explored...
  3. doi request reprint Predictors of competing mortality in advanced head and neck cancer
    Loren K Mell
    University of California San Diego, Moores Cancer Center, Department of Radiation Oncology, 3855 Health Sciences Dr MC 0843, La Jolla, CA 92129, USA
    J Clin Oncol 28:15-20. 2010
    ..Analyses of risk factors for competing mortality may be useful in outcomes reporting and designing clinical trials...
  4. doi request reprint Predictors of competing mortality in early breast cancer
    Loren K Mell
    Department of Radiation Oncology, University of California San Diego Moores Cancer Center, La Jolla, California 92129, USA
    Cancer 116:5365-73. 2010
    ..Death in the absence of disease recurrence (competing mortality) is an important determinant of disease-free survival (DFS) in early breast cancer. The authors sought to identify predictors of this event using competing risks modeling...
  5. pmc Normal tissue complication probability modeling of acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy
    Brent S Rose
    Department of Radiation Oncology and Center for Advanced Radiotherapy Technologies, University of California, San Diego, La Jolla, CA 92093 0843, USA
    Int J Radiat Oncol Biol Phys 79:800-7. 2011
    ....
  6. doi request reprint Correlation between radiation dose to ¹⁸F-FDG-PET defined active bone marrow subregions and acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy
    Brent S Rose
    Department of Radiation Oncology and Center for Advanced Radiotherapy Technologies, Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, CA, USA
    Int J Radiat Oncol Biol Phys 83:1185-91. 2012
    ....
  7. doi request reprint Prospective study of functional bone marrow-sparing intensity modulated radiation therapy with concurrent chemotherapy for pelvic malignancies
    Yun Liang
    Department of Radiation Oncology, and Center for Advanced Radiotherapy Technologies, University of California, San Diego, La Jolla, California 92093, USA
    Int J Radiat Oncol Biol Phys 85:406-14. 2013
    ....
  8. doi request reprint Normal tissue complication probability analysis of acute gastrointestinal toxicity in cervical cancer patients undergoing intensity modulated radiation therapy and concurrent cisplatin
    Daniel R Simpson
    Center for Advanced Radiotherapy Technologies, Department of Radiation Oncology, University of California San Diego, La Jolla, CA, USA
    Int J Radiat Oncol Biol Phys 83:e81-6. 2012
    ....
  9. pmc A survey of image-guided radiation therapy use in the United States
    Daniel R Simpson
    Department of Radiation Oncology, Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, California 92093 0843, USA
    Cancer 116:3953-60. 2010
    ..Image-guided radiation therapy (IGRT) is a novel array of in-room imaging modalities that are used for tumor localization and patient setup in radiation oncology. The prevalence of IGRT use among US radiation oncologists is unknown...
  10. doi request reprint Optimized planning target volume for intact cervical cancer
    Alvin Khan
    Department of Radiation Oncology, Center for Advanced Radiotherapy Technologies, University of California, San Diego, La Jolla, CA, USA
    Int J Radiat Oncol Biol Phys 83:1500-5. 2012
    ..To model interfraction clinical target volume (CTV) variation in patients with intact cervical cancer and design a planning target volume (PTV) that minimizes normal tissue dose while maximizing CTV coverage...
  11. ncbi request reprint Validated Competing Event Model for the Stage I-II Endometrial Cancer Population
    Ruben Carmona
    Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California
    Int J Radiat Oncol Biol Phys 89:888-98. 2014
    ..Early-stage endometrial cancer patients are at higher risk of noncancer mortality than of cancer mortality. Competing event models incorporating comorbidity could help identify women most likely to benefit from treatment intensification...
  12. pmc Clinical practice patterns of lung stereotactic body radiation therapy in the United States: a secondary analysis
    Hubert Pan
    Department of Radiation Oncology, Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, CA 92093, USA
    Am J Clin Oncol 36:269-72. 2013
    ..Although recent studies have shown that SBRT provides effective local tumor control in medically inoperable early-stage lung cancer patients, its implementation in clinical practice is unknown...
  13. doi request reprint Outcomes for patients with cervical cancer treated with extended-field intensity-modulated radiation therapy and concurrent cisplatin
    Lindsay G Jensen
    Department of Radiation Oncology, University of California San Diego, La Jolla, CA 92093, USA
    Int J Gynecol Cancer 23:119-25. 2013
    ..To evaluate disease outcomes and toxicity in patients with cervical cancer treated with extended-field intensity-modulated radiotherapy...
  14. doi request reprint Racial disparity in consultation, treatment, and the impact on survival in metastatic colorectal cancer
    Daniel R Simpson
    Affiliations of authors Center for Advanced Radiotherapy Technologies, Department of Radiation Medicine and Applied Science DRS, JHG, LKM, JDM, Department of Family and Preventive Medicine MEM, Division of Gastroenterology, Department of Internal Medicine SG, Division of Hematology Oncology GH, PF, Department of Surgery SR, Moores Cancer Center DRS, MEM, SG, JHG, LKM, GH, PF, SR, JDM, University of California San Diego, La Jolla, California San Diego Veterans Affairs Healthcare System, San Diego, California SG Department of Radiation Oncology, Stanford University, Stanford, California QL
    J Natl Cancer Inst 105:1814-20. 2013
    ..The purpose of this study was to examine disparity in specialist consultation and multimodality treatment and the impact that treatment inequality has on survival...
  15. pmc Impact of bone marrow radiation dose on acute hematologic toxicity in cervical cancer: principal component analysis on high dimensional data
    Yun Liang
    Department of Radiation Oncology, Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, California, USA
    Int J Radiat Oncol Biol Phys 78:912-9. 2010
    ..To study the effects of increasing pelvic bone marrow (BM) radiation dose on acute hematologic toxicity in patients undergoing chemoradiotherapy, using a novel modeling approach to preserve the local spatial dose information...
  16. doi request reprint Feasibility study on dosimetry verification of volumetric-modulated arc therapy-based total marrow irradiation
    Yun Liang
    Department of Radiation Oncology, University of California San Diego, La Jolla, CA, USA
    J Appl Clin Med Phys 14:3852. 2013
    ..7% and 2.4%. A dosimetry verification procedure involving both 2D and 3D was developed for VMAT-based TMI. The initial results are encouraging and warrant further investigation in clinical trials...
  17. doi request reprint Population-based study of competing mortality in head and neck cancer
    Brent S Rose
    Department of Radiation Oncology, 3855 Health Sciences Dr, MC0843, La Jolla, CA 92093, USA
    J Clin Oncol 29:3503-9. 2011
    ..Variation in competing mortality risk complicates individual treatment choices and design and interpretation of clinical studies...
  18. doi request reprint Race and competing mortality in advanced head and neck cancer
    Kaveh Zakeri
    Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, United States
    Oral Oncol 50:40-4. 2014
    ..Black patients with head and neck cancer (HNC) have poorer survival and disease control compared to non-black patients, but disparities in death from non-cancer causes (i.e., competing mortality) are less well-studied...
  19. pmc Competing event risk stratification may improve the design and efficiency of clinical trials: secondary analysis of SWOG 8794
    Kaveh Zakeri
    Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92093, United States
    Contemp Clin Trials 34:74-9. 2013
    ..Composite endpoints can be problematic in the presence of competing risks when a treatment does not affect events comprising the endpoint equally...
  20. doi request reprint Daily online cone beam computed tomography to assess interfractional motion in patients with intact cervical cancer
    Neelam Tyagi
    Department of Radiation Oncology and Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, California 92093 0843, USA
    Int J Radiat Oncol Biol Phys 80:273-80. 2011
    ..To quantify interfraction motion in patients with intact cervical cancer and assess implications for clinical target volume (CTV) coverage and required planning margins...
  21. pmc A survey of stereotactic body radiotherapy use in the United States
    Hubert Pan
    Department of Radiation Oncology, Center for Advanced Radiotherapy Technologies, University of California at San Diego, La Jolla, California, USA
    Cancer 117:4566-72. 2011
    ..To the authors' knowledge, the prevalence of SBRT use among radiation oncologists in the United States is unknown...
  22. doi request reprint Utilization of advanced imaging technologies for target delineation in radiation oncology
    Daniel R Simpson
    Department of Radiation Oncology and Center for Advanced Radiotherapy Technologies, Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, California 92093 0843, USA
    J Am Coll Radiol 6:876-83. 2009
    ..The aim of this study was to evaluate the utilization of advanced imaging technologies for target delineation among radiation oncologists in the United States...
  23. doi request reprint Cause-specific effects of radiotherapy and lymphadenectomy in stage I-II endometrial cancer: a population-based study
    Loren K Mell
    Affiliations of authors Department of Radiation Medicine and Applied Sciences LKM, RC, SG, TL, JW and Department of Reproductive Medicine, Division of Gynecologic Oncology CCS, University of California San Diego, La Jolla, CA Department of Family and Preventive Medicine, Biostatistics and Bioinformatics, University of California San Diego Medical Center, San Diego, CA FV
    J Natl Cancer Inst 105:1656-66. 2013
    ..The primary study aim was to estimate the cause-specific effects of adjuvant radiotherapy and lymphadenectomy on competing causes of mortality...
  24. doi request reprint Liver motion during cone beam computed tomography guided stereotactic body radiation therapy
    Justin C Park
    Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Med Phys 39:6431-42. 2012
    ..The purpose of this study was to investigate such motion characteristics based on fiducial markers tracked with the x-ray projections of the CBCT scans, taken immediately prior to the treatments...
  25. ncbi request reprint Dosimetric comparison study between intensity modulated radiation therapy and three-dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer
    William Y Song
    Department of Radiation Oncology, University of California San Diego, La Jolla, CA, USA
    J Appl Clin Med Phys 11:3255. 2010
    ..Further studies are, however, needed to fully exploit the benefits of protons for general use in cervical cancer...
  26. ncbi request reprint Pharmacologic normal tissue protection in clinical radiation oncology: focus on amifostine
    Loren K Mell
    University of California San Diego, Department of Radiation Oncology, La Jolla, California, USA
    Expert Opin Drug Metab Toxicol 4:1341-50. 2008
    ..Amifostine is a cytoprotector that can reduce toxicity and potentially improve the therapeutic ratio of radiotherapy...