HALEY MELIKIAN

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Insertion of tetracysteine motifs into dopamine transporter extracellular domains
    Deanna M Navaroli
    Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e9113. 2010
  2. ncbi request reprint Neurotransmitter transporter trafficking: endocytosis, recycling, and regulation
    Haley E Melikian
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, United States
    Pharmacol Ther 104:17-27. 2004
  3. pmc The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines
    Merewyn K Loder
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts School of Medicine, 303 Belmont Street, Worcester, MA 01604, USA
    J Biol Chem 278:22168-74. 2003
  4. pmc Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization
    Katherine L Holton
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, Massachusetts 01604, USA
    Nat Neurosci 8:881-8. 2005
  5. pmc Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent
    Ekaterina Boudanova
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, USA
    Neuropharmacology 54:605-12. 2008
  6. pmc Dopamine transporter endocytic determinants: carboxy terminal residues critical for basal and PKC-stimulated internalization
    Ekaterina Boudanova
    Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Cell Neurosci 39:211-7. 2008

Collaborators

  • Deanna M Navaroli
  • Ekaterina Boudanova
  • Merewyn K Loder
  • Katherine L Holton
  • Zachary Stevens

Detail Information

Publications7

  1. pmc Insertion of tetracysteine motifs into dopamine transporter extracellular domains
    Deanna M Navaroli
    Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e9113. 2010
    ..This is the first demonstration of successful introduction of a tetracysteine motif into a DAT extracellular domain, and may hold promise for use of biarsenic dyes in live DAT imaging studies...
  2. ncbi request reprint Neurotransmitter transporter trafficking: endocytosis, recycling, and regulation
    Haley E Melikian
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, United States
    Pharmacol Ther 104:17-27. 2004
    ..This review focuses on what is currently understood about constitutive and regulated transporter trafficking, and poses a model wherein endocytic trafficking dynamically primes transporters for multi-faceted regulatory events...
  3. pmc The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines
    Merewyn K Loder
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts School of Medicine, 303 Belmont Street, Worcester, MA 01604, USA
    J Biol Chem 278:22168-74. 2003
    ..Additionally, the differential sensitivity to expression level exhibited by constitutive and regulated DAT trafficking suggests that these two processes are mediated by independent cellular mechanisms...
  4. pmc Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization
    Katherine L Holton
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, Massachusetts 01604, USA
    Nat Neurosci 8:881-8. 2005
    ..The DAT endocytic signal does not conform to classic internalization motifs, suggesting that SLC6 neurotransmitter transporters may have evolved unique endocytic mechanisms...
  5. pmc Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent
    Ekaterina Boudanova
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, USA
    Neuropharmacology 54:605-12. 2008
    ..These results suggest that the mechanisms responsible for AMPH-mediated DAT internalization are independent from those governing PKC-sensitive DAT endocytosis...
  6. pmc Dopamine transporter endocytic determinants: carboxy terminal residues critical for basal and PKC-stimulated internalization
    Ekaterina Boudanova
    Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Cell Neurosci 39:211-7. 2008
    ..Our results support a model whereby residues within the 587-590 stretch may serve as a locus for a PKC-sensitive braking mechanism that tempers basal DAT internalization rates...

Research Grants11

  1. Trafficking and Regulation of Monoamine Transporters
    Haley E Melikian; Fiscal Year: 2010
    ....
  2. Trafficking and Regulation of Monoamine Transporters
    HALEY MELIKIAN; Fiscal Year: 2002
    ..Moreover, the outcomes will greatly improve our understanding of the factors contributing to monoamine availability and signaling in the brain. ..
  3. Trafficking and Regulation of Monoamine Transporters
    HALEY MELIKIAN; Fiscal Year: 2009
    ....
  4. The Role of Dopamine Transporter Trafficking in Psychostimulant Addiction
    HALEY MELIKIAN; Fiscal Year: 2007
    ..The current proposal aims to develop an animal model in which the targets of amphetamine in the brain are modified, to determine whether the actions of amphetamine on these target proteins contribute to the addictive process. ..
  5. Trafficking and Regulation of Monoamine Transporters
    HALEY MELIKIAN; Fiscal Year: 2006
    ..Moreover, the outcomes will greatly improve our understanding of the factors contributing to monoamine availability and signaling in the brain. ..
  6. Trafficking and Regulation of Monoamine Transporters
    HALEY MELIKIAN; Fiscal Year: 2005
    ..Moreover, the outcomes will greatly improve our understanding of the factors contributing to monoamine availability and signaling in the brain. ..
  7. Trafficking and Regulation of Monoamine Transporters
    HALEY MELIKIAN; Fiscal Year: 2004
    ..Moreover, the outcomes will greatly improve our understanding of the factors contributing to monoamine availability and signaling in the brain. ..
  8. Monoamine Transporter Phosphorylation and Trafficking
    HALEY MELIKIAN; Fiscal Year: 2003
    ..moreover, the outcomes will enhance our understanding of the factors contributing to monoamine availability and signaling in the brain. ..
  9. Trafficking and Regulation of Monoamine Transporters
    HALEY MELIKIAN; Fiscal Year: 2003
    ..Moreover, the outcomes will greatly improve our understanding of the factors contributing to monoamine availability and signaling in the brain. ..