William Melega

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Hypothalamic deep brain stimulation reduces weight gain in an obesity-animal model
    William P Melega
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e30672. 2012
  2. ncbi request reprint Methamphetamine increases basal ganglia iron to levels observed in aging
    William P Melega
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    Neuroreport 18:1741-5. 2007
  3. ncbi request reprint Dizocilpine and reduced body temperature do not prevent methamphetamine-induced neurotoxicity in the vervet monkey: [11C]WIN 35,428 - positron emission tomography studies
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Neurosci Lett 258:17-20. 1998
  4. ncbi request reprint l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    J Pharmacol Exp Ther 288:752-8. 1999
  5. ncbi request reprint Long-term methamphetamine-induced decreases of [(11)C]WIN 35,428 binding in striatum are reduced by GDNF: PET studies in the vervet monkey
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles CA 90095 1735, USA
    Synapse 35:243-9. 2000
  6. ncbi request reprint Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: brain neurotoxicity and behavioral profiles
    William P Melega
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
    Neuropsychopharmacology 33:1441-52. 2008
  7. ncbi request reprint Methamphetamine blood concentrations in human abusers: application to pharmacokinetic modeling
    William P Melega
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Synapse 61:216-20. 2007
  8. ncbi request reprint Functional stereotactic radiosurgery involving a dedicated linear accelerator and gamma unit: a comparison study
    Timothy D Solberg
    Department of Radiation Oncology, University of California, Los Angeles School of Medicine, Los Angeles 90095 6951, USA
    J Neurosurg 101:373-80. 2004
  9. ncbi request reprint Ethological and 6-[18F]fluoro-L-DOPA-PET profiles of long-term vulnerability to chronic amphetamine
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Behav Brain Res 84:259-68. 1997
  10. ncbi request reprint Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeys
    L A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Neuropsychopharmacology 24:370-8. 2001

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc Hypothalamic deep brain stimulation reduces weight gain in an obesity-animal model
    William P Melega
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e30672. 2012
    ..These results in a porcine obesity model demonstrate the efficacy and behavioral safety of a low frequency VMH-DBS application as a potential clinical strategy for modulation of body weight...
  2. ncbi request reprint Methamphetamine increases basal ganglia iron to levels observed in aging
    William P Melega
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    Neuroreport 18:1741-5. 2007
    ....
  3. ncbi request reprint Dizocilpine and reduced body temperature do not prevent methamphetamine-induced neurotoxicity in the vervet monkey: [11C]WIN 35,428 - positron emission tomography studies
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Neurosci Lett 258:17-20. 1998
    ..These results provide evidence that different regulatory factors maintain the integrity of the rodent and primate striatal dopamine systems...
  4. ncbi request reprint l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    J Pharmacol Exp Ther 288:752-8. 1999
    ..Collectively, these results suggest that the acute increases in extracellular dopamine observed after deprenyl are not due uniquely to metabolically generated l-MeAmp but also to other actions of deprenyl at the dopamine terminal...
  5. ncbi request reprint Long-term methamphetamine-induced decreases of [(11)C]WIN 35,428 binding in striatum are reduced by GDNF: PET studies in the vervet monkey
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles CA 90095 1735, USA
    Synapse 35:243-9. 2000
    ....
  6. ncbi request reprint Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: brain neurotoxicity and behavioral profiles
    William P Melega
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
    Neuropsychopharmacology 33:1441-52. 2008
    ....
  7. ncbi request reprint Methamphetamine blood concentrations in human abusers: application to pharmacokinetic modeling
    William P Melega
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Synapse 61:216-20. 2007
    ..Collectively, these data present evidence for a METH exposure pattern distinct from high dose-METH abuse and provide the rationale for assessing potential brain pathology associated with such lower dose-METH exposure...
  8. ncbi request reprint Functional stereotactic radiosurgery involving a dedicated linear accelerator and gamma unit: a comparison study
    Timothy D Solberg
    Department of Radiation Oncology, University of California, Los Angeles School of Medicine, Los Angeles 90095 6951, USA
    J Neurosurg 101:373-80. 2004
    ..The purpose of this work was to investigate the targeting and dosimetric characteristics of a linear accelerator (LINAC) system dedicated for stereotactic radiosurgery compared with those of a commercial gamma knife (GK) unit...
  9. ncbi request reprint Ethological and 6-[18F]fluoro-L-DOPA-PET profiles of long-term vulnerability to chronic amphetamine
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Behav Brain Res 84:259-68. 1997
    ..Changes in striatal dopamine function as indexed with FDOPA-PET are not correlated with post-Amp alterations in behaviors and moreover, expression of those behaviors is context-dependent...
  10. ncbi request reprint Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeys
    L A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Neuropsychopharmacology 24:370-8. 2001
    ..m.) or vehicle. Fluoxetine-treated subjects (n = 6) had significantly lower Impulsivity Index scores than controls (n = 12). The results from these two investigations provide evidence for serotonergic influences on social impulsivity...
  11. ncbi request reprint Recovery of striatal dopamine function after acute amphetamine- and methamphetamine-induced neurotoxicity in the vervet monkey
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Brain Res 766:113-20. 1997
    ..This disparity between striatum and substantia nigra reactivity to systemic administration of amphetamines suggests that each has unique dopamine system regulatory mechanisms...
  12. ncbi request reprint Radiosurgery performed with the aid of a 3-mm collimator in the subthalamic nucleus and substantia nigra of the vervet monkey
    A A De Salles
    Department of Surgery, University of California at Los Angeles School of Medicine, California 90095 6975, USA
    J Neurosurg 95:990-7. 2001
    ..Postmortem immunohistochemical studies were conducted to determine the extent of lesion-induced radiobiological effects...
  13. ncbi request reprint Evaluation of a stereotactic frame for repositioning of the rat brain in serial positron emission tomography imaging studies
    D J Rubins
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 1833 Leconte Ave, CHS 28 115, Los Angeles, CA, USA
    J Neurosci Methods 107:63-70. 2001
    ..4% (SD 2.7%) using the sharp ear bars and 6.8% (SD 2.5%) using the blunt ear bars. This methodology has the potential to improve quantitative assessment for serial PET studies...
  14. ncbi request reprint Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse
    A K Cho
    Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, USA
    Synapse 39:161-6. 2001
    ....
  15. pmc Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkey
    B M Way
    Department of Molecular and Medical Pharmacology, 23 120 CHS, David Geffen School of Medicine at the University of California at Los Angeles, Box 951735, Los Angeles, CA 90095 1735, USA
    Neuroscience 148:937-48. 2007
    ..Collectively, these results suggest that the serotoninergic innervation is organized according to both cortical type and area, and is thus structured to differentially modulate information processing within the OFC...
  16. pmc Mitochondrial dysfunction, oxidative stress, and apoptosis revealed by proteomic and transcriptomic analyses of the striata in two mouse models of Parkinson's disease
    Mark H Chin
    Department of Molecular and Medical Pharmacology, Human Genetics, Laboratory of Neuroimaging, Department of Neurology, and Surgery, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, California 90095, USA
    J Proteome Res 7:666-77. 2008
    ..These results constitute one of the largest descriptive data sets integrating protein and transcript changes for these neurotoxin models with many similar end point phenotypes but distinct mechanisms...
  17. ncbi request reprint Patterns of methamphetamine abuse and their consequences
    Arthur K Cho
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    J Addict Dis 21:21-34. 2002
    ..This article reviews aspects of METH pharmacokinetics and related molecular pharmacodynamics that represent METH pharmacology and then relates those actions to their potential to produce neurotoxicity in humans...
  18. ncbi request reprint Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge
    MEGHAN L O'NEIL
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, 90095 1735, USA
    Synapse 60:465-73. 2006
    ..The results show that ED-METH pretreatment produces reductions in DAT binding and the DA response during a subsequent METH binge by altering pharmacodynamic and not pharmacokinetic parameters...
  19. ncbi request reprint Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization
    David S Segal
    Department of Psychiatry, University of California, San Diego, School of Medicine, 0603, La Jolla, CA 92093, USA
    Psychopharmacology (Berl) 180:501-12. 2005
    ..These data are discussed in terms of damage to dopamine terminals and compensatory adjustments in mechanisms maintaining functional dopaminergic transmission...
  20. pmc Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease
    Vanessa M Brown
    Department of Molecular and Medical Pharmacology, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Genome Res 12:868-84. 2002
    ....
  21. ncbi request reprint Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge
    David S Segal
    Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Neuropsychopharmacology 28:1730-40. 2003
    ....
  22. ncbi request reprint Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain
    Daniel J Rubins
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neuroimage 20:2100-18. 2003
    ..Its automated features, and applicability to different radioligands and brain regions, will facilitate quantitative rat brain PET assessment procedures...
  23. ncbi request reprint The fetal and neonatal brain protein neuronatin protects PC12 cells against certain types of toxic insult
    Shuang Zheng
    Department of Biological Chemistry, School of Medicine, University of California, Los Angeles, 650 Charles Young Drive, Los Angeles, CA 90095, USA
    Brain Res Dev Brain Res 136:101-10. 2002
    ..These studies suggest that the function of neuronatin during development could be to protect developing cells from toxic insult occurring during that period...
  24. doi request reprint Modulation of food intake following deep brain stimulation of the ventromedial hypothalamus in the vervet monkey. Laboratory investigation
    Goran Lacan
    Division of Neurosurgery, Department of Surgery, David Geffen School of Medicine at UCLA, 3 VA Greater Los Angeles Healthcare System, Los Angeles, California 90095, USA
    J Neurosurg 108:336-42. 2008
    ..In this study, the authors assessed the feasibility of ventromedial hypothalamus (VMH) DBS in freely moving vervet monkeys to modulate food intake as a model for the potential treatment of eating disorders...
  25. doi request reprint Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways
    Shaoying Lee
    School of Dentistry, University of California at Los Angeles, Los Angeles, CA, USA
    J Acquir Immune Defic Syndr 48:531-40. 2008
    ..An immediate early viral protein, Replication and transcription activator (RTA), is responsible for the virus switch from latency to active replication...

Research Grants9

  1. BRAIN AND BEHAVIOR ALTERATIONS AFTER METHAMPHETAMINE
    William Melega; Fiscal Year: 1999
    ....
  2. Brain and Behavioral Alterations After Methamphetamine
    William Melega; Fiscal Year: 2004
    ..This paradigm will represent a validated primate model to evaluate the efficacy of pharmacotherapies designed for treatment of neurological and behavioral deficits associated with human METH abuse. ..