W P Melega

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Ethological and 6-[18F]fluoro-L-DOPA-PET profiles of long-term vulnerability to chronic amphetamine
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Behav Brain Res 84:259-68. 1997
  2. ncbi request reprint Recovery of striatal dopamine function after acute amphetamine- and methamphetamine-induced neurotoxicity in the vervet monkey
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Brain Res 766:113-20. 1997
  3. ncbi request reprint Dizocilpine and reduced body temperature do not prevent methamphetamine-induced neurotoxicity in the vervet monkey: [11C]WIN 35,428 - positron emission tomography studies
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Neurosci Lett 258:17-20. 1998
  4. ncbi request reprint Long-term methamphetamine-induced decreases of [(11)C]WIN 35,428 binding in striatum are reduced by GDNF: PET studies in the vervet monkey
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles CA 90095 1735, USA
    Synapse 35:243-9. 2000
  5. ncbi request reprint l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    J Pharmacol Exp Ther 288:752-8. 1999
  6. ncbi request reprint Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeys
    L A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Neuropsychopharmacology 24:370-8. 2001
  7. ncbi request reprint Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse
    A K Cho
    Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, USA
    Synapse 39:161-6. 2001
  8. ncbi request reprint Evaluation of a stereotactic frame for repositioning of the rat brain in serial positron emission tomography imaging studies
    D J Rubins
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 1833 Leconte Ave, CHS 28 115, Los Angeles, CA, USA
    J Neurosci Methods 107:63-70. 2001
  9. pmc Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkey
    B M Way
    Department of Molecular and Medical Pharmacology, 23 120 CHS, David Geffen School of Medicine at the University of California at Los Angeles, Box 951735, Los Angeles, CA 90095 1735, USA
    Neuroscience 148:937-48. 2007

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Ethological and 6-[18F]fluoro-L-DOPA-PET profiles of long-term vulnerability to chronic amphetamine
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Behav Brain Res 84:259-68. 1997
    ..Changes in striatal dopamine function as indexed with FDOPA-PET are not correlated with post-Amp alterations in behaviors and moreover, expression of those behaviors is context-dependent...
  2. ncbi request reprint Recovery of striatal dopamine function after acute amphetamine- and methamphetamine-induced neurotoxicity in the vervet monkey
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Brain Res 766:113-20. 1997
    ..This disparity between striatum and substantia nigra reactivity to systemic administration of amphetamines suggests that each has unique dopamine system regulatory mechanisms...
  3. ncbi request reprint Dizocilpine and reduced body temperature do not prevent methamphetamine-induced neurotoxicity in the vervet monkey: [11C]WIN 35,428 - positron emission tomography studies
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    Neurosci Lett 258:17-20. 1998
    ..These results provide evidence that different regulatory factors maintain the integrity of the rodent and primate striatal dopamine systems...
  4. ncbi request reprint Long-term methamphetamine-induced decreases of [(11)C]WIN 35,428 binding in striatum are reduced by GDNF: PET studies in the vervet monkey
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles CA 90095 1735, USA
    Synapse 35:243-9. 2000
    ....
  5. ncbi request reprint l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine
    W P Melega
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    J Pharmacol Exp Ther 288:752-8. 1999
    ..Collectively, these results suggest that the acute increases in extracellular dopamine observed after deprenyl are not due uniquely to metabolically generated l-MeAmp but also to other actions of deprenyl at the dopamine terminal...
  6. ncbi request reprint Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeys
    L A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Neuropsychopharmacology 24:370-8. 2001
    ..m.) or vehicle. Fluoxetine-treated subjects (n = 6) had significantly lower Impulsivity Index scores than controls (n = 12). The results from these two investigations provide evidence for serotonergic influences on social impulsivity...
  7. ncbi request reprint Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse
    A K Cho
    Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, USA
    Synapse 39:161-6. 2001
    ....
  8. ncbi request reprint Evaluation of a stereotactic frame for repositioning of the rat brain in serial positron emission tomography imaging studies
    D J Rubins
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 1833 Leconte Ave, CHS 28 115, Los Angeles, CA, USA
    J Neurosci Methods 107:63-70. 2001
    ..4% (SD 2.7%) using the sharp ear bars and 6.8% (SD 2.5%) using the blunt ear bars. This methodology has the potential to improve quantitative assessment for serial PET studies...
  9. pmc Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkey
    B M Way
    Department of Molecular and Medical Pharmacology, 23 120 CHS, David Geffen School of Medicine at the University of California at Los Angeles, Box 951735, Los Angeles, CA 90095 1735, USA
    Neuroscience 148:937-48. 2007
    ..Collectively, these results suggest that the serotoninergic innervation is organized according to both cortical type and area, and is thus structured to differentially modulate information processing within the OFC...