S Meizel

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Amino acid neurotransmitter receptor/chloride channels of mammalian sperm and the acrosome reaction
    S Meizel
    Department of Cell Biology and Human Anatomy, University of California School of Medicine, Davis 95616 8643, USA
    Biol Reprod 56:569-74. 1997
  2. ncbi request reprint Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction
    Stanley Meizel
    Department of Cell Biology and Human Anatomy, University of California at Davis, School of Medicine, One Shields Avenue, Davis, CA, USA
    Mol Reprod Dev 72:250-8. 2005
  3. ncbi request reprint The sperm, a neuron with a tail: 'neuronal' receptors in mammalian sperm
    Stanley Meizel
    Department of Cell Biology and Human Anatomy, University of California, Davis School of Medicine, Davis, California, USA
    Biol Rev Camb Philos Soc 79:713-32. 2004
  4. ncbi request reprint Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor
    Jung Ho Son
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California 95616 8643, USA
    Biol Reprod 68:1348-53. 2003
  5. ncbi request reprint The zona pellucida-initiated acrosome reaction: defect due to mutations in the sperm glycine receptor/Cl(-) channel
    Y Sato
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California, 95616 8643, USA
    Dev Biol 227:211-8. 2000
  6. ncbi request reprint A role for the human sperm glycine receptor/Cl(-) channel in the acrosome reaction initiated by recombinant ZP3
    Christopher Bray
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, Davis, California 95616 8643, USA
    Biol Reprod 66:91-7. 2002
  7. ncbi request reprint Acetylcholine causes an increase of intracellular calcium in human sperm
    C Bray
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA, USA
    Mol Hum Reprod 11:881-9. 2005
  8. ncbi request reprint Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) [corrected] in sperm
    Priyadarsini Kumar
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616, USA
    Biochem Biophys Res Commun 342:522-8. 2006
  9. ncbi request reprint Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility
    Christopher Bray
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, 95616 8643, USA
    Biol Reprod 73:807-14. 2005
  10. ncbi request reprint Nicotinic acetylcholine receptor subunits and associated proteins in human sperm
    Priyadarsini Kumar
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 280:25928-35. 2005

Research Grants

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Amino acid neurotransmitter receptor/chloride channels of mammalian sperm and the acrosome reaction
    S Meizel
    Department of Cell Biology and Human Anatomy, University of California School of Medicine, Davis 95616 8643, USA
    Biol Reprod 56:569-74. 1997
    ....
  2. ncbi request reprint Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction
    Stanley Meizel
    Department of Cell Biology and Human Anatomy, University of California at Davis, School of Medicine, One Shields Avenue, Davis, CA, USA
    Mol Reprod Dev 72:250-8. 2005
    ..While defects in either the GlyR or the alpha7nAChR completely inhibit the ZP-initiated AR, fertilization by these mutant sperm can still occur in vitro, probably due to sperm that complete spontaneous AR on the ZP...
  3. ncbi request reprint The sperm, a neuron with a tail: 'neuronal' receptors in mammalian sperm
    Stanley Meizel
    Department of Cell Biology and Human Anatomy, University of California, Davis School of Medicine, Davis, California, USA
    Biol Rev Camb Philos Soc 79:713-32. 2004
    ..The persuasiveness of the evidence varies depending on the receptor being considered, but there is strong experimental support for the presence and importance of a number of 'neuronal' receptors in sperm...
  4. ncbi request reprint Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor
    Jung Ho Son
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California 95616 8643, USA
    Biol Reprod 68:1348-53. 2003
    ..These studies with mouse sperm and ovary-derived ZP strongly support our previous conclusion that activation of an alpha7nAChR is important to the mammalian AR initiated by the egg ZP...
  5. ncbi request reprint The zona pellucida-initiated acrosome reaction: defect due to mutations in the sperm glycine receptor/Cl(-) channel
    Y Sato
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California, 95616 8643, USA
    Dev Biol 227:211-8. 2000
    ..Moreover, a monoclonal antibody against GlyR completely blocked ZP initiation of AR in normal mouse sperm. Our results are consistent with an essential role for the sperm GlyR in the ZP-initiated AR...
  6. ncbi request reprint A role for the human sperm glycine receptor/Cl(-) channel in the acrosome reaction initiated by recombinant ZP3
    Christopher Bray
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, Davis, California 95616 8643, USA
    Biol Reprod 66:91-7. 2002
    ....
  7. ncbi request reprint Acetylcholine causes an increase of intracellular calcium in human sperm
    C Bray
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA, USA
    Mol Hum Reprod 11:881-9. 2005
    ..A Ca2+ influx in the sperm midpiece appeared to accompany the Ca2+ influx seen in the head. These observations confirm an ionotropic role for nAChRs in sperm function...
  8. ncbi request reprint Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) [corrected] in sperm
    Priyadarsini Kumar
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616, USA
    Biochem Biophys Res Commun 342:522-8. 2006
    ....
  9. ncbi request reprint Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility
    Christopher Bray
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, 95616 8643, USA
    Biol Reprod 73:807-14. 2005
    ..This is the first genetic evidence that sperm nicotinic acetylcholine receptors are important for maintenance of normal sperm motility...
  10. ncbi request reprint Nicotinic acetylcholine receptor subunits and associated proteins in human sperm
    Priyadarsini Kumar
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 280:25928-35. 2005
    ..Antagonists of tyrosine phosphorylation inhibited the acetylcholine-initiated acrosome reaction, suggesting the involvement of a SRC kinase in the acrosome reaction...
  11. doi request reprint Identification and spatial distribution of glycine receptor subunits in human sperm
    Priyadarsini Kumar
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California 95616, USA
    Reproduction 136:387-90. 2008
    ....
  12. ncbi request reprint A nicotinic acetylcholine receptor is involved in the arosome reaction of human sperm initiated by recombinant human ZP3
    Christopher Bray
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California 95616 8643, USA
    Biol Reprod 67:782-8. 2002
    ..This nAChR ligand-gated ion channel may be important to the signal transduction events of ZP-initiated AR in vivo...
  13. ncbi request reprint Recognition of a human sperm surface protein involved in the progesterone-initiated acrosome reaction by antisera against an endomembrane progesterone binding protein from porcine liver
    M Buddhikot
    Department of Cell Biology and Human Anatomy, University of California, School of Medicine, Davis 95616 8643, USA
    Mol Cell Endocrinol 158:187-93. 1999
    ..These results suggest that a sperm protein with at least partial homology to the liver endomembrane P4-binding protein, is a putative P4-receptor on the sperm plasma membrane involved in the P4-initiated AR...
  14. ncbi request reprint Human sperm acrosome reaction-initiating activity associated with the human cumulus oophorus and mural granulosa cells
    J E Siiteri
    Department of Human Anatomy, School of Medicine, University of California, Davis 95616
    J Exp Zool 246:71-80. 1988
    ..We propose that the sources of the 50,000 MW human follicular fluid AR activity are the cumulus oophorus and the mural granulosa cells...
  15. ncbi request reprint Detection of glycine receptor/Cl- channel beta subunit transcripts in mouse testis
    Yoko Sato
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, 95616 8643, USA
    Zygote 10:105-8. 2002
    ..In situ hybridisation analysis demonstrated that GlyR beta subunit mRNAs were expressed within the germ cells of seminiferous tubules in those mice...

Research Grants8

  1. SPERM GLYCINE RECEPTOR AND ZONA-INITIATED EXOCYTOSIS
    Stanley Meizel; Fiscal Year: 2000
    ..In Aim 5, the P.I. will solubilze boar sperm membranes and isolate the receptor by affinity chromatography. Biochemical characterization of the isolated receptor will be performed. ..
  2. SPERM GLYCINE RECEPTORS AND ZONA-INITIATED EXOCYTOSIS
    Stanley Meizel; Fiscal Year: 2006
    ..abstract_text> ..